{"id":"https://openalex.org/W4393074846","doi":"https://doi.org/10.1158/1538-7445.am2024-1213","title":"Abstract 1213: Tissue-specific thresholds and microenvironment correlates of tumor mutation burden associated with immunotherapy benefit and prognosis in microsatellite stable cancers","display_name":"Abstract 1213: Tissue-specific thresholds and microenvironment correlates of tumor mutation burden associated with immunotherapy benefit and prognosis in microsatellite stable cancers","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393074846","doi":"https://doi.org/10.1158/1538-7445.am2024-1213"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-1213","doi":"https://doi.org/10.1158/1538-7445.am2024-1213","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-1213","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072425742","display_name":"Maishara Muquith","orcid":"https://orcid.org/0000-0002-9333-8558","observed_orcids":["https://orcid.org/0000-0002-9333-8558"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maishara Muquith","raw_affiliation_strings":["1UT Southwestern, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Southwestern, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017646772","display_name":"Magdalena Espinoza","orcid":"https://orcid.org/0009-0003-3830-0746","observed_orcids":["https://orcid.org/0009-0003-3830-0746"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magdalena Espinoza","raw_affiliation_strings":["1UT Southwestern, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Southwestern, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029537789","display_name":"Andrew Elliott","orcid":"https://orcid.org/0000-0001-8494-8031","observed_orcids":["https://orcid.org/0000-0001-8494-8031"]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Elliott","raw_affiliation_strings":["2Caris Life Sciences, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Caris Life Sciences, Dallas, TX;","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080544645","display_name":"Joanne Xiu","orcid":"https://orcid.org/0000-0001-8744-5827","observed_orcids":["https://orcid.org/0000-0001-8744-5827"]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne Xiu","raw_affiliation_strings":["2Caris Life Sciences, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Caris Life Sciences, Dallas, TX;","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081366644","display_name":"Andreas Seeber","orcid":"https://orcid.org/0000-0001-8529-7824","observed_orcids":["https://orcid.org/0000-0001-8529-7824"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andreas Seeber","raw_affiliation_strings":["3Medical University of Innsbruck, Innsbruck, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Medical University of Innsbruck, Innsbruck, Austria;","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075201353","display_name":"Wafik S. El\u2010Deiry","orcid":"https://orcid.org/0000-0002-9577-8266","observed_orcids":["https://orcid.org/0000-0002-9577-8266"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wafik El-Deiry","raw_affiliation_strings":["4Brown University, Providence, RI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Brown University, Providence, RI;","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018645768","display_name":"Emmanuel S. Antonarakis","orcid":"https://orcid.org/0000-0003-0031-9655","observed_orcids":["https://orcid.org/0000-0003-0031-9655","https://orcid.org/0000-0003-3531-3851"]},"institutions":[{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel S. Antonarakis","raw_affiliation_strings":["5Masonic Cancer Center, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Masonic Cancer Center, Minneapolis, MN;","institution_ids":["https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060200394","display_name":"Stephanie L. Graff","orcid":"https://orcid.org/0000-0003-1928-1722","observed_orcids":["https://orcid.org/0000-0003-1928-1722"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Graff","raw_affiliation_strings":["4Brown University, Providence, RI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Brown University, Providence, RI;","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009072858","display_name":"Michael J. Hall","orcid":"https://orcid.org/0000-0003-4515-3409","observed_orcids":["https://orcid.org/0000-0003-4515-3409"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Hall","raw_affiliation_strings":["6Fox Chase Cancer Center, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Fox Chase Cancer Center, Philadelphia, PA;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012061864","display_name":"Hossein Borghaei","orcid":"https://orcid.org/0000-0002-2577-4454","observed_orcids":["https://orcid.org/0000-0002-2577-4454"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hossein Borghaei","raw_affiliation_strings":["6Fox Chase Cancer Center, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Fox Chase Cancer Center, Philadelphia, PA;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029428307","display_name":"Dave S.\ufffdB. Hoon","orcid":"https://orcid.org/0000-0003-1915-3683","observed_orcids":["https://orcid.org/0000-0003-1915-3683"]},"institutions":[{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dave S. Hoon","raw_affiliation_strings":["7Saint John's Cancer Institute, Santa Monica, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Saint John's Cancer Institute, Santa Monica, CA;","institution_ids":["https://openalex.org/I4210104056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043871151","display_name":"Stephen V. Liu","orcid":"https://orcid.org/0000-0002-4852-3914","observed_orcids":["https://orcid.org/0000-0002-4852-3914"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen V. Liu","raw_affiliation_strings":["8Georgetown University, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Georgetown University, Washington, DC;","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058710250","display_name":"Patrick C. Ma","orcid":"https://orcid.org/0000-0002-8425-1223","observed_orcids":["https://orcid.org/0000-0002-8425-1223"]},"institutions":[{"id":"https://openalex.org/I4405268258","display_name":"Penn State Cancer Institute","ror":"https://ror.org/00bzx1854","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405268258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick C. Ma","raw_affiliation_strings":["9Penn State Cancer Institute, Hershey, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Penn State Cancer Institute, Hershey, PA;","institution_ids":["https://openalex.org/I4405268258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058325420","display_name":"Rana R. McKay","orcid":"https://orcid.org/0000-0002-0581-7963","observed_orcids":["https://orcid.org/0000-0002-0581-7963"]},"institutions":[{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rana R. McKay","raw_affiliation_strings":["10Moores Cancer Center, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Moores Cancer Center, San Diego, CA;","institution_ids":["https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061224094","display_name":"Trisha Michel Wise-Draper","orcid":"https://orcid.org/0000-0002-7279-4028","observed_orcids":["https://orcid.org/0000-0002-7279-4028"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trisha Wise-Draper","raw_affiliation_strings":["11University of Cincinnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11University of Cincinnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061373605","display_name":"John Lindsay Marshall","orcid":"https://orcid.org/0000-0002-3449-2344","observed_orcids":["https://orcid.org/0000-0002-3449-2344"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Marshall","raw_affiliation_strings":["8Georgetown University, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Georgetown University, Washington, DC;","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066769011","display_name":"George W. Sledge","orcid":"https://orcid.org/0000-0003-0297-0775","observed_orcids":["https://orcid.org/0000-0003-0297-0775"]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George W. Sledge","raw_affiliation_strings":["2Caris Life Sciences, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Caris Life Sciences, Dallas, TX;","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082951042","display_name":"David B. Spetzler","orcid":"https://orcid.org/0000-0002-9531-0970","observed_orcids":["https://orcid.org/0000-0002-9531-0970"]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Spetzler","raw_affiliation_strings":["2Caris Life Sciences, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Caris Life Sciences, Dallas, TX;","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068560690","display_name":"Hao Zhu","orcid":"https://orcid.org/0000-0002-8417-9698","observed_orcids":["https://orcid.org/0000-0002-8417-9698","https://orcid.org/0009-0005-1863-978X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Zhu","raw_affiliation_strings":["1UT Southwestern, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Southwestern, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017798169","display_name":"David Hsieh","orcid":"https://orcid.org/0000-0002-5428-3494","observed_orcids":["https://orcid.org/0000-0002-5428-3494"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Hsieh","raw_affiliation_strings":["1UT Southwestern, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Southwestern, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"1213","last_page":"1213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.9940000176429749},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pd-1-pd-l1-blockade","display_name":"PD-1/PD-L1 blockade","score":0.9259999990463257},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5619999766349792},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.6060000061988831},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.7390000224113464},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9739999771118164},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.753000020980835},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":0.9649999737739563},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6556650400161743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4996337890625},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4967237114906311},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.4645725190639496},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4435957074165344},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4429682791233063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41623181104660034},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40543609857559204},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3885852098464966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2932519018650055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1991334855556488},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.11856907606124878},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09113010764122009}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-1213","doi":"https://doi.org/10.1158/1538-7445.am2024-1213","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-1213","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393147316","https://openalex.org/W4386293163","https://openalex.org/W4409690513","https://openalex.org/W4281673946","https://openalex.org/W4281650266","https://openalex.org/W2909679049","https://openalex.org/W4362580434","https://openalex.org/W4389250357","https://openalex.org/W2987711192","https://openalex.org/W4223939762"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Immune":[2],"checkpoint":[3,78],"inhibitors":[4],"(ICIs)":[5],"targeting":[6],"anti-PD-1/L1":[7,75,365],"have":[8,352],"expanded":[9],"the":[10,46,101,118,149,274,280,288,362,369,375,453],"treatment":[11,104,317],"landscape":[12],"against":[13],"cancers,":[14,200],"but":[15,121],"are":[16],"only":[17],"effective":[18],"in":[19,56,117,225,249,263,268,344,374,445],"a":[20,36,57,251,325,335,345],"subset":[21,346],"of":[22,39,103,165,205,328,347,364,371,378,435,452],"patients":[23,63,135],"across":[24,65,216,331],"all":[25,226],"cancer":[26,107,155,174,230,294,332],"types.":[27,108,156],"Tumor":[28],"mutation":[29,437],"burden":[30,438],"(TMB)":[31],"is":[32],"postulated":[33],"to":[34,148,265,360],"be":[35,255],"generic":[37],"determinant":[38],"ICI":[40,119,131,302,379],"dependent-tumor":[41],"rejection.":[42],"Here,":[43],"we":[44],"clarify":[45],"association":[47],"between":[48,338],"TMB":[49,145,152,180,236,247,271,290,298,305,329,339,358],"and":[50,81,96,132,197,208,210,218,233,316,334,340,356,367,432,443],"survival":[51,167,184,252,282,309,320],"outcomes":[52,341],"among":[53],"microsatellite-stable":[54],"cancers":[55,448],"real-world":[58],"clinicogenomic":[59],"cohort":[60],"including":[61],"70,698":[62],"distributed":[64],"27":[66,171],"histologies.":[67],"Methods:":[68],"Patients":[69,109],"were":[70,115,124,136,158,213,238,285,322],"segregated":[71],"into":[72],"mutually":[73],"exclusive":[74],"(N=14,736,":[76],"immune":[77],"inhibitor,":[79],"ICI)":[80],"non-ICI":[82,97,133],"cohorts":[83],"(N=55,962)":[84],"if":[85],"they":[86],"had":[87,176],"received":[88],"pembrolizumab,":[89],"nivolumab,":[90],"atezolizumab,":[91],"durvalumab,":[92],"avelumab,":[93],"or":[94,141,311],"cemiplimab,":[95],"therapies,":[98,366],"respectively,":[99],"during":[100],"course":[102],"for":[105,153,292,354,456],"individual":[106,154,293],"treated":[110],"with":[111,183,240,243,257,273,301,308,440],"chemo-immunotherapy":[112],"combination":[113],"regimens":[114],"included":[116],"cohorts,":[120,134],"anti-CTLA-4":[122],"agents":[123],"excluded":[125],"from":[126,260],"both":[127,130],"cohorts.":[128],"For":[129],"reiteratively":[137],"categorized":[138],"as":[139,201,203,279],"TMB-high":[140],"-low":[142],"using":[143,161],"increasing":[144],"thresholds":[146,272,431],"up":[147],"90th":[150],"percentile":[151],"Outcomes":[157],"then":[159],"assessed":[160],"Cox":[162],"regression":[163],"analyses":[164],"overall":[166],"(OS).":[168],"Results:":[169],"Across":[170],"histologies,":[172],"12":[173],"types":[175,231],"at":[177],"least":[178],"one":[179],"cutoff":[181,248],"associated":[182,239,307,439],"benefit":[185,253,310,442],"upon":[186],"ICIs":[187,258],"(melanoma,":[188],"NSCLC,":[189],"SCLC,":[190],"bladder,":[191],"cervical,":[192],"colorectal,":[193],"gastric,":[194],"ovarian,":[195],"head":[196],"neck,":[198],"vulvar":[199],"well":[202],"carcinoma":[204],"unknown":[206],"primary,":[207],"sarcoma),":[209],"these":[211],"associations":[212],"generally":[214],"conserved":[215],"sex":[217],"age":[219],"groups,":[220],"although":[221],"not":[222],"necessarily":[223],"significant":[224],"cases.":[227],"In":[228],"two":[229],"(cholangiocarcinoma":[232],"neuroendocrine":[234],"tumors),":[235],"cutoffs":[237,330,359],"worse":[241],"OS":[242],"ICIs.":[244],"The":[245],"lowest":[246,281],"which":[250],"could":[254],"detected":[256],"ranged":[259],"2":[261],"mut/Mb":[262,267],"melanoma":[264],"9":[266],"colorectal":[269],"cancer.":[270],"greatest":[275],"predictive":[276],"value":[277],"(defined":[278],"hazard":[283],"ratio)":[284],"frequently":[286],"near":[287],"highest":[289],"examined":[291],"types,":[295,333],"suggesting":[296],"that":[297],"may":[299,351],"scale":[300],"benefit.":[303],"Conclusion:":[304],"was":[306,342],"detriment":[312],"depending":[313],"on":[314],"tissue":[315,372],"context.":[318],"Detectable":[319],"benefits":[321],"noted":[323],"over":[324],"broad":[326],"range":[327],"dose-dependent":[336],"relationship":[337],"observed":[343],"cancers.":[348],"These":[349],"results":[350],"implications":[353],"cancer-agnostic":[355],"universal":[357],"guide":[361],"use":[363],"underline":[368],"importance":[370],"context":[373],"clinical":[376],"development":[377],"biomarkers.":[380],"Citation":[381],"Format:":[382],"Maishara":[383],"Muquith,":[384],"Magdalena":[385],"Espinoza,":[386],"Andrew":[387],"Elliott,":[388],"Joanne":[389],"Xiu,":[390],"Andreas":[391],"Seeber,":[392],"Wafik":[393],"El-Deiry,":[394],"Emmanuel":[395],"S.":[396,406],"Antonarakis,":[397],"Stephanie":[398],"Graff,":[399],"Michael":[400],"J.":[401],"Hall,":[402],"Hossein":[403],"Borghaei,":[404],"Dave":[405],"Hoon,":[407],"Stephen":[408],"V.":[409],"Liu,":[410],"Patrick":[411],"C.":[412],"Ma,":[413],"Rana":[414],"R.":[415],"McKay,":[416],"Trisha":[417],"Wise-Draper,":[418],"John":[419],"Marshall,":[420],"George":[421],"W.":[422],"Sledge,":[423],"David":[424,428],"Spetzler,":[425],"Hao":[426],"Zhu,":[427],"Hsieh.":[429],"Tissue-specific":[430],"microenvironment":[433],"correlates":[434],"tumor":[436],"immunotherapy":[441],"prognosis":[444],"microsatellite":[446],"stable":[447],"[abstract].":[449],"In:":[450],"Proceedings":[451],"American":[454],"Association":[455],"Cancer":[457,475],"Research":[458],"Annual":[459],"Meeting":[460],"2024;":[461],"Part":[462],"1":[463],"(Regular":[464],"Abstracts);":[465],"2024":[466],"Apr":[467],"5-10;":[468],"San":[469],"Diego,":[470],"CA.":[471],"Philadelphia":[472],"(PA):":[473],"AACR;":[474],"Res":[476],"2024;84(6_Suppl):Abstract":[477],"nr":[478],"1213.":[479]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-03-23T00:00:00"}
