{"id":"https://openalex.org/W4393074995","doi":"https://doi.org/10.1158/1538-7445.am2024-6168","title":"Abstract 6168: Sex-distinct patterns of molecular pathways associated with brain tumor edema","display_name":"Abstract 6168: Sex-distinct patterns of molecular pathways associated with brain tumor edema","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393074995","doi":"https://doi.org/10.1158/1538-7445.am2024-6168"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-6168","doi":"https://doi.org/10.1158/1538-7445.am2024-6168","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6168","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087584073","display_name":"Pamela Jackson","orcid":"https://orcid.org/0000-0002-8424-4007","observed_orcids":["https://orcid.org/0000-0002-8424-4007"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela R. Jackson","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055893427","display_name":"Lee A. Curtin","orcid":"https://orcid.org/0000-0002-4083-3803","observed_orcids":["https://orcid.org/0000-0002-4083-3803"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee Curtin","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078763626","display_name":"Sara Ranjbar","orcid":"https://orcid.org/0000-0002-4344-1282","observed_orcids":["https://orcid.org/0000-0002-4344-1282"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Ranjbar","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027970167","display_name":"Kyle Singleton","orcid":"https://orcid.org/0000-0002-9969-8474","observed_orcids":["https://orcid.org/0000-0002-9969-8474"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle W. Singleton","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014909652","display_name":"Maciej M. Mruga\u0142a","orcid":"https://orcid.org/0000-0002-4027-7173","observed_orcids":["https://orcid.org/0000-0002-4027-7173"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maciej M. Mrugala","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049823734","display_name":"Richard S. Zimmerman","orcid":"https://orcid.org/0000-0002-9911-6817","observed_orcids":["https://orcid.org/0000-0002-9911-6817"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard S. Zimmerman","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018865729","display_name":"Bernard R. Bendok","orcid":"https://orcid.org/0000-0002-3506-3074","observed_orcids":["https://orcid.org/0000-0002-3506-3074"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard R. Bendok","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046673359","display_name":"Peter Canoll","orcid":"https://orcid.org/0000-0002-7001-0226","observed_orcids":["https://orcid.org/0000-0002-7001-0226"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Canoll","raw_affiliation_strings":["2Columbia University Irving Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Columbia University Irving Medical Center, New York, NY","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014011778","display_name":"Kristin R. Swanson","orcid":"https://orcid.org/0000-0002-2464-6119","observed_orcids":["https://orcid.org/0000-0002-2464-6119"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin R. Swanson","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"6168","last_page":"6168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9909999966621399},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.8569999933242798},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"gene set enrichment analysis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cell-type-deconvolution","display_name":"cell type deconvolution","score":0.9639999866485596},{"id":"https://openalex.org/keywords/respiratory-pathways","display_name":"respiratory pathways","score":0.5789999961853027},{"id":"https://openalex.org/keywords/t2-weighted-mri","display_name":"T2-weighted MRI","score":0.7289999723434448},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C3019162651","wikidata":"https://www.wikidata.org/wiki/Q979168","display_name":"Brain edema","level":2,"score":0.5464391708374023},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5090045928955078},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42753419280052185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4267459213733673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39037802815437317},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.34786200523376465},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32068461179733276}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-6168","doi":"https://doi.org/10.1158/1538-7445.am2024-6168","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6168","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404236999","https://openalex.org/W4309017525","https://openalex.org/W4280553465","https://openalex.org/W1982550524","https://openalex.org/W2927665237","https://openalex.org/W39675087","https://openalex.org/W2899814549","https://openalex.org/W4385546544","https://openalex.org/W6927159489","https://openalex.org/W2131147182"],"abstract_inverted_index":{"Abstract":[0],"Magnetic":[1],"resonance":[2],"imaging":[3,22,256],"(MRI)":[4],"is":[5,24,36],"a":[6,53],"centerpiece":[7],"of":[8,11,28,56,108,114,175,190,229,257,291,302],"clinical":[9],"management":[10],"brain":[12,39,230,296],"tumor":[13,40,231,297],"patients,":[14],"yet":[15],"the":[16,100,106,226,237,303],"biology":[17,35],"underlying":[18],"even":[19],"commonly":[20],"interpreted":[21],"changes":[23,212,241],"unclear.":[25],"The":[26,80,92],"purpose":[27],"this":[29],"project":[30],"was":[31,47],"to":[32,60,104,188,224,253],"understand":[33],"what":[34],"associated":[37,232,294],"with":[38,73,215,244,295],"edema":[41,64,101,148,298],"abundance":[42,65],"and":[43,77,84,89,94,112,151,162,170,185,247,259],"if":[44],"that":[45],"association":[46],"sex":[48],"distinct.":[49],"We":[50],"have":[51,180],"developed":[52],"two-compartment":[54],"model":[55,103],"MRI":[57,243],"signal":[58],"intensity":[59,78],"quantitatively":[61],"estimate":[62,105],"relative":[63],"from":[66,133,218],"T2-weighted":[67],"MRIs.":[68],"Multiparametric":[69],"MRIs":[70,214],"were":[71,82,97,144,201,209],"preprocessed":[72,95],"bias":[74],"field":[75],"correction":[76],"normalization.":[79],"images":[81,96],"co-registered":[83],"segmented":[85],"for":[86,140,203,306],"abnormal":[87],"regions":[88,189],"normal":[90],"tissue.":[91],"segmentations":[93],"utilized":[98],"in":[99],"mathematical":[102],"fraction":[107,113],"extracellular":[109],"space":[110,116],"(Fecs)":[111],"intracellular":[115],"(Fics).":[117],"Through":[118,167],"an":[119,222],"ongoing":[120],"image-localized":[121,219],"biopsy":[122],"collection":[123],"protocol,":[124],"we":[125,179],"analyzed":[126],"179":[127],"samples":[128,200,208],"(Female:":[129,136],"75;":[130],"Male:":[131,138],"104)":[132],"55":[134],"patients":[135,258],"21;":[137],"34)":[139],"bulk":[141],"RNA-Seq.":[142],"Samples":[143],"characterized":[145],"by":[146],"their":[147],"Fecs":[149],"scores":[150],"underwent":[152],"differential":[153,168],"expression,":[154],"gene":[155,171,183],"set":[156,172],"enrichment":[157,173],"analysis":[158],"using":[159,165],"MSigDB":[160],"hallmarks":[161],"cellular":[163,245],"deconvolution":[164],"CIBERSORTx.":[166],"expression":[169,184],"analyses":[174],"these":[176],"spatial":[177],"biopsies,":[178],"identified":[181],"sex-distinct":[182,238],"pathways":[186,249,293],"corresponding":[187],"high":[191],"vs":[192],"low":[193],"edema.":[194,234],"Within":[195],"highly":[196],"edematous":[197],"regions,":[198],"male":[199],"amplified":[202],"respiratory":[204],"pathways,":[205],"while":[206],"female":[207],"suppressed.":[210],"Connecting":[211],"on":[213,242],"molecular":[216,248,292],"markers":[217],"biopsies":[220],"provides":[221],"opportunity":[223],"identify":[225],"biological":[227],"drivers":[228],"imageable":[233],"Specifically,":[235],"elucidating":[236],"patterns":[239,290],"connecting":[240],"populations":[246],"could":[250],"be":[251],"used":[252],"better":[254],"interpret":[255],"interpreting":[260],"treatment":[261],"response.":[262],"Citation":[263],"Format:":[264],"Pamela":[265],"R.":[266,282,287],"Jackson,":[267],"Lee":[268],"Curtin,":[269],"Sara":[270],"Ranjbar,":[271],"Kyle":[272],"W.":[273],"Singleton,":[274],"Maciej":[275],"M.":[276],"Mrugala,":[277],"Richard":[278],"S.":[279],"Zimmerman,":[280],"Bernard":[281],"Bendok,":[283],"Peter":[284],"Canoll,":[285],"Kristin":[286],"Swanson.":[288],"Sex-distinct":[289],"[abstract].":[299],"In:":[300],"Proceedings":[301],"American":[304],"Association":[305],"Cancer":[307,325],"Research":[308],"Annual":[309],"Meeting":[310],"2024;":[311],"Part":[312],"1":[313],"(Regular":[314],"Abstracts);":[315],"2024":[316],"Apr":[317],"5-10;":[318],"San":[319],"Diego,":[320],"CA.":[321],"Philadelphia":[322],"(PA):":[323],"AACR;":[324],"Res":[326],"2024;84(6_Suppl):Abstract":[327],"nr":[328],"6168.":[329]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-23T00:00:00"}