{"id":"https://openalex.org/W4393075437","doi":"https://doi.org/10.1158/1538-7445.am2024-5521","title":"Abstract 5521: Nicotine promotes perineural brain metastasis of lung cancer by activating GABAergic neurons","display_name":"Abstract 5521: Nicotine promotes perineural brain metastasis of lung cancer by activating GABAergic neurons","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393075437","doi":"https://doi.org/10.1158/1538-7445.am2024-5521"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-5521","doi":"https://doi.org/10.1158/1538-7445.am2024-5521","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5521","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002422880","display_name":"Shih-Ying Wu","orcid":"https://orcid.org/0000-0002-0439-0806","observed_orcids":["https://orcid.org/0000-0002-0439-0806"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shih-Ying Wu","raw_affiliation_strings":["1Wake Forest University School of Medicine, Winston-Salem, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Wake Forest University School of Medicine, Winston-Salem, NC;","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002955341","display_name":"Abhishek Tyagi","orcid":"https://orcid.org/0000-0002-0155-2099","observed_orcids":["https://orcid.org/0000-0002-0155-2099"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhishek Tyagi","raw_affiliation_strings":["1Wake Forest University School of Medicine, Winston-Salem, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Wake Forest University School of Medicine, Winston-Salem, NC;","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046135518","display_name":"Ravindra Pramod Deshpande","orcid":"https://orcid.org/0000-0002-4634-9967","observed_orcids":["https://orcid.org/0000-0002-4634-9967"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravindra Pramod Deshpande","raw_affiliation_strings":["1Wake Forest University School of Medicine, Winston-Salem, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Wake Forest University School of Medicine, Winston-Salem, NC;","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011443826","display_name":"Kerui Wu","orcid":"https://orcid.org/0000-0002-5504-8875","observed_orcids":["https://orcid.org/0000-0002-5504-8875"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerui Wu","raw_affiliation_strings":["2University of North Carolina Greensboro, Greensboro, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of North Carolina Greensboro, Greensboro, NC","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102633920","display_name":"Eleanor Cecile Smith","orcid":"https://orcid.org/0000-0001-8502-8974","observed_orcids":["https://orcid.org/0000-0001-8502-8974"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleanor Cecile Smith","raw_affiliation_strings":["1Wake Forest University School of Medicine, Winston-Salem, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Wake Forest University School of Medicine, Winston-Salem, NC;","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039382964","display_name":"Kounosuke Watabe","orcid":"https://orcid.org/0000-0001-7441-6322","observed_orcids":["https://orcid.org/0000-0001-7441-6322"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kounosuke Watabe","raw_affiliation_strings":["1Wake Forest University School of Medicine, Winston-Salem, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Wake Forest University School of Medicine, Winston-Salem, NC;","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"5521","last_page":"5521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.8220000267028809},{"id":"https://openalex.org/keywords/lung-cancer-brain-metastasis","display_name":"lung cancer brain metastasis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/gabaergic-neurons","display_name":"GABAergic neurons","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gat1","display_name":"GABA transporter 1","score":0.7839999794960022},{"id":"https://openalex.org/keywords/microglial-polarization","display_name":"microglial polarization","score":0.7110000252723694},{"id":"https://openalex.org/keywords/m2-microglia","display_name":"M2 microglia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/gaba-shunt","display_name":"GABA shunt","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.6039999723434448},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.753000020980835},{"id":"https://openalex.org/keywords/gaba-release","display_name":"GABA release","score":0.5820000171661377},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.6733282208442688},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.6535338163375854},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6043129563331604},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6009321212768555},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.580952525138855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5746926665306091},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5373382568359375},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46027445793151855},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.31424903869628906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31366896629333496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23123949766159058},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.04821160435676575}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-5521","doi":"https://doi.org/10.1158/1538-7445.am2024-5521","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5521","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7204257172","https://openalex.org/W2955911554","https://openalex.org/W3028978477","https://openalex.org/W4282960362","https://openalex.org/W4409629310","https://openalex.org/W2954500708","https://openalex.org/W4407757493","https://openalex.org/W7130720388","https://openalex.org/W3181601066","https://openalex.org/W2056074587"],"abstract_inverted_index":{"Abstract":[0],"Tobacco":[1],"smoking":[2,16,199,220,253,258],"significantly":[3,202],"increases":[4],"the":[5,11,32,56,74,99,106,112,128,177,188,207,217,268,279,319,322,341,359,379,420],"incidence":[6,33],"of":[7,34,45,98,105,130,135,180,209,219,245,270,281,321,337,361,381,409,419],"brain":[8,18,22,35,51,133,150,184,213,225,236,274,386,407],"metastasis.":[9,52,214,275,387],"However,":[10,123],"pathological":[12],"mechanism":[13],"by":[14,94,152,186,243,331,358,412],"which":[15,49,148,286],"promotes":[17,149,405],"metastasis":[19,36,134,151,185,226,237,408],"through":[20,318],"modulating":[21],"microenvironment":[23],"is":[24,37,125],"yet":[25],"poorly":[26],"understood.":[27],"We":[28,138,172,191,255],"previously":[29],"showed":[30],"that":[31,140,161,175,193,257,349,368],"associated":[38],"with":[39,197,233,298,385],"nicotine":[40,141,222,246,260,277],"intake.":[41],"Nicotine":[42,404],"enhanced":[43,352],"polarization":[44],"M2":[46,262],"pro-tumor":[47],"microglia,":[48,285],"promoted":[50,287],"In":[53],"addition":[54],"to":[55,90,144,167,306],"immune":[57],"surveillance":[58],"role,":[59],"microglial":[60],"cells":[61,68,182,238,297,366],"also":[62,173],"control":[63],"neuronal":[64],"synapse":[65,71,81],"formation.":[66],"Microglial":[67],"promote":[69,91],"neuron":[70],"formation":[72,93,156,205],"in":[73,111,132,212,227,251,272,314,364],"developing":[75],"brain,":[76,113],"whereas":[77],"microglia":[78,143,263,311,351],"depletion":[79],"suppresses":[80,183],"density.":[82],"Furthermore,":[83,276],"microglia-secreted":[84],"microRNAs":[85],"(miRNAs)":[86],"have":[87],"been":[88],"shown":[89],"synaptic":[92,155,204,265],"targeting":[95],"synapse-related":[96],"genes":[97],"DKK-Wnt":[100],"family.":[101],"Neurons":[102],"are":[103,116],"one":[104],"most":[107],"abundant":[108],"cell":[109,170],"types":[110],"and":[114,157,206,221,240,259,267,295,367],"they":[115],"highly":[117],"specialized":[118],"for":[119,378,423],"cell-to-cell":[120],"signal":[121],"activation.":[122],"little":[124],"known":[126],"about":[127],"roles":[129],"neurons":[131,304,356,415],"lung":[136,194,234,382,410],"cancer.":[137],"hypothesize":[139,174],"stimulates":[142],"secrete":[145],"exosomal":[146],"miR-32-3p,":[147],"augmenting":[153],"GABAergic":[154,291,342,414],"hence":[158],"releasing":[159],"GABA":[160,178,189,210,271,288,323,327,353,362],"serves":[162,372],"as":[163,373],"a":[164,198,252,334,369,374],"metabolic":[165],"substrate":[166],"fuel":[168],"tumor":[169,181,316,344,365],"growth.":[171],"inhibiting":[176],"transporter":[179,211,328],"blocking":[187],"shunt.":[190],"found":[192,256],"cancer":[195,235,383,411],"patients":[196,384],"history":[200],"had":[201],"higher":[203],"expression":[208,269],"To":[215],"investigate":[216],"effect":[218],"intake":[223],"on":[224],"vivo,":[228],"mice":[229],"were":[230],"intracardially":[231],"transplanted":[232],"(H2030BrM":[239],"PC9BrM)":[241],"followed":[242,357],"administration":[244],"or":[247,333],"cigarette":[248],"smoke":[249],"exposure":[250],"chamber.":[254],"increased":[261,278,315],"polarization,":[264],"formation,":[266],"mouse":[273],"secretion":[280],"miR-32-3p":[282],"from":[283,290,303,309,355],"nicotine-pretreated":[284],"release":[289,354],"neurons.":[292],"Treating":[293],"H2030BrM":[294],"PC9BrM":[296],"conditioned":[299],"medium":[300],"(CM)":[301],"obtained":[302],"exposed":[305],"CM":[307],"derived":[308],"nicotine-treated":[310],"exosomes":[312],"resulted":[313],"growth":[317],"activation":[320],"shunt":[324,363],"pathway.":[325],"Blocking":[326],"1":[329,430],"(GAT1)":[330],"CRISPR/Cas9":[332],"small":[335],"molecule":[336],"GAT1":[338],"inhibitor":[339,371],"suppressed":[340],"neuron-induced":[343],"progression.":[345],"Our":[346],"results":[347],"indicate":[348],"nicotine-activated":[350],"promotion":[360],"GAT":[370],"promising":[375],"therapeutic":[376],"tool":[377],"treatment":[380],"Citation":[388],"Format:":[389],"Shih-Ying":[390],"Wu,":[391,398],"Abhishek":[392],"Tyagi,":[393],"Ravindra":[394],"Pramod":[395],"Deshpande,":[396],"Kerui":[397],"Eleanor":[399],"Cecile":[400],"Smith,":[401],"Kounosuke":[402],"Watabe.":[403],"perineural":[406],"activating":[413],"[abstract].":[416],"In:":[417],"Proceedings":[418],"American":[421],"Association":[422],"Cancer":[424,442],"Research":[425],"Annual":[426],"Meeting":[427],"2024;":[428],"Part":[429],"(Regular":[431],"Abstracts);":[432],"2024":[433],"Apr":[434],"5-10;":[435],"San":[436],"Diego,":[437],"CA.":[438],"Philadelphia":[439],"(PA):":[440],"AACR;":[441],"Res":[443],"2024;84(6_Suppl):Abstract":[444],"nr":[445],"5521.":[446]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-23T00:00:00"}