{"id":"https://openalex.org/W4392805841","doi":"https://doi.org/10.1097/med.0000000000000858","title":"Potassium-competitive acid blockers and acid-related disorders","display_name":"Potassium-competitive acid blockers and acid-related disorders","publication_year":2024,"publication_date":"2024-03-14","ids":{"openalex":"https://openalex.org/W4392805841","doi":"https://doi.org/10.1097/med.0000000000000858","pmid":"https://pubmed.ncbi.nlm.nih.gov/38483115"},"language":"en","primary_location":{"id":"doi:10.1097/med.0000000000000858","doi":"https://doi.org/10.1097/med.0000000000000858","is_oa":false,"landing_page_url":"https://doi.org/10.1097/med.0000000000000858","pdf_url":null,"source":{"id":"https://openalex.org/S177297213","display_name":"Current Opinion in Endocrinology Diabetes and Obesity","issn_l":"1752-296X","issn":["1752-296X","1752-2978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Endocrinology, Diabetes &amp; Obesity","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007540007","display_name":"Kevin Z. Huang","orcid":"https://orcid.org/0000-0002-6915-8557","observed_orcids":["https://orcid.org/0000-0002-6915-8557"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Z. Huang","raw_affiliation_strings":["Boston University Chobanian & Avedisian School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Chobanian & Avedisian School of Medicine","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026086311","display_name":"Horst Christian Weber","orcid":"https://orcid.org/0000-0001-9005-6988","observed_orcids":["https://orcid.org/0000-0001-9005-6988"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Christian Weber","raw_affiliation_strings":["Boston University Chobanian & Avedisian School of Medicine","VA Boston Healthcare System, Section of Gastroenterology and Hepatology, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Chobanian & Avedisian School of Medicine","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"VA Boston Healthcare System, Section of Gastroenterology and Hepatology, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I2801671727"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8186,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.5856833,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"31","issue":"3","first_page":"107","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11958","display_name":"Dental Erosion and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/potassium-competitive-acid-blocker","display_name":"potassium-competitive acid blocker","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vonoprazan","display_name":"vonoprazan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erosive-esophagitis","display_name":"erosive esophagitis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.9139999747276306},{"id":"https://openalex.org/keywords/non-erosive-reflux-disease","display_name":"non-erosive reflux disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/helicobacter-pylori-eradication","display_name":"Helicobacter pylori eradication","score":0.9449999928474426},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9169999957084656},{"id":"https://openalex.org/keywords/on-demand-treatment","display_name":"on-demand treatment","score":0.824999988079071},{"id":"https://openalex.org/keywords/gastric-acid-suppression","display_name":"gastric acid suppression","score":0.8130000233650208},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.5129275321960449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39292019605636597},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3825927972793579},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3412492871284485},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05780905485153198}],"mesh":[{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/med.0000000000000858","doi":"https://doi.org/10.1097/med.0000000000000858","is_oa":false,"landing_page_url":"https://doi.org/10.1097/med.0000000000000858","pdf_url":null,"source":{"id":"https://openalex.org/S177297213","display_name":"Current Opinion in Endocrinology Diabetes and Obesity","issn_l":"1752-296X","issn":["1752-296X","1752-2978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Endocrinology, Diabetes &amp; Obesity","raw_type":"journal-article"},{"id":"pmid:38483115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38483115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in endocrinology, diabetes, and obesity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1992734182","https://openalex.org/W2034557914","https://openalex.org/W2084243744","https://openalex.org/W2115870674","https://openalex.org/W2135287136","https://openalex.org/W2301012193","https://openalex.org/W2479651042","https://openalex.org/W2492840086","https://openalex.org/W2550831966","https://openalex.org/W2563981115","https://openalex.org/W2593141353","https://openalex.org/W2903814021","https://openalex.org/W2907196410","https://openalex.org/W2921597163","https://openalex.org/W2945155413","https://openalex.org/W2968018058","https://openalex.org/W2977520261","https://openalex.org/W2985640214","https://openalex.org/W2987027580","https://openalex.org/W3037077231","https://openalex.org/W3087658661","https://openalex.org/W3123870255","https://openalex.org/W3130983601","https://openalex.org/W3178762669","https://openalex.org/W3216394740","https://openalex.org/W4200606185","https://openalex.org/W4206922227","https://openalex.org/W4214698029","https://openalex.org/W4281872253","https://openalex.org/W4298088828","https://openalex.org/W4298326761","https://openalex.org/W4304014277","https://openalex.org/W4306690160","https://openalex.org/W4309364835","https://openalex.org/W4315651630","https://openalex.org/W4323035302","https://openalex.org/W4366352746","https://openalex.org/W4366815991","https://openalex.org/W4367598794","https://openalex.org/W4387033369","https://openalex.org/W4389538795","https://openalex.org/W4391151316","https://openalex.org/W4391746186","https://openalex.org/W4391821862"],"related_works":["https://openalex.org/W3130983601","https://openalex.org/W4298326761","https://openalex.org/W4410479413","https://openalex.org/W3121321924","https://openalex.org/W4403489480","https://openalex.org/W2237539734","https://openalex.org/W7159931888","https://openalex.org/W7090807920","https://openalex.org/W7223045326","https://openalex.org/W4295358070"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Potassium-competitive":[3],"acid":[4,57],"blockers":[5],"(PCABs)":[6],"represent":[7],"a":[8,144,180],"new":[9,33],"class":[10],"of":[11,16,22,55,70,97,102,111,117,123,134,138,147],"compounds":[12],"for":[13,26,72,100,115,136,149,158,186],"the":[14,23,68,86,93],"treatment":[15,116,137,184],"acid-related":[17,36],"disorders.":[18,37],"Recent":[19],"FDA":[20,132,182],"approval":[21,133],"PCAB":[24,87,177],"vonoprazan":[25,88,112,124,135,148,178],"erosive":[27,73,118,139,187],"esophagitis":[28,129],"has":[29],"started":[30],"an":[31],"important":[32],"approach":[34],"to":[35,41,113],"RECENT":[38],"FINDINGS:":[39],"Compared":[40],"conventional":[42],"proton":[43],"pump":[44],"inhibitors":[45],"(PPIs),":[46],"PCABs":[47,71],"provide":[48],"more":[49,61],"rapid,":[50],"potent,":[51],"and":[52,60,78,155,195],"sustained":[53],"suppression":[54],"gastric":[56],"with":[58,127],"faster":[59],"durable":[62],"symptom":[63],"relief.":[64],"Studies":[65],"have":[66,107],"demonstrated":[67,109],"efficacy":[69],"esophagitis,":[74,119],"nonerosive":[75,159,196],"reflux":[76,152,160,197],"disease,":[77],"peptic":[79],"ulcer":[80],"disease":[81,153,198],"including":[82],"H.":[83,103],"pylori.":[84,104],"However,":[85],"was":[89],"only":[90],"approved":[91,183],"in":[92,125,131,192],"US":[94],"as":[95],"part":[96],"combination":[98],"therapy":[99,157],"eradication":[101],"Clinical":[105],"trials":[106],"now":[108],"noninferiority":[110],"lansoprazole":[114],"particularly":[120],"noting":[121],"superiority":[122],"patients":[126],"severe":[128],"resulting":[130],"esophagitis.":[140,188],"Emerging":[141],"data":[142,170],"suggests":[143],"possible":[145,190],"utility":[146],"PPI-resistant":[150,193],"gastroesophageal":[151],"(GERD)":[154],"on-demand":[156],"disease.":[161],"Vonoprazan":[162],"is":[163,171,179],"generally":[164],"well":[165,173],"tolerated":[166],"but":[167],"long-term":[168],"safety":[169],"not":[172],"established.":[174],"SUMMARY:":[175],"The":[176],"newly":[181],"option":[185],"Its":[189],"role":[191],"GERD":[194],"warrants":[199],"further":[200],"investigation.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-03-15T00:00:00"}
