{"id":"https://openalex.org/W4393085394","doi":"https://doi.org/10.1158/1538-7445.am2024-5550","title":"Abstract 5550: Crosstalk of estrogen receptor \u0392 with tumor microenvironment signaling explains tumor suppressor actions in TNBC","display_name":"Abstract 5550: Crosstalk of estrogen receptor \u0392 with tumor microenvironment signaling explains tumor suppressor actions in TNBC","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393085394","doi":"https://doi.org/10.1158/1538-7445.am2024-5550"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-5550","doi":"https://doi.org/10.1158/1538-7445.am2024-5550","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5550","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035249389","display_name":"Kristina Diana A. Zambo","orcid":"https://orcid.org/0000-0003-2247-8104","observed_orcids":["https://orcid.org/0000-0003-2247-8104"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina Diana A. Zambo","raw_affiliation_strings":["1Houston Methodist, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024123429","display_name":"Harika Nagandla","orcid":"https://orcid.org/0000-0003-4528-2390","observed_orcids":["https://orcid.org/0000-0003-4528-2390"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harika Nagandla","raw_affiliation_strings":["1Houston Methodist, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070648208","display_name":"Kim Cuong Cap","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim Cuong Cap","raw_affiliation_strings":["1Houston Methodist, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102634217","display_name":"A.L Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aireana Phillips","raw_affiliation_strings":["1Houston Methodist, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028321649","display_name":"Fotis Nikolos","orcid":"https://orcid.org/0000-0002-8622-0017","observed_orcids":["https://orcid.org/0000-0002-8622-0017"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fotis Nikolos","raw_affiliation_strings":["1Houston Methodist, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018059076","display_name":"Wei Qian","orcid":"https://orcid.org/0009-0006-3344-3555","observed_orcids":["https://orcid.org/0009-0006-3344-3555"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Qian","raw_affiliation_strings":["1Houston Methodist, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052132950","display_name":"Jianying Zhou","orcid":"https://orcid.org/0000-0002-8924-935X","observed_orcids":["https://orcid.org/0000-0002-8924-935X","https://orcid.org/0009-0003-7889-3451"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianying Zhou","raw_affiliation_strings":["1Houston Methodist, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025409813","display_name":"Jenny C. Chang","orcid":"https://orcid.org/0000-0002-0890-9302","observed_orcids":["https://orcid.org/0000-0002-0890-9302"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny Chang","raw_affiliation_strings":["1Houston Methodist, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012771029","display_name":"Christoforos G. Thomas","orcid":"https://orcid.org/0000-0003-3003-2954","observed_orcids":["https://orcid.org/0000-0003-3003-2954"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoforos Thomas","raw_affiliation_strings":["1Houston Methodist, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1295876152"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"5550","last_page":"5550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.859000027179718},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7179999947547913},{"id":"https://openalex.org/keywords/immune-cell-crosstalk","display_name":"immune cell crosstalk","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tumor-suppressor-function","display_name":"tumor suppressor function","score":0.7509999871253967},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5709999799728394},{"id":"https://openalex.org/keywords/ligand-screening","display_name":"ligand screening","score":0.6539999842643738},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.850034773349762},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6768224835395813},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6568519473075867},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6010978817939758},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.568345844745636},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4875728487968445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35101014375686646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32883626222610474},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.30483996868133545},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.27381783723831177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2638740539550781},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22867217659950256},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08896473050117493},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-5550","doi":"https://doi.org/10.1158/1538-7445.am2024-5550","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5550","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7129204529","https://openalex.org/W3201159364","https://openalex.org/W3089911641","https://openalex.org/W4306643011","https://openalex.org/W3033852492","https://openalex.org/W2592318546","https://openalex.org/W2088279063","https://openalex.org/W3130077711","https://openalex.org/W3023849935","https://openalex.org/W4323320156"],"abstract_inverted_index":{"Abstract":[0],"Triple":[1],"Negative":[2],"Breast":[3],"Cancer":[4,298,316],"(TNBC)":[5],"is":[6,60,91],"a":[7,82,102,130],"subtype":[8],"of":[9,17,21,37,45,56,65,97,121,184,196,203,211,226,240,246,250,276,293],"breast":[10,23,28,212],"cancer":[11,213],"lacking":[12],"molecular":[13],"targets,":[14],"possessing":[15],"one":[16],"the":[18,35,63,95,99,117,122,140,168,182,194,197,206,231,237,244,294],"poorest":[19],"prognoses":[20],"all":[22],"cancers.":[24],"Recent":[25],"studies":[26,228],"using":[27],"tumor":[29,67,118,281,285],"samples":[30],"show":[31],"an":[32],"association":[33],"between":[34],"expression":[36],"estrogen":[38,112,277],"receptor":[39,100,124,278],"\u03b2":[40,123],"(ER\u03b2)":[41],"and":[42,70,135,143,152,165,177,180,188,208,219,248],"improved":[43],"survival":[44],"patients":[46],"with":[47,170,221,280],"TNBC.":[48,86,106,251],"ER\u03b2":[49,89,146,204,241],"-":[50,59],"whose":[51],"function":[52,120],"largely":[53],"opposes":[54],"that":[55,138,192,201],"oncogenic":[57],"ER\u03b1":[58],"involved":[61],"in":[62,77,154,163,166,243,288],"regulation":[64],"many":[66],"repressive":[68],"pathways":[69,218],"has":[71],"lately":[72],"been":[73],"observed":[74],"to":[75,93,110,116,133,161,174],"partake":[76],"immune":[78,222],"modulation,":[79],"thus":[80],"presenting":[81],"promising":[83],"target":[84,156],"for":[85,105,145,233,297],"Discovering":[87],"selective":[88],"agonists":[90],"critical":[92],"understanding":[94],"potential":[96,239],"activating":[98],"as":[101,147],"therapy":[103],"approach":[104],"It":[107],"enables":[108],"us":[109],"elicit":[111],"signaling":[113,283],"response":[114],"specific":[115],"suppressive":[119],"subtype.":[125],"We":[126,159,199],"have":[127],"set":[128],"out":[129],"screening":[131],"process":[132],"test":[134],"identify":[136],"ligands":[137],"display":[139],"greatest":[141],"activation":[142,202],"specificity":[144],"determined":[148],"by":[149,215],"reporter":[150],"assays":[151],"changes":[153],"downstream":[155],"gene":[157],"expression.":[158],"selected":[160],"study":[162],"vitro":[164],"vivo":[167],"compounds":[169],"optimal":[171],"biological":[172],"activity":[173],"delineate":[175],"tumor-intrinsic":[176],"-extrinsic":[178],"effects":[179],"validate":[181],"mechanism":[183],"action":[185],"employing":[186],"human":[187],"mouse":[189],"cell":[190],"models":[191],"reflect":[193],"heterogeneity":[195],"disease.":[198],"propose":[200],"decreases":[205],"proliferative":[207],"metastatic":[209],"ability":[210],"cells":[214],"altering":[216],"cellular":[217],"crosstalk":[220],"cells.":[223],"The":[224],"results":[225],"these":[227],"help":[229],"lay":[230],"groundwork":[232],"further":[234],"research":[235],"on":[236],"clinical":[238],"especially":[242],"realm":[245],"immunotherapy":[247],"treatment":[249],"Citation":[252],"Format:":[253],"Kristina":[254],"Diana":[255],"A.":[256],"Zambo,":[257],"Harika":[258],"Nagandla,":[259],"Kim":[260],"Cuong":[261],"Cap,":[262],"Aireana":[263],"Phillips,":[264],"Fotis":[265],"Nikolos,":[266],"Wei":[267],"Qian,":[268],"Jianying":[269],"Zhou,":[270],"Jenny":[271],"Chang,":[272],"Christoforos":[273],"Thomas.":[274],"Crosstalk":[275],"\u0392":[279],"microenvironment":[282],"explains":[284],"suppressor":[286],"actions":[287],"TNBC":[289],"[abstract].":[290],"In:":[291],"Proceedings":[292],"American":[295],"Association":[296],"Research":[299],"Annual":[300],"Meeting":[301],"2024;":[302],"Part":[303],"1":[304],"(Regular":[305],"Abstracts);":[306],"2024":[307],"Apr":[308],"5-10;":[309],"San":[310],"Diego,":[311],"CA.":[312],"Philadelphia":[313],"(PA):":[314],"AACR;":[315],"Res":[317],"2024;84(6_Suppl):Abstract":[318],"nr":[319],"5550.":[320]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-03-23T00:00:00"}
