{"id":"https://openalex.org/W4393085295","doi":"https://doi.org/10.1158/1538-7445.am2024-7498","title":"Abstract 7498: Acoustophoresis enriches tumor cell clusters from patients with metastatic prostate cancer","display_name":"Abstract 7498: Acoustophoresis enriches tumor cell clusters from patients with metastatic prostate cancer","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393085295","doi":"https://doi.org/10.1158/1538-7445.am2024-7498"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-7498","doi":"https://doi.org/10.1158/1538-7445.am2024-7498","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-7498","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058989650","display_name":"Cecilia Magnusson","orcid":"https://orcid.org/0000-0002-0186-7736","observed_orcids":["https://orcid.org/0000-0002-0186-7736"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Cecilia Magnusson","raw_affiliation_strings":["1Lund University, Lund, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lund University, Lund, Sweden;","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017299669","display_name":"Per Augustsson","orcid":"https://orcid.org/0000-0001-8542-7924","observed_orcids":["https://orcid.org/0000-0001-8542-7924"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Augustsson","raw_affiliation_strings":["1Lund University, Lund, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lund University, Lund, Sweden;","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058015180","display_name":"Andreas Lenshof","orcid":"https://orcid.org/0000-0003-2887-6365","observed_orcids":["https://orcid.org/0000-0003-2887-6365"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andreas Lenshof","raw_affiliation_strings":["1Lund University, Lund, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lund University, Lund, Sweden;","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075364603","display_name":"Andreas Josefsson","orcid":"https://orcid.org/0000-0002-2013-0887","observed_orcids":["https://orcid.org/0000-0002-2013-0887"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andreas Josefsson","raw_affiliation_strings":["2Ume\u00e5 University, Ume\u00e5, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Ume\u00e5 University, Ume\u00e5, Sweden;","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015634061","display_name":"Anders S Bjartell","orcid":"https://orcid.org/0000-0002-5761-3786","observed_orcids":["https://orcid.org/0000-0002-5761-3786"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Bjartell","raw_affiliation_strings":["1Lund University, Lund, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lund University, Lund, Sweden;","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087403158","display_name":"Yvonne Ceder","orcid":"https://orcid.org/0000-0002-8705-8293","observed_orcids":["https://orcid.org/0000-0002-8705-8293"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Yvonne Ceder","raw_affiliation_strings":["1Lund University, Lund, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lund University, Lund, Sweden;","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056770711","display_name":"Hans G. Lilja","orcid":"https://orcid.org/0000-0001-5871-7846","observed_orcids":["https://orcid.org/0000-0001-5871-7846"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans Lilja","raw_affiliation_strings":["3MSKCC, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3MSKCC, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053411065","display_name":"Thomas Laurell","orcid":"https://orcid.org/0000-0002-2486-3607","observed_orcids":["https://orcid.org/0000-0002-2486-3607"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Thomas Laurell","raw_affiliation_strings":["1Lund University, Lund, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lund University, Lund, Sweden;","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"7498","last_page":"7498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acoustophoresis","display_name":"acoustophoresis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ctc-clusters","display_name":"CTC clusters","score":0.75},{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/label-free-cell-separation","display_name":"label-free cell separation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/microfluidic-cell-separation","display_name":"microfluidic cell separation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/cellsearch-comparison","display_name":"CellSearch comparison","score":0.9229999780654907},{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.5350000262260437},{"id":"https://openalex.org/keywords/sample-storage-time","display_name":"sample storage time","score":0.5630000233650208},{"id":"https://openalex.org/keywords/non-invasive-cancer-monitoring","display_name":"non-invasive cancer monitoring","score":0.6880000233650208},{"id":"https://openalex.org/keywords/tumor-cell-aggregates","display_name":"tumor cell aggregates","score":0.45100000500679016},{"id":"https://openalex.org/keywords/white-blood-cell-separation","display_name":"white blood cell separation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/imaging-flow-cytometry","display_name":"imaging flow cytometry","score":0.5720000267028809},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7317255735397339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6537635326385498},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5239420533180237},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48793813586235046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47962531447410583},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4165729880332947}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-7498","doi":"https://doi.org/10.1158/1538-7445.am2024-7498","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-7498","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4395115364","https://openalex.org/W4282914711","https://openalex.org/W2055060669","https://openalex.org/W1493878906","https://openalex.org/W2098193018","https://openalex.org/W2890014866","https://openalex.org/W2475659315","https://openalex.org/W7048269546","https://openalex.org/W2188445635","https://openalex.org/W7007917437"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"A":[2],"subset":[3],"of":[4,20,30,35,76,187,195,234,253,293,296,315,335,367,380,415],"aggressive":[5],"prostate":[6,96,262,410],"cancers":[7],"(PCa)":[8],"progress":[9],"to":[10,14,27,44,61,107,158,277,287,331,357,377],"invade":[11],"surrounding":[12],"tissue":[13],"form":[15],"distant":[16],"metastases":[17],"by":[18,127,131],"shed":[19],"circulating":[21,78],"tumor":[22,79,403],"cells":[23,63,116,154,266],"(CTCs).":[24],"However,":[25],"due":[26],"the":[28,33,74,108,161,237,251,289,329,416],"scarcity":[29],"CTCs":[31,188,196,235,239,297,336],"among":[32,236],"millions":[34],"nucleated":[36,171],"blood":[37,89,92,153,172,281],"cells,":[38],"there":[39],"is":[40,223,286,306,321,362],"an":[41],"unmet":[42],"need":[43],"improve":[45],"CTC":[46,326],"isolation":[47,82],"assays.":[48],"Our":[49,176],"technique":[50],"Acoustophoresis":[51,320,401],"uses":[52],"standing":[53],"ultrasound":[54,159],"waves":[55],"in":[56,119,160,189,298],"a":[57,136,224,307,322,352],"flow-through":[58],"microfluidic":[59],"chamber":[60],"discriminate":[62],"based":[64,123],"on":[65,256],"their":[66],"size,":[67],"density,":[68],"and":[69,99,104,125,129,147,165,185,197,228,267,300,354,361,370],"compressibility.":[70],"Method:":[71],"We":[72,283,318],"analyzed":[73,130],"effectiveness":[75],"acoustophoretic":[77,257],"cell":[80,90,114,203,205,211,264,340,404],"(CTC)":[81],"from":[83,93,170,406],"6":[84],"mL":[85,121],"PFA":[86],"fixed":[87,261],"red":[88],"lysed":[91],"12":[94,120],"metastatic":[95,316,368,409],"cancer":[97,202,263,411],"patients":[98,190,299,407],"20":[100],"healthy":[101],"control":[102,301],"subjects":[103],"compared":[105],"it":[106],"golden":[109],"standard":[110],"CellSearch.":[111,345],"For":[112],"acoustic":[113,294],"separation,":[115],"were":[117,207,213],"diluted":[118],"PBS":[122],"buffer":[124],"separated":[126,169],"acoustophoresis":[128,164,181,222,305,375],"imaging":[132],"flow":[133],"cytometry":[134],"using":[135],"standardized":[137],"antibody":[138],"panel":[139],"(EpCAM,":[140],"cytokeratin,":[141],"CD45,":[142],"CD66b,":[143],"DAPI).":[144],"Generally,":[145],"CTCs,":[146],"clusters":[148,186,206,212,341,379,405],"migrate":[149],"faster":[150],"than":[151,217],"white":[152],"(WBCs)":[155],"when":[156],"exposed":[157],"microchannel":[162],"during":[163],"can":[166,273],"therefore":[167,230],"be":[168,274],"cells.":[173,219],"Major":[174],"findings:":[175],"pilot":[177],"study":[178,292],"shows":[179],"that":[180,270],"finds":[182],"both":[183],"singlets":[184],"as":[191,193,337,339,351],"well":[192,338],"aggregates":[194],"WBCs.":[198,268],"In":[199,220],"total,":[200],"67":[201],"containing":[204,215],"identified.":[208],"Most":[209],"identified":[210],"small,":[214],"less":[216],"4":[218],"addition,":[221],"label-free":[225],"separation":[226,258,295],"technique,":[227],"could":[229],"identify":[231,378],"additional":[232],"subclasses":[233,334],"detected":[238],"with":[240,328,344,364,408],"e.g.,":[241],"EpCAM":[242],"low/-":[243],"expression.":[244],"Further,":[245],"we":[246],"provide":[247],"extensive":[248],"data":[249],"for":[250,260,310,325,419],"effect":[252],"storage":[254],"time":[255],"performance":[259],"line":[265],"Demonstrating":[269],"sample":[271],"processing":[272],"done":[275],"up":[276],"72":[278],"hours":[279],"after":[280],"sampling.":[282],"believe":[284,319],"this":[285],"date":[288],"most":[290],"comprehensive":[291],"subjects.":[302],"Conclusion:":[303],"Label-free":[304],"potential":[308],"method":[309],"future":[311],"non-invasive":[312],"molecular":[313],"interrogation":[314],"cancers.":[317],"promising":[323,353],"technology":[324],"enrichment":[327],"possibility":[330],"detect":[332],"new":[333],"not":[342],"detectable":[343],"CTC-clusters":[346],"has":[347],"previously":[348],"been":[349],"proposed":[350],"potent":[355],"predictor":[356],"monitor":[358],"progressive":[359],"disease":[360,369],"associated":[363],"earlier":[365],"onset":[366],"poor":[371],"prognosis,":[372],"which":[373],"makes":[374],"ability":[376],"high":[381],"interest.":[382],"Citation":[383],"Format:":[384],"Cecilia":[385],"Magnusson,":[386],"Per":[387],"Augustsson,":[388],"Andreas":[389,391],"Lenshof,":[390],"Josefsson,":[392],"Anders":[393],"Bjartell,":[394],"Yvonne":[395],"Ceder,":[396],"Hans":[397],"Lilja,":[398],"Thomas":[399],"Laurell.":[400],"enriches":[402],"[abstract].":[412],"In:":[413],"Proceedings":[414],"American":[417],"Association":[418],"Cancer":[420,438],"Research":[421],"Annual":[422],"Meeting":[423],"2024;":[424],"Part":[425],"1":[426],"(Regular":[427],"Abstracts);":[428],"2024":[429],"Apr":[430],"5-10;":[431],"San":[432],"Diego,":[433],"CA.":[434],"Philadelphia":[435],"(PA):":[436],"AACR;":[437],"Res":[439],"2024;84(6_Suppl):Abstract":[440],"nr":[441],"7498.":[442]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-03-23T00:00:00"}
