{"id":"https://openalex.org/W4393076462","doi":"https://doi.org/10.1158/1538-7445.am2024-1784","title":"Abstract 1784: Glucose metabolism and de novo palmitate synthesis under normoxia and hypoxia in breast cancer cells that preferentially metastasize to lung and liver","display_name":"Abstract 1784: Glucose metabolism and de novo palmitate synthesis under normoxia and hypoxia in breast cancer cells that preferentially metastasize to lung and liver","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393076462","doi":"https://doi.org/10.1158/1538-7445.am2024-1784"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-1784","doi":"https://doi.org/10.1158/1538-7445.am2024-1784","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-1784","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018735247","display_name":"Marjorie Anne Layosa","orcid":"https://orcid.org/0000-0001-5080-0127","observed_orcids":["https://orcid.org/0000-0001-5080-0127"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marjorie Anne A. Layosa","raw_affiliation_strings":["1Purdue University, West Lafayette, IN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Purdue University, West Lafayette, IN;","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104636825","display_name":"Morgan Conrad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan Conrad","raw_affiliation_strings":["1Purdue University, West Lafayette, IN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Purdue University, West Lafayette, IN;","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036400845","display_name":"Stephen David Hursting","orcid":"https://orcid.org/0000-0003-3605-2833","observed_orcids":["https://orcid.org/0000-0003-3605-2833"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Hursting","raw_affiliation_strings":["2University of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026812062","display_name":"Dorothy Teegarden","orcid":"https://orcid.org/0000-0002-7045-3748","observed_orcids":["https://orcid.org/0000-0002-7045-3748"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothy Teegarden","raw_affiliation_strings":["1Purdue University, West Lafayette, IN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Purdue University, West Lafayette, IN;","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"1784","last_page":"1784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.14839999377727509,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.875},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8500000238418579},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/atp-citrate-lyase","display_name":"ATP citrate lyase","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8050000071525574},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-kinase","display_name":"pyruvate dehydrogenase kinase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pyruvate-carboxylase","display_name":"pyruvate carboxylase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9070000052452087},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.5590000152587891},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.5550000071525574},{"id":"https://openalex.org/keywords/etomoxir","display_name":"etomoxir","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6473335027694702},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5779718160629272},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4758974015712738},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.45357808470726013},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4519087076187134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.440592885017395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42200767993927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39892977476119995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3852798044681549},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3837858736515045},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34221315383911133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34090614318847656},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.10938388109207153},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-1784","doi":"https://doi.org/10.1158/1538-7445.am2024-1784","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-1784","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7148709306","https://openalex.org/W4409628725","https://openalex.org/W4417076429","https://openalex.org/W4322739700","https://openalex.org/W7170175130","https://openalex.org/W1522403727","https://openalex.org/W2063631892","https://openalex.org/W2156519214","https://openalex.org/W2123819868","https://openalex.org/W3047352252"],"abstract_inverted_index":{"Abstract":[0],"Cancer":[1,444,462],"cells":[2,22,37,353,428],"are":[3,201],"exposed":[4],"to":[5,23,25,41,101,129,143,192,259,278,293,357,381,394,399,432],"variable":[6],"oxygen":[7,373],"and":[8,46,53,55,95,115,199,309,383,416,423,434],"nutrient":[9],"availability":[10],"during":[11,215],"the":[12,31,71,179,254,280,440],"metastatic":[13],"process":[14],"which":[15,126],"can":[16],"influence":[17],"metabolic":[18,32],"adaptations":[19,33],"of":[20,34,69,122,151,164,187,207,232,239,250,290,439],"cancer":[21,36,352,378,397,427],"metastasize":[24,40,356,431],"distant":[26,400],"sites.":[27],"Thus,":[28,375],"we":[29],"investigated":[30],"breast":[35,351,377,396,426],"that":[38,195,212,241,256,333,346,354,429],"preferentially":[39,355,430],"lung":[42,358,433],"(metM-WntLung":[43],"cells;":[44,49],"MLg)":[45],"liver":[47,435],"(metM-WntLiver":[48],"MLr)":[50],"in":[51,75,80,98,113,140,145,155,169,176,220,224,264,283,285,330,338,341,350,369,371,425],"normoxia":[52,284,422],"hypoxia":[54,424],"at":[56,298],"different":[57,372],"glucose":[58,138,157,276,300,347,382],"concentrations.":[59,160],"In":[60,287],"normoxia,":[61,146,225],"14C-glucose":[62],"uptake":[63],"is":[64,84,173,217,261,328,336,367],"similar,":[65],"but":[66,361],"mRNA":[67,120,162,230,248,312],"abundance":[68,163,231,249,313],"hexokinase,":[70],"initial":[72],"rate-limiting":[73,167],"step":[74,168],"glycolysis,":[76],"was":[77,110,116,303],"22%":[78],"higher":[79,87,112,119,175,219,228,263,306,329,368],"MLg":[81,99,114,141,188,223,339,370],"cells.":[82],"This":[83,302],"consistent":[85,147,226],"with":[86,148,227],"13C6-glucose":[88,109,327],"flux":[89],"into":[90],"glycolytic":[91,319],"metabolites":[92,277],"pyruvate":[93,233,243,251,258],"(M+3)":[94,97],"lactate":[96],"compared":[100,142,191],"MLr.":[102,286],"Also,":[103],"de":[104,322,362,384,417],"novo":[105,323,363,385,418],"palmitate":[106,324,334,419],"synthesis":[107,198,325,335,366,388,420],"from":[108,326],"7.6%":[111],"accompanied":[117,304],"by":[118,153,189,296,305],"expression":[121,206],"ATP-citrate":[123],"lyase":[124],"(ACLY),":[125],"converts":[127,257],"citrate":[128],"acetyl-CoA":[130],"for":[131,203,275,443],"fatty":[132,170,180,196,364,386],"acid":[133,171,181,197,365,387],"synthesis.":[134],"These":[135],"suggest":[136],"greater":[137],"metabolism":[139,415],"MLr":[144,152,221,229,265],"reduced":[149,185],"viability":[150,186,289],"39%":[154],"high":[156,299],"(25":[158],"mM)":[159],"Further,":[161],"CPT1A,":[165],"a":[166,209,237,271,318,391],"oxidation,":[172],"23%":[174],"MLg.":[177,204],"Moreover,":[178],"oxidation":[182,200],"inhibition":[183],"(etomoxir)":[184],"26.7%":[190],"MLr,":[193,291],"suggesting":[194,314,332],"critical":[202],"Protein":[205],"HIF1\u03b1,":[208],"transcription":[210],"factor":[211],"induces":[213],"glycolysis":[214],"hypoxia,":[216,288],"1.5-fold":[218],"than":[222,267],"dehydrogenase":[234,244],"kinase":[235],"(PDK1),":[236],"target":[238],"HIF1\u03b1":[240],"inhibits":[242],"(PDH)":[245],"activity.":[246],"Surprisingly,":[247],"carboxylase":[252],"(PC),":[253],"enzyme":[255],"oxaloacetate,":[260],"also":[262],"(39%)":[266],"MLg,":[268,294,331],"thus":[269],"supporting":[270],"potential":[272,392],"alternative":[273],"mechanism":[274],"enter":[279],"TCA":[281],"cycle":[282],"relative":[292],"increased":[295],"11%":[297],"concentration.":[301],"hexokinase":[307],"(33%)":[308],"PDK1":[310],"(83%)":[311],"MLr\u2019s":[315],"shift":[316],"towards":[317],"phenotype.":[320],"However,":[321],"maintained":[337],"even":[340],"hypoxia.":[342],"Altogether,":[343],"results":[344],"demonstrate":[345],"utilization":[348],"shifts":[349],"vs":[359],"liver,":[360],"conditions.":[374],"targeting":[376],"cells\u2019":[379],"adaptation":[380],"may":[389],"be":[390],"strategy":[393],"prevent":[395],"progression":[398],"organs.":[401],"Citation":[402],"Format:":[403],"Marjorie":[404],"Anne":[405],"A.":[406],"Layosa,":[407],"Morgan":[408],"Conrad,":[409],"Stephen":[410],"Hursting,":[411],"Dorothy":[412],"Teegarden.":[413],"Glucose":[414],"under":[421],"[abstract].":[436],"In:":[437],"Proceedings":[438],"American":[441],"Association":[442],"Research":[445],"Annual":[446],"Meeting":[447],"2024;":[448],"Part":[449],"1":[450],"(Regular":[451],"Abstracts);":[452],"2024":[453],"Apr":[454],"5-10;":[455],"San":[456],"Diego,":[457],"CA.":[458],"Philadelphia":[459],"(PA):":[460],"AACR;":[461],"Res":[463],"2024;84(6_Suppl):Abstract":[464],"nr":[465],"1784.":[466]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-03-23T00:00:00"}
