{"id":"https://openalex.org/W4393074409","doi":"https://doi.org/10.1158/1538-7445.am2024-772","title":"Abstract 772: Investigation of gender disparity in liver tumor formation using a hydrodynamic tail vein injection mouse model","display_name":"Abstract 772: Investigation of gender disparity in liver tumor formation using a hydrodynamic tail vein injection mouse model","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393074409","doi":"https://doi.org/10.1158/1538-7445.am2024-772"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-772","doi":"https://doi.org/10.1158/1538-7445.am2024-772","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-772","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Araceli Bernal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Araceli Bernal","raw_affiliation_strings":["1The University of Texas Health Science Center At San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas Health Science Center At San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101321736","display_name":"Morgana McLaughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgana McLaughlin","raw_affiliation_strings":["1The University of Texas Health Science Center At San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas Health Science Center At San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075986880","display_name":"Ankur Tiwari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ankur Tiwari","raw_affiliation_strings":["1The University of Texas Health Science Center At San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas Health Science Center At San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060716953","display_name":"Francisco G. Cigarroa","orcid":"https://orcid.org/0000-0002-7432-8880","observed_orcids":["https://orcid.org/0000-0002-7432-8880"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco Cigarroa","raw_affiliation_strings":["1The University of Texas Health Science Center At San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas Health Science Center At San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056931880","display_name":"Lu\u2010Zhe Sun","orcid":"https://orcid.org/0000-0001-7117-4559","observed_orcids":["https://orcid.org/0000-0001-7117-4559"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LuZhe Sun","raw_affiliation_strings":["1The University of Texas Health Science Center At San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas Health Science Center At San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"772","last_page":"772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8299999833106995},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.5860000252723694},{"id":"https://openalex.org/keywords/hydrodynamic-tail-vein-injection","display_name":"hydrodynamic tail vein injection","score":0.9129999876022339},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.8100000023841858},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8230000138282776},{"id":"https://openalex.org/keywords/sleeping-beauty-transposon","display_name":"Sleeping Beauty transposon","score":0.9909999966621399},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumor-burden","display_name":"tumor burden","score":0.527999997138977},{"id":"https://openalex.org/keywords/bioluminescence-imaging","display_name":"bioluminescence imaging","score":0.7279999852180481},{"id":"https://openalex.org/keywords/transgene-integration","display_name":"transgene integration","score":0.5149999856948853},{"id":"https://openalex.org/keywords/liver-cancer-risk-factors","display_name":"liver cancer risk factors","score":0.4269999861717224},{"id":"https://openalex.org/keywords/hormonal-regulation-of-tumor-growth","display_name":"hormonal regulation of tumor growth","score":0.5720000267028809},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.6610000133514404},{"id":"https://openalex.org/keywords/fvb-nj-mice","display_name":"FVB/NJ mice","score":0.7229999899864197},{"id":"https://openalex.org/keywords/luciferase","display_name":"luciferase","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2777202286","wikidata":"https://www.wikidata.org/wiki/Q9609","display_name":"Vein","level":2,"score":0.5315316319465637},{"id":"https://openalex.org/C3017562151","wikidata":"https://www.wikidata.org/wiki/Q632901","display_name":"Tail vein","level":3,"score":0.4383099377155304},{"id":"https://openalex.org/C2779033008","wikidata":"https://www.wikidata.org/wiki/Q464543","display_name":"Portal vein","level":2,"score":0.4277316927909851},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3901440501213074},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.368272602558136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3657756447792053},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3512389063835144},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.328971803188324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3210684657096863},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11745494604110718},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.08685523271560669}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-772","doi":"https://doi.org/10.1158/1538-7445.am2024-772","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-772","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409624324","https://openalex.org/W2581834274","https://openalex.org/W3015285797","https://openalex.org/W2078648547","https://openalex.org/W2922546709","https://openalex.org/W2089033948","https://openalex.org/W2998175365","https://openalex.org/W1982082371","https://openalex.org/W2356526981","https://openalex.org/W2321633126"],"abstract_inverted_index":{"Abstract":[0],"The":[1,47,94,294],"incidence":[2],"of":[3,10,84,106,118,155,168,211,242,265,343,447,465],"hepatocellular":[4],"carcinoma":[5],"(HCC),":[6],"the":[7,82,87,104,110,113,119,204,220,228,239,259,266,279,312,317,330,350,363,401,407,432,466],"major":[8],"form":[9],"liver":[11,48,107,240,318,451],"cancer,":[12],"is":[13,25,31,49,55,292,366],"4":[14],"times":[15],"higher":[16,299],"in":[17,20,37,41,109,131,140,181,213,238,258,278,349,368,382,388,450],"men":[18],"than":[19,227,311,329],"women.":[21],"This":[22],"gender":[23,120,138,256,448],"disparity":[24,121,139,449],"difficult":[26],"to":[27,33,39,58,68,125,253,274,338,360],"study":[28],"since":[29],"it":[30],"believed":[32],"be":[34,254],"multifactorial,":[35],"due":[36],"part":[38],"differences":[40],"risk":[42],"factors,":[43],"behaviors,":[44],"and":[45,62,115,148,163,171,189,216,244,262,286,307,346,354,357,372,386,393,415],"hormones.":[46],"a":[50,70,76,137,159,169,380,455],"sexually":[51],"dimorphic":[52],"organ":[53],"that":[54,250,281,321],"extremely":[56],"susceptible":[57],"interactions":[59],"with":[60,75,219,284,400],"estrogens":[61],"androgens.":[63],"Estrogen":[64],"has":[65],"been":[66,398],"proven":[67],"have":[69,397],"protective":[71],"effect":[72,80],"against":[73],"HCC":[74],"demonstrable":[77],"gender-related":[78],"hormonal":[79],"on":[81],"growth":[83],"HCC,":[85],"though":[86],"underlying":[88],"mechanisms":[89],"are":[90,333],"not":[91],"fully":[92],"understood.":[93],"hydrodynamic":[95,456],"tail":[96,457],"vein":[97,458],"injection":[98,459],"(HTVI)":[99],"mouse":[100,460],"model":[101,461],"allows":[102],"for":[103,469],"induction":[105],"tumors":[108,369],"host.":[111],"Eliminating":[112],"social":[114],"behavioral":[116],"aspects":[117],"will":[122,427],"allow":[123],"us":[124],"determine":[126,361,376],"what":[127],"role":[128,381],"estrogen":[129,378],"plays":[130],"tumor":[132,141,276,327,351,384,452],"development.":[133],"In":[134],"our":[135,429],"study,":[136],"development":[142,385],"was":[143,198,236,272],"observed":[144],"between":[145,187,413],"6-week-old":[146],"male":[147,188,215,229,243,295,371,392,414],"female":[149,190,217,221,245,313,322,373,389,395,417],"FVB/NJ":[150],"mice":[151,191,218,222,280,296,323,396,418],"injected":[152,283,399],"via":[153],"HTVI":[154,167],"plasmids":[156],"expressing":[157,175],"c-MET,":[158],"mutated":[160],"beta-catenin":[161],"(b-Cat)":[162],"Sleeping":[164,172],"Beauty":[165,173],"transposon.":[166],"Luciferase":[170],"transposon":[174],"plasmid":[176,404],"showed":[177],"no":[178,255],"significant":[179],"difference":[180,257],"photon":[182,205],"flux":[183,206],"by":[184,208],"bioluminescence":[185],"imaging":[186,197],"24":[192],"hours":[193],"after":[194,202],"injection.":[195],"When":[196],"repeated":[199],"one":[200],"week":[201],"injection,":[203],"reduced":[207],"an":[209],"order":[210],"magnitude":[212],"both":[214],"showing":[223],"more":[224],"uniform":[225],"reduction":[226],"mice.":[230,246,314,374],"Similar":[231],"luciferase":[232,289,291],"gene":[233],"copy":[234,341],"number":[235,342],"detected":[237],"tissue":[241],"These":[247],"data":[248],"suggest":[249],"there":[251],"appears":[252],"transient":[260],"expression":[261,365],"stable":[263],"integration":[264],"transfected":[267],"plasmid.":[268],"Plasma":[269],"alpha-fetoprotein":[270],"(AFP)":[271],"used":[273],"monitor":[275],"formation":[277,453],"were":[282,419],"c-MET":[285,345],"b-Cat":[287,347],"without":[288],"as":[290],"immunogenic.":[293],"had":[297,324],"significantly":[298],"AFP":[300,411],"levels":[301,412],"at":[302,423,431],"3.5":[303],"weeks,":[304,306],"8":[305],"12":[308],"weeks":[309],"post-injection":[310],"At":[315],"termination,":[316],"weight":[319],"confirmed":[320],"much":[325],"lower":[326],"burden":[328],"males.":[331],"We":[332,426],"currently":[334],"using":[335,355,454],"quantitative":[336],"PCR":[337],"confirm":[339],"similar":[340],"exogenous":[344],"inserted":[348],"cell":[352],"genome":[353],"RT-qPCR":[356],"Western":[358],"blotting":[359],"whether":[362,377],"transgene":[364],"different":[367],"from":[370],"To":[375],"played":[379],"preventing":[383],"progression":[387],"mice,":[390],"six-week-old":[391],"ovariectomized":[394,416],"same":[402],"oncogene":[403],"combination":[405],"plus":[406],"sleeping":[408],"beauty.":[409],"Interestingly,":[410],"comparable":[420],"when":[421],"measured":[422],"3":[424],"weeks.":[425],"present":[428],"findings":[430],"meeting.":[433],"Citation":[434],"Format:":[435],"Araceli":[436],"Bernal,":[437],"Morgana":[438],"McLaughlin,":[439],"Ankur":[440],"Tiwari,":[441],"Francisco":[442],"Cigarroa,":[443],"LuZhe":[444],"Sun.":[445],"Investigation":[446],"[abstract].":[462],"In:":[463],"Proceedings":[464],"American":[467],"Association":[468],"Cancer":[470,488],"Research":[471],"Annual":[472],"Meeting":[473],"2024;":[474],"Part":[475],"1":[476],"(Regular":[477],"Abstracts);":[478],"2024":[479],"Apr":[480],"5-10;":[481],"San":[482],"Diego,":[483],"CA.":[484],"Philadelphia":[485],"(PA):":[486],"AACR;":[487],"Res":[489],"2024;84(6_Suppl):Abstract":[490],"nr":[491],"772.":[492]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-03-23T00:00:00"}