{"id":"https://openalex.org/W4392880481","doi":"https://doi.org/10.1007/s11523-024-01038-z","title":"Modelling the Effectiveness of Tepotinib in Comparison to Standard-of-Care Treatments in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) Harbouring METex14 Skipping in the UK","display_name":"Modelling the Effectiveness of Tepotinib in Comparison to Standard-of-Care Treatments in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) Harbouring METex14 Skipping in the UK","publication_year":2024,"publication_date":"2024-03-01","ids":{"openalex":"https://openalex.org/W4392880481","doi":"https://doi.org/10.1007/s11523-024-01038-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/38492157","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10963552"},"language":"en","primary_location":{"id":"doi:10.1007/s11523-024-01038-z","doi":"https://doi.org/10.1007/s11523-024-01038-z","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1007/s11523-024-01038-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11523-024-01038-z.pdf","source":{"id":"https://openalex.org/S163958984","display_name":"Targeted Oncology","issn_l":"1776-2596","issn":["1776-2596","1776-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11523-024-01038-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114015167","display_name":"R. Batteson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rachael Batteson","raw_affiliation_strings":["Delta Hat Ltd, Nottingham, UK. rbatteson@deltahat.com","Delta Hat Ltd, Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delta Hat Ltd, Nottingham, UK. rbatteson@deltahat.com","institution_ids":[]},{"raw_affiliation_string":"Delta Hat Ltd, Nottingham, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058585329","display_name":"Emma S. Hook","orcid":"https://orcid.org/0000-0002-6503-2850","observed_orcids":["https://orcid.org/0000-0002-6503-2850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma Hook","raw_affiliation_strings":["Delta Hat Ltd, Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delta Hat Ltd, Nottingham, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046932679","display_name":"H. Wheat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hollie Wheat","raw_affiliation_strings":["Delta Hat Ltd, Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delta Hat Ltd, Nottingham, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033526386","display_name":"Anthony James Hatswell","orcid":"https://orcid.org/0000-0003-1129-326X","observed_orcids":["https://orcid.org/0000-0003-1129-326X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony J. Hatswell","raw_affiliation_strings":["Delta Hat Ltd, Nottingham, UK","Department of Statistical Science, UCL, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delta Hat Ltd, Nottingham, UK","institution_ids":[]},{"raw_affiliation_string":"Department of Statistical Science, UCL, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083292431","display_name":"Helene Vioix","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I4405266695","display_name":"Merck Healthcare KGaA, Darmstadt (Germany)","ror":"https://ror.org/04vpzfb52","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helene Vioix","raw_affiliation_strings":["Global Evidence and Value Department, Merck Healthcare KGaA, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Evidence and Value Department, Merck Healthcare KGaA, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas McLean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086951","display_name":"Merck Serono Ltd. (United Kingdom)","ror":"https://ror.org/00148fb49","country_code":"GB","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210086951"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas McLean","raw_affiliation_strings":["Merck Serono Ltd., an affiliate of Merck KGaA, Feltham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Serono Ltd., an affiliate of Merck KGaA, Feltham, UK","institution_ids":["https://openalex.org/I4210086951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023208306","display_name":"Stamatia Theodora Alexopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086951","display_name":"Merck Serono Ltd. (United Kingdom)","ror":"https://ror.org/00148fb49","country_code":"GB","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210086951"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stamatia Theodora Alexopoulos","raw_affiliation_strings":["Merck Serono Ltd., an affiliate of Merck KGaA, Feltham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Serono Ltd., an affiliate of Merck KGaA, Feltham, UK","institution_ids":["https://openalex.org/I4210086951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102772258","display_name":"Shobhit Baijal","orcid":"https://orcid.org/0000-0002-5842-6886","observed_orcids":["https://orcid.org/0000-0002-5842-6886"]},"institutions":[{"id":"https://openalex.org/I1308923049","display_name":"University Hospitals Birmingham NHS Foundation Trust","ror":"https://ror.org/014ja3n03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shobhit Baijal","raw_affiliation_strings":["University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK","institution_ids":["https://openalex.org/I1308923049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001058762","display_name":"Paul K. Paik","orcid":"https://orcid.org/0000-0002-9464-3984","observed_orcids":["https://orcid.org/0000-0002-9464-3984"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul K. Paik","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA","Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5114015167"],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":0.8417,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.70311443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"19","issue":"2","first_page":"191","last_page":"201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.7699999809265137,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.7699999809265137,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.22450000047683716,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tepotinib","display_name":"tepotinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/met-exon-14-skipping","display_name":"MET exon 14 skipping","score":0.9660000205039978},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9229999780654907},{"id":"https://openalex.org/keywords/met-inhibitors","display_name":"MET inhibitors","score":0.8619999885559082},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.9100000262260437},{"id":"https://openalex.org/keywords/survival-benefit","display_name":"survival benefit","score":0.546999990940094},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.8009999990463257},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.902999997138977},{"id":"https://openalex.org/keywords/nintedanib","display_name":"nintedanib","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.5770000219345093},{"id":"https://openalex.org/keywords/indirect-treatment-comparison","display_name":"indirect treatment comparison","score":0.7379999756813049},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.8550000190734863},{"id":"https://openalex.org/keywords/vision-trial","display_name":"VISION trial","score":0.6919999718666077},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6850000023841858},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9366501569747925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6181129813194275},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6173806190490723},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5433739423751831},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.5067055821418762},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48484671115875244},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4711139500141144},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.4643761217594147},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4423132538795471},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43638724088668823},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4208764135837555},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.210472971200943},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s11523-024-01038-z","doi":"https://doi.org/10.1007/s11523-024-01038-z","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1007/s11523-024-01038-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11523-024-01038-z.pdf","source":{"id":"https://openalex.org/S163958984","display_name":"Targeted Oncology","issn_l":"1776-2596","issn":["1776-2596","1776-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10963552","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10963552","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10963552/pdf/11523_2024_Article_1038.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Target Oncol","raw_type":"Text"},{"id":"pmid:38492157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38492157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted oncology","raw_type":"Journal Article"},{"id":"pmh:oai:frl.publisso.de:frl:6518869","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10963552","pdf_url":null,"source":{"id":"https://openalex.org/S4377196269","display_name":"PUBLISSO (German National Library of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Targeted oncology, 19(2):191-201","raw_type":"Zeitschriftenartikel"}],"best_oa_location":{"id":"doi:10.1007/s11523-024-01038-z","doi":"https://doi.org/10.1007/s11523-024-01038-z","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1007/s11523-024-01038-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11523-024-01038-z.pdf","source":{"id":"https://openalex.org/S163958984","display_name":"Targeted Oncology","issn_l":"1776-2596","issn":["1776-2596","1776-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392880481.pdf","grobid_xml":"https://content.openalex.org/works/W4392880481.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1982967337","https://openalex.org/W1999130958","https://openalex.org/W2010770530","https://openalex.org/W2013564592","https://openalex.org/W2140980839","https://openalex.org/W2163351155","https://openalex.org/W2170030318","https://openalex.org/W2337016604","https://openalex.org/W2534193912","https://openalex.org/W2796582438","https://openalex.org/W2802552316","https://openalex.org/W2883422525","https://openalex.org/W2889307896","https://openalex.org/W2925446385","https://openalex.org/W2944120833","https://openalex.org/W2946166987","https://openalex.org/W2965226350","https://openalex.org/W3000445801","https://openalex.org/W3009099064","https://openalex.org/W3021911855","https://openalex.org/W3031018272","https://openalex.org/W3120933346","https://openalex.org/W3128646645","https://openalex.org/W3137208756","https://openalex.org/W3152878368","https://openalex.org/W3154805493","https://openalex.org/W3155376330","https://openalex.org/W3165293110","https://openalex.org/W4210992155","https://openalex.org/W4311339096","https://openalex.org/W4311359313","https://openalex.org/W4311361042","https://openalex.org/W4321254002","https://openalex.org/W4379278548"],"related_works":["https://openalex.org/W7172398605","https://openalex.org/W4411919642","https://openalex.org/W4379278548","https://openalex.org/W7162511491","https://openalex.org/W4379282323","https://openalex.org/W4388046112","https://openalex.org/W4221101315","https://openalex.org/W7160517029","https://openalex.org/W4282968376","https://openalex.org/W7131818085"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patients":[1],"with":[2,33,44,277],"non-small":[3,20,34,122],"cell":[4,21,35,123],"lung":[5,22,36,124],"cancer":[6,37,125],"harbouring":[7,38],"mesenchymal-epithelial":[8],"transition":[9],"exon":[10],"14":[11],"(METex14)":[12],"skipping":[13,40,133],"typically":[14],"demonstrate":[15],"poorer":[16],"prognosis":[17],"than":[18],"overall":[19,121,151],"cancer.":[23],"Until":[24],"recently,":[25],"no":[26],"targeted":[27],"treatments":[28,46],"were":[29,108,155],"available":[30],"for":[31,91,147,297],"patients":[32,235],"METex14":[39,132],"in":[41,120,130,197,208,233,245],"the":[42,52,77,101,131,158,171,176,213,260,268,282,285,288,300],"UK,":[43],"limited":[45],"available.":[47],"OBJECTIVE:":[48],"This":[49],"study":[50],"estimates":[51],"long-term":[53],"survival":[54,78,146,149,187,222],"and":[55,79,89,93,126,140,145,150,161,194,200,205,226,236,238,257,262],"quality-adjusted":[56,80,142,251],"life-year":[57,81,143,252],"benefit":[58],"of":[59,66,83,224,271,284,303],"MET":[60],"inhibitor":[61],"tepotinib":[62,84,179,215,298],"versus":[63,85,189,229,241,299],"current":[64,301],"standard":[65,302],"care":[67],"from":[68,100,267],"a":[69,165,184,220],"UK":[70],"perspective.":[71],"METHODS:":[72],"A":[73],"partitioned-survival":[74],"model":[75],"assessed":[76,163],"benefits":[82],"immunotherapy":[86],"\u00b1":[87,191,202,231,243],"chemotherapy":[88,90,192,232],"untreated":[92,198,234,261],"previously":[94,209,246,263],"treated":[95,210,247,264],"patients,":[96,199],"respectively,":[97],"using":[98,164],"evidence":[99,129,270,286],"single-arm":[102],"VISION":[103],"trial":[104],"(NCT02864992).":[105],"Two":[106],"approaches":[107],"used":[109],"to":[110,182,218],"inform":[111],"an":[112],"indirect":[113,172,272],"treatment":[114,173,273],"comparison:":[115],"(1)":[116],"published":[117,177],"clinical":[118],"trials":[119],"(2)":[127],"real-world":[128,269],"population.":[134],"Results":[135,266],"are":[136,275],"presented":[137],"as":[138],"median":[139,185,221],"total":[141,250],"gain":[144,188,223,253],"progression-free":[148,186],"survival.":[152],"Survival":[153],"curves":[154],"validated":[156],"against":[157,175],"external":[159],"literature":[160],"uncertainty":[162],"probabilistic":[166],"sensitivity":[167],"analysis.":[168],"RESULTS:":[169],"Using":[170],"comparison":[174],"literature,":[178],"is":[180,216],"estimated":[181,217],"have":[183,219,292],"pembrolizumab":[190,230],"(11.0":[193],"9.2":[195,227],"months)":[196,207],"docetaxel":[201,242],"nintedanib":[203,244],"(5.1":[204],"6.4":[206],"patients.":[211,248],"Across":[212],"populations,":[214],"15.4":[225],"months":[228,240],"12.8":[237],"5.1":[239],"The":[249],"ranges":[254],"between":[255],"0.56":[256],"1.17":[258],"across":[259],"populations.":[265],"comparisons":[274],"consistent":[276],"these":[278],"findings.":[279],"CONCLUSIONS:":[280],"Despite":[281],"limitations":[283],"base,":[287],"numerous":[289],"analyses":[290],"conducted":[291],"consistently":[293],"indicated":[294],"positive":[295],"outcomes":[296],"care.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-03-17T00:00:00"}
