{"id":"https://openalex.org/W4393076160","doi":"https://doi.org/10.1158/1538-7445.am2024-5851","title":"Abstract 5851: Dysregulated RNA splicing promotes AML quiescence and chemoresistance","display_name":"Abstract 5851: Dysregulated RNA splicing promotes AML quiescence and chemoresistance","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393076160","doi":"https://doi.org/10.1158/1538-7445.am2024-5851"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-5851","doi":"https://doi.org/10.1158/1538-7445.am2024-5851","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5851","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100746973","display_name":"Eric Wang","orcid":"https://orcid.org/0000-0001-7865-6702","observed_orcids":["https://orcid.org/0000-0001-7865-6702"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Wang","raw_affiliation_strings":["1The Jackson Laboratory for Genomic Medicine, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory for Genomic Medicine, Farmington, CT;","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029143645","display_name":"Cuijuan Han","orcid":"https://orcid.org/0000-0002-7165-7785","observed_orcids":["https://orcid.org/0000-0002-7165-7785"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cuijuan Han","raw_affiliation_strings":["1The Jackson Laboratory for Genomic Medicine, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory for Genomic Medicine, Farmington, CT;","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039025820","display_name":"Alexander Calderon","orcid":"https://orcid.org/0000-0002-7134-6282","observed_orcids":["https://orcid.org/0000-0002-7134-6282"]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Calderon","raw_affiliation_strings":["1The Jackson Laboratory for Genomic Medicine, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory for Genomic Medicine, Farmington, CT;","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104262881","display_name":"Abimbo Lawal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abimbo Lawal","raw_affiliation_strings":["1The Jackson Laboratory for Genomic Medicine, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory for Genomic Medicine, Farmington, CT;","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039599082","display_name":"Nidhi Hariramani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nidhi Hariramani","raw_affiliation_strings":["1The Jackson Laboratory for Genomic Medicine, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Jackson Laboratory for Genomic Medicine, Farmington, CT;","institution_ids":["https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021875398","display_name":"Edie I. Crosse","orcid":"https://orcid.org/0000-0002-0477-7365","observed_orcids":["https://orcid.org/0000-0002-0477-7365"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edie Crosse","raw_affiliation_strings":["2Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032741707","display_name":"Robert K. Bradley","orcid":"https://orcid.org/0000-0002-8046-1063","observed_orcids":["https://orcid.org/0000-0002-8046-1063"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Bradley","raw_affiliation_strings":["2Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"5851","last_page":"5851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.843999981880188},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.843999981880188},{"id":"https://openalex.org/keywords/btg2","display_name":"BTG2","score":0.996999979019165},{"id":"https://openalex.org/keywords/relapsed-aml","display_name":"relapsed AML","score":0.7829999923706055},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.796999990940094},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.6107219457626343},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.60624760389328},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5494208335876465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4828672707080841},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45000767707824707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.430003821849823},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.4166988134384155},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23250970244407654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20027482509613037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-5851","doi":"https://doi.org/10.1158/1538-7445.am2024-5851","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5851","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412119851","https://openalex.org/W2004879467","https://openalex.org/W4389233834","https://openalex.org/W4417004256","https://openalex.org/W4392243740","https://openalex.org/W4312070028","https://openalex.org/W7167661438","https://openalex.org/W4417223417","https://openalex.org/W4401244672","https://openalex.org/W2885591944"],"abstract_inverted_index":{"Abstract":[0],"Chemotherapy":[1],"is":[2,88,108],"the":[3,75,79,190],"first-line":[4],"treatment":[5],"for":[6,193],"patients":[7,22,36,65],"with":[8,25],"acute":[9],"myeloid":[10],"leukemia":[11],"(AML).":[12],"Although":[13],"most":[14],"achieve":[15],"initial":[16],"remission,":[17],"an":[18,109,142],"estimated":[19],"50%":[20],"of":[21,31,55,62,78,125,189],"will":[23],"relapse":[24,38,69,92],"poor":[26],"clinical":[27],"outcome.":[28],"The":[29],"paucity":[30],"genetic":[32],"lesions":[33],"in":[34,59,90,131,137],"AML":[35,64,91,132,182],"that":[37,44,74,101,114,145],"from":[39],"chemotherapy":[40,96,129,147,160],"implicate":[41],"non-genetic":[42],"alterations":[43],"mediate":[45],"chemoresistance.":[46],"In":[47],"this":[48],"study,":[49],"we":[50,99],"conducted":[51],"a":[52,60,118,151],"longitudinal":[53],"analysis":[54],"alternative":[56],"splicing":[57,180],"changes":[58],"cohort":[61],"19":[63],"at":[66],"diagnosis":[67],"and":[68,94,120,149,184],"post-chemotherapy":[70],"treatment.":[71],"We":[72],"found":[73],"long":[76],"isoform":[77],"transcription":[80],"factor-encoding":[81],"gene":[82,105],"RUNX1":[83],"(also":[84],"known":[85],"as":[86],"RUNX1C)":[87],"upregulated":[89],"cohorts":[93],"conferred":[95],"resistance.":[97],"Mechanistically,":[98],"show":[100],"B":[102],"cell":[103],"translocation":[104],"2":[106],"(BTG2)":[107],"RUNX1C":[110,126],"isoform-specific":[111,143],"transcriptional":[112],"target":[113],"promote":[115],"transition":[116],"into":[117],"quiescent":[119],"treatment-resistant":[121],"state.":[122],"Direct":[123],"targeting":[124],"mRNA":[127],"augments":[128],"response":[130],"patient-derived":[133],"xenograft":[134],"(PDX)":[135],"models":[136],"vivo.":[138],"These":[139],"findings":[140],"uncover":[141],"functionality":[144],"influences":[146],"responsiveness":[148],"offers":[150],"therapeutic":[152],"strategy":[153],"to":[154,158],"sensitize":[155],"leukemic":[156],"cells":[157],"conventional":[159],"treatments.":[161],"Citation":[162],"Format:":[163],"Eric":[164],"Wang,":[165],"Cuijuan":[166],"Han,":[167],"Alexander":[168],"Calderon,":[169],"Abimbo":[170],"Lawal,":[171],"Nidhi":[172],"Hariramani,":[173],"Edie":[174],"Crosse,":[175],"Robert":[176],"Bradley.":[177],"Dysregulated":[178],"RNA":[179],"promotes":[181],"quiescence":[183],"chemoresistance":[185],"[abstract].":[186],"In:":[187],"Proceedings":[188],"American":[191],"Association":[192],"Cancer":[194,212],"Research":[195],"Annual":[196],"Meeting":[197],"2024;":[198],"Part":[199],"1":[200],"(Regular":[201],"Abstracts);":[202],"2024":[203],"Apr":[204],"5-10;":[205],"San":[206],"Diego,":[207],"CA.":[208],"Philadelphia":[209],"(PA):":[210],"AACR;":[211],"Res":[213],"2024;84(6_Suppl):Abstract":[214],"nr":[215],"5851.":[216]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-03-23T00:00:00"}