{"id":"https://openalex.org/W4392812752","doi":"https://doi.org/10.2174/0113816128286111240229074810","title":"Compounds based on Adamantyl-substituted Amino Acids and Peptides as Potential Antiviral Drugs Acting as Viroporin Inhibitors","display_name":"Compounds based on Adamantyl-substituted Amino Acids and Peptides as Potential Antiviral Drugs Acting as Viroporin Inhibitors","publication_year":2024,"publication_date":"2024-03-14","ids":{"openalex":"https://openalex.org/W4392812752","doi":"https://doi.org/10.2174/0113816128286111240229074810","pmid":"https://pubmed.ncbi.nlm.nih.gov/38482627"},"language":"en","primary_location":{"id":"doi:10.2174/0113816128286111240229074810","doi":"https://doi.org/10.2174/0113816128286111240229074810","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0113816128286111240229074810","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064603403","display_name":"Timur Mansurovich Garaev","orcid":"https://orcid.org/0000-0002-3651-5730","observed_orcids":["https://orcid.org/0000-0002-3651-5730","https://orcid.org/0000-0001-5142-4661"]},"institutions":[{"id":"https://openalex.org/I4210099524","display_name":"Gamalei Institute of Epidemiology and Microbiology","ror":"https://ror.org/01616eq90","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210099524"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Timur M. Garaev","raw_affiliation_strings":["The Gamaleya National Center for Epidemiology and Microbiology, 18 Gamaleya St., Moscow 123098, Russia"],"raw_orcid":"https://orcid.org/0000-0002-3651-5730","affiliations":[{"raw_affiliation_string":"The Gamaleya National Center for Epidemiology and Microbiology, 18 Gamaleya St., Moscow 123098, Russia","institution_ids":["https://openalex.org/I4210099524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012725682","display_name":"\u0422. \u0412. \u0413\u0440\u0435\u0431\u0435\u043d\u043d\u0438\u043a\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-6141-9361","observed_orcids":["https://orcid.org/0000-0002-6141-9361"]},"institutions":[{"id":"https://openalex.org/I4210099524","display_name":"Gamalei Institute of Epidemiology and Microbiology","ror":"https://ror.org/01616eq90","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210099524"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatyana V. Grebennikova","raw_affiliation_strings":["The Gamaleya National Center for Epidemiology and Microbiology, 18 Gamaleya St., Moscow 123098, Russia"],"raw_orcid":"https://orcid.org/0000-0002-6141-9361","affiliations":[{"raw_affiliation_string":"The Gamaleya National Center for Epidemiology and Microbiology, 18 Gamaleya St., Moscow 123098, Russia","institution_ids":["https://openalex.org/I4210099524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032834843","display_name":"Varvara V. Lebedeva","orcid":"https://orcid.org/0000-0002-3088-0403","observed_orcids":["https://orcid.org/0000-0002-3088-0403"]},"institutions":[{"id":"https://openalex.org/I4210099524","display_name":"Gamalei Institute of Epidemiology and Microbiology","ror":"https://ror.org/01616eq90","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210099524"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Varvara V. Lebedeva","raw_affiliation_strings":["The Gamaleya National Center for Epidemiology and Microbiology, 18 Gamaleya St., Moscow 123098, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Gamaleya National Center for Epidemiology and Microbiology, 18 Gamaleya St., Moscow 123098, Russia","institution_ids":["https://openalex.org/I4210099524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017230585","display_name":"Varvara  Vladimirovna Avdeeva","orcid":"https://orcid.org/0000-0002-0655-1052","observed_orcids":["https://orcid.org/0000-0002-0655-1052"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210108652","display_name":"NS Kurnakova Institute of General and Inorganic Chemistry","ror":"https://ror.org/01hy2c330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210108652","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Varvara V. Avdeeva","raw_affiliation_strings":["Kurnakov\nInstitute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow 119991, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0655-1052","affiliations":[{"raw_affiliation_string":"Kurnakov\nInstitute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow 119991, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210108652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058981471","display_name":"\u041b\u0430\u0440\u0438\u0447\u0435\u0432 \u0412\u0438\u043a\u0442\u043e\u0440 \u0424\u0438\u043b\u0438\u043f\u043f\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0001-8262-5650","observed_orcids":["https://orcid.org/0000-0001-8262-5650"]},"institutions":[{"id":"https://openalex.org/I4210099524","display_name":"Gamalei Institute of Epidemiology and Microbiology","ror":"https://ror.org/01616eq90","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210099524"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Viktor F. Larichev","raw_affiliation_strings":["The Gamaleya National Center for Epidemiology and Microbiology, 18 Gamaleya St., Moscow 123098, Russia"],"raw_orcid":"https://orcid.org/0000-0001-8262-5650","affiliations":[{"raw_affiliation_string":"The Gamaleya National Center for Epidemiology and Microbiology, 18 Gamaleya St., Moscow 123098, Russia","institution_ids":["https://openalex.org/I4210099524"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017230585"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210108652"],"apc_list":null,"apc_paid":null,"fwci":0.2748,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.21931355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"30","issue":"12","first_page":"912","last_page":"920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.267300009727478,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.267300009727478,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.18199999630451202,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.14470000565052032,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.8769999742507935},{"id":"https://openalex.org/keywords/h5n1-avian-influenza","display_name":"H5N1 avian influenza","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9869999885559082},{"id":"https://openalex.org/keywords/coronavirus","display_name":"coronavirus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/virucidal-activity","display_name":"virucidal activity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/viral-membrane-fusion","display_name":"viral fusion","score":0.34200000762939453},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.7520009875297546},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.518441915512085},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5037032961845398},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.45457762479782104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4528924822807312},{"id":"https://openalex.org/C3020804797","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Hepatitis virus","level":3,"score":0.4440884292125702},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4344472587108612},{"id":"https://openalex.org/C2777374534","wikidata":"https://www.wikidata.org/wiki/Q409761","display_name":"Amantadine","level":2,"score":0.4150053560733795},{"id":"https://openalex.org/C3019983190","wikidata":"https://www.wikidata.org/wiki/Q157661","display_name":"Hepatitis a virus","level":3,"score":0.4101521372795105},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3811343312263489},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3644123673439026},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3510423004627228}],"mesh":[{"descriptor_ui":"D000086082","descriptor_name":"Viroporin Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000086082","descriptor_name":"Viroporin Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000086082","descriptor_name":"Viroporin Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/0113816128286111240229074810","doi":"https://doi.org/10.2174/0113816128286111240229074810","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0113816128286111240229074810","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:38482627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38482627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W834955807","https://openalex.org/W1463801548","https://openalex.org/W1913161278","https://openalex.org/W1989016584","https://openalex.org/W2004116821","https://openalex.org/W2008601231","https://openalex.org/W2030441312","https://openalex.org/W2032452247","https://openalex.org/W2037087307","https://openalex.org/W2040402142","https://openalex.org/W2050997685","https://openalex.org/W2057575940","https://openalex.org/W2067712778","https://openalex.org/W2069750537","https://openalex.org/W2076248125","https://openalex.org/W2078275706","https://openalex.org/W2082643644","https://openalex.org/W2093577667","https://openalex.org/W2098864163","https://openalex.org/W2098918223","https://openalex.org/W2126706756","https://openalex.org/W2135865322","https://openalex.org/W2152102165","https://openalex.org/W2152793674","https://openalex.org/W2169376557","https://openalex.org/W2286398299","https://openalex.org/W2418203839","https://openalex.org/W2753322653","https://openalex.org/W2754415252","https://openalex.org/W2765747712","https://openalex.org/W2788318617","https://openalex.org/W2976530897","https://openalex.org/W2982606919","https://openalex.org/W2985021031","https://openalex.org/W2989904947","https://openalex.org/W3004900093","https://openalex.org/W3009678818","https://openalex.org/W3012090543","https://openalex.org/W3019201413","https://openalex.org/W3020300207","https://openalex.org/W3080596815","https://openalex.org/W3089241778","https://openalex.org/W3104531605","https://openalex.org/W3125304574","https://openalex.org/W3128880495","https://openalex.org/W3148521889","https://openalex.org/W3166974776","https://openalex.org/W4210916192","https://openalex.org/W4213457829","https://openalex.org/W4214603620","https://openalex.org/W4221023693","https://openalex.org/W4246840460","https://openalex.org/W4256612586","https://openalex.org/W4281633917","https://openalex.org/W4283012193","https://openalex.org/W4320498968","https://openalex.org/W4323929199","https://openalex.org/W4387167033","https://openalex.org/W4387454663"],"related_works":["https://openalex.org/W2754415252","https://openalex.org/W6942383614","https://openalex.org/W3042510746","https://openalex.org/W7006259351","https://openalex.org/W2466339146","https://openalex.org/W2124779230","https://openalex.org/W1764270605","https://openalex.org/W4414701070","https://openalex.org/W4402199179","https://openalex.org/W4412930049"],"abstract_inverted_index":{"The":[0],"discussion":[1],"has":[2,74],"revolved":[3],"around":[4],"the":[5,41,45,84,100,103,107],"derivatives":[6,39],"of":[7,47,91,106],"amino":[8,37,92],"acids":[9,93],"and":[10,14,27,63,94],"peptides":[11],"containing":[12,49],"carbocycles":[13],"their":[15],"potential":[16],"antiviral":[17],"activity":[18,57],"in":[19,83],"vitro":[20],"against":[21],"influenza":[22,61],"A,":[23],"hepatitis":[24,64],"C":[25,65],"viruses,":[26],"coronavirus.":[28],"Studies":[29],"conducted":[30],"on":[31],"cell":[32],"cultures":[33],"reveal":[34],"that":[35],"aminoadamantane":[36],"acid":[38],"exhibit":[40],"capacity":[42],"to":[43,60,99],"hinder":[44],"replication":[46],"viruses":[48],"viroporins.":[50],"Furthermore,":[51],"certain":[52],"compounds":[53],"demonstrate":[54],"potent":[55],"virucidal":[56],"with":[58,102],"respect":[59],"A/H5N1":[62],"virus":[66],"particles.":[67],"A":[68],"conceptual":[69],"framework":[70],"for":[71],"viroporin":[72],"inhibitors":[73],"been":[75],"introduced,":[76],"incorporating":[77],"carbocyclic":[78],"motifs":[79],"as":[80],"membranotropic":[81],"carriers":[82],"structure,":[85],"alongside":[86],"a":[87],"functional":[88],"segment":[89],"comprised":[90],"peptides.":[95],"These":[96],"components":[97],"correspond":[98],"interaction":[101],"inner":[104],"surface":[105],"channel's":[108],"pore":[109],"or":[110],"another":[111],"target":[112],"protein.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-03-15T00:00:00"}