{"id":"https://openalex.org/W4392809107","doi":"https://doi.org/10.1038/s41590-024-01788-y","title":"Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components","display_name":"Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components","publication_year":2024,"publication_date":"2024-03-14","ids":{"openalex":"https://openalex.org/W4392809107","doi":"https://doi.org/10.1038/s41590-024-01788-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/38486019","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13239758"},"language":"en","primary_location":{"id":"doi:10.1038/s41590-024-01788-y","doi":"https://doi.org/10.1038/s41590-024-01788-y","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41590-024-01788-y","pdf_url":null,"source":{"id":"https://openalex.org/S41063453","display_name":"Nature Immunology","issn_l":"1529-2908","issn":["1529-2908","1529-2916"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2489867/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035364171","display_name":"Andrea Mencarelli","orcid":"https://orcid.org/0000-0003-0961-1572","observed_orcids":["https://orcid.org/0000-0003-0961-1572"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["CN","SG"],"is_corresponding":false,"raw_author_name":"Andrea Mencarelli","raw_affiliation_strings":["Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore, Singapore","Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034519667","display_name":"Pradeep Bist","orcid":"https://orcid.org/0000-0001-6163-9105","observed_orcids":["https://orcid.org/0000-0001-6163-9105","https://orcid.org/0000-0003-0662-4626"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Pradeep Bist","raw_affiliation_strings":["Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore, Singapore"],"raw_orcid":"https://orcid.org/0000-0001-6163-9105","affiliations":[{"raw_affiliation_string":"Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015291887","display_name":"Hae Woong Choi","orcid":"https://orcid.org/0000-0001-9372-1875","observed_orcids":["https://orcid.org/0000-0001-9372-1875"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hae Woong Choi","raw_affiliation_strings":["Department of Pathology, Duke University Medical Center, Durham, NC, USA"],"raw_orcid":"https://orcid.org/0000-0001-9372-1875","affiliations":[{"raw_affiliation_string":"Department of Pathology, Duke University Medical Center, Durham, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037432364","display_name":"Hanif Javanmard Khameneh","orcid":"https://orcid.org/0000-0002-1737-0388","observed_orcids":["https://orcid.org/0000-0002-1737-0388"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]},{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH","SG"],"is_corresponding":false,"raw_author_name":"Hanif Javanmard Khameneh","raw_affiliation_strings":["Singapore Immunology Network (SIgN), Agency for Science and Research (A*Star), Singapore, Singapore","Universit\u00e0 della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine (IRB), Bellinzona, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-1737-0388","affiliations":[{"raw_affiliation_string":"Singapore Immunology Network (SIgN), Agency for Science and Research (A*Star), Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]},{"raw_affiliation_string":"Universit\u00e0 della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine (IRB), Bellinzona, Switzerland","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012542550","display_name":"Alessandra Mortellaro","orcid":"https://orcid.org/0000-0003-1744-2430","observed_orcids":["https://orcid.org/0000-0003-1744-2430"]},"institutions":[{"id":"https://openalex.org/I4210142418","display_name":"The San Raffaele Telethon Institute for Gene Therapy","ror":"https://ror.org/036jn4298","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210142418","https://openalex.org/I4210153126","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Mortellaro","raw_affiliation_strings":["San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1744-2430","affiliations":[{"raw_affiliation_string":"San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210142418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030259389","display_name":"Soman N. Abraham","orcid":"https://orcid.org/0000-0002-1662-2096","observed_orcids":["https://orcid.org/0000-0002-1662-2096"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG","US"],"is_corresponding":true,"raw_author_name":"Soman N. Abraham","raw_affiliation_strings":["Department of Immunology, Duke University Medical Center, Durham, NC, USA. soman.abraham@duke.edu","Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC, USA. soman.abraham@duke.edu","Department of Pathology, Duke University Medical Center, Durham, NC, USA. soman.abraham@duke.edu","Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore, Singapore. soman.abraham@duke.edu","Department of Pathology, Duke University Medical Center, Durham, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-1662-2096","affiliations":[{"raw_affiliation_string":"Department of Immunology, Duke University Medical Center, Durham, NC, USA. soman.abraham@duke.edu","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC, USA. soman.abraham@duke.edu","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pathology, Duke University Medical Center, Durham, NC, USA. soman.abraham@duke.edu","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore, Singapore. soman.abraham@duke.edu","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Department of Pathology, Duke University Medical Center, Durham, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5030259389"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126298","https://openalex.org/I4210126319"],"apc_list":{"value":12290,"currency":"USD","value_usd":12290},"apc_paid":null,"fwci":4.9873,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.96376784,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"25","issue":"4","first_page":"693","last_page":"702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.39010000228881836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/anaphylaxis","display_name":"anaphylaxis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nlrp3","display_name":"NLRP3","score":0.9539999961853027},{"id":"https://openalex.org/keywords/asc","display_name":"ASC","score":0.996999979019165},{"id":"https://openalex.org/keywords/ige-mediated-anaphylaxis","display_name":"IgE-mediated anaphylaxis","score":0.722000002861023},{"id":"https://openalex.org/keywords/nek7","display_name":"NEK7","score":0.6330000162124634},{"id":"https://openalex.org/keywords/pyk2","display_name":"Pyk2","score":0.949999988079071},{"id":"https://openalex.org/keywords/interleukin-1beta-processing","display_name":"interleukin-1\u03b2 processing","score":0.8799999952316284},{"id":"https://openalex.org/keywords/granule-secretion","display_name":"granule secretion","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.9665788412094116},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.645821750164032},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.6246128678321838},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.540247917175293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5320913195610046},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.44123587012290955},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.4364146888256073},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.4287782609462738},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4216964840888977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3646359443664551},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.360114723443985},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2148967981338501},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12357482314109802},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11498621106147766},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07503804564476013},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000707","descriptor_name":"Anaphylaxis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41590-024-01788-y","doi":"https://doi.org/10.1038/s41590-024-01788-y","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41590-024-01788-y","pdf_url":null,"source":{"id":"https://openalex.org/S41063453","display_name":"Nature Immunology","issn_l":"1529-2908","issn":["1529-2908","1529-2916"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Immunology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2489867/v1","doi":"https://doi.org/10.21203/rs.3.rs-2489867/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2489867/v1","pdf_url":"https://www.researchsquare.com/article/rs-2489867/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:38486019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38486019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13239758","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13239758/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Immunol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2489867/v1","doi":"https://doi.org/10.21203/rs.3.rs-2489867/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2489867/v1","pdf_url":"https://www.researchsquare.com/article/rs-2489867/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5789018236","display_name":"Platelet- mast cell interactions as determinants of the vascular pathology in septic shock.","funder_award_id":"R01GM144606","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8797264964","display_name":null,"funder_award_id":"R01-GM144606","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320316262","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392809107.pdf","grobid_xml":"https://content.openalex.org/works/W4392809107.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1512958442","https://openalex.org/W1529674879","https://openalex.org/W1561041814","https://openalex.org/W1593760300","https://openalex.org/W1936565989","https://openalex.org/W1965898267","https://openalex.org/W1974163512","https://openalex.org/W1974412717","https://openalex.org/W1977445502","https://openalex.org/W1978568961","https://openalex.org/W1982042604","https://openalex.org/W1982386486","https://openalex.org/W1987535382","https://openalex.org/W2001946532","https://openalex.org/W2015082452","https://openalex.org/W2042433863","https://openalex.org/W2043544635","https://openalex.org/W2043992563","https://openalex.org/W2048921995","https://openalex.org/W2051380634","https://openalex.org/W2059540883","https://openalex.org/W2069948647","https://openalex.org/W2084517753","https://openalex.org/W2085435814","https://openalex.org/W2092126110","https://openalex.org/W2108237409","https://openalex.org/W2131929080","https://openalex.org/W2132781656","https://openalex.org/W2143658570","https://openalex.org/W2146670169","https://openalex.org/W2148236394","https://openalex.org/W2158947246","https://openalex.org/W2160025183","https://openalex.org/W2166865493","https://openalex.org/W2175663749","https://openalex.org/W2254807163","https://openalex.org/W2269386617","https://openalex.org/W2347163170","https://openalex.org/W2511584288","https://openalex.org/W2539837353","https://openalex.org/W2541799514","https://openalex.org/W2593240146","https://openalex.org/W2598169234","https://openalex.org/W2724425486","https://openalex.org/W2778840601","https://openalex.org/W2784685271","https://openalex.org/W2785879864","https://openalex.org/W2800287140","https://openalex.org/W2810072585","https://openalex.org/W2911922390","https://openalex.org/W2943293743","https://openalex.org/W2964003958","https://openalex.org/W3007908201","https://openalex.org/W3014474086","https://openalex.org/W3022219741","https://openalex.org/W4211217520","https://openalex.org/W4233483087","https://openalex.org/W6773988861"],"related_works":["https://openalex.org/W112381369","https://openalex.org/W7221319387","https://openalex.org/W3203074555","https://openalex.org/W7166251183","https://openalex.org/W2271934922","https://openalex.org/W2028457710","https://openalex.org/W1963492948","https://openalex.org/W2519300650","https://openalex.org/W2808165460","https://openalex.org/W4385687834"],"abstract_inverted_index":{"Abstract":[0],"Inflammasome":[1],"components,":[2],"NLRP3":[3,44,54,76,101],"and":[4,45,50,55,87,117,145],"ASC":[5,56,78],"are":[6],"cytosolic":[7],"proteins":[8],"which":[9],"upon":[10],"sensing":[11],"endotoxins/danger":[12],"cues,":[13],"form":[14,81],"multimeric":[15],"complexes":[16],"to":[17,66,69,80,89],"process":[18],"IL-1\u03b2":[19,39,148],"for":[20],"secretion.":[21],"Here,":[22],"we":[23],"reveal":[24],"that":[25],"the":[26,70],"iconic":[27],"IgE/antigen":[28],"(Ag)":[29],"mediated":[30,42,133],"mast":[31],"cell":[32,71],"(MC)":[33],"degranulation,":[34,125],"an":[35,100],"activity":[36],"independent":[37],"of":[38,135,147],"secretion":[40],"is":[41,97,109],"by":[43,122],"ASC.":[46],"IgE/Ag":[47,115,132],"stimulated":[48],"NEK7":[49],"Pyk2":[51],"kinases":[52],"induce":[53],"deposition":[57],"on":[58],"granules":[59,68,113],"forming":[60],"a":[61],"distinct":[62],"protein":[63],"complex":[64],"(granulosome)":[65],"chaperone":[67],"surface.":[72],"MCs":[73],"deficient":[74],"in":[75,85,93,104,129,150],"or":[77],"fail":[79,88],"granulosomes,":[82],"degranulate":[83],"poorly":[84],"vitro":[86],"evoke":[90],"systemic":[91],"anaphylaxis":[92,96,128],"mice.":[94,130],"IgE/Ag-triggered":[95],"prevented":[98],"with":[99,143],"inhibitor.":[102],"Interestingly,":[103],"endotoxin":[105,136],"primed":[106,137],"MCs,":[107,138],"pro-IL-1\u03b2":[108],"rapidly":[110],"packaged":[111],"into":[112],"after":[114,124],"stimulation":[116],"processed":[118],"within":[119],"granule":[120],"remnants":[121],"proteases":[123],"causing":[126],"lethal":[127],"During":[131],"degranulation":[134,141],"granulosomes":[139],"promote":[140],"combined":[142],"exteriorization":[144],"processing":[146],"resulting":[149],"severe":[151],"inflammation.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-03-15T00:00:00"}
