{"id":"https://openalex.org/W4393072549","doi":"https://doi.org/10.1158/1538-7445.am2024-4262","title":"Abstract 4262: AI-driven analysis of collagen characteristics in the tumor immune microenvironment predicts immune checkpoint inhibitors treatment responsiveness in gastric cancer","display_name":"Abstract 4262: AI-driven analysis of collagen characteristics in the tumor immune microenvironment predicts immune checkpoint inhibitors treatment responsiveness in gastric cancer","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393072549","doi":"https://doi.org/10.1158/1538-7445.am2024-4262"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-4262","doi":"https://doi.org/10.1158/1538-7445.am2024-4262","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-4262","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100317742","display_name":"Minji Kim","orcid":"https://orcid.org/0009-0002-6027-3556","observed_orcids":["https://orcid.org/0009-0002-6027-3556","https://orcid.org/0009-0007-6512-8047"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minji Kim","raw_affiliation_strings":["1Mayo Clinic, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088334950","display_name":"Ekaterina Redekop","orcid":"https://orcid.org/0009-0009-9662-0370","observed_orcids":["https://orcid.org/0009-0009-9662-0370"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekaterina Redekop","raw_affiliation_strings":["2University of California, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of California, Los Angeles, CA;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110037583","display_name":"Yoon-Ho Choi","orcid":"https://orcid.org/0000-0001-6831-4450","observed_orcids":["https://orcid.org/0000-0001-6831-4450"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoonho Choi","raw_affiliation_strings":["1Mayo Clinic, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023527433","display_name":"Sung Hak Lee","orcid":"https://orcid.org/0000-0003-1020-5838","observed_orcids":["https://orcid.org/0000-0003-1020-5838","https://orcid.org/0000-0002-1030-381X"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Hak Lee","raw_affiliation_strings":["3The Catholic University of Korea, Seoul, Republic of Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Catholic University of Korea, Seoul, Republic of Korea;","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000246711","display_name":"Jae\u2010Ho Cheong","orcid":"https://orcid.org/0000-0002-1703-1781","observed_orcids":["https://orcid.org/0000-0002-1703-1781"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Ho Cheong","raw_affiliation_strings":["4Yonsei University College of Medicine, Seoul, Republic of Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Yonsei University College of Medicine, Seoul, Republic of Korea;","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102831968","display_name":"Yu Aoki","orcid":"https://orcid.org/0000-0002-1254-4596","observed_orcids":["https://orcid.org/0000-0002-1254-4596"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Aoki","raw_affiliation_strings":["5National Cancer Center Hospital East, Kashiwa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5National Cancer Center Hospital East, Kashiwa, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015799240","display_name":"Kohei Shitara","orcid":"https://orcid.org/0000-0001-5196-3630","observed_orcids":["https://orcid.org/0000-0001-5196-3630"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Shitara","raw_affiliation_strings":["5National Cancer Center Hospital East, Kashiwa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5National Cancer Center Hospital East, Kashiwa, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027668952","display_name":"Tae Hyun Hwang","orcid":"https://orcid.org/0000-0002-6668-7269","observed_orcids":["https://orcid.org/0000-0002-6668-7269"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae Hyun Hwang","raw_affiliation_strings":["1Mayo Clinic, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"4262","last_page":"4262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.10029999911785126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9229999780654907},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8840000033378601},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8669999837875366},{"id":"https://openalex.org/keywords/collagen-fiber-orientation","display_name":"collagen fiber orientation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/second-harmonic-generation","display_name":"second harmonic generation","score":0.5410000085830688},{"id":"https://openalex.org/keywords/attention-based-multiple-instance-learning","display_name":"attention-based multiple instance learning","score":0.9020000100135803},{"id":"https://openalex.org/keywords/whole-slide-images","display_name":"whole slide images","score":0.7799999713897705},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.5529999732971191},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7713054418563843},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7077681422233582},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6546468138694763},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.550642728805542},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5429612398147583},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47361254692077637},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3497309684753418},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3457711637020111},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30372560024261475},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2749093472957611}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-4262","doi":"https://doi.org/10.1158/1538-7445.am2024-4262","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-4262","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399489216","https://openalex.org/W4404065297","https://openalex.org/W4415900356","https://openalex.org/W2062397335","https://openalex.org/W4396955845","https://openalex.org/W4393096226","https://openalex.org/W4411772349","https://openalex.org/W4403090009","https://openalex.org/W4385607695","https://openalex.org/W4404064139"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Recent":[2],"studies":[3],"indicate":[4],"a":[5,79,129,168,181,280,300,316,323,332,357],"correlation":[6],"between":[7],"increased":[8],"stromal":[9,31],"composition":[10],"in":[11,57,89,95,102,282,303,337,343,366,395,406],"tumors":[12],"and":[13,42,48,69,78,86,112,163,195,199,243,285,340,362],"resistance":[14],"to":[15,65,84,97,176,222,258,345],"immune":[16,43,398,401],"checkpoint":[17,402],"inhibitors":[18,403],"(ICIs)":[19],"across":[20],"various":[21,188],"cancer":[22,39,347,408],"types.":[23],"Specifically,":[24],"the":[25,30,35,50,53,90,98,209,225,253,260,263,296,338,396,413],"extracellular":[26],"matrix":[27],"(ECM)":[28],"within":[29,350],"compartment":[32],"significantly":[33,271],"influence":[34],"tumor":[36,177,182,397],"microenvironment,":[37],"affecting":[38],"cell":[40,44],"proliferation":[41],"recruitment.":[45],"However,":[46],"identifying":[47],"quantifying":[49],"ECM":[51],"at":[52],"collagen":[54,88,189,204,231,283,336,360,393],"fiber":[55,193,200,205,268,286],"level":[56],"whole":[58],"slide":[59],"images":[60],"(WSIs)":[61],"is":[62],"challenging":[63],"due":[64],"its":[66,93,341],"inherent":[67],"heterogeneity":[68],"complexity.":[70],"In":[71],"this":[72],"work,":[73],"we":[74],"utilized":[75],"statistical":[76,301],"analysis":[77,334,391],"deep":[80],"learning":[81,217],"(DL)-based":[82],"approach":[83],"identify":[85],"assess":[87,259],"ECM,":[91,339],"examining":[92],"characteristics":[94,394],"relation":[96,344],"ICIs":[99,118,274,277,348],"treatment":[100,119,226,306,368,404],"response":[101,131,134,227,349],"gastric":[103,346,407],"cancer.":[104],"Methods:":[105],"We":[106,166,185,354],"analyzed":[107],"116":[108,236],"WSIs":[109],"of":[110,235,262,320,326,335,392,412],"hematoxylin":[111],"eosin":[113],"(H&E)":[114],"stained":[115],"slides":[116,155,238],"before":[117],"from":[120,208],"three":[121],"institutions.":[122],"Responders":[123],"were":[124,147,156,270],"defined":[125],"as":[126],"those":[127,136],"with":[128,137,273,322],"complete":[130],"or":[132,142],"partial":[133],"(N=18);":[135],"stable":[138],"disease":[139,144],"(SD)":[140],"(N=34)":[141],"progressive":[143],"(PD)":[145],"(N=64)":[146],"considered":[148],"non-responders":[149],"(N=98).":[150],"For":[151],"non-responders,":[152,295],"post-treatment":[153],"H&E":[154],"available":[157],"for":[158,416],"21":[159],"patients;":[160],"SD":[161],"(N=5)":[162],"PD":[164,297],"(N=16).":[165],"applied":[167],"DL-based":[169],"second":[170],"harmonic":[171],"generation":[172],"(SHG)":[173],"synthesis":[174],"algorithm":[175],"regions":[178],"identified":[179],"by":[180,290,308],"detection":[183],"model.":[184],"then":[186],"calculated":[187],"properties,":[190],"including":[191],"volume,":[192],"orientation":[194,287],"alignment,":[196],"waviness,":[197],"straightness,":[198],"thickness,":[201],"based":[202,229],"on":[203,230],"centerlines":[206],"extracted":[207],"generated":[210],"SHG":[211],"images.":[212],"An":[213],"attention-based":[214],"multiple":[215],"instance":[216],"(ABMIL)":[218],"model":[219,314,358],"was":[220,239,256],"trained":[221,264],"automatically":[223],"predict":[224],"solely":[228],"features.":[232],"The":[233,250,312],"dataset":[234],"pre-treatment":[237],"divided":[240],"into":[241],"training":[242],"validation":[244],"subsets":[245],"using":[246,359],"stratified":[247],"3-fold":[248],"cross-validation.":[249],"area":[251],"under":[252],"curve":[254],"(AUC)":[255],"used":[257],"performance":[261],"models.":[265],"Results:":[266],"Collagen":[267],"features":[269,361],"associated":[272],"response.":[275,369],"Notably,":[276],"responders":[278],"have":[279],"decrease":[281,302],"waviness":[284,304],"variation":[288],"(p-value<0.05,":[289,307],"Mann-Whitney":[291,309],"U":[292,310],"test).":[293,311],"Among":[294],"group":[298],"showed":[299],"after":[305],"ABMIL":[313],"achieved":[315],"mean":[317],"AUC":[318],"score":[319],"0.823,":[321],"standard":[324],"deviation":[325],"0.023.":[327],"Conclusion:":[328],"This":[329],"study":[330],"provides":[331],"comprehensive":[333],"properties":[342],"Tumor":[351],"Immune":[352],"Microenvironment.":[353],"also":[355],"developed":[356],"demonstrated":[363],"high":[364],"accuracy":[365],"predicting":[367],"Citation":[370],"Format:":[371],"Minji":[372],"Kim,":[373],"Ekaterina":[374],"Redekop,":[375],"Yoonho":[376],"Choi,":[377],"Sung":[378],"Hak":[379],"Lee,":[380],"Jae-Ho":[381],"Cheong,":[382],"Yu":[383],"Aoki,":[384],"Kohei":[385],"Shitara,":[386],"Tae":[387],"Hyun":[388],"Hwang.":[389],"AI-driven":[390],"microenvironment":[399],"predicts":[400],"responsiveness":[405],"[abstract].":[409],"In:":[410],"Proceedings":[411],"American":[414],"Association":[415],"Cancer":[417,435],"Research":[418],"Annual":[419],"Meeting":[420],"2024;":[421],"Part":[422],"1":[423],"(Regular":[424],"Abstracts);":[425],"2024":[426],"Apr":[427],"5-10;":[428],"San":[429],"Diego,":[430],"CA.":[431],"Philadelphia":[432],"(PA):":[433],"AACR;":[434],"Res":[436],"2024;84(6_Suppl):Abstract":[437],"nr":[438],"4262.":[439]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-03-23T00:00:00"}
