{"id":"https://openalex.org/W4393040901","doi":"https://doi.org/10.1002/cbic.202400005","title":"Climbing into their Skin to Understand Contextual Protein\u2013Protein Associations and Localizations: Functional Investigations in Transgenic Live Model Organisms","display_name":"Climbing into their Skin to Understand Contextual Protein\u2013Protein Associations and Localizations: Functional Investigations in Transgenic Live Model Organisms","publication_year":2024,"publication_date":"2024-03-21","ids":{"openalex":"https://openalex.org/W4393040901","doi":"https://doi.org/10.1002/cbic.202400005","pmid":"https://pubmed.ncbi.nlm.nih.gov/38511872"},"language":"en","primary_location":{"id":"doi:10.1002/cbic.202400005","doi":"https://doi.org/10.1002/cbic.202400005","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbic.202400005","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.202400005","source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.202400005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060276866","display_name":"Marcus J. C. Long","orcid":"https://orcid.org/0000-0002-0343-9671","observed_orcids":["https://orcid.org/0000-0002-0343-9671"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marcus J. C. Long","raw_affiliation_strings":["University of Lausanne (UNIL), Epalinges, 1066 Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lausanne (UNIL), Epalinges, 1066 Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012739930","display_name":"Yimon Aye","orcid":"https://orcid.org/0000-0002-1256-4159","observed_orcids":["https://orcid.org/0000-0002-1256-4159"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Yimon Aye","raw_affiliation_strings":["Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, 1015 Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-1256-4159","affiliations":[{"raw_affiliation_string":"Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, 1015 Switzerland","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012739930"],"corresponding_institution_ids":["https://openalex.org/I5124864"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":{"value":4220,"currency":"USD","value_usd":4220},"fwci":0.1588,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.14560237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"25","issue":"8","first_page":"e202400005","last_page":"e202400005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.2775999903678894,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.14890000224113464,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7879999876022339},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.8230000138282776},{"id":"https://openalex.org/keywords/chemical-biology","display_name":"chemical biology","score":0.4860000014305115},{"id":"https://openalex.org/keywords/protein-function","display_name":"protein function","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5854981541633606},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5453088879585266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4714456796646118},{"id":"https://openalex.org/C95038775","wikidata":"https://www.wikidata.org/wiki/Q22857","display_name":"Climbing","level":2,"score":0.43688786029815674},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4176982343196869},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25157153606414795},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15814918279647827},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10813641548156738}],"mesh":[{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019921","descriptor_name":"Biotinylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/cbic.202400005","doi":"https://doi.org/10.1002/cbic.202400005","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbic.202400005","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.202400005","source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},{"id":"pmid:38511872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38511872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chembiochem : a European journal of chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:serval.unil.ch:BIB_0739F71EFEB9","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_0739F71EFEB9","pdf_url":"https://iris.unil.ch/bitstreams/49ba5406-1a92-4832-9c48-4b1053bcdadc/download","source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chembiochem, vol. 25, no. 8, pp. e202400005","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:infoscience.epfl.ch:310487","doi":null,"is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/207248","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WoS","raw_type":"review"},{"id":"pmh:oai:iris.unil.ch:iris/62711","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/62711","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1002/cbic.202400005","doi":"https://doi.org/10.1002/cbic.202400005","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbic.202400005","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.202400005","source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320915","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052"},{"id":"https://openalex.org/F4320323831","display_name":"Universit\u00e9 de Lausanne","ror":"https://ror.org/019whta54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393040901.pdf","grobid_xml":"https://content.openalex.org/works/W4393040901.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1992496728","https://openalex.org/W1994014539","https://openalex.org/W2040147065","https://openalex.org/W2061676392","https://openalex.org/W2079310705","https://openalex.org/W2093178531","https://openalex.org/W2094751519","https://openalex.org/W2135021129","https://openalex.org/W2544233446","https://openalex.org/W2580620104","https://openalex.org/W2613209849","https://openalex.org/W2613629789","https://openalex.org/W2626907936","https://openalex.org/W2705421977","https://openalex.org/W2724863579","https://openalex.org/W2738373318","https://openalex.org/W2752904899","https://openalex.org/W2783330512","https://openalex.org/W2888439550","https://openalex.org/W2888618670","https://openalex.org/W2889257276","https://openalex.org/W2897640620","https://openalex.org/W2906889822","https://openalex.org/W2907855283","https://openalex.org/W2946436049","https://openalex.org/W2982637165","https://openalex.org/W3002469579","https://openalex.org/W3026797206","https://openalex.org/W3081005361","https://openalex.org/W3109256473","https://openalex.org/W3119285888","https://openalex.org/W3123064828","https://openalex.org/W3172467551","https://openalex.org/W3177901966","https://openalex.org/W3195740361","https://openalex.org/W3198499670","https://openalex.org/W3201756606","https://openalex.org/W4210242329","https://openalex.org/W4226102213","https://openalex.org/W4281490484","https://openalex.org/W4283796562","https://openalex.org/W4293084539","https://openalex.org/W4296870042","https://openalex.org/W4304014316","https://openalex.org/W4306742827","https://openalex.org/W4307362500","https://openalex.org/W4307766901","https://openalex.org/W4311481768","https://openalex.org/W4362608025","https://openalex.org/W4376618234"],"related_works":["https://openalex.org/W4283713765","https://openalex.org/W2104624706","https://openalex.org/W4415692506","https://openalex.org/W2594887579","https://openalex.org/W7142790550","https://openalex.org/W2975567343","https://openalex.org/W2979768870","https://openalex.org/W2523341447","https://openalex.org/W3119880555","https://openalex.org/W2597769938"],"abstract_inverted_index":{"Borrowing":[0],"some":[1],"quotes":[2],"from":[3],"Harper":[4],"Lee's":[5],"novel":[6],"\"To":[7],"Kill":[8],"A":[9],"Mockingbird\"":[10],"to":[11,19,47,51,83],"help":[12],"frame":[13],"our":[14],"manuscript,":[15],"we":[16],"discuss":[17],"methods":[18,69],"profile":[20],"local":[21],"proteomes.":[22],"We":[23,43],"initially":[24],"focus":[25],"on":[26],"chemical":[27],"biology":[28],"regimens":[29],"that":[30],"function":[31,87],"in":[32],"live":[33],"organisms":[34],"and":[35,74,88,92],"use":[36],"reactive":[37,59],"biotin":[38],"species":[39],"for":[40,95],"this":[41],"purpose.":[42],"then":[44],"consider":[45],"ways":[46],"add":[48],"new":[49,91],"dimensions":[50],"these":[52],"experimental":[53],"regimens,":[54],"principally":[55],"by":[56],"releasing":[57],"less":[58],"(i.":[60],"e.,":[61],"more":[62],"selective)":[63],"(preter)natural":[64],"electrophiles.":[65],"Although":[66],"electrophile":[67],"release":[68],"may":[70],"have":[71],"lower":[72],"resolution":[73],"label":[75],"fewer":[76],"proteins":[77],"than":[78],"biotinylation":[79],"methods,":[80],"their":[81],"ability":[82],"probe":[84],"simultaneously":[85],"protein":[86],"locale":[89],"raises":[90],"interesting":[93],"possibilities":[94],"the":[96],"field.":[97]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-03-22T00:00:00"}