{"id":"https://openalex.org/W4393085380","doi":"https://doi.org/10.1158/1538-7445.am2024-5540","title":"Abstract 5540: Single cell multiomic analysis of human brain metastasis reveals conserved dormancy population","display_name":"Abstract 5540: Single cell multiomic analysis of human brain metastasis reveals conserved dormancy population","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393085380","doi":"https://doi.org/10.1158/1538-7445.am2024-5540"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-5540","doi":"https://doi.org/10.1158/1538-7445.am2024-5540","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5540","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049861172","display_name":"Remi V. Klotz","orcid":"https://orcid.org/0000-0003-2100-0635","observed_orcids":["https://orcid.org/0000-0003-2100-0635","https://orcid.org/0000-0002-4726-8413"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Remi Klotz","raw_affiliation_strings":["1University of Maryland, Baltimore, Baltimore, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Maryland, Baltimore, Baltimore, MD;","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319144","display_name":"Yiru Wang","orcid":"https://orcid.org/0000-0003-4556-6449","observed_orcids":["https://orcid.org/0000-0003-4556-6449","https://orcid.org/0009-0002-7501-635X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiru Wang","raw_affiliation_strings":["1University of Maryland, Baltimore, Baltimore, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Maryland, Baltimore, Baltimore, MD;","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094221927","display_name":"Anu D. Sunkara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anu Sunkara","raw_affiliation_strings":["1University of Maryland, Baltimore, Baltimore, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Maryland, Baltimore, Baltimore, MD;","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092123070","display_name":"Frank Attenelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Attenelo","raw_affiliation_strings":["2University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039053483","display_name":"Min Yu","orcid":"https://orcid.org/0000-0002-3969-8720","observed_orcids":["https://orcid.org/0000-0002-3969-8720"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Yu","raw_affiliation_strings":["1University of Maryland, Baltimore, Baltimore, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Maryland, Baltimore, Baltimore, MD;","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"5540","last_page":"5540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.10080000013113022,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-dormancy","display_name":"tumor dormancy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/circadian-rhythm-genes","display_name":"circadian rhythm genes","score":0.7940000295639038},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.699999988079071},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7429999709129333},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.9559999704360962},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.9300000071525574},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-subpopulations","display_name":"tumor cell subpopulations","score":0.8420000076293945},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.7269999980926514},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5731506943702698},{"id":"https://openalex.org/C3527866","wikidata":"https://www.wikidata.org/wiki/Q162267","display_name":"Dormancy","level":3,"score":0.5595895051956177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44346556067466736},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.17744308710098267},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.13285386562347412},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.09830641746520996},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-5540","doi":"https://doi.org/10.1158/1538-7445.am2024-5540","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5540","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379984859","https://openalex.org/W4392376328","https://openalex.org/W4384405030","https://openalex.org/W4386790401","https://openalex.org/W3151679678","https://openalex.org/W7148736455","https://openalex.org/W3119930520","https://openalex.org/W7155606386","https://openalex.org/W7132856017","https://openalex.org/W2810255010"],"abstract_inverted_index":{"Abstract":[0],"This":[1,129,146,228,261],"study":[2],"explores":[3],"the":[4,22,69,161,167,218,253,308],"complex":[5],"realm":[6],"of":[7,28,45,221,236,268,296,307],"brain":[8,37,127,174,226,237,250,269,298],"metastasis,":[9,238],"pivotal":[10],"in":[11,35,98,118,126,136,144,160,178,194,206,224,246],"crafting":[12],"effective":[13],"anti-tumor":[14],"strategies.":[15],"Leveraging":[16],"single-cell":[17],"multi-omics":[18,229],"sequencing,":[19],"we":[20,210],"profiled":[21],"transcriptomes":[23],"and":[24,31,68,73,91,164,187,204,242,249,258],"chromatin":[25,66],"accessibility":[26],"landscapes":[27],"tumor":[29,56,72,222,251,259],"cells":[30,110,163],"their":[32,123],"surrounding":[33],"microenvironment":[34],"human":[36,225,297],"metastases":[38,270],"that":[39,134],"originated":[40],"from":[41,107],"across":[42],"a":[43,81,105,153,232,240],"spectrum":[44],"primary":[46],"cancers.":[47],"Our":[48,101],"investigations":[49],"have":[50],"identified":[51],"distinct,":[52],"yet":[53],"uniformly":[54],"present,":[55],"cell":[57,142,199,293],"subpopulations,":[58],"each":[59],"defined":[60],"by":[61,85],"unique":[62],"gene":[63,202],"expression":[64,203],"patterns,":[65],"accessibility,":[67],"interactions":[70],"between":[71,255],"stromal":[74],"cells.":[75],"Notably,":[76],"one":[77],"such":[78],"subpopulation":[79],"exhibits":[80],"dormancy":[82,223,302],"signature,":[83],"characterized":[84],"enhanced":[86],"interferon":[87],"response,":[88],"oxidative":[89],"phosphorylation,":[90],"upregulated":[92],"HLA":[93],"class":[94],"molecules,":[95],"alongside":[96],"alterations":[97],"circadian":[99,119,137,155,256],"rhythms.":[100],"trajectory":[102],"analysis":[103,215,295],"charts":[104],"course":[106],"these":[108],"dormant":[109,162],"to":[111,150,172,189,216],"rapidly":[112],"proliferating":[113],"ones,":[114],"with":[115,131],"notable":[116],"shifts":[117],"rhythm":[120,156],"genes,":[121],"underscoring":[122],"potential":[124,274],"role":[125],"metastasis.":[128],"aligns":[130],"recent":[132],"findings":[133],"disruptions":[135],"rhythms":[138,257],"can":[139],"modify":[140],"stem":[141],"characteristics":[143],"glioblastomas.":[145],"insight":[147],"led":[148],"us":[149],"focus":[151],"on":[152,166],"specific":[154],"gene,":[157],"highly":[158],"active":[159],"located":[165],"HER2":[168],"amplicon\u2014an":[169],"area":[170],"linked":[171],"high":[173],"metastasis":[175,247,299],"relapse":[176],"rates":[177],"patients.":[179],"We've":[180],"developed":[181],"inducible":[182],"models":[183],"for":[184,277,311],"both":[185],"overexpression":[186],"knockdown":[188],"scrutinize":[190],"this":[191],"gene's":[192],"impact":[193],"her2":[195],"positive":[196],"breast":[197],"cancer":[198],"lines,":[200],"examining":[201],"proliferation":[205],"vitro.":[207],"Complementing":[208],"this,":[209],"are":[211],"conducting":[212],"spatial":[213],"transcriptomic":[214],"evaluate":[217],"microenvironmental":[219],"regulation":[220],"metastases.":[227],"approach":[230],"reveals":[231,300],"nuanced":[233],"regulatory":[234],"landscape":[235],"highlighting":[239],"novel":[241],"often":[243],"overlooked":[244],"factor":[245],"progression":[248],"relapse:":[252],"interplay":[254],"dormancy.":[260],"discovery":[262],"not":[263],"only":[264],"deepens":[265],"our":[266],"understanding":[267],"but":[271],"also":[272],"opens":[273],"new":[275],"avenues":[276],"therapeutic":[278],"interventions.":[279],"Citation":[280],"Format:":[281],"Remi":[282],"Klotz,":[283],"Yiru":[284],"Wang,":[285],"Anu":[286],"Sunkara,":[287],"Frank":[288],"Attenelo,":[289],"Min":[290],"Yu.":[291],"Single":[292],"multiomic":[294],"conserved":[301],"population":[303],"[abstract].":[304],"In:":[305],"Proceedings":[306],"American":[309],"Association":[310],"Cancer":[312,330],"Research":[313],"Annual":[314],"Meeting":[315],"2024;":[316],"Part":[317],"1":[318],"(Regular":[319],"Abstracts);":[320],"2024":[321],"Apr":[322],"5-10;":[323],"San":[324],"Diego,":[325],"CA.":[326],"Philadelphia":[327],"(PA):":[328],"AACR;":[329],"Res":[331],"2024;84(6_Suppl):Abstract":[332],"nr":[333],"5540.":[334]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-23T00:00:00"}