{"id":"https://openalex.org/W4392854060","doi":"https://doi.org/10.1158/1078-0432.25415340","title":"Supplementary Table S2 from Phase I Study of ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer Progressing on Enzalutamide","display_name":"Supplementary Table S2 from Phase I Study of ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer Progressing on Enzalutamide","publication_year":2024,"publication_date":"2024-03-15","ids":{"openalex":"https://openalex.org/W4392854060","doi":"https://doi.org/10.1158/1078-0432.25415340"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.25415340","doi":"https://doi.org/10.1158/1078-0432.25415340","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.25415340","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.25415340","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062426672","display_name":"Wassim M. Abida","orcid":"https://orcid.org/0000-0002-9006-7043","observed_orcids":["https://orcid.org/0000-0002-9006-7043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wassim Abida","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9006-7043","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024065466","display_name":"Andrew Warren Hahn","orcid":"https://orcid.org/0000-0002-4153-205X","observed_orcids":["https://orcid.org/0000-0002-4153-205X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew W. Hahn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4153-205X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088518998","display_name":"Neal D. Shore","orcid":"https://orcid.org/0000-0001-5767-0548","observed_orcids":["https://orcid.org/0000-0001-5767-0548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neal Shore","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5767-0548","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100763587","display_name":"Neeraj Agarwal","orcid":"https://orcid.org/0000-0003-1076-0428","observed_orcids":["https://orcid.org/0000-0003-1076-0428","https://orcid.org/0000-0001-6574-8499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neeraj Agarwal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1076-0428","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024372930","display_name":"PAUL R. SIEBER","orcid":"https://orcid.org/0000-0002-6064-9683","observed_orcids":["https://orcid.org/0000-0002-6064-9683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Sieber","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6064-9683","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101655026","display_name":"Matthew R. Smith","orcid":"https://orcid.org/0000-0002-5983-8989","observed_orcids":["https://orcid.org/0000-0002-5983-8989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew R. Smith","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5983-8989","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091696839","display_name":"Tanya Barauskas Dorff","orcid":"https://orcid.org/0000-0001-5990-298X","observed_orcids":["https://orcid.org/0000-0001-5990-298X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanya Dorff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5990-298X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041002400","display_name":"Paul Monk","orcid":"https://orcid.org/0000-0002-0508-2987","observed_orcids":["https://orcid.org/0000-0002-0508-2987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Monk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0508-2987","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046387277","display_name":"Matthew B. Rettig","orcid":"https://orcid.org/0000-0002-7394-3056","observed_orcids":["https://orcid.org/0000-0002-7394-3056"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Rettig","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7394-3056","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012521305","display_name":"Rupal Patel","orcid":"https://orcid.org/0009-0005-5978-2179","observed_orcids":["https://orcid.org/0009-0005-5978-2179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rupal Patel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-5978-2179","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063018405","display_name":"Anne Page","orcid":"https://orcid.org/0009-0006-7692-4703","observed_orcids":["https://orcid.org/0009-0006-7692-4703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Page","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-7692-4703","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018947577","display_name":"Maureen Duff","orcid":"https://orcid.org/0009-0002-5393-4248","observed_orcids":["https://orcid.org/0009-0002-5393-4248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maureen Duff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-5393-4248","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077912031","display_name":"Rongda Xu","orcid":"https://orcid.org/0000-0003-0719-7005","observed_orcids":["https://orcid.org/0000-0003-0719-7005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rongda Xu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0719-7005","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089701962","display_name":"Jian Wang","orcid":"https://orcid.org/0009-0004-9735-2578","observed_orcids":["https://orcid.org/0009-0004-9735-2578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-9735-2578","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074808010","display_name":"Shravani R. Barkund","orcid":"https://orcid.org/0009-0001-1620-0942","observed_orcids":["https://orcid.org/0009-0001-1620-0942"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shravani Barkund","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-1620-0942","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057054848","display_name":"Aleksandr Pankov","orcid":"https://orcid.org/0000-0003-1251-2911","observed_orcids":["https://orcid.org/0000-0003-1251-2911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aleksandr Pankov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1251-2911","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060075125","display_name":"Amber W. Wang","orcid":"https://orcid.org/0000-0001-5073-3980","observed_orcids":["https://orcid.org/0000-0001-5073-3980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amber Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5073-3980","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040110214","display_name":"Melissa R. Junttila","orcid":"https://orcid.org/0000-0003-3538-1192","observed_orcids":["https://orcid.org/0000-0003-3538-1192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa R. Junttila","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3538-1192","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041698432","display_name":"Pratik S. Multani","orcid":"https://orcid.org/0000-0001-8358-3560","observed_orcids":["https://orcid.org/0000-0001-8358-3560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pratik S. Multani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8358-3560","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022839853","display_name":"Anneleen Daemen","orcid":"https://orcid.org/0000-0001-6287-7105","observed_orcids":["https://orcid.org/0000-0001-6287-7105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anneleen Daemen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6287-7105","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009723460","display_name":"Edna Chow Maneval","orcid":"https://orcid.org/0000-0001-8131-755X","observed_orcids":["https://orcid.org/0000-0001-8131-755X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edna Chow Maneval","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8131-755X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008820123","display_name":"Christopher J. Logothetis","orcid":"https://orcid.org/0000-0002-6365-1711","observed_orcids":["https://orcid.org/0000-0002-6365-1711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher J. Logothetis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6365-1711","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017288060","display_name":"Michael J. Morris","orcid":"https://orcid.org/0000-0002-9454-0096","observed_orcids":["https://orcid.org/0000-0002-9454-0096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Morris","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9454-0096","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.8510000109672546},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glucocorticoid-receptor-antagonist","display_name":"glucocorticoid receptor antagonist","score":0.9520000219345093},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cell-free-rna","display_name":"cell-free RNA","score":0.8209999799728394},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.9919331073760986},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7773173451423645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6027708053588867},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5236812829971313},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4390449523925781},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4344240427017212},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.423051118850708},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.3864271640777588},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36815500259399414},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33844220638275146},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3336030840873718},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25329387187957764}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.25415340","doi":"https://doi.org/10.1158/1078-0432.25415340","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.25415340","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.25415340.v1","doi":"https://doi.org/10.1158/1078-0432.25415340.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.25415340.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/25415340","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Table_S2_from_Phase_I_Study_of_ORIC-101_a_Glucocorticoid_Receptor_Antagonist_in_Combination_with_Enzalutamide_in_Patients_with_Metastatic_Castration-resistant_Prostate_Cancer_Progressing_on_Enzalutamide/25415340","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.25415340","doi":"https://doi.org/10.1158/1078-0432.25415340","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.25415340","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392853536","https://openalex.org/W4390919243","https://openalex.org/W4200348192","https://openalex.org/W4200136145","https://openalex.org/W4361890472","https://openalex.org/W3008288974","https://openalex.org/W4362627763","https://openalex.org/W2999327001"],"abstract_inverted_index":{"Supplementary":[0],"Table":[1],"2.ctDNA":[2],"Data":[3,8],"for":[4,9],"29":[5],"and":[6],"cfRNA":[7],"26":[10],"Patients":[11],"in":[12],"Dose":[13]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-16T00:00:00"}