{"id":"https://openalex.org/W4392880833","doi":"https://doi.org/10.1038/s41467-024-46722-w","title":"Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1","display_name":"Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1","publication_year":2024,"publication_date":"2024-03-16","ids":{"openalex":"https://openalex.org/W4392880833","doi":"https://doi.org/10.1038/s41467-024-46722-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/38493146","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10944535"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-46722-w","doi":"https://doi.org/10.1038/s41467-024-46722-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-46722-w","pdf_url":"https://www.nature.com/articles/s41467-024-46722-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-024-46722-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012939975","display_name":"Nitesh Khandelwal","orcid":"https://orcid.org/0000-0002-6319-8048","observed_orcids":["https://orcid.org/0000-0002-6319-8048"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitesh Kumar Khandelwal","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California - San Francisco, San Francisco, CA, 94158, USA","Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California - San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036859117","display_name":"Thomas M. Tomasiak","orcid":"https://orcid.org/0000-0002-5884-5968","observed_orcids":["https://orcid.org/0000-0002-5884-5968"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas M. Tomasiak","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA. tomasiak@arizona.edu","Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":"https://orcid.org/0000-0002-5884-5968","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA. tomasiak@arizona.edu","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036859117"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":6790,"currency":"USD","value_usd":6790},"apc_paid":{"value":6790,"currency":"USD","value_usd":6790},"fwci":3.1889,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.93961567,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"2389","last_page":"2389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ycf1","display_name":"ycf1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.7540000081062317},{"id":"https://openalex.org/keywords/regulatory-domain","display_name":"regulatory domain","score":0.7879999876022339},{"id":"https://openalex.org/keywords/autoinhibition","display_name":"autoinhibition","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.8059999942779541},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.5960000157356262},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7016040682792664},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.6098668575286865},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5549710392951965},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.49536192417144775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4905478358268738},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4655051827430725},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45201194286346436},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.4207920432090759},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3827996253967285},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.3274599313735962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30506837368011475},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14372438192367554},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13892579078674316},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.09762275218963623}],"mesh":[{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-024-46722-w","doi":"https://doi.org/10.1038/s41467-024-46722-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-46722-w","pdf_url":"https://www.nature.com/articles/s41467-024-46722-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2023.06.22.546176","doi":"https://doi.org/10.1101/2023.06.22.546176","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.06.22.546176","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/06/22/2023.06.22.546176.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10944535","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10944535","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10944535/pdf/41467_2024_Article_46722.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:38493146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38493146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46722-w","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-46722-w","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:6821288c06054450bec9a5b11d854742","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6821288c06054450bec9a5b11d854742","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)","raw_type":"article"},{"id":"pmh:oai:osti.gov:2471634","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/2471634","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1038/s41467-024-46722-w","doi":"https://doi.org/10.1038/s41467-024-46722-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-46722-w","pdf_url":"https://www.nature.com/articles/s41467-024-46722-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3508161151","display_name":null,"funder_award_id":"grid.436923.9","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4677923812","display_name":null,"funder_award_id":"AI156270","funder_id":"https://openalex.org/F4320309123","funder_display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4872775453","display_name":null,"funder_award_id":"OD011981","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5718375046","display_name":null,"funder_award_id":"grid.436923.9","funder_id":"https://openalex.org/F4320309233","funder_display_name":"Oregon Health and Science University"},{"id":"https://openalex.org/G5868986941","display_name":"Pacific Northwest Center for Cryo-EM","funder_award_id":"U24GM129547","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6780141363","display_name":null,"funder_award_id":"436923.9","funder_id":"https://openalex.org/F4320309233","funder_display_name":"Oregon Health and Science University"},{"id":"https://openalex.org/G7562546725","display_name":null,"funder_award_id":"436923.9","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7673727097","display_name":null,"funder_award_id":"grid.436923.9","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G7913850483","display_name":null,"funder_award_id":"grid.436923.9","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G860964591","display_name":"JEOL JEM-1400 Transmission Electron Microscope","funder_award_id":"1s10od011981-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000859284","display_name":"ATP Binding Cassette (ABC) Transporters in Fungal Drug Tolerance","funder_award_id":"R01AI156270","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G973194890","display_name":null,"funder_award_id":"OD011981","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320309233","display_name":"Oregon Health and Science University","ror":"https://ror.org/009avj582"},{"id":"https://openalex.org/F4320310160","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392880833.pdf","grobid_xml":"https://content.openalex.org/works/W4392880833.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1497015848","https://openalex.org/W1570043275","https://openalex.org/W1966528069","https://openalex.org/W1975971473","https://openalex.org/W1976348985","https://openalex.org/W1980444360","https://openalex.org/W1981820162","https://openalex.org/W1989009320","https://openalex.org/W2004394635","https://openalex.org/W2010242646","https://openalex.org/W2010691166","https://openalex.org/W2039599894","https://openalex.org/W2050179344","https://openalex.org/W2057865646","https://openalex.org/W2064434946","https://openalex.org/W2074473216","https://openalex.org/W2101638068","https://openalex.org/W2104136593","https://openalex.org/W2144081223","https://openalex.org/W2154520761","https://openalex.org/W2169357831","https://openalex.org/W2271635813","https://openalex.org/W2436697353","https://openalex.org/W2587625522","https://openalex.org/W2589923912","https://openalex.org/W2593511418","https://openalex.org/W2602180809","https://openalex.org/W2734356283","https://openalex.org/W2765322245","https://openalex.org/W2797365943","https://openalex.org/W2801376357","https://openalex.org/W2953320394","https://openalex.org/W2973457155","https://openalex.org/W2994662366","https://openalex.org/W3006850052","https://openalex.org/W3034544918","https://openalex.org/W3049001491","https://openalex.org/W3069653331","https://openalex.org/W3083406432","https://openalex.org/W3088158751","https://openalex.org/W3127948229","https://openalex.org/W3161335805","https://openalex.org/W3177828909","https://openalex.org/W3182767159","https://openalex.org/W3213779066","https://openalex.org/W4200551850","https://openalex.org/W4221071430","https://openalex.org/W4317938023","https://openalex.org/W4353055525","https://openalex.org/W4376126459","https://openalex.org/W4379207267","https://openalex.org/W4391531087","https://openalex.org/W4392155415","https://openalex.org/W4392367307"],"related_works":["https://openalex.org/W4221071430","https://openalex.org/W4401991385","https://openalex.org/W7119528653","https://openalex.org/W6902062478","https://openalex.org/W2123420986","https://openalex.org/W1976348985","https://openalex.org/W1989009320","https://openalex.org/W2002029772","https://openalex.org/W4220729170","https://openalex.org/W2076860446"],"abstract_inverted_index":{"Yeast":[0],"Cadmium":[1],"Factor":[2],"1":[3],"(Ycf1)":[4],"sequesters":[5],"glutathione":[6],"and":[7,59,83,107,121],"glutathione-heavy":[8],"metal":[9],"conjugates":[10],"into":[11],"yeast":[12],"vacuoles":[13],"as":[14],"a":[15,113,149],"cellular":[16],"detoxification":[17],"mechanism.":[18,54],"Ycf1":[19,67,80,102,152],"belongs":[20],"to":[21],"the":[22,37,65,78,86,101,122,131,137,142,145],"C":[23],"subfamily":[24],"of":[25,56,64,71,112,117,133,144,157],"ATP":[26],"Binding":[27],"Cassette":[28],"(ABC)":[29],"transporters":[30],"characterized":[31],"by":[32,154],"long":[33],"flexible":[34],"linkers,":[35],"notably":[36],"regulatory":[38],"domain":[39],"(R-domain).":[40],"R-domain":[41,73,88,146,158],"phosphorylation":[42,134],"is":[43],"necessary":[44],"for":[45,151],"activity,":[46],"whereas":[47],"dephosphorylation":[48],"induces":[49],"autoinhibition":[50],"through":[51],"an":[52,91,95,118],"undefined":[53],"Because":[55],"its":[57],"transient":[58],"dynamic":[60],"nature,":[61],"no":[62],"structure":[63,93],"dephosphorylated":[66,79],"exists,":[68],"limiting":[69],"understanding":[70],"this":[72],"regulation.":[74],"Here,":[75],"we":[76],"capture":[77],"using":[81],"cryo-EM":[82],"show":[84],"that":[85,111,140],"unphosphorylated":[87],"indeed":[89],"forms":[90],"ordered":[92],"with":[94],"unexpected":[96],"hairpin":[97,138],"topology":[98],"bound":[99],"within":[100,136],"substrate":[103],"cavity.":[104],"This":[105],"architecture":[106],"binding":[108],"mode":[109],"resemble":[110],"viral":[114],"peptide":[115,126],"inhibitor":[116],"ABC":[119],"transporter":[120],"secreted":[123],"bacterial":[124],"WXG":[125],"toxins.":[127],"We":[128],"further":[129],"reveal":[130],"subset":[132],"sites":[135],"turn":[139],"drive":[141],"reorganization":[143],"conformation,":[147],"suggesting":[148],"mechanism":[150],"activation":[153],"phosphorylation-dependent":[155],"release":[156],"mediated":[159],"autoinhibition.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2024-03-17T00:00:00"}
