{"id":"https://openalex.org/W4392852691","doi":"https://doi.org/10.1016/j.heliyon.2024.e27928","title":"Integrated transcriptome sequencing and weighted gene co-expression network analysis reveals key genes of papillary thyroid carcinomas","display_name":"Integrated transcriptome sequencing and weighted gene co-expression network analysis reveals key genes of papillary thyroid carcinomas","publication_year":2024,"publication_date":"2024-03-15","ids":{"openalex":"https://openalex.org/W4392852691","doi":"https://doi.org/10.1016/j.heliyon.2024.e27928","pmid":"https://pubmed.ncbi.nlm.nih.gov/38560266","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10981042"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2024.e27928","doi":"https://doi.org/10.1016/j.heliyon.2024.e27928","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e27928","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.heliyon.2024.e27928","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113074872","display_name":"Lingfeng Pan","orcid":"https://orcid.org/0009-0004-5846-3216","observed_orcids":["https://orcid.org/0009-0004-5846-3216"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingfeng Pan","raw_affiliation_strings":["Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060468648","display_name":"Lianbo Zhang","orcid":"https://orcid.org/0000-0003-2020-1355","observed_orcids":["https://orcid.org/0000-0003-2020-1355","https://orcid.org/0009-0002-9023-7505"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianbo Zhang","raw_affiliation_strings":["Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076041008","display_name":"Jingyao Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyao Fu","raw_affiliation_strings":["Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109548843","display_name":"Keyu Shen","orcid":"https://orcid.org/0009-0001-2294-5457","observed_orcids":["https://orcid.org/0009-0001-2294-5457"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keyu Shen","raw_affiliation_strings":["Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100330229","display_name":"Guang Zhang","orcid":"https://orcid.org/0000-0001-9064-9345","observed_orcids":["https://orcid.org/0000-0001-9064-9345"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guang Zhang","raw_affiliation_strings":["Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100330229"],"corresponding_institution_ids":["https://openalex.org/I194450716"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":3.6659,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.93570119,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"7","first_page":"e27928","last_page":"e27928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":1.0},{"id":"https://openalex.org/keywords/key-genes","display_name":"key genes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.9639999866485596},{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"gene co-expression network","score":0.7139999866485596},{"id":"https://openalex.org/keywords/protein-protein-interaction-modules","display_name":"protein-protein interaction modules","score":0.7599999904632568},{"id":"https://openalex.org/keywords/avpr1a","display_name":"AVPR1A","score":0.8450000286102295},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.703000009059906},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5659999847412109},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9359999895095825},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8209999799728394},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.7929999828338623},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8460000157356262},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9150000214576721},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/estrogen-responsiveness","display_name":"estrogen response","score":0.6169999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7256789803504944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6381566524505615},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5813618302345276},{"id":"https://openalex.org/C2778022302","wikidata":"https://www.wikidata.org/wiki/Q18207329","display_name":"Gene co-expression network","level":5,"score":0.5507923364639282},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.513029932975769},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5005316734313965},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.49345698952674866},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4819347858428955},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4428033232688904},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4418308138847351},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.42334187030792236},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.42122024297714233},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4205147624015808},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32778218388557434},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.heliyon.2024.e27928","doi":"https://doi.org/10.1016/j.heliyon.2024.e27928","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e27928","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10981042","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10981042","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10981042/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmid:38560266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38560266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d357e48f93d2480b97f27a2bda585927","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d357e48f93d2480b97f27a2bda585927","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 10, Iss 7, Pp e27928- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2024.e27928","doi":"https://doi.org/10.1016/j.heliyon.2024.e27928","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e27928","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5546486623","display_name":null,"funder_award_id":"82072184","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392852691.pdf","grobid_xml":"https://content.openalex.org/works/W4392852691.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1762135529","https://openalex.org/W1966327575","https://openalex.org/W1984185945","https://openalex.org/W1984958477","https://openalex.org/W1988281132","https://openalex.org/W2035618305","https://openalex.org/W2041735615","https://openalex.org/W2047998870","https://openalex.org/W2098376600","https://openalex.org/W2103017472","https://openalex.org/W2108173334","https://openalex.org/W2118263932","https://openalex.org/W2125508691","https://openalex.org/W2129468595","https://openalex.org/W2130410032","https://openalex.org/W2136850043","https://openalex.org/W2137734450","https://openalex.org/W2146512944","https://openalex.org/W2154362705","https://openalex.org/W2158217645","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2164970807","https://openalex.org/W2169353806","https://openalex.org/W2220427818","https://openalex.org/W2464424134","https://openalex.org/W2499311996","https://openalex.org/W2537623931","https://openalex.org/W2607129810","https://openalex.org/W2736730167","https://openalex.org/W2765224588","https://openalex.org/W2779807772","https://openalex.org/W2783246442","https://openalex.org/W2806546430","https://openalex.org/W2903130587","https://openalex.org/W2944615242","https://openalex.org/W2946657092","https://openalex.org/W3005628292","https://openalex.org/W3006170674","https://openalex.org/W3012330016","https://openalex.org/W3014696431","https://openalex.org/W3030331449","https://openalex.org/W3041699323","https://openalex.org/W3048067092","https://openalex.org/W3088334344","https://openalex.org/W3106909450","https://openalex.org/W3111734687","https://openalex.org/W3128646645","https://openalex.org/W3169523992","https://openalex.org/W3169937091","https://openalex.org/W3178259396","https://openalex.org/W3179531185","https://openalex.org/W3205666815","https://openalex.org/W3211505122","https://openalex.org/W4294216483","https://openalex.org/W4319295035","https://openalex.org/W4322217009","https://openalex.org/W4388837956","https://openalex.org/W6752610787","https://openalex.org/W6790598159"],"related_works":["https://openalex.org/W3133946745","https://openalex.org/W2886606910","https://openalex.org/W3048067092","https://openalex.org/W3217537120","https://openalex.org/W2794128797","https://openalex.org/W4402144837","https://openalex.org/W1871680547","https://openalex.org/W2922057407","https://openalex.org/W2888682149","https://openalex.org/W3114135321"],"abstract_inverted_index":{"Objective:":[0],"Papillary":[1],"thyroid":[2,10],"carcinoma":[3],"(PTC)":[4],"accounts":[5],"for":[6,247],"the":[7,32,61,102,152,167,230,255],"majority":[8],"of":[9,34,40,115,196,212,232],"cancers":[11],"and":[12,55,71,101,109,119,136,138,146,154,191,205,216],"has":[13],"a":[14],"high":[15,156],"recurrence":[16],"rate.":[17],"We":[18],"aimed":[19],"to":[20,27,80],"screen":[21],"key":[22,83,87,129,197,213,233,239],"genes":[23,51,88,130,133,140,172,198,234,240],"involved":[24,123,175],"in":[25,60,124,151,166,176,235],"PTC":[26,41,54,258],"provide":[28],"novel":[29,252],"insights":[30,253],"into":[31,254],"mechanisms":[33,256],"PTC.":[35,236,248],"Methods:":[36],"Seven":[37],"microarray":[38],"datasets":[39,223],"were":[42,58,78,89,117,148,173,224],"downloaded":[43],"from":[44,92],"gene":[45,73,96,214],"expression":[46,157,169,195,218],"omnibus":[47],"database.":[48],"Differentially":[49],"expressed":[50],"(DEGs)":[52],"between":[53],"normal":[56],"samples":[57],"screened":[59],"merged":[62],"dataset.":[63],"Then,":[64],"protein-protein":[65],"interaction":[66],"(PPIs)":[67],"functional":[68],"modules":[69],"analysis":[70,76,99],"weighted":[72],"co-expression":[74],"network":[75],"(WGCNA)":[77],"utilized":[79],"identify":[81],"PTC-associated":[82],"genes.":[84],"The":[85,194,209,238],"identified":[86],"then":[90],"characterized":[91],"various":[93],"aspects,":[94],"including":[95],"set":[97],"enrichment":[98],"(GSEA)":[100],"associations":[103],"with":[104,201,226],"immune":[105,202],"infiltration,":[106],"methylation":[107,207],"levels":[108,219],"prognosis.":[110],"Results:":[111],"A":[112],"large":[113],"numbers":[114],"DEGs":[116,121],"identified,":[118],"these":[120],"are":[122],"several":[125],"cancer":[126],"pathways.":[127],"Nine":[128],"(including":[131],"down-regulated":[132],"GNA14,":[134],"AVPR1A,":[135],"WFS1,":[137],"up-regulated":[139],"LAMB3,":[141],"PLAU,":[142],"MET,":[143],"MFGE8,":[144],"PRSS23,":[145],"SERPINA1)":[147],"identified.":[149],"Patients":[150],"AVPR1A":[153],"GNA14":[155],"groups":[158],"had":[159],"better":[160],"disease-free":[161],"survival":[162],"(DFS)":[163],"than":[164],"those":[165],"low":[168],"group.":[170],"Key":[171],"mainly":[174],"P53":[177],"pathway,":[178],"estrogen":[179],"response,":[180],"apoptosis,":[181],"glycolysis,":[182],"NOTCH":[183],"signaling,":[184,190],"epithelial":[185],"mesenchymal":[186],"transition,":[187],"WNT_beta":[188],"catenin":[189],"inflammatory":[192],"response.":[193],"was":[199],"associated":[200],"cell":[203],"infiltration":[204],"corresponding":[206],"levels.":[208],"verification":[210],"results":[211],"proteins":[215],"mRNA":[217],"using":[220],"external":[221],"validation":[222],"consistent":[225],"our":[227],"expectations,":[228],"implying":[229],"involvements":[231],"Conclusion:":[237],"may":[241],"serve":[242],"as":[243],"potential":[244],"therapeutic":[245],"targets":[246],"This":[249],"study":[250],"provides":[251],"underlying":[257],"development.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-03-16T00:00:00"}
