{"id":"https://openalex.org/W4393072503","doi":"https://doi.org/10.1158/1538-7445.am2024-5117","title":"Abstract 5117: CK2 inhibiton exhibits synergistic effect in acute lymphoblastic leukemia","display_name":"Abstract 5117: CK2 inhibiton exhibits synergistic effect in acute lymphoblastic leukemia","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393072503","doi":"https://doi.org/10.1158/1538-7445.am2024-5117"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-5117","doi":"https://doi.org/10.1158/1538-7445.am2024-5117","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5117","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051910761","display_name":"Daniel Bogush","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Gary Bogush","raw_affiliation_strings":["1Penn State College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Penn State College of Medicine, Hershey, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030744957","display_name":"Joseph W. Schramm","orcid":"https://orcid.org/0000-0003-4572-6764","observed_orcids":["https://orcid.org/0000-0003-4572-6764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Schramm","raw_affiliation_strings":["1Penn State College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Penn State College of Medicine, Hershey, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010036237","display_name":"Katarina Dovat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarina Dovat","raw_affiliation_strings":["1Penn State College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Penn State College of Medicine, Hershey, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012215574","display_name":"Yali Ding","orcid":"https://orcid.org/0009-0005-3629-1908","observed_orcids":["https://orcid.org/0009-0005-3629-1908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yali Ding","raw_affiliation_strings":["1Penn State College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Penn State College of Medicine, Hershey, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007998163","display_name":"Chingakham Ranjit Singh","orcid":"https://orcid.org/0000-0003-2840-3066","observed_orcids":["https://orcid.org/0000-0003-2840-3066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chingakham Singh","raw_affiliation_strings":["1Penn State College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Penn State College of Medicine, Hershey, PA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072518893","display_name":"Sinisa Dovat","orcid":"https://orcid.org/0000-0003-3906-6165","observed_orcids":["https://orcid.org/0000-0003-3906-6165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sinisa Dovat","raw_affiliation_strings":["1Penn State College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Penn State College of Medicine, Hershey, PA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"5117","last_page":"5117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cx-4945","display_name":"CX-4945","score":0.8989999890327454},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9210000038146973},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.8849999904632568},{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.8289999961853027},{"id":"https://openalex.org/keywords/pre-b-acute-lymphoblastic-leukemia","display_name":"pre-B acute lymphoblastic leukemia","score":0.828000009059906},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.7639999985694885},{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.7850000262260437},{"id":"https://openalex.org/keywords/ikaros","display_name":"Ikaros","score":0.9639999866485596},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6140000224113464},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9039999842643738},{"id":"https://openalex.org/keywords/nalm-6-cells","display_name":"Nalm-6 cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.48899999260902405},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.6081777811050415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4532916247844696},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4445570111274719},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.44313299655914307},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3734419345855713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3509265184402466},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3114217519760132},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24329587817192078}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-5117","doi":"https://doi.org/10.1158/1538-7445.am2024-5117","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5117","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409632402","https://openalex.org/W7148954934","https://openalex.org/W4237293220","https://openalex.org/W4405050959","https://openalex.org/W3134386978","https://openalex.org/W2986090507","https://openalex.org/W3134407254","https://openalex.org/W2341394478","https://openalex.org/W3177832559","https://openalex.org/W3009589018"],"abstract_inverted_index":{"Abstract":[0],"Survival":[1],"for":[2,77,92,337,397],"pre-B":[3],"cell":[4,238],"Acute":[5],"lymphoblastic":[6,33,344,388],"leukemia":[7,34,345,389],"(B":[8],"ALL)":[9],"has":[10,48],"improved":[11],"greatly,":[12],"however.":[13],"High":[14],"risk":[15],"(HR)":[16],"subgroups":[17],"continue":[18],"to":[19,57,70,171,200,211,218,261,360],"result":[20],"in":[21,95,101,107,119,129,163,181,189,221,225,277,290,339,354,386],"significant":[22,60],"mortality":[23],"and":[24,55,74,159,247,305,325],"morbidity":[25,76],"of":[26,62,83,98,139,167,175,216,230,267,271,283,301,308,393],"pediatric":[27],"oncology":[28],"patients.":[29,110,131],"Pediatric":[30],"T-cell":[31],"acute":[32,343,387],"(T-ALL)":[35],"is":[36,90,154,160,335],"a":[37,59,115,147,182,226,252,263,293,298,330],"lethal":[38],"disease,":[39],"often":[40,161],"associated":[41],"with":[42,141,185,196,223,297],"high-risk":[43,63],"clinical":[44],"features.":[45],"T-ALL":[46],"therapy":[47],"made":[49],"less":[50],"improvement":[51],"than":[52],"B":[53,79],"ALL":[54,109,130],"continues":[56],"represent":[58],"number":[61],"outcomes.":[64],"Novel":[65],"treatment":[66],"strategies":[67],"are":[68,105],"required":[69],"overcome":[71,87],"chemotherapy":[72,88],"resistance":[73,89],"improve":[75],"HR":[78],"ALL.":[80],"The":[81,165,207,241,257,269,318],"development":[82],"treatments":[84],"that":[85,136,321],"can":[86],"essential":[91],"improving":[93],"survival":[94],"T-ALL.":[96],"Deletions":[97],"IKZF1,":[99],"resulting":[100],"decreased":[102],"IKAROS":[103,122,144,158,176],"function,":[104],"present":[106],"High-risk":[108],"Casein":[111],"kinase":[112,117,152],"2":[113],"(CK2),":[114],"protein":[116],"upregulated":[118,162],"ALL,":[120],"phosphorylates":[121],"preventing":[123],"DNA":[124],"binding":[125],"reducing":[126],"transcriptional":[127,148],"regulation":[128],"Past":[132],"studies":[133,348],"have":[134],"shown":[135],"pharmacologic":[137],"inhibition":[138],"CK2":[140,286,322,381],"CX-4945":[142,178,224,288,302],"rescues":[143],"function":[145],"as":[146,251],"regulator.":[149],"Receptor":[150],"tyrosine":[151],"c-KIT":[153,186,274,326],"transcriptionally":[155],"regulated":[156],"by":[157],"cancer.":[164],"purpose":[166],"this":[168],"study":[169,258],"was":[170,209,234,249,259,295,311],"determine":[172,212,262],"whether":[173],"restoration":[174],"via":[177],"would":[179],"act":[180],"synergistic":[183,331,364,384],"manner":[184],"inhibitor":[187,287],"imatinib":[188,197,217],"ALL.Methods/results":[190],"B-ALL":[191,279],"Nalm6":[192,278],"cells":[193],"were":[194,243],"treated":[195],"over":[198],"72-hours":[199],"establish":[201],"the":[202,213,394],"half-maximal":[203],"inhibitory":[204],"concentration":[205,214],"(IC50).":[206],"IC50":[208,282],"used":[210,220],"range":[215,266],"be":[219],"combination":[222,253,294],"72-hour":[227],"synergy":[228,248,310,353],"analysis":[229],"cytotoxicity..":[231],"Cell":[232],"viability":[233],"measured":[235],"using":[236,245],"WST-1":[237],"proliferation":[239],"assay.":[240],"data":[242,319],"analyzed":[244],"Calcusyn":[246],"defined":[250],"index":[254],"below":[255],"0.85.":[256],"repeated":[260],"more":[264,362],"precise":[265],"synergy.":[268],"cytotoxicity":[270],"single":[272],"drug":[273],"inhibitor,":[275,323,327],"Imatinib,":[276],"yielded":[280],"an":[281],"25uM":[284],"while":[285],"resulted":[289],"4uM.":[291],"When":[292],"administered":[296],"constant":[299],"dose":[300,315],"at":[303,313],"4uM":[304],"varying":[306],"concentrations":[307],"imatinib,":[309,328],"observed":[312],"multiple":[314],"combinations.":[316],"Conclusion:":[317],"shows":[320],"CX-4945,":[324],"exhibit":[329],"therapeutic":[332],"effect.":[333,365],"Imatinib":[334],"indicated":[336],"use":[338],"Philadelphia":[340,413],"positive":[341],"(Ph+)":[342],"so":[346],"future":[347],"will":[349],"include":[350],"testing":[351],"CX-4945/imatinib":[352],"Ph+":[355],"BALL":[356],"where":[357],"we":[358],"expect":[359],"see":[361],"potent":[363],"Citation":[366],"Format:":[367],"Daniel":[368],"Gary":[369],"Bogush,":[370],"Joseph":[371],"Schramm,":[372],"Katarina":[373],"Dovat,":[374],"Yali":[375],"Ding,":[376],"Chingakham":[377],"Singh,":[378],"Sinisa":[379],"Dovat.":[380],"inhibiton":[382],"exhibits":[383],"effect":[385],"[abstract].":[390],"In:":[391],"Proceedings":[392],"American":[395],"Association":[396],"Cancer":[398,416],"Research":[399],"Annual":[400],"Meeting":[401],"2024;":[402],"Part":[403],"1":[404],"(Regular":[405],"Abstracts);":[406],"2024":[407],"Apr":[408],"5-10;":[409],"San":[410],"Diego,":[411],"CA.":[412],"(PA):":[414],"AACR;":[415],"Res":[417],"2024;84(6_Suppl):Abstract":[418],"nr":[419],"5117.":[420]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-23T00:00:00"}
