{"id":"https://openalex.org/W4392887367","doi":"https://doi.org/10.1227/neu.0000000000002809_388","title":"388 The First Endovascular Rat Glioma Model for Pre-clinical Evaluation of Intra-arterial Therapeutics","display_name":"388 The First Endovascular Rat Glioma Model for Pre-clinical Evaluation of Intra-arterial Therapeutics","publication_year":2024,"publication_date":"2024-03-15","ids":{"openalex":"https://openalex.org/W4392887367","doi":"https://doi.org/10.1227/neu.0000000000002809_388"},"language":"en","primary_location":{"id":"doi:10.1227/neu.0000000000002809_388","doi":"https://doi.org/10.1227/neu.0000000000002809_388","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0000000000002809_388","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038102032","display_name":"Jaims Lim","orcid":"https://orcid.org/0000-0002-9847-3601","observed_orcids":["https://orcid.org/0000-0002-9847-3601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaims Lim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003162837","display_name":"Ammad A. Baig","orcid":"https://orcid.org/0000-0002-8241-6864","observed_orcids":["https://orcid.org/0000-0002-8241-6864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ammad Baig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075041038","display_name":"Brianna M. Donnelly","orcid":"https://orcid.org/0000-0002-4109-0589","observed_orcids":["https://orcid.org/0000-0002-4109-0589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brianna M. Donnelly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018943967","display_name":"Lee Daniel Chaves","orcid":"https://orcid.org/0000-0001-9922-5012","observed_orcids":["https://orcid.org/0000-0001-9922-5012"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee Chaves","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026892831","display_name":"Suyog U. Pol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suyog Pol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079924329","display_name":"Carmon Koenigsknecht","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmon Koenigsknecht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013871153","display_name":"Donald Pionessa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald Pionessa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021590251","display_name":"Bennett Reuben Levy","orcid":"https://orcid.org/0000-0002-9450-3113","observed_orcids":["https://orcid.org/0000-0002-9450-3113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bennett Reuben Levy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055467666","display_name":"Liza C. Gutierrez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liza Gutierrez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049607907","display_name":"Vincent M. Tutino","orcid":"https://orcid.org/0000-0002-1331-2551","observed_orcids":["https://orcid.org/0000-0002-1331-2551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent Tutino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028101627","display_name":"Elad I. Levy","orcid":"https://orcid.org/0000-0002-6208-3724","observed_orcids":["https://orcid.org/0000-0002-6208-3724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elad I. Levy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037816826","display_name":"Adnan Hussain Siddiqui","orcid":"https://orcid.org/0000-0002-9519-0059","observed_orcids":["https://orcid.org/0000-0002-9519-0059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adnan Hussain Siddiqui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.281,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49738151,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"70","issue":"Supplement_1","first_page":"117","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.7770000100135803},{"id":"https://openalex.org/keywords/intra-arterial-chemotherapy","display_name":"intra-arterial chemotherapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/c6-glioma","display_name":"C6 glioma","score":0.8379999995231628},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5649999976158142},{"id":"https://openalex.org/keywords/femoral-artery-catheterization","display_name":"femoral artery catheterization","score":0.843999981880188},{"id":"https://openalex.org/keywords/internal-carotid-artery","display_name":"internal carotid artery","score":0.8569999933242798},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9210000038146973},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":1.0},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":1.0},{"id":"https://openalex.org/keywords/preclinical-drug-testing","display_name":"preclinical drug testing","score":0.5910000205039978},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9612090587615967},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.6813100576400757},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6712641716003418},{"id":"https://openalex.org/C2779723990","wikidata":"https://www.wikidata.org/wiki/Q707174","display_name":"Femoral artery","level":2,"score":0.652042806148529},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.5996477007865906},{"id":"https://openalex.org/C2778333808","wikidata":"https://www.wikidata.org/wiki/Q515848","display_name":"Internal carotid artery","level":2,"score":0.5164585113525391},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.4209986925125122},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.37200355529785156},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33451536297798157},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.28341734409332275},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.2537305951118469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2393915355205536},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20160898566246033},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1227/neu.0000000000002809_388","doi":"https://doi.org/10.1227/neu.0000000000002809_388","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0000000000002809_388","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4375950437","https://openalex.org/W4401197095","https://openalex.org/W4386019058","https://openalex.org/W4327608154","https://openalex.org/W2435724074","https://openalex.org/W4408504419","https://openalex.org/W1893609016","https://openalex.org/W4413464522","https://openalex.org/W2013497246","https://openalex.org/W2575565425"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Several":[1],"translational":[2],"animal":[3,20],"models":[4],"have":[5],"been":[6],"described":[7],"assessing":[8],"intra-arterial":[9],"(IA)":[10],"treatments":[11],"for":[12,106,186,248,252],"malignant":[13],"gliomas.":[14],"We":[15,226],"describe":[16],"the":[17,70,97,135,228,240],"first":[18,229],"endovascular":[19,148,230],"model":[21,234],"that":[22,235],"allows":[23,236],"testing":[24],"of":[25,188,209,213,218,239,245,256],"IA":[26,199,220,231,246],"drug":[27],"delivery":[28],"as":[29],"first-line":[30],"treatment,":[31],"which":[32,66],"is":[33],"difficult":[34],"to":[35,69,81,140,198],"do":[36],"in":[37,96],"actual":[38],"patients.":[39],"METHODS:":[40],"Wistar":[41],"rats":[42,89,123,163,183,204],"underwent":[43,124],"left":[44,71,98,136],"femoral":[45,125,190],"artery":[46,74,126,139],"catherization":[47],"with":[48,60,92,128,158,167,170],"a":[49],"Balt":[50],"Magic":[51],"1.2F":[52],"catheter":[53],"or":[54,131],"Marathon":[55],"Flow":[56],"directed":[57],"1.5F":[58],"Microcatheter":[59],"an":[61],"Asahi":[62],"Chikai":[63],"0.008":[64],"micro-guidewire":[65],"was":[67,79,153,156,177],"navigated":[68],"internal":[72,137],"carotid":[73,138],"under":[75],"x-ray.":[76],"25%":[77],"mannitol":[78],"administered":[80],"test":[82,141],"blood":[83],"brain":[84],"barrier":[85],"breakdown":[86],"(BBBB).":[87],"Additional":[88,122],"were":[90,104,117,164,184],"implanted":[91,166],"C6":[93,101,168],"glioma":[94,233],"cells":[95],"frontal":[99],"lobe.":[100],"Glioma-Implanted":[102],"Rats":[103],"monitored":[105],"overall":[107],"survival":[108,176],"and":[109,143,150,193,215,243,254],"tumor":[110],"growth.":[111],"Tumor":[112],"volumes":[113],"from":[114],"MRI":[115],"images":[116],"calculated":[118],"utilizing":[119],"3D":[120],"slicer.":[121],"catheterization":[127,191,238],"Bevacizumab,":[129],"carboplatin,":[130,214],"irinotecan":[132,219],"injected":[133],"into":[134],"feasibility":[142],"safety.":[144],"RESULTS:":[145],"A":[146],"successful":[147],"access":[149,253],"BBBB":[151,155,194],"protocol":[152,192],"established.":[154],"confirmed":[157,171],"positive":[159],"Evans-blue":[160],"staining.":[161],"10":[162,207],"successfully":[165],"gliomas":[169,249],"growths":[172],"on":[173],"MRI.":[174],"Overall":[175],"19.75":[178],"\u00b1":[179],"2.21":[180],"days.":[181],"5":[182],"utilized":[185],"development":[187],"our":[189],"testing.":[195],"With":[196],"regards":[197],"chemotherapy":[200],"dosage":[201],"testing,":[202],"control":[203],"tolerated":[205],"targeted":[206],"mg/kg":[208,212,217],"bevascizumab,":[210],"2.4":[211],"15":[216],"ICA":[221],"injections":[222],"without":[223,250],"complications.":[224],"CONCLUSIONS:":[225],"present":[227],"rat":[232],"selective":[237],"intracranial":[241],"vasculature":[242],"assessment":[244],"therapies":[247],"need":[251],"sacrifice":[255],"proximal":[257],"cerebrovasculature.":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-03-17T00:00:00"}
