{"id":"https://openalex.org/W4392812288","doi":"https://doi.org/10.1186/s12862-024-02221-6","title":"\u201cPatchiness\u201d in mechanical stiffness across a tumor as an early-stage marker for malignancy","display_name":"\u201cPatchiness\u201d in mechanical stiffness across a tumor as an early-stage marker for malignancy","publication_year":2024,"publication_date":"2024-03-14","ids":{"openalex":"https://openalex.org/W4392812288","doi":"https://doi.org/10.1186/s12862-024-02221-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/38486161","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10938681"},"language":"en","primary_location":{"id":"doi:10.1186/s12862-024-02221-6","doi":"https://doi.org/10.1186/s12862-024-02221-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12862-024-02221-6","pdf_url":"https://bmcecolevol.biomedcentral.com/counter/pdf/10.1186/s12862-024-02221-6","source":{"id":"https://openalex.org/S4210180929","display_name":"BMC Ecology and Evolution","issn_l":"2730-7182","issn":["2730-7182"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Ecology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcecolevol.biomedcentral.com/counter/pdf/10.1186/s12862-024-02221-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009835449","display_name":"Zibah Mirzakhel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zibah Mirzakhel","raw_affiliation_strings":["Department of Mechanical Engineering, San Diego State University","Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043232106","display_name":"Gudur Ashrith Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gudur Ashrith Reddy","raw_affiliation_strings":["Department of Mechanical Engineering, San Diego State University","Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer Boman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Boman","raw_affiliation_strings":["Department of Mechanical Engineering, San Diego State University","Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104151317","display_name":"Brianna Manns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brianna Manns","raw_affiliation_strings":["Department of Mechanical Engineering, San Diego State University","Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104258367","display_name":"Savannah ter Veer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Savannah Van Teer","raw_affiliation_strings":["Department of Mechanical Engineering, San Diego State University","Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088911087","display_name":"Parag Katira","orcid":"https://orcid.org/0000-0001-9873-5117","observed_orcids":["https://orcid.org/0000-0001-9873-5117"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Parag Katira","raw_affiliation_strings":["Department of Mechanical Engineering, San Diego State University","Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9873-5117","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA","institution_ids":["https://openalex.org/I26538001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088911087"],"corresponding_institution_ids":["https://openalex.org/I26538001"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.8949,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66003592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"24","issue":"1","first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-mechanics","display_name":"cell mechanics","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tumor-malignancy-prediction","display_name":"tumor malignancy prediction","score":0.5329999923706055},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.6610000133514404},{"id":"https://openalex.org/keywords/in-silico-modeling","display_name":"in silico modeling","score":0.6549999713897705},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6117405891418457},{"id":"https://openalex.org/C180478619","wikidata":"https://www.wikidata.org/wiki/Q7574066","display_name":"Spatial heterogeneity","level":2,"score":0.6030998229980469},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.49813222885131836},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.48460114002227783},{"id":"https://openalex.org/C3018028425","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumor heterogeneity","level":3,"score":0.43346428871154785},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4205721616744995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4171958863735199},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31032460927963257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16506657004356384},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.11648669838905334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07570615410804749},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004463","descriptor_name":"Ecology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12862-024-02221-6","doi":"https://doi.org/10.1186/s12862-024-02221-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12862-024-02221-6","pdf_url":"https://bmcecolevol.biomedcentral.com/counter/pdf/10.1186/s12862-024-02221-6","source":{"id":"https://openalex.org/S4210180929","display_name":"BMC Ecology and Evolution","issn_l":"2730-7182","issn":["2730-7182"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Ecology and Evolution","raw_type":"journal-article"},{"id":"doi:10.1101/2023.07.31.551398","doi":"https://doi.org/10.1101/2023.07.31.551398","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.07.31.551398","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/08/02/2023.07.31.551398.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10938681","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10938681","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10938681/pdf/12862_2024_Article_2221.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Ecol Evol","raw_type":"Text"},{"id":"pmid:38486161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38486161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC ecology and evolution","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:289659dd3457479c966edbdcf7d00ad9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/289659dd3457479c966edbdcf7d00ad9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Ecology and Evolution, Vol 24, Iss 1, Pp 1-12 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12862-024-02221-6","doi":"https://doi.org/10.1186/s12862-024-02221-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12862-024-02221-6","pdf_url":"https://bmcecolevol.biomedcentral.com/counter/pdf/10.1186/s12862-024-02221-6","source":{"id":"https://openalex.org/S4210180929","display_name":"BMC Ecology and Evolution","issn_l":"2730-7182","issn":["2730-7182"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Ecology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5010630567","display_name":null,"funder_award_id":"W911NF-17-1-0413","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G7452299184","display_name":null,"funder_award_id":"W911NF","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"}],"funders":[{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392812288.pdf","grobid_xml":"https://content.openalex.org/works/W4392812288.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W141628841","https://openalex.org/W629214565","https://openalex.org/W1504058224","https://openalex.org/W1844651504","https://openalex.org/W1866104439","https://openalex.org/W1885354525","https://openalex.org/W1975523864","https://openalex.org/W1975553175","https://openalex.org/W1976520890","https://openalex.org/W1977902779","https://openalex.org/W1979353842","https://openalex.org/W1981413140","https://openalex.org/W1989095124","https://openalex.org/W1991971871","https://openalex.org/W1994380399","https://openalex.org/W1996152000","https://openalex.org/W1996757213","https://openalex.org/W1998818894","https://openalex.org/W2000465700","https://openalex.org/W2001998785","https://openalex.org/W2021232061","https://openalex.org/W2024908172","https://openalex.org/W2030642623","https://openalex.org/W2031514600","https://openalex.org/W2036145275","https://openalex.org/W2043967411","https://openalex.org/W2045434770","https://openalex.org/W2058071556","https://openalex.org/W2058096164","https://openalex.org/W2058317253","https://openalex.org/W2064915680","https://openalex.org/W2065475665","https://openalex.org/W2069598084","https://openalex.org/W2072817575","https://openalex.org/W2086819694","https://openalex.org/W2088631628","https://openalex.org/W2090588873","https://openalex.org/W2092412094","https://openalex.org/W2092994838","https://openalex.org/W2093370261","https://openalex.org/W2096595594","https://openalex.org/W2097970956","https://openalex.org/W2100303404","https://openalex.org/W2115205179","https://openalex.org/W2116413963","https://openalex.org/W2117692326","https://openalex.org/W2121670729","https://openalex.org/W2154061152","https://openalex.org/W2168957713","https://openalex.org/W2173637151","https://openalex.org/W2179429273","https://openalex.org/W2283084142","https://openalex.org/W2320872702","https://openalex.org/W2325985016","https://openalex.org/W2333189702","https://openalex.org/W2342170628","https://openalex.org/W2372077962","https://openalex.org/W2417406783","https://openalex.org/W2461921588","https://openalex.org/W2476542314","https://openalex.org/W2479420012","https://openalex.org/W2481082227","https://openalex.org/W2566638417","https://openalex.org/W2588123864","https://openalex.org/W2591822351","https://openalex.org/W2593381699","https://openalex.org/W2597440646","https://openalex.org/W2599250996","https://openalex.org/W2615584725","https://openalex.org/W2753965489","https://openalex.org/W2781699305","https://openalex.org/W2804149869","https://openalex.org/W2902133313","https://openalex.org/W2952948597","https://openalex.org/W2957594695","https://openalex.org/W2973213667","https://openalex.org/W2994618810","https://openalex.org/W3081702406","https://openalex.org/W3112147748","https://openalex.org/W3130998469","https://openalex.org/W3139790095","https://openalex.org/W3160105984","https://openalex.org/W3185872641","https://openalex.org/W3210992994","https://openalex.org/W4200559225","https://openalex.org/W4225397953","https://openalex.org/W4282935130","https://openalex.org/W4286602763","https://openalex.org/W4297977585","https://openalex.org/W4297996266","https://openalex.org/W4302293767","https://openalex.org/W4383868458"],"related_works":["https://openalex.org/W2783309714","https://openalex.org/W2610943291","https://openalex.org/W3012798913","https://openalex.org/W3125225959","https://openalex.org/W4413030510","https://openalex.org/W2902818963","https://openalex.org/W4313649693","https://openalex.org/W2962957201","https://openalex.org/W4385399731","https://openalex.org/W2159835158"],"abstract_inverted_index":{"Mechanical":[0],"phenotyping":[1,83],"of":[2,25,51,79,90,123,129,149,178,195,205,226],"tumors,":[3],"either":[4,256],"at":[5],"an":[6,201,234,264,279],"individual":[7,124],"cell":[8,12,94,105,139,151,185],"level":[9,14],"or":[10,62,229,246,259],"tumor":[11,63,110,228],"population":[13,95,140,204],"is":[15,37,74,168,175,278],"gaining":[16],"traction":[17],"as":[18,59,64,275],"a":[19,55,60,65,75,144,171,192,209,213,227],"diagnostic":[20,26],"tool.":[21],"However,":[22],"the":[23,46,116,120,127,134,147,161,176,179,196,224],"extent":[24],"and":[27,93,109,126,142,164,240,271],"prognostic":[28],"information":[29,80],"that":[30,71,115,189,223,252],"can":[31,136,232,262],"be":[32,233],"gained":[33],"through":[34],"these":[35,130,219],"measurements":[36],"still":[38],"unclear.":[39],"In":[40],"this":[41,72],"work,":[42],"we":[43,221,250],"focus":[44],"on":[45,218],"heterogeneity":[47,73,103,118,159,183],"in":[48,81,104,119,160,184,243,267,282],"mechanical":[49,82,121],"properties":[50,122],"cells":[52,125,206],"obtained":[53],"from":[54],"single":[56],"source":[57,78],"such":[58],"tissue":[61,108,155,230,253,269],"potential":[66],"novel":[67],"biomarker.":[68],"We":[69,85,187],"believe":[70],"conventionally":[76],"overlooked":[77],"data.":[84],"use":[86],"mechanics-based":[87],"in-silico":[88],"models":[89],"cell-cell":[91],"interactions":[92],"dynamics":[96,141],"within":[97,133,153],"3D":[98],"environments":[99],"to":[100,181],"probe":[101],"how":[102],"mechanics":[106],"drives":[107],"dynamics.":[111],"Our":[112],"simulations":[113],"show":[114,208],"initial":[117],"arrangement":[128],"heterogenous":[131],"sub-populations":[132],"environment":[135],"dictate":[137],"overall":[138,158,202],"cause":[143],"shift":[145,211],"towards":[146,212],"growth":[148],"malignant":[150,215,238],"phenotypes":[152],"healthy":[154,203,247],"environments.":[156],"The":[157],"cellular":[162],"mechanotype":[163],"their":[165],"spatial":[166],"distributions":[167],"quantified":[169],"by":[170,257],"\"patchiness\"":[172,225],"index,":[173],"which":[174,200],"ratio":[177],"global":[180],"local":[182],"populations.":[186],"observe":[188],"there":[190],"exists":[191],"threshold":[193],"value":[194],"patchiness":[197,277],"index":[198],"beyond":[199],"will":[207],"steady":[210],"more":[214],"phenotype.":[216],"Based":[217],"results,":[220],"propose":[222],"sample,":[231],"early":[235],"indicator":[236],"for":[237],"transformation":[239],"cancer":[241],"occurrence":[242],"benign":[244],"tumors":[245],"tissues.":[248],"Additionally,":[249],"suggest":[251],"patchiness,":[254],"measured":[255],"biochemical":[258],"biophysical":[260],"markers,":[261],"become":[263],"important":[265,280],"metric":[266,281],"predicting":[268],"health":[270],"disease":[272],"likelihood":[273],"just":[274],"landscape":[276],"ecology.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-03-15T00:00:00"}