{"id":"https://openalex.org/W4393074936","doi":"https://doi.org/10.1158/1538-7445.am2024-6223","title":"Abstract 6223: Personalized MRI-informed forecasting of prostate cancer progression during active surveillance","display_name":"Abstract 6223: Personalized MRI-informed forecasting of prostate cancer progression during active surveillance","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393074936","doi":"https://doi.org/10.1158/1538-7445.am2024-6223"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-6223","doi":"https://doi.org/10.1158/1538-7445.am2024-6223","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2024-6223","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034372072","display_name":"Guillermo Lorenzo Gomez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148771","display_name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago","ror":"https://ror.org/05n7xcf53","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210148771"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Guillermo Lorenzo Gomez","raw_affiliation_strings":["1Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain;","institution_ids":["https://openalex.org/I4210148771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012404343","display_name":"Chengyue Wu","orcid":"https://orcid.org/0000-0002-3789-404X","observed_orcids":["https://orcid.org/0000-0002-3789-404X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chengyue Wu","raw_affiliation_strings":["2The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032806351","display_name":"Joshua P. Yung","orcid":"https://orcid.org/0000-0003-3752-5997","observed_orcids":["https://orcid.org/0000-0003-3752-5997"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua P. Yung","raw_affiliation_strings":["2The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051786644","display_name":"John Francis Ward","orcid":"https://orcid.org/0000-0001-6027-8774","observed_orcids":["https://orcid.org/0000-0001-6027-8774"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. Ward","raw_affiliation_strings":["2The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050535603","display_name":"H\u00e9ctor G\u00f3mez","orcid":"https://orcid.org/0000-0002-2553-9091","observed_orcids":["https://orcid.org/0000-0002-2553-9091"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hector Gomez","raw_affiliation_strings":["3Purdue University, West Lafayette, IN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Purdue University, West Lafayette, IN;","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020143872","display_name":"Alessandro Reali","orcid":"https://orcid.org/0000-0002-0639-7067","observed_orcids":["https://orcid.org/0000-0002-0639-7067"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Reali","raw_affiliation_strings":["4University of Pavia, Pavia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of Pavia, Pavia, Italy;","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027619317","display_name":"Thomas E. Yankeelov","orcid":"https://orcid.org/0000-0001-6201-3913","observed_orcids":["https://orcid.org/0000-0001-6201-3913"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Yankeelov","raw_affiliation_strings":["5The University of Texas at Austin, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047017840","display_name":"Aradhana M. Venkatesan","orcid":"https://orcid.org/0000-0002-5033-0820","observed_orcids":["https://orcid.org/0000-0002-5033-0820"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aradhana M. Venkatesan","raw_affiliation_strings":["2The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031451887","display_name":"Thomas J.R. Hughes","orcid":"https://orcid.org/0000-0001-7024-8368","observed_orcids":["https://orcid.org/0000-0001-7024-8368","https://orcid.org/0009-0008-4299-5145"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Hughes","raw_affiliation_strings":["5The University of Texas at Austin, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"6223","last_page":"6223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0551999993622303,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/active-surveillance","display_name":"active surveillance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-progression-prediction","display_name":"tumor progression prediction","score":0.6520000100135803},{"id":"https://openalex.org/keywords/multiparametric-mri","display_name":"multiparametric MRI","score":0.9039999842643738},{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tumor-cell-density","display_name":"tumor cell density","score":0.7919999957084656},{"id":"https://openalex.org/keywords/prostate-segmentation","display_name":"prostate segmentation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/deformable-image-registration","display_name":"deformable image registration","score":0.6119999885559082},{"id":"https://openalex.org/keywords/low-and-intermediate-risk-prostate-cancer","display_name":"low- and intermediate-risk prostate cancer","score":0.6850000023841858},{"id":"https://openalex.org/keywords/diffusion-weighted-imaging","display_name":"diffusion-weighted imaging","score":0.7310000061988831},{"id":"https://openalex.org/keywords/longitudinal-imaging","display_name":"longitudinal imaging","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7336091995239258},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6956692934036255},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5552416443824768},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5021641254425049},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47876039147377014},{"id":"https://openalex.org/C2910607126","wikidata":"https://www.wikidata.org/wiki/Q48790829","display_name":"Multiparametric MRI","level":4,"score":0.4270308017730713},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41854023933410645},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3558470606803894}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-6223","doi":"https://doi.org/10.1158/1538-7445.am2024-6223","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2024-6223","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362543739","https://openalex.org/W4282969523","https://openalex.org/W4387348558","https://openalex.org/W4392357705","https://openalex.org/W7133725429","https://openalex.org/W7168484868","https://openalex.org/W4415990258","https://openalex.org/W4379282350","https://openalex.org/W4319333219","https://openalex.org/W3173933350"],"abstract_inverted_index":{"Abstract":[0],"Low":[1],"and":[2,34,95,150,236,320,335,339,346,349,372,378,383,415,444],"intermediate-risk":[3],"prostate":[4,35,160,479],"cancer":[5,480],"(PCa)":[6],"patients":[7,115],"are":[8,173,193,420],"eligible":[9],"for":[10,196,311,492],"active":[11,483],"surveillance":[12,484],"(AS),":[13],"whereby":[14],"treatment":[15,445],"is":[16,23,155,163,220,429],"delayed":[17,63],"until":[18],"progression":[19,405,436,481],"to":[20,74,123,244,282,433],"higher-risk":[21],"disease":[22],"detected":[24],"via":[25],"longitudinal":[26,190],"multiparametric":[27],"magnetic":[28],"resonance":[29],"imaging":[30,191],"(mpMRI)":[31],"scans,":[32],"biopsies,":[33],"specific":[36],"antigen":[37],"(PSA)":[38],"tests.":[39],"However,":[40],"AS":[41,76,438],"relies":[42],"on":[43,157,165],"a":[44,62,78,89,105,144,240,252,256,306,331,430],"population-based":[45],"observational":[46],"paradigm":[47,81],"in":[48,61,134,227,437],"which":[49,162],"standard":[50,100],"testing":[51],"frequencies":[52],"may":[53],"not":[54],"match":[55],"the":[56,137,158,189,201,204,211,215,224,232,245,263,274,342,352,367,394,398,489],"patient\u2019s":[57,159],"tumor":[58,85,140,147,205,228,241,268,312,327],"dynamics,":[59],"resulting":[60],"diagnosis":[64],"of":[65,136,139,146,214,258,276,314,326,337,347,360,370,380,389,397,403,478,488],"progressive":[66],"disease.":[67],"To":[68,186],"address":[69],"these":[70,422],"issues,":[71],"we":[72,103,238,250],"propose":[73],"advance":[75],"towards":[77],"patient-specific":[79],"predictive":[80],"by":[82,93,222,406],"leveraging":[83],"computational":[84],"forecasts":[86,266],"obtained":[87,120,181,209,305,392],"with":[88,108,203],"biomechanistic":[90,129],"model":[91,130,154,202,219,265,318],"informed":[92],"mpMRI":[94,118,344,354],"clinical":[96],"data":[97],"collected":[98],"during":[99,126,447,482],"AS.":[101,127,448],"Here,":[102],"present":[104],"retrospective":[106],"study":[107],"n":[109,291,301],"=":[110,292,302],"16":[111],"PCa":[112,132,361,390,404,435],"cases.":[113],"All":[114],"had":[116],"three":[117],"scans":[119],"over":[121,417],"2.6":[122],"5.6":[124],"years":[125],"Our":[128],"describes":[131],"growth":[133],"terms":[135],"dynamics":[138],"cell":[141,148,170,206,229,328],"density":[142,171,207,230,329],"as":[143,285],"combination":[145],"mobility":[149],"net":[151],"proliferation.":[152],"The":[153,218,323,357,386],"defined":[156],"geometry,":[161],"segmented":[164],"T2-weighted":[166],"MRI":[167,184],"data.":[168,185],"Tumor":[169],"estimates":[172],"derived":[174],"from":[175,182,210,255,262,393],"apparent":[176],"diffusion":[177],"coefficient":[178,309],"(ADC)":[179],"maps":[180],"diffusion-weighted":[183],"facilitate":[187],"modeling,":[188],"datasets":[192],"non-rigidly":[194],"co-registered":[195],"each":[197],"patient.":[198],"We":[199,304],"initialize":[200],"map":[208,213],"ADC":[212],"first":[216],"scan.":[217],"parameterized":[221],"minimizing":[223],"model-data":[225],"mismatch":[226],"at":[231,273,316,341,351,374],"second":[233,343],"scan":[234,247],"date,":[235,345,355],"then":[237],"perform":[239],"forecast":[242],"up":[243],"third":[246,353],"date.":[248],"Finally,":[249],"build":[251],"logistic":[253,358],"classifier":[254,359],"panel":[257],"model-based":[259,399],"biomarkers":[260,400],"calculated":[261],"personalized":[264],"(e.g.,":[267],"volume,":[269],"total":[270],"proliferation":[271],"activity)":[272],"times":[275],"histopathological":[277],"assessment":[278],"(i.e.,":[279],"biopsy,":[280],"surgery)":[281],"classify":[283],"tumors":[284],"low":[286],"risk":[287,296,362,391],"(Gleason":[288,297],"score":[289,298,334],"3+3,":[290],"16)":[293],"or":[294],"intermediate-high":[295],"\u2265":[299],"3+4,":[300],"15).":[303],"concordance":[307],"correlation":[308],"(CCC)":[310],"volume":[313],"0.89":[315],"both":[317],"calibration":[319],"forecasting":[321,427,477],"horizon.":[322],"spatial":[324],"fit":[325],"yielded":[330,363],"median":[332],"Dice":[333],"CCC":[336],"0.80":[338],"0.59":[340],"0.76":[348],"0.60":[350],"respectively.":[356,385],"an":[364],"area":[365],"under":[366],"ROC":[368],"curve":[369],"0.90":[371],"operates":[373],"optimal":[375],"sensitivity,":[376],"specificity,":[377],"accuracy":[379],"86.7%,":[381],"93.8%,":[382],"90.3%,":[384],"time":[387],"trajectories":[388],"temporal":[395],"predictions":[396],"enabled":[401],"identification":[402],"more":[407],"than":[408],"1":[409,499],"year.":[410],"Thus,":[411],"while":[412],"further":[413],"development":[414],"validation":[416],"larger":[418],"cohorts":[419],"required,":[421],"results":[423],"suggest":[424],"that":[425],"our":[426],"technology":[428],"promising":[431],"tool":[432],"predict":[434],"and,":[439],"hence,":[440],"optimally":[441],"guide":[442],"monitoring":[443],"decisions":[446],"Citation":[449],"Format:":[450],"Guillermo":[451],"Lorenzo":[452],"Gomez,":[453,463],"Chengyue":[454],"Wu,":[455],"Joshua":[456],"P.":[457],"Yung,":[458],"John":[459],"F.":[460],"Ward,":[461],"Hector":[462],"Alessandro":[464],"Reali,":[465],"Thomas":[466,472],"E.":[467],"Yankeelov,":[468],"Aradhana":[469],"M.":[470],"Venkatesan,":[471],"J.":[473],"Hughes.":[474],"Personalized":[475],"MRI-informed":[476],"[abstract].":[485],"In:":[486],"Proceedings":[487],"American":[490],"Association":[491],"Cancer":[493,511],"Research":[494],"Annual":[495],"Meeting":[496],"2024;":[497],"Part":[498],"(Regular":[500],"Abstracts);":[501],"2024":[502],"Apr":[503],"5-10;":[504],"San":[505],"Diego,":[506],"CA.":[507],"Philadelphia":[508],"(PA):":[509],"AACR;":[510],"Res":[512],"2024;84(6_Suppl):Abstract":[513],"nr":[514],"6223.":[515]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-03-23T00:00:00"}
