{"id":"https://openalex.org/W4393076005","doi":"https://doi.org/10.1158/1538-7445.am2024-3115","title":"Abstract 3115: Systematic analysis of gene mutations and therapeutic efficacy via ex vivo hematological vitroscreen platform","display_name":"Abstract 3115: Systematic analysis of gene mutations and therapeutic efficacy via ex vivo hematological vitroscreen platform","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393076005","doi":"https://doi.org/10.1158/1538-7445.am2024-3115"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-3115","doi":"https://doi.org/10.1158/1538-7445.am2024-3115","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-3115","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009443091","display_name":"Fu-Ju Chou","orcid":"https://orcid.org/0000-0002-0727-5416","observed_orcids":["https://orcid.org/0000-0002-0727-5416"]},"institutions":[{"id":"https://openalex.org/I4210136821","display_name":"Champions Oncology (United States)","ror":"https://ror.org/04gbdgm24","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136821"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fu-Ju Chou","raw_affiliation_strings":["1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ","institution_ids":["https://openalex.org/I4210136821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064003777","display_name":"Stefano Cairo","orcid":"https://orcid.org/0000-0002-4725-5970","observed_orcids":["https://orcid.org/0000-0002-4725-5970"]},"institutions":[{"id":"https://openalex.org/I4210136821","display_name":"Champions Oncology (United States)","ror":"https://ror.org/04gbdgm24","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136821"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefano Cairo","raw_affiliation_strings":["1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ","institution_ids":["https://openalex.org/I4210136821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008592521","display_name":"Mara Gilardi","orcid":"https://orcid.org/0000-0001-8730-3642","observed_orcids":["https://orcid.org/0000-0001-8730-3642"]},"institutions":[{"id":"https://openalex.org/I4210136821","display_name":"Champions Oncology (United States)","ror":"https://ror.org/04gbdgm24","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136821"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mara Gilardi","raw_affiliation_strings":["1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ","institution_ids":["https://openalex.org/I4210136821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031866950","display_name":"Abhay U. Andar","orcid":"https://orcid.org/0000-0001-6647-7870","observed_orcids":["https://orcid.org/0000-0001-6647-7870"]},"institutions":[{"id":"https://openalex.org/I4210136821","display_name":"Champions Oncology (United States)","ror":"https://ror.org/04gbdgm24","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136821"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhay Andar","raw_affiliation_strings":["1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ","institution_ids":["https://openalex.org/I4210136821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010521632","display_name":"Karin Abarca-Heidemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136821","display_name":"Champions Oncology (United States)","ror":"https://ror.org/04gbdgm24","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136821"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karin Abarca-Heidemann","raw_affiliation_strings":["1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ","institution_ids":["https://openalex.org/I4210136821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101996583","display_name":"Maria Mancini","orcid":"https://orcid.org/0000-0001-9379-7335","observed_orcids":["https://orcid.org/0000-0001-9379-7335"]},"institutions":[{"id":"https://openalex.org/I4210136821","display_name":"Champions Oncology (United States)","ror":"https://ror.org/04gbdgm24","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136821"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Mancini","raw_affiliation_strings":["1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Champions Oncology, Inc. (Hackensack, NJ), Hackensack, NJ","institution_ids":["https://openalex.org/I4210136821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210136821"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"3115","last_page":"3115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/flt3-mutation","display_name":"FLT3 mutation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gilteritinib","display_name":"gilteritinib","score":0.9919999837875366},{"id":"https://openalex.org/keywords/flt3-inhibitors","display_name":"FLT3 inhibitors","score":0.949999988079071},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.6499999761581421},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.8320000171661377},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6119999885559082},{"id":"https://openalex.org/keywords/patient-derived-cell-models","display_name":"patient-derived cell models","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.5090000033378601},{"id":"https://openalex.org/keywords/high-throughput-drug-screening","display_name":"high-throughput drug screening","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cell-surface-markers","display_name":"cell surface markers","score":0.6779999732971191},{"id":"https://openalex.org/keywords/relapsed-refractory-aml","display_name":"relapsed/refractory AML","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8592571020126343},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5448701977729797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4659493863582611},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4321366548538208},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4200848937034607},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3768506646156311},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3672851324081421},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34640419483184814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33588504791259766}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-3115","doi":"https://doi.org/10.1158/1538-7445.am2024-3115","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-3115","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3012614383","https://openalex.org/W2615038909","https://openalex.org/W7117246573","https://openalex.org/W4389231005","https://openalex.org/W3033269068","https://openalex.org/W2970298208","https://openalex.org/W2972731908","https://openalex.org/W4225159491","https://openalex.org/W3088000764","https://openalex.org/W2901218741"],"abstract_inverted_index":{"Abstract":[0],"Acute":[1],"myeloid":[2],"leukemia":[3],"(AML)":[4],"is":[5,221],"a":[6,30,76,173,222],"common":[7],"hematological":[8,72,94,259],"malignancy":[9],"found":[10],"in":[11,23,40,47,56,66,125,172,180,202,213],"adult":[12],"patients,":[13,128],"and":[14,86,97,113,129,253],"FMS-like":[15],"tyrosine":[16],"kinase":[17],"3":[18,32],"gene":[19,251],"(FLT3)":[20],"mutation":[21],"occurs":[22],"about":[24],"30%":[25],"of":[26,61,83,131,141,152,178,190,230,250,265],"patients.":[27,53],"In":[28,117],"2019,":[29],"phase":[31],"clinical":[33,109,215],"trial":[34],"suggested":[35],"that":[36,219],"gilteritinib":[37,124,145,163],"treatment":[38,146],"resulted":[39],"significantly":[41,159],"longer":[42],"survival":[43],"than":[44,164,187],"salvage":[45],"chemotherapy":[46],"relapsed":[48],"or":[49],"refractory":[50],"FLT3-mutated":[51],"AML":[52,57,127,192],"Targeting":[54],"FLT3-mutants":[55,156,182],"has":[58],"become":[59],"one":[60],"the":[62,81,153,181,188,203,211,266],"important":[63],"therapeutic":[64,254],"strategies":[65],"this":[67,118],"decade.":[68],"The":[69],"ex":[70,257],"vivo":[71,120,258],"VitroScreen":[73,220],"platform":[74,261],"provides":[75],"powerful":[77],"tool":[78,226],"to":[79,162,200],"evaluate":[80],"performance":[82],"FLT3":[84],"inhibitors":[85],"other":[87],"test":[88],"articles.":[89],"With":[90],"Champions":[91],"Oncology\u2019s":[92],"primary":[93],"repository":[95],"(https://www.championsoncology.com/hematological-vitroscreen)":[96],"proprietary":[98],"LUMIN":[99],"Bioinformatics":[100],"platform,":[101],"we":[102,122],"classified":[103],"models":[104,132,157,166,179,193],"based":[105,149],"on":[106,150],"patient":[107],"responses,":[108],"annotation,":[110],"NGS":[111],"data,":[112],"cell":[114,142],"surface":[115],"markers.":[116],"Ex":[119],"study,":[121],"tested":[123],"30":[126],"8":[130],"were":[133,147],"identified":[134],"as":[135],"FLT-3":[136],"mutants\u2019":[137],"carrier.":[138],"Fold":[139],"changes":[140],"viability":[143],"after":[144],"assessed":[148],"quantitation":[151],"ATP":[154],"present.":[155],"showed":[158],"higher":[160,185],"sensitivity":[161],"FLT3-WT":[165,204],"(IC50,":[167],"132.56":[168],"nM":[169],"vs.":[170],"234.16nM)":[171],"6-day":[174],"assay.":[175],"Only":[176],"25%":[177],"group":[183],"had":[184],"IC50":[186,195],"average":[189],"all":[191],"(n=28,":[194],"=":[196],"204.05":[197],"nM),":[198],"compared":[199],"53%":[201],"group.":[205],"Our":[206],"preclinical":[207],"data":[208],"highly":[209],"match":[210],"observations":[212],"previous":[214],"trials,":[216],"which":[217],"suggest":[218],"reliable":[223],"high":[224],"throughput":[225],"for":[227,269],"drug":[228,231],"development":[229],"resistant":[232],"cancers.":[233],"Citation":[234],"Format:":[235],"Fu-Ju":[236],"Chou,":[237],"Stefano":[238],"Cairo,":[239],"Mara":[240],"Gilardi,":[241],"Abhay":[242],"Andar,":[243],"Karin":[244],"Abarca-Heidemann,":[245],"Maria":[246],"Mancini.":[247],"Systematic":[248],"analysis":[249],"mutations":[252],"efficacy":[255],"via":[256],"vitroscreen":[260],"[abstract].":[262],"In:":[263],"Proceedings":[264],"American":[267],"Association":[268],"Cancer":[270,288],"Research":[271],"Annual":[272],"Meeting":[273],"2024;":[274],"Part":[275],"1":[276],"(Regular":[277],"Abstracts);":[278],"2024":[279],"Apr":[280],"5-10;":[281],"San":[282],"Diego,":[283],"CA.":[284],"Philadelphia":[285],"(PA):":[286],"AACR;":[287],"Res":[289],"2024;84(6_Suppl):Abstract":[290],"nr":[291],"3115.":[292]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-03-23T00:00:00"}
