{"id":"https://openalex.org/W4393071287","doi":"https://doi.org/10.1158/1538-7445.am2024-4856","title":"Abstract 4856: Sex differences in childhood leukemia genomics","display_name":"Abstract 4856: Sex differences in childhood leukemia genomics","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393071287","doi":"https://doi.org/10.1158/1538-7445.am2024-4856"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-4856","doi":"https://doi.org/10.1158/1538-7445.am2024-4856","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-4856","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021611287","display_name":"Lindsay A. Williams","orcid":"https://orcid.org/0000-0003-3842-4629","observed_orcids":["https://orcid.org/0000-0003-3842-4629"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay A. Williams","raw_affiliation_strings":["1University of Minnesota, Woodbury, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Minnesota, Woodbury, MN;","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059198403","display_name":"Lauren J. Mills","orcid":"https://orcid.org/0000-0002-8914-2587","observed_orcids":["https://orcid.org/0000-0002-8914-2587"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren J. Mills","raw_affiliation_strings":["2University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094218712","display_name":"Sofia Barragan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sofia Barragan","raw_affiliation_strings":["2University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000082261","display_name":"Peter M. Gordon","orcid":"https://orcid.org/0000-0002-3159-1881","observed_orcids":["https://orcid.org/0000-0002-3159-1881"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter M. Gordon","raw_affiliation_strings":["2University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062825028","display_name":"Jenny N. Poynter","orcid":"https://orcid.org/0000-0002-8460-3938","observed_orcids":["https://orcid.org/0000-0002-8460-3938"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny N. Poynter","raw_affiliation_strings":["2University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"4856","last_page":"4856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6129999756813049},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9319999814033508},{"id":"https://openalex.org/keywords/survival-disparities","display_name":"survival disparities","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cytogenetic-subtypes","display_name":"cytogenetic subtypes","score":0.8730000257492065},{"id":"https://openalex.org/keywords/etv6-runx1","display_name":"ETV6-RUNX1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/kmt2a","display_name":"KMT2A","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bcr-abl1","display_name":"BCR-ABL1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pecan","display_name":"Carya illinoinensis","score":0.6159999966621399},{"id":"https://openalex.org/keywords/children-s-oncology-group","display_name":"Children's Oncology Group","score":0.7979999780654907},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C2779401946","wikidata":"https://www.wikidata.org/wiki/Q5097982","display_name":"Childhood leukemia","level":4,"score":0.7355559468269348},{"id":"https://openalex.org/C2992894027","wikidata":"https://www.wikidata.org/wiki/Q5097977","display_name":"Childhood cancer","level":3,"score":0.5495931506156921},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5275344848632812},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4187769889831543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.411864697933197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38042309880256653},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.356309711933136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.343034565448761},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1636221706867218},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.1400405764579773},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11295673251152039}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-4856","doi":"https://doi.org/10.1158/1538-7445.am2024-4856","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-4856","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729},{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.5676000118255615}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2100113364","https://openalex.org/W4309858906","https://openalex.org/W4389089918","https://openalex.org/W4405054064","https://openalex.org/W2983732268","https://openalex.org/W4214705541","https://openalex.org/W2223173982","https://openalex.org/W7221179076","https://openalex.org/W3097541653","https://openalex.org/W3048718815"],"abstract_inverted_index":{"Abstract":[0],"Males":[1],"have":[2],"higher":[3],"ALL":[4,10,22,53,117,218,267,287,308],"and":[5,8,25,49,54,122,137,177,219,254,272],"AML":[6,105,172,192,215,220,245,368],"incidence":[7],"worse":[9,154],"survival":[11,23,79,156,246,268,288],"using":[12,68],"population-based":[13,252],"data.":[14],"Somatic":[15],"genetics":[16],"may":[17,289],"play":[18],"a":[19],"role":[20],"in":[21,40,52,61,73,86,96,214,227,244,247,249,260,266,286,326,406],"disparities":[24],"highlight":[26],"potential":[27],"sex":[28,38,82,113,130,141,168,189,203,212,225,242,323],"specific":[29,271],"treatment":[30,292],"strategies":[31],"for":[32,116,119,157,171,174,417],"future":[33],"study.":[34],"Therefore,":[35],"we":[36,77],"evaluated":[37],"differences":[39,80,213,226,243,265,285,405],"gene":[41],"expression":[42],"(RNA":[43],"seq),":[44],"copy":[45],"number":[46,198],"variation":[47],"(CNV),":[48],"somatic":[50,233,282],"mutation":[51],"AML.":[55],"We":[56],"stratified":[57],"by":[58,81,112,167,188,262,322],"cytogenomic":[59],"subtypes":[60,85,124,136,179,221],"publicly":[62,87],"available":[63,88],"data":[64,89],"from":[65,91,140,202,304,333],"clinical":[66],"cohorts":[67],"St.":[69],"Jude":[70],"PeCan":[71,261,307,327],"(subtypes":[72],"Table":[74,300],"1).":[75,126,181,208],"Then,":[76],"explored":[78],"within":[83,123,178],"cytogenetic":[84],"collected":[90],"Children\u2019s":[92],"Oncology":[93],"Group":[94],"patients":[95],"the":[97,196,414],"NCI":[98],"TARGET":[99],"dataset":[100],"(ALL":[101],"n=387,":[102],"63%":[103],"male;":[104,161],"n=151,":[106],"51%":[107,371],"male).":[108],"Differentially":[109,164],"expressed":[110,132,143,165,186,205,257,278,319,335],"genes":[111,133,144,166,187,206,258,321,336],"were":[114,128,145,169,183,210,223,240,269],"identified":[115,139,170,201,259,332],"adjusting":[118,173],"subtype":[120,175,270],"(n=214)":[121],"(Table":[125,180,207],"There":[127,182,209,239],"no":[129,184,211,224,241],"differentially":[131,142,185,204,256,277,318,334],"shared":[134,190],"across":[135,191],"pathways":[138,200,331],"few.":[146],"In":[147,217],"ETV6-RUNX1,":[148],"there":[149,222],"was":[150],"as":[151],"suggestion":[152],"of":[153,199,317,329,413],"10-year":[155],"males":[158],"(n=44,":[159],"61%":[160],"Log-Rank":[162],"p=0.068).":[163],"(n=537)":[176],"subtypes.":[193,263],"KMT2A":[194,363,378],"had":[195],"highest":[197],"survival.":[216],"CNVs":[228],"(all":[229,235],"t-test":[230],"p>0.05)":[231],"or":[232,281,297],"mutations":[234],"Fisher\u2019s":[236],"Exact":[237],"p>0.05).":[238],"TARGET,":[248],"agreement":[250],"with":[251],"studies,":[253],"few":[255],"Sex":[264,284,404],"not":[273],"heavily":[274],"dependent":[275],"on":[276,291],"genes,":[279],"CNVs,":[280],"mutation.":[283],"depend":[290],"received,":[293],"response":[294],"to":[295],"therapy,":[296],"other":[298],"characteristics.":[299],"1.":[301],"Select":[302],"characteristics":[303],"leukemia":[305,408],"cases":[306],"SubtypeTotal":[309,369],"n=247,":[310],"58%":[311],"male":[312,372],"N":[313],"(%":[314],"male)":[315],"Number":[316,328],"autosomal":[320],"(male-female":[324],"expression)":[325],"biologic":[330],"(Reactome)":[337],"BCR-ABL1":[338],"76":[339],"(68)":[340],"48":[341],"8":[342],"DUX4-IGH":[343],"54":[344],"(57)":[345],"218":[346],"0":[347,362,367,377],"ETV6-RUNX1":[348],"50":[349],"(52)":[350],"86":[351],"1":[352,387,424],"hyperdiploid":[353],"14":[354],"(64)":[355],"3,199":[356],"2":[357],"iAMP21":[358],"12":[359],"(50)":[360,380],"120":[361],"41":[364],"(51)":[365],"216":[366],"n=149,":[370],"CBFB-MYH11":[373],"34":[374],"(55)":[375],"7":[376],"44":[379],"422":[381],"19":[382],"RUNX1-RUNX1T1":[383],"61":[384],"(46)":[385],"30":[386],"Citation":[388],"Format:":[389],"Lindsay":[390],"A.":[391],"Williams,":[392],"Lauren":[393],"J.":[394],"Mills,":[395],"Sofia":[396],"Barragan,":[397],"Peter":[398],"M.":[399],"Gordon,":[400],"Jenny":[401],"N.":[402],"Poynter.":[403],"childhood":[407],"genomics":[409],"[abstract].":[410],"In:":[411],"Proceedings":[412],"American":[415],"Association":[416],"Cancer":[418,436],"Research":[419],"Annual":[420],"Meeting":[421],"2024;":[422],"Part":[423],"(Regular":[425],"Abstracts);":[426],"2024":[427],"Apr":[428],"5-10;":[429],"San":[430],"Diego,":[431],"CA.":[432],"Philadelphia":[433],"(PA):":[434],"AACR;":[435],"Res":[437],"2024;84(6_Suppl):Abstract":[438],"nr":[439],"4856.":[440]},"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2024-03-23T00:00:00"}