{"id":"https://openalex.org/W4393071271","doi":"https://doi.org/10.1158/1538-7445.am2024-5370","title":"Abstract 5370: Tumor-intrinsic cGAS-STING activation promotes anti-tumor inflammatory response in osteosarcoma","display_name":"Abstract 5370: Tumor-intrinsic cGAS-STING activation promotes anti-tumor inflammatory response in osteosarcoma","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393071271","doi":"https://doi.org/10.1158/1538-7445.am2024-5370"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-5370","doi":"https://doi.org/10.1158/1538-7445.am2024-5370","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2024-5370","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021372718","display_name":"Elizabeth P. Young","orcid":"https://orcid.org/0000-0003-3953-8273","observed_orcids":["https://orcid.org/0000-0003-3953-8273"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth \"Betsy\" Peale Young","raw_affiliation_strings":["1UCSF - University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSF - University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012503365","display_name":"Christine Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Johnson","raw_affiliation_strings":["1UCSF - University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSF - University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021539098","display_name":"Alex Gia Lee","orcid":"https://orcid.org/0000-0003-0107-5920","observed_orcids":["https://orcid.org/0000-0003-0107-5920","https://orcid.org/0000-0002-4583-0740"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex G. Lee","raw_affiliation_strings":["1UCSF - University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSF - University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026362990","display_name":"Alejandro Sweet-Cordero","orcid":"https://orcid.org/0000-0002-9787-9351","observed_orcids":["https://orcid.org/0000-0002-9787-9351"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Alejandro Sweet-Cordero","raw_affiliation_strings":["1UCSF - University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSF - University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"5370","last_page":"5370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.996999979019165},{"id":"https://openalex.org/keywords/cold-tumor-microenvironment","display_name":"cold tumor microenvironment","score":0.9179999828338623},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8980000019073486},{"id":"https://openalex.org/keywords/innate-immune-evasion","display_name":"innate immune evasion","score":0.6380000114440918},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tumor-subtypes","display_name":"tumor subtypes","score":0.6039999723434448},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6309999823570251},{"id":"https://openalex.org/keywords/sting-agonist","display_name":"STING agonist","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.7290385365486145},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.6356744766235352},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5948271155357361},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5490747094154358},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41497501730918884},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34763142466545105},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-5370","doi":"https://doi.org/10.1158/1538-7445.am2024-5370","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2024-5370","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389240058","https://openalex.org/W4415549061","https://openalex.org/W7223235926","https://openalex.org/W4414026366","https://openalex.org/W4311098666","https://openalex.org/W4296131254","https://openalex.org/W7211901112","https://openalex.org/W2954248267","https://openalex.org/W7163138519","https://openalex.org/W4220685386"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"\u201ccold\u201d":[2],"tumor":[3,66,127,136,158],"microenvironment":[4],"(TME)":[5],"is":[6,258],"often":[7],"seen":[8],"in":[9,42,65,73,90,108,146,150,153,237,253,276,300],"patients":[10],"with":[11,132,139,172],"osteosarcoma":[12,301],"(OS).":[13],"Genomic":[14],"instability,":[15],"characteristic":[16],"of":[17,48,79,92,105,111,118,166,193,220,235,239,261,305],"OS,":[18],"can":[19,35],"stimulate":[20],"the":[21,26,49,103,116,177,180,221,254,259,306],"cGAS-STING":[22,50,140,294],"pathway":[23,32,51],"and":[24,60,98,135,200,227,244,272],"activate":[25,273],"innate":[27,54],"immune":[28,40,55,274],"system.":[29],"Tumor-intrinsic":[30,142,293],"STING":[31,96,106,120,143,173,182,222,242,247,270],"silencing":[33],"mechanisms":[34],"link":[36],"genomic":[37,58],"instability":[38,59],"to":[39,57,101,241,264,268],"evasion":[41],"OS.":[43,74],"We":[44,185,230],"hypothesize":[45],"that":[46,246],"dysregulation":[47],"suppresses":[52],"an":[53,70],"response":[56,299],"plays":[61],"a":[62,76,109,147,154,216,250],"key":[63],"role":[64],"progression":[67],"through":[68],"establishing":[69],"immunosuppressive":[71],"TME":[72],"Using":[75],"novel":[77],"panel":[78],"11":[80],"OS":[81,112,167,236],"patient-derived":[82],"cell":[83,169],"lines,":[84],"we":[85,99,125,161],"have":[86,231],"identified":[87],"two":[88,233],"groups":[89],"terms":[91,238],"capacity":[93],"for":[94,176,191,211,309],"tumor-intrinsic":[95,119],"activation,":[97],"aim":[100],"unravel":[102],"mechanism":[104,267],"repression":[107],"subset":[110],"tumors.":[113],"To":[114],"investigate":[115],"effects":[117],"activation":[121,144,183,223,243,248,295],"on":[122,157,225],"macrophage":[123],"polarization":[124],"employed":[126],"conditioned":[128],"media":[129],"(TCM)":[130],"assays":[131],"murine-derived":[133],"macrophages":[134,152],"lines":[137,170],"treated":[138,171],"agonism.":[141],"resulted":[145],"significant":[148,217],"increase":[149],"pro-inflammatory":[151],"manner":[155],"dependent":[156],"STING.":[159],"Lastly,":[160],"performed":[162,201],"bulk":[163],"RNA":[164],"seq":[165],"PDX":[168],"agonist,":[174],"defining":[175],"first":[178],"time":[179],"OS-specific":[181],"signature.":[184],"then":[186],"evaluated":[187],"primary":[188],"patient":[189],"samples":[190,206],"evidence":[192],"this":[194,212,277],"signature":[195,224],"by":[196],"single":[197],"sample":[198],"GSEA":[199],"survival":[202],"analysis":[203],"after":[204],"stratifying":[205],"as":[207],"high":[208],"or":[209],"low":[210],"signature,":[213],"which":[214,257],"demonstrated":[215,245],"protective":[218,251],"effect":[219,252],"progression-free":[226],"overall":[228],"survival.":[229],"defined":[232],"subtypes":[234],"responsiveness":[240],"has":[249],"human":[255],"disease,":[256],"foundation":[260],"current":[262],"efforts":[263],"identify":[265],"targetable":[266],"reverse":[269],"unresponsiveness":[271],"surveillance":[275],"cancer.":[278],"Citation":[279],"Format:":[280],"Elizabeth":[281],"\"Betsy\"":[282],"Peale":[283],"Young,":[284],"Christine":[285],"Johnson,":[286],"Alex":[287],"G.":[288],"Lee,":[289],"Eric":[290],"Alejandro":[291],"Sweet-Cordero.":[292],"promotes":[296],"anti-tumor":[297],"inflammatory":[298],"[abstract].":[302],"In:":[303],"Proceedings":[304],"American":[307],"Association":[308],"Cancer":[310,328],"Research":[311],"Annual":[312],"Meeting":[313],"2024;":[314],"Part":[315],"1":[316],"(Regular":[317],"Abstracts);":[318],"2024":[319],"Apr":[320],"5-10;":[321],"San":[322],"Diego,":[323],"CA.":[324],"Philadelphia":[325],"(PA):":[326],"AACR;":[327],"Res":[329],"2024;84(6_Suppl):Abstract":[330],"nr":[331],"5370.":[332]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-23T00:00:00"}
