{"id":"https://openalex.org/W4392796920","doi":"https://doi.org/10.1073/pnas.2315248121","title":"Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53","display_name":"Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53","publication_year":2024,"publication_date":"2024-03-14","ids":{"openalex":"https://openalex.org/W4392796920","doi":"https://doi.org/10.1073/pnas.2315248121","pmid":"https://pubmed.ncbi.nlm.nih.gov/38483995","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10963014"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2315248121","doi":"https://doi.org/10.1073/pnas.2315248121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2315248121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2315248121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029306361","display_name":"Abhishiktha Godthi","orcid":"https://orcid.org/0000-0002-5324-1495","observed_orcids":["https://orcid.org/0000-0002-5324-1495"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhishiktha Godthi","raw_affiliation_strings":["Department of Biology, The University of Iowa, Iowa City, IA 52242-1324","Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The University of Iowa, Iowa City, IA 52242-1324","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007493529","display_name":"Sehee Min","orcid":"https://orcid.org/0000-0001-5077-4643","observed_orcids":["https://orcid.org/0000-0001-5077-4643"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sehee Min","raw_affiliation_strings":["Department of Biology, The University of Iowa, Iowa City, IA 52242-1324","Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The University of Iowa, Iowa City, IA 52242-1324","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103180428","display_name":"Srijit Das","orcid":"https://orcid.org/0000-0002-0402-3256","observed_orcids":["https://orcid.org/0000-0002-0402-3256"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srijit Das","raw_affiliation_strings":["Department of Biology, The University of Iowa, Iowa City, IA 52242-1324"],"raw_orcid":"https://orcid.org/0000-0002-0402-3256","affiliations":[{"raw_affiliation_string":"Department of Biology, The University of Iowa, Iowa City, IA 52242-1324","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Johnny Cruz-Corchado","orcid":"https://orcid.org/0000-0002-6940-9870","observed_orcids":["https://orcid.org/0000-0002-6940-9870"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johnny Cruz-Corchado","raw_affiliation_strings":["Department of Biology, The University of Iowa, Iowa City, IA 52242-1324","Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263"],"raw_orcid":"https://orcid.org/0000-0002-6940-9870","affiliations":[{"raw_affiliation_string":"Department of Biology, The University of Iowa, Iowa City, IA 52242-1324","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034876883","display_name":"Andrew Deonarine","orcid":"https://orcid.org/0000-0001-7852-9674","observed_orcids":["https://orcid.org/0000-0001-7852-9674"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Deonarine","raw_affiliation_strings":["Department of Biology, The University of Iowa, Iowa City, IA 52242-1324"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The University of Iowa, Iowa City, IA 52242-1324","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089815341","display_name":"Kara Misel\u2010Wuchter","orcid":"https://orcid.org/0000-0002-8046-0626","observed_orcids":["https://orcid.org/0000-0002-8046-0626"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara Misel-Wuchter","raw_affiliation_strings":["Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242"],"raw_orcid":"https://orcid.org/0000-0002-8046-0626","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033770359","display_name":"Priya Darshinee A. Issuree","orcid":"https://orcid.org/0000-0002-8886-6436","observed_orcids":["https://orcid.org/0000-0002-8886-6436"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya D. Issuree","raw_affiliation_strings":["Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063463617","display_name":"Veena Prahlad","orcid":"https://orcid.org/0000-0002-0413-6074","observed_orcids":["https://orcid.org/0000-0002-0413-6074"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Veena Prahlad","raw_affiliation_strings":["Department of Biology, The University of Iowa, Iowa City, IA 52242-1324","Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263"],"raw_orcid":"https://orcid.org/0000-0002-0413-6074","affiliations":[{"raw_affiliation_string":"Department of Biology, The University of Iowa, Iowa City, IA 52242-1324","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063463617"],"corresponding_institution_ids":["https://openalex.org/I126307644","https://openalex.org/I1292894508"],"apc_list":null,"apc_paid":null,"fwci":1.025,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.74234234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"121","issue":"12","first_page":"e2315248121","last_page":"e2315248121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.7990000247955322},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8830000162124634},{"id":"https://openalex.org/keywords/dauer-formation","display_name":"dauer formation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/nutrient-availability","display_name":"nutrient availability","score":0.8019999861717224},{"id":"https://openalex.org/keywords/food-availability","display_name":"food availability","score":0.6029999852180481},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.5370000004768372},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.6309999823570251},{"id":"https://openalex.org/keywords/phosphofructokinase","display_name":"phosphofructokinase","score":0.843999981880188},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9139999747276306},{"id":"https://openalex.org/keywords/neuroimmune-signaling","display_name":"neuroimmune signaling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8906800746917725},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.855694591999054},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6328688859939575},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4807853102684021},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4690927267074585},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4513401985168457},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4289931654930115},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.41592320799827576},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32536834478378296},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.270210862159729}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2315248121","doi":"https://doi.org/10.1073/pnas.2315248121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2315248121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/2022.11.22.517560","doi":"https://doi.org/10.1101/2022.11.22.517560","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.11.22.517560","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/11/24/2022.11.22.517560.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10963014","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10963014","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10963014/pdf/pnas.202315248.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:38483995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38483995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2315248121","doi":"https://doi.org/10.1073/pnas.2315248121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2315248121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7129129794","display_name":"Investigating how intestinal innate immunity confers neuroprotection using C. elegans","funder_award_id":"R01AG060616","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000865705","display_name":"Caenorhabditis Genetics Center","funder_award_id":"P40OD010440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000868713","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA086862","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000874975","display_name":"Training in Mechanisms of Parasitism","funder_award_id":"T32AI007511","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000894521","display_name":"Investigating how stress induced changes in maternal serotonin affect offspring development and stress resilience","funder_award_id":"R01MH126282","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320315473","display_name":"Institute of Science and Technology Austria","ror":"https://ror.org/03gnh5541"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392796920.pdf","grobid_xml":"https://content.openalex.org/works/W4392796920.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W1503853782","https://openalex.org/W1662930619","https://openalex.org/W1948999853","https://openalex.org/W1964730983","https://openalex.org/W1976416661","https://openalex.org/W1979653032","https://openalex.org/W1986006829","https://openalex.org/W1987738372","https://openalex.org/W1991091416","https://openalex.org/W1991510903","https://openalex.org/W1992455232","https://openalex.org/W1995008569","https://openalex.org/W1996579090","https://openalex.org/W1999989614","https://openalex.org/W2000823493","https://openalex.org/W2001003549","https://openalex.org/W2005184851","https://openalex.org/W2005676064","https://openalex.org/W2006818360","https://openalex.org/W2014170738","https://openalex.org/W2024295381","https://openalex.org/W2044567627","https://openalex.org/W2048663475","https://openalex.org/W2052719407","https://openalex.org/W2054712073","https://openalex.org/W2056673369","https://openalex.org/W2062629127","https://openalex.org/W2066660409","https://openalex.org/W2066919447","https://openalex.org/W2068060627","https://openalex.org/W2069868576","https://openalex.org/W2075481535","https://openalex.org/W2076489829","https://openalex.org/W2076676971","https://openalex.org/W2088197864","https://openalex.org/W2097265502","https://openalex.org/W2098127707","https://openalex.org/W2103856526","https://openalex.org/W2106937415","https://openalex.org/W2112327312","https://openalex.org/W2117275311","https://openalex.org/W2117955779","https://openalex.org/W2120936083","https://openalex.org/W2134622083","https://openalex.org/W2136545880","https://openalex.org/W2138416557","https://openalex.org/W2139735087","https://openalex.org/W2141932099","https://openalex.org/W2142842603","https://openalex.org/W2144498949","https://openalex.org/W2144875446","https://openalex.org/W2145304907","https://openalex.org/W2146366384","https://openalex.org/W2148226984","https://openalex.org/W2159779491","https://openalex.org/W2161697010","https://openalex.org/W2166969664","https://openalex.org/W2169804929","https://openalex.org/W2171730432","https://openalex.org/W2212495537","https://openalex.org/W2225716095","https://openalex.org/W2289419346","https://openalex.org/W2416735522","https://openalex.org/W2468705431","https://openalex.org/W2553407138","https://openalex.org/W2576526246","https://openalex.org/W2588354379","https://openalex.org/W2757860389","https://openalex.org/W2765873986","https://openalex.org/W2786636755","https://openalex.org/W2796511790","https://openalex.org/W2809122250","https://openalex.org/W2914147828","https://openalex.org/W2920295176","https://openalex.org/W2938629106","https://openalex.org/W2989977128","https://openalex.org/W2996848303","https://openalex.org/W2999339913","https://openalex.org/W3017836382","https://openalex.org/W3022167651","https://openalex.org/W3025513346","https://openalex.org/W3126283360","https://openalex.org/W3126534170","https://openalex.org/W3159866456","https://openalex.org/W3162684406","https://openalex.org/W3166253214","https://openalex.org/W3206332266","https://openalex.org/W3213902573","https://openalex.org/W4210410370","https://openalex.org/W4214822336","https://openalex.org/W4232690806","https://openalex.org/W4238773213","https://openalex.org/W4249150672","https://openalex.org/W4253399191","https://openalex.org/W4284693043","https://openalex.org/W4286797661","https://openalex.org/W4295885862","https://openalex.org/W4304987610","https://openalex.org/W4365484664","https://openalex.org/W4384934670","https://openalex.org/W6680973815","https://openalex.org/W6820227922","https://openalex.org/W7075658468","https://openalex.org/W7099372246"],"related_works":["https://openalex.org/W6889748815","https://openalex.org/W4410350379","https://openalex.org/W2011364906","https://openalex.org/W2016075650","https://openalex.org/W2047495081","https://openalex.org/W18165357","https://openalex.org/W2123521850","https://openalex.org/W2032285280","https://openalex.org/W3003508000","https://openalex.org/W2945202325"],"abstract_inverted_index":{"Abstract":[0],"During":[1,159],"metazoan":[2,160,616],"development,":[3,161],"how":[4,363],"cell":[5,107,374,482,560],"division":[6,483,620],"and":[7,36,61,80,84,103,119,124,147,170,204,259,272,278,280,322,333,347,379,401,445,460,480,522,569,621,652,666,676,704],"metabolic":[8,171,271,571,677],"programs":[9],"are":[10,125,328,405,429,539],"coordinated":[11,165,371,627],"with":[12,166,382,484,628],"nutrient":[13,21,101,162,629,699],"availability":[14,22,102,163,700],"remains":[15,389],"unclear.":[16],"Here,":[17,467],"we":[18,468],"show":[19,469,576,632],"that":[20,201,305,311,397,470,558,577,599,618,633],"signaled":[23],"by":[24,38,55,330,431,486,553,636,646],"the":[25,40,43,68,120,149,167,182,185,241,307,364,383,471,488,491,506,514,548,585,600,604,619,647,658,681,721],"neuronal":[26,500,648],"cytokine,":[27,650],"ILC-17.1":[28,53,98,501,517,662,671],"switches":[29,525],"C.":[30,155,187,210,472,492,595,641,730],"elegans":[31,156,188,211,473,493,596,642,731],"development":[32,146,291,528],"between":[33],"reproductive":[34,293,668],"growth":[35,169,203,312,319,344,531,565],"dormancy":[37],"controlling":[39,487],"activity":[41,172,489,504],"of":[42,70,117,122,130,142,151,173,243,353,386,395,417,490,508,516,550,580,587,594,603,623,660,684,695,712,723],"tumor":[44,494,536],"suppressor":[45,495,537],"p53":[46,496],"ortholog,":[47,475,497],"CEP-1.":[48,498],"Specifically,":[49,499],"upon":[50],"food":[51,478,509],"availability,":[52,479],"signaling":[54,99,645,672],"amphid":[56],"neurons":[57,332],"promotes":[58],"glucose":[59],"utilization":[60],"suppresses":[62,502,664],"CEP-1/p53":[63,72,143,503,519,581],"to":[64,87,106,127,199,289,336,435,510,532,590,680,701],"allow":[65],"growth.":[66,512,705],"In":[67,425,454,657],"absence":[69,586],"ILC-17.1,":[71,476,651],"is":[73,164,180,380,520,643,697],"activated,":[74,521],"upregulates":[75],"cell-cycle":[76],"inhibitors,":[77],"decreases":[78],"phosphofructokinase":[79],"cytochrome":[81],"C":[82],"expression,":[83],"causes":[85],"larvae":[86,212,253,264,269,685],"arrest":[88,260,566,683],"as":[89,239,261,464,686],"stress-resistant,":[90],"quiescent":[91,687],"dauers.":[92,688],"We":[93,631],"propose":[94],"a":[95,138,152,190,195,370,415,555,615,708,724],"model":[96],"whereby":[97],"links":[100],"energy":[104,452,702],"metabolism":[105,402,485,703],"cycle":[108,561],"progression":[109],"through":[110,176,644],"CEP-1/p53.":[111],"These":[112],"studies":[113,300,575,690,719],"describe":[114],"ancestral":[115,693],"functions":[116,579],"IL-17s":[118,456],"p53-family":[121],"proteins":[123,396,407],"relevant":[126],"our":[128,718],"understanding":[129],"neuroimmune":[131],"mechanisms":[132],"in":[133,144,184,240,284,369,373,403,450,505,541,584,614,640,714,729],"cancer.":[134],"They":[135,706],"also":[136,181,358,457,582],"reveal":[137,707],"DNA":[139,552,588,709],"damage-independent":[140,710],"function":[141,602,694,711],"invertebrate":[145,186,715],"support":[148,720],"existence":[150,722],"previously":[153,725],"undescribed":[154,726],"dauer":[157,308,349,360,365,727],"pathway.":[158],"division,":[168],"individual":[174],"cells":[175,335,434,625],"cell-cell":[177,399],"communication.":[178],"This":[179],"case":[183],",":[189,597],"free-living":[191],"bacterivore,":[192],"which":[193,637],"displays":[194],"dramatic":[196],"developmental":[197,257,592,601],"plasticity":[198],"ensure":[200],"its":[202,653],"reproduction":[205],"match":[206],"available":[207],"resources(1\u201310).":[208],"When":[209],"hatch":[213,234],"under":[214,235],"optimal":[215],"conditions":[216,297],"(at":[217],"20\u00b0C,":[218],"low":[219],"population":[220,247],"densities,":[221,248],"on":[222],"abundant":[223],"food)":[224],"they":[225,233,546],"develop":[226],"continuously":[227],"into":[228,292],"reproducing":[229],"adults.":[230],"However,":[231],"if":[232],"suboptimal":[236],"conditions,":[237],"such":[238,463],"paucity":[242],"food,":[244,661],"at":[245],"high":[246,250],"or":[249,567],"ambient":[251],"temperatures,":[252],"implement":[254],"an":[255,692],"alternative":[256],"program":[258,557],"quiescent,":[262],"stress-resistant":[263],"called":[265,408],"\u2018dauer\u2018":[266],"larvae.":[267],"Dauer":[268],"display":[270],"organismal":[273],"phenotypes":[274],"specialized":[275,432],"for":[276,287],"dispersal":[277],"survival,":[279],"can":[281],"remain":[282],"arrested":[283],"this":[285,524,638],"state":[286],"months":[288],"resume":[290],"adults":[294],"when":[295],"favorable":[296],"return(1\u201310).":[298],"Previous":[299],"have":[301,608],"identified":[302],"molecular":[303],"pathways":[304,388],"mediate":[306,398],"decision,":[309],"showing":[310],"promoting":[313,345],"molecules":[314],"like":[315],"insulins,":[316],"transforming":[317],"\u03b2":[318],"factor":[320],"(TGF\u03b2/DAF-7)":[321],"lipid":[323],"based":[324],"dafachronic":[325],"acid":[326],"hormones":[327],"released":[329,430],"sensory":[331],"other":[334],"license":[337,511],"continued":[338],"development;":[339],"adverse":[340],"environments":[341],"inhibit":[342],"these":[343,427,578],"signals":[346,477],"trigger":[348],"arrest(1\u201311).":[350],"A":[351],"number":[352],"quantitative":[354],"trait":[355],"loci":[356],"(QTL)":[357],"modulate":[359],"(12).":[361],"Yet,":[362],"entry":[366],"decision":[367],"results":[368],"change":[372],"fates":[375],"across":[376,422],"different":[377],"tissues":[378],"linked":[381],"systemic":[384],"shut-down":[385],"anabolic":[387],"poorly":[390],"understood.":[391],"An":[392],"important":[393],"group":[394],"communication":[400],"metazoa":[404],"secreted":[406],"cytokines(13,":[409],"14).":[410],"The":[411,534],"IL-17":[412,474,649,696],"cytokines":[413,428],"constitute":[414],"family":[416,606],"proinflammatory":[418],"cytokines,":[419],"highly":[420],"conserved":[421],"animal":[423],"phyla.":[424],"mammals,":[426],"immune":[433,437],"activate":[436],"surveillance,":[438],"enhance":[439],"barrier":[440],"function,":[441],"promote":[442,458],"wound":[443],"healing,":[444],"play":[446],"crucial":[447],"immunometabolic":[448],"roles":[449],"maintaining":[451],"homeostasis(15).":[453],"humans,":[455],"cancers":[459],"autoimmune":[461],"disease":[462],"psoriasis(16,":[465],"17).":[466],"coordinates":[481],"presence":[507,659],"Upon":[513],"loss":[515],"signaling,":[518],"remarkably,":[523],"whole":[526],"organism":[527],"from":[529],"continuous":[530],"dormancy.":[533],"p53-like":[535],"genes":[538],"found":[540],"all":[542],"multicellular":[543],"animals":[544],"where":[545],"prevent":[547],"transmission":[549],"damaged":[551],"activating":[554],"multifaceted":[556],"controls":[559,570],"checkpoints,":[562],"mediates":[563],"reversible":[564,682],"apoptosis,":[568],"flux":[572],"(18\u201322).":[573],"Our":[574,689],"act,":[583],"damage,":[589],"control":[591,654],"quiescence":[593],"suggesting":[598],"p53-gene":[605],"could":[607],"shaped":[609],"their":[610],"evolution(23\u201325).":[611],"Significance":[612],"Development":[613],"requires":[617],"differentiation":[622],"diverse":[624],"be":[626],"availability.":[630],"one":[634],"mechanism":[635],"occurs":[639],"over":[655],"p53/CEP-1.":[656],"release":[663],"p53/CEP-1":[665,713],"allows":[667],"growth;":[669],"decreased":[670],"activates":[673],"p53/CEP-1-dependent":[674],"transcription":[675],"programs,":[678],"leading":[679],"suggest":[691],"linking":[698],"development.":[716],"Finally,":[717],"pathway":[728],".":[732]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-03-15T00:00:00"}