{"id":"https://openalex.org/W4393073059","doi":"https://doi.org/10.1158/1538-7445.am2024-6837","title":"Abstract 6837: Prolonged effects of hypoxia in luminal breast cancer cells","display_name":"Abstract 6837: Prolonged effects of hypoxia in luminal breast cancer cells","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393073059","doi":"https://doi.org/10.1158/1538-7445.am2024-6837"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-6837","doi":"https://doi.org/10.1158/1538-7445.am2024-6837","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6837","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015839398","display_name":"Aidan Moriarty","orcid":"https://orcid.org/0000-0002-9502-937X","observed_orcids":["https://orcid.org/0000-0002-9502-937X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aidan Moriarty","raw_affiliation_strings":["1University of Maryland School of Medicine, Baltimore, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Maryland School of Medicine, Baltimore, MD;","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079975410","display_name":"Oihana Iriondo","orcid":"https://orcid.org/0000-0002-7464-5026","observed_orcids":["https://orcid.org/0000-0002-7464-5026"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oihana Iriondo","raw_affiliation_strings":["2USC Keck School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2USC Keck School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044845624","display_name":"Yonatan Amzaleg","orcid":"https://orcid.org/0000-0002-8576-9702","observed_orcids":["https://orcid.org/0000-0002-8576-9702"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yonatan Amzaleg","raw_affiliation_strings":["2USC Keck School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2USC Keck School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049861172","display_name":"Remi V. Klotz","orcid":"https://orcid.org/0000-0003-2100-0635","observed_orcids":["https://orcid.org/0000-0003-2100-0635","https://orcid.org/0000-0002-4726-8413"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Remi Klotz","raw_affiliation_strings":["1University of Maryland School of Medicine, Baltimore, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Maryland School of Medicine, Baltimore, MD;","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039053483","display_name":"Min Yu","orcid":"https://orcid.org/0000-0002-3969-8720","observed_orcids":["https://orcid.org/0000-0002-3969-8720"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Yu","raw_affiliation_strings":["1University of Maryland School of Medicine, Baltimore, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Maryland School of Medicine, Baltimore, MD;","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"6837","last_page":"6837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/luminal-breast-cancer","display_name":"luminal breast cancer","score":0.8920000195503235},{"id":"https://openalex.org/keywords/reoxygenation","display_name":"reoxygenation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9240000247955322},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.7689999938011169},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.7300000190734863},{"id":"https://openalex.org/keywords/metastatic-potential","display_name":"metastatic potential","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7774670720100403},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7050511837005615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5795465707778931},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47199323773384094},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4690478444099426},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40379756689071655},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33155882358551025},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32475781440734863},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19360199570655823},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.10026907920837402},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-6837","doi":"https://doi.org/10.1158/1538-7445.am2024-6837","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6837","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396587414","https://openalex.org/W4402938813","https://openalex.org/W4321749665","https://openalex.org/W2536224487","https://openalex.org/W3211311201","https://openalex.org/W2982182315","https://openalex.org/W2802893198","https://openalex.org/W2048463107","https://openalex.org/W7164132055","https://openalex.org/W2327738067"],"abstract_inverted_index":{"Abstract":[0],"Metastasis":[1],"is":[2,20,240,252],"the":[3,17,43,66,167,171,214,256,275,310],"main":[4],"cause":[5],"of":[6,16,174,181,207,274,278,299,309],"tumor-related":[7],"mortality":[8],"in":[9,42,65,91,138,162,187,249,301],"breast":[10,99,140,152,303],"cancer":[11,29,62,80,100,141,153,304],"patients.":[12],"Improving":[13],"our":[14,250,272],"understanding":[15,273],"metastatic":[18,33,122],"cascade":[19],"imperative":[21],"to":[22,125,129,135,157,169,213,254],"improve":[23,271],"patient":[24],"outcomes.":[25],"Prior":[26],"research":[27,52,90,248,269],"indicates":[28,103],"cells":[30,63,81,111,118,126,142,197,305],"with":[31,242],"increased":[32],"potential":[34,123],"have":[35],"acquired":[36],"adaptive":[37],"properties":[38],"induced":[39,225],"by":[40,226],"factors":[41],"tumor":[44,94],"microenvironment":[45],"(TME),":[46],"including":[47],"hypoxia.":[48,130],"However,":[49],"previous":[50],"hypoxia":[51,227,279,300],"has":[53],"primarily":[54],"focused":[55],"on":[56,149,280],"signaling":[57],"changes":[58,75,107,137,224,258],"that":[59,76,104,115,178,183,236,259],"occur":[60,78],"when":[61,86],"are":[64,108],"hypoxic":[67,188,265],"TME":[68],"and":[69,98,114,220,234,283],"does":[70],"not":[71,127],"account":[72],"for":[73,263,313],"long-term":[74],"may":[77,260],"once":[79],"re-enter":[82],"normoxia,":[83],"such":[84],"as":[85,192],"they":[87],"metastasize.":[88],"Our":[89],"patient-derived":[92],"circulating":[93],"cell":[95,101,154],"(CTCs)":[96],"lines":[97,102,155],"certain":[105],"transcriptional":[106],"maintained":[109,191],"after":[110,196],"leave":[112],"hypoxia,":[113],"these":[116],"post-hypoxic":[117,150,215,238],"maintain":[119],"a":[120,179,201,205,243],"higher":[121],"compared":[124,156],"exposed":[128],"Taking":[131],"an":[132],"un-biased":[133],"approach":[134],"define":[136],"hypoxia-exposed":[139],"upon":[143],"reoxygenation,":[144],"we":[145],"performed":[146,231],"bulk":[147],"RNA-Seq":[148],"luminal":[151,302],"normoxic":[158],"controls":[159],"cultured":[160],"either":[161],"adherent":[163],"or":[164,194],"suspension":[165],"conditions,":[166],"latter":[168],"mimic":[170],"physiological":[172],"context":[173],"CTCs.":[175],"We":[176,229],"found":[177],"subset":[180,206],"genes":[182,210],"were":[184,190,198,211],"differentially":[185,208],"expressed":[186,209],"conditions":[189],"up-":[193],"down-regulated":[195],"reoxygenated,":[199],"indicating":[200],"\u201chypoxic":[202],"memory\u201d.":[203],"Additionally,":[204],"unique":[212],"cells,":[216],"demonstrating":[217],"both":[218],"prolonged":[219,276],"novel":[221],"gene":[222],"expression":[223],"exposure.":[228],"also":[230],"functional":[232],"assays":[233],"observed":[235],"this":[237,264,268],"state":[239],"associated":[241],"more":[244],"aggressive":[245],"phenotype.":[246],"Current":[247],"lab":[251],"on-going":[253],"understand":[255],"epigenetic":[257],"be":[261],"responsible":[262],"memory.":[266],"Overall,":[267],"will":[270],"consequences":[277],"CTC":[281],"biology":[282],"metastasis.":[284],"Citation":[285],"Format:":[286],"Aidan":[287],"Moriarty,":[288],"Oihana":[289],"Iriondo,":[290],"Yonatan":[291],"Amzaleg,":[292],"Remi":[293],"Klotz,":[294],"Min":[295],"Yu.":[296],"Prolonged":[297],"effects":[298],"[abstract].":[306],"In:":[307],"Proceedings":[308],"American":[311],"Association":[312],"Cancer":[314,332],"Research":[315],"Annual":[316],"Meeting":[317],"2024;":[318],"Part":[319],"1":[320],"(Regular":[321],"Abstracts);":[322],"2024":[323],"Apr":[324],"5-10;":[325],"San":[326],"Diego,":[327],"CA.":[328],"Philadelphia":[329],"(PA):":[330],"AACR;":[331],"Res":[333],"2024;84(6_Suppl):Abstract":[334],"nr":[335],"6837.":[336]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2024-03-23T00:00:00"}