{"id":"https://openalex.org/W4393038035","doi":"https://doi.org/10.7554/elife.95168.1","title":"Longitudinal Awake Imaging of Deep Mouse Brain Microvasculature with Super-resolution Ultrasound Localization Microscopy","display_name":"Longitudinal Awake Imaging of Deep Mouse Brain Microvasculature with Super-resolution Ultrasound Localization Microscopy","publication_year":2024,"publication_date":"2024-03-21","ids":{"openalex":"https://openalex.org/W4393038035","doi":"https://doi.org/10.7554/elife.95168.1"},"language":"en","primary_location":{"id":"doi:10.7554/elife.95168.1","doi":"https://doi.org/10.7554/elife.95168.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.95168.1","pdf_url":"https://elifesciences.org/reviewed-preprints/95168v1.pdf","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://elifesciences.org/reviewed-preprints/95168v1.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101678589","display_name":"Yike Wang","orcid":"https://orcid.org/0009-0003-0113-6014","observed_orcids":["https://orcid.org/0009-0003-0113-6014"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yike Wang","raw_affiliation_strings":["Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign"],"raw_orcid":"https://orcid.org/0009-0003-0113-6014","affiliations":[{"raw_affiliation_string":"Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022062699","display_name":"Matthew R. Lowerison","orcid":"https://orcid.org/0000-0002-1125-4554","observed_orcids":["https://orcid.org/0000-0002-1125-4554"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Lowerison","raw_affiliation_strings":["Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign"],"raw_orcid":"https://orcid.org/0000-0002-1125-4554","affiliations":[{"raw_affiliation_string":"Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059624579","display_name":"Qi You","orcid":"https://orcid.org/0000-0002-2706-1394","observed_orcids":["https://orcid.org/0000-0002-2706-1394"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi You","raw_affiliation_strings":["Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","Department of Bioengineering, University of Illinois Urbana-Champaign"],"raw_orcid":"https://orcid.org/0000-0002-2706-1394","affiliations":[{"raw_affiliation_string":"Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Bioengineering, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101990581","display_name":"Bing\u2010Ze Lin","orcid":"https://orcid.org/0000-0001-7323-4236","observed_orcids":["https://orcid.org/0000-0001-7323-4236"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing-Ze Lin","raw_affiliation_strings":["Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060781519","display_name":"Daniel A. Llano","orcid":"https://orcid.org/0000-0003-0933-1837","observed_orcids":["https://orcid.org/0000-0003-0933-1837"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Llano","raw_affiliation_strings":["Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign","Neuroscience Program, University of Illinois Urbana-Champaign"],"raw_orcid":"https://orcid.org/0000-0003-0933-1837","affiliations":[{"raw_affiliation_string":"Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Neuroscience Program, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075793088","display_name":"Pengfei Song","orcid":"https://orcid.org/0000-0002-9103-6345","observed_orcids":["https://orcid.org/0000-0002-9103-6345"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pengfei Song","raw_affiliation_strings":["Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","Department of Bioengineering, University of Illinois Urbana-Champaign","Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign","Neuroscience Program, University of Illinois Urbana-Champaign"],"raw_orcid":"https://orcid.org/0000-0002-9103-6345","affiliations":[{"raw_affiliation_string":"Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Bioengineering, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Neuroscience Program, University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.08420000225305557,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultrasound-localization-microscopy","display_name":"ultrasound localization microscopy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cerebral-microvasculature","display_name":"cerebral microvasculature","score":0.7979999780654907},{"id":"https://openalex.org/keywords/deep-tissue-imaging","display_name":"deep tissue imaging","score":0.7300000190734863},{"id":"https://openalex.org/keywords/anesthetic-effects","display_name":"anesthetic effects","score":0.7450000047683716},{"id":"https://openalex.org/keywords/longitudinal-imaging","display_name":"longitudinal imaging","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cerebral-blood-flow-velocity","display_name":"cerebral blood flow velocity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/mouse-brain","display_name":"mouse brain","score":0.7319999933242798},{"id":"https://openalex.org/keywords/midbrain","display_name":"midbrain","score":0.45500001311302185},{"id":"https://openalex.org/keywords/cortex","display_name":"cortex","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5916398167610168},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5517890453338623},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.4997410774230957},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4806146025657654},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.350664347410202},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33986273407936096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32647356390953064},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3225128650665283},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2568764090538025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22470074892044067},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.15936324000358582},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09319058060646057},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08595296740531921}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.95168.1","doi":"https://doi.org/10.7554/elife.95168.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.95168.1","pdf_url":"https://elifesciences.org/reviewed-preprints/95168v1.pdf","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.95168.1","doi":"https://doi.org/10.7554/elife.95168.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.95168.1","pdf_url":"https://elifesciences.org/reviewed-preprints/95168v1.pdf","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3149276963","display_name":"CAREER: Super-resolution Ultrasound Imaging for High-resolution Functional Mapping of the Brain","funder_award_id":"2237166","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5429895392","display_name":"Next-Generation Ultrasound Localization Microscopy","funder_award_id":"R21EB030072","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7374897213","display_name":"High-resolution cerebral microvascular imaging for characterizing vascular dysfunction in Alzheimer's disease mouse model","funder_award_id":"1r56ns131516-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7781281167","display_name":"Super-resolution imaging of brain microvascular changes in a model of Alzheimer Disease","funder_award_id":"1r21ag077173-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320315474","display_name":"Chan Zuckerberg Initiative","ror":"https://ror.org/02qenvm24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393038035.pdf","grobid_xml":"https://content.openalex.org/works/W4393038035.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1532734690","https://openalex.org/W1605312092","https://openalex.org/W1964426997","https://openalex.org/W1988784644","https://openalex.org/W1994043618","https://openalex.org/W1994966878","https://openalex.org/W1999653836","https://openalex.org/W2019189459","https://openalex.org/W2026985912","https://openalex.org/W2033708119","https://openalex.org/W2034985625","https://openalex.org/W2040378254","https://openalex.org/W2053013902","https://openalex.org/W2070712157","https://openalex.org/W2084049870","https://openalex.org/W2084193611","https://openalex.org/W2088427193","https://openalex.org/W2089133038","https://openalex.org/W2089680506","https://openalex.org/W2105916176","https://openalex.org/W2111291288","https://openalex.org/W2164979083","https://openalex.org/W2174473997","https://openalex.org/W2263258819","https://openalex.org/W2344621938","https://openalex.org/W2473784504","https://openalex.org/W2512639889","https://openalex.org/W2513047215","https://openalex.org/W2517589701","https://openalex.org/W2553362503","https://openalex.org/W2577529438","https://openalex.org/W2599467169","https://openalex.org/W2752285373","https://openalex.org/W2772101345","https://openalex.org/W2780318688","https://openalex.org/W2793842820","https://openalex.org/W2883394240","https://openalex.org/W2901816049","https://openalex.org/W2902168103","https://openalex.org/W2932627566","https://openalex.org/W2943437051","https://openalex.org/W2973406408","https://openalex.org/W2979545998","https://openalex.org/W3006529112","https://openalex.org/W3014929655","https://openalex.org/W3026291620","https://openalex.org/W3039906298","https://openalex.org/W3046235423","https://openalex.org/W3096283175","https://openalex.org/W3120126666","https://openalex.org/W3129083342","https://openalex.org/W3134988681","https://openalex.org/W3136804908","https://openalex.org/W3137368506","https://openalex.org/W3152706483","https://openalex.org/W3158782517","https://openalex.org/W3165352648","https://openalex.org/W3190839224","https://openalex.org/W3212040016","https://openalex.org/W3216841949","https://openalex.org/W4225515608","https://openalex.org/W4226086376","https://openalex.org/W4289783375","https://openalex.org/W4293162314","https://openalex.org/W4297023441","https://openalex.org/W4311471970","https://openalex.org/W4320481616"],"related_works":["https://openalex.org/W4408020805","https://openalex.org/W4224270887","https://openalex.org/W7160933968","https://openalex.org/W4412977866","https://openalex.org/W4411107838","https://openalex.org/W7162573940","https://openalex.org/W4402381313","https://openalex.org/W4225863333","https://openalex.org/W4320481616","https://openalex.org/W4312504675"],"abstract_inverted_index":{"Abstract":[0],"Super-resolution":[1],"ultrasound":[2],"localization":[3],"microscopy":[4],"(ULM)":[5],"is":[6,169,183],"an":[7],"emerging":[8],"imaging":[9,77,148,162,176],"modality":[10],"that":[11,96,190],"resolves":[12],"capillary-scale":[13],"microvasculature":[14],"in":[15,63,78,118,124,133,146,177],"deep":[16],"tissues.":[17],"However,":[18],"existing":[19],"preclinical":[20],"ULM":[21,41,62,76,92,94,127,175,187],"applications":[22,189],"are":[23],"largely":[24],"constrained":[25],"to":[26,70,86,107],"anesthetized":[27],"animals,":[28],"introducing":[29],"confounding":[30],"vascular":[31],"effects":[32],"such":[33],"as":[34],"vasodilation":[35],"and":[36,47,74,121,193],"altered":[37],"hemodynamics.":[38],"As":[39],"such,":[40],"quantifications":[42],"(e.g.,":[43],"vessel":[44],"diameter,":[45],"density,":[46],"flow":[48,136],"velocity)":[49],"may":[50],"be":[51],"confounded":[52],"by":[53],"the":[54,59,88,119,125,150,158,165,170,178],"use":[55],"of":[56,61,102,149,164],"anesthesia,":[57],"undermining":[58],"usefulness":[60],"practice.":[64],"Here":[65],"we":[66],"introduce":[67],"a":[68,99,130],"method":[69],"address":[71],"this":[72],"limitation":[73],"achieve":[75],"awake":[79,89,108,143,179,192],"mouse":[80,180],"brain.":[81],"Pupillary":[82],"monitoring":[83],"was":[84,115],"used":[85],"confirm":[87],"state":[90],"during":[91],"imaging.":[93],"revealed":[95,129],"veins":[97],"showed":[98],"greater":[100],"degree":[101],"vascularity":[103],"reduction":[104,114,132],"from":[105],"anesthesia":[106],"states":[109],"than":[110],"did":[111],"arteries.":[112],"The":[113],"most":[116],"significant":[117,123,131],"midbrain":[120],"least":[122],"cortex.":[126],"also":[128],"venous":[134],"blood":[135],"velocity":[137],"across":[138],"different":[139],"brain":[140,153,188],"regions":[141],"under":[142],"conditions.":[144],"Serial":[145],"vivo":[147],"same":[151],"animal":[152],"at":[154],"weekly":[155],"intervals":[156],"demonstrated":[157],"highly":[159],"robust":[160],"longitudinal":[161,174],"capability":[163],"proposed":[166],"technique.":[167],"This":[168],"first":[171],"study":[172],"demonstrating":[173],"brain,":[181],"which":[182],"essential":[184],"for":[185],"many":[186],"require":[191],"behaving":[194],"animals.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-03-22T00:00:00"}