{"id":"https://openalex.org/W4392772014","doi":"https://doi.org/10.1111/jog.15916","title":"Role of the mitophagy\u2010apoptosis axis in the pathogenesis of polycystic ovarian syndrome","display_name":"Role of the mitophagy\u2010apoptosis axis in the pathogenesis of polycystic ovarian syndrome","publication_year":2024,"publication_date":"2024-02-28","ids":{"openalex":"https://openalex.org/W4392772014","doi":"https://doi.org/10.1111/jog.15916","pmid":"https://pubmed.ncbi.nlm.nih.gov/38417972"},"language":"en","primary_location":{"id":"doi:10.1111/jog.15916","doi":"https://doi.org/10.1111/jog.15916","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jog.15916","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jog.15916","source":{"id":"https://openalex.org/S4210240629","display_name":"Journal of obstetrics and gynaecology research","issn_l":"1341-8076","issn":["1341-8076","1447-0756"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obstetrics and Gynaecology Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jog.15916","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040233451","display_name":"Hiroshi Kobayashi","orcid":"https://orcid.org/0000-0002-8124-6269","observed_orcids":["https://orcid.org/0000-0002-8124-6269"]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Kobayashi","raw_affiliation_strings":["Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, Kashihara, Japan","Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8124-6269","affiliations":[{"raw_affiliation_string":"Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, Kashihara, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101138776","display_name":"Hiroshi Shigetomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405283125","display_name":"ASKA (Japan)","ror":"https://ror.org/0125cx945","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405283125"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Shigetomi","raw_affiliation_strings":["Department of Gynecology and Reproductive Medicine, Aska Ladies Clinic, Nara, Japan","Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Reproductive Medicine, Aska Ladies Clinic, Nara, Japan","institution_ids":["https://openalex.org/I4405283125"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sho Matsubara","orcid":"https://orcid.org/0000-0002-4323-5470","observed_orcids":["https://orcid.org/0000-0002-4323-5470"]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho Matsubara","raw_affiliation_strings":["Department of Medicine, Kei Oushin Clinic, Nishinomiya, Japan","Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4323-5470","affiliations":[{"raw_affiliation_string":"Department of Medicine, Kei Oushin Clinic, Nishinomiya, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022017855","display_name":"Chiharu Yoshimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153019","display_name":"Nara Prefecture General Medical Center","ror":"https://ror.org/00bhf8j88","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387153019","https://openalex.org/I4405284808"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chiharu Yoshimoto","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan","Department of Obstetrics and Gynecology, Nara Prefecture General Medical Center, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Nara Prefecture General Medical Center, Nara, Japan","institution_ids":["https://openalex.org/I4387153019"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113763213","display_name":"Shogo Imanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shogo Imanaka","raw_affiliation_strings":["Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, Kashihara, Japan","Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, Kashihara, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040233451"],"corresponding_institution_ids":["https://openalex.org/I64926303"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":null,"fwci":0.7759,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.57955801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"50","issue":"5","first_page":"775","last_page":"792"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/oocytes","display_name":"oocytes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.8169999718666077},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mitochondrial-quality-control","display_name":"mitochondrial quality control","score":0.5580000281333923},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.9247704744338989},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.7938336133956909},{"id":"https://openalex.org/C2777092462","wikidata":"https://www.wikidata.org/wiki/Q15334407","display_name":"MFN2","level":5,"score":0.699943482875824},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.613876461982727},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5690537095069885},{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.5181192755699158},{"id":"https://openalex.org/C169415338","wikidata":"https://www.wikidata.org/wiki/Q18031951","display_name":"TFAM","level":4,"score":0.4876798391342163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4685704708099365},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.4589570164680481},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45775967836380005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.422633558511734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39976930618286133},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.3593250811100006},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.340626984834671},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.2709004580974579},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24071010947227478},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.23703360557556152},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.16064834594726562},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.11530280113220215},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07495781779289246}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/jog.15916","doi":"https://doi.org/10.1111/jog.15916","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jog.15916","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jog.15916","source":{"id":"https://openalex.org/S4210240629","display_name":"Journal of obstetrics and gynaecology research","issn_l":"1341-8076","issn":["1341-8076","1447-0756"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obstetrics and Gynaecology Research","raw_type":"journal-article"},{"id":"pmid:38417972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38417972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of obstetrics and gynaecology research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/jog.15916","doi":"https://doi.org/10.1111/jog.15916","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jog.15916","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jog.15916","source":{"id":"https://openalex.org/S4210240629","display_name":"Journal of obstetrics and gynaecology research","issn_l":"1341-8076","issn":["1341-8076","1447-0756"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obstetrics and Gynaecology Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1363519628","display_name":"Differentiation of benign and malignant ovarian tumors using the novel tumor marker tissue factor pathway inhibitor 2","funder_award_id":"22K09576","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2189877814","display_name":"\u65b0\u305f\u306a\u7d4c\u815f\u5149\u5b66\u30d7\u30ed\u30fc\u30d6\u306b\u3088\u308b\u5b50\u5bae\u5185\u819c\u75c7\u95a2\u9023\u4e0d\u598a\u75c7\u306e\u975e\u4fb5\u8972\u7684\u4e88\u77e5","funder_award_id":"23K08806","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4049908798","display_name":"Development of non-hormonal therapy for endometriosis by inducing oxidative suicide","funder_award_id":"22K09549","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6397073287","display_name":"Non-invasive prediction of the severity of endometriosis-related infertility using a novel magnetic resonance relaxometry technique","funder_award_id":"22K09643","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392772014.pdf","grobid_xml":"https://content.openalex.org/works/W4392772014.grobid-xml"},"referenced_works_count":130,"referenced_works":["https://openalex.org/W1015286906","https://openalex.org/W1128977061","https://openalex.org/W1204135122","https://openalex.org/W1442950912","https://openalex.org/W1598453492","https://openalex.org/W1931041435","https://openalex.org/W1964876127","https://openalex.org/W1972008706","https://openalex.org/W1990567986","https://openalex.org/W1994640446","https://openalex.org/W1998010000","https://openalex.org/W1998129514","https://openalex.org/W2007570393","https://openalex.org/W2009502977","https://openalex.org/W2035217519","https://openalex.org/W2045970460","https://openalex.org/W2047608730","https://openalex.org/W2050593976","https://openalex.org/W2053829558","https://openalex.org/W2061320431","https://openalex.org/W2066193715","https://openalex.org/W2075553679","https://openalex.org/W2084300141","https://openalex.org/W2086538614","https://openalex.org/W2091045958","https://openalex.org/W2096308078","https://openalex.org/W2098627094","https://openalex.org/W2105412616","https://openalex.org/W2105415039","https://openalex.org/W2116192451","https://openalex.org/W2123009569","https://openalex.org/W2123627670","https://openalex.org/W2123874077","https://openalex.org/W2126868334","https://openalex.org/W2132421508","https://openalex.org/W2135173604","https://openalex.org/W2139018626","https://openalex.org/W2141695252","https://openalex.org/W2143151643","https://openalex.org/W2151877403","https://openalex.org/W2156480732","https://openalex.org/W2157268169","https://openalex.org/W2159754384","https://openalex.org/W2172288279","https://openalex.org/W2186418777","https://openalex.org/W2280212630","https://openalex.org/W2293576268","https://openalex.org/W2401605092","https://openalex.org/W2406601643","https://openalex.org/W2408790813","https://openalex.org/W2498412557","https://openalex.org/W2518372159","https://openalex.org/W2537233294","https://openalex.org/W2559178581","https://openalex.org/W2563894969","https://openalex.org/W2621206961","https://openalex.org/W2736266913","https://openalex.org/W2749693449","https://openalex.org/W2770187348","https://openalex.org/W2782372606","https://openalex.org/W2782727455","https://openalex.org/W2783398868","https://openalex.org/W2789687467","https://openalex.org/W2800328458","https://openalex.org/W2803052640","https://openalex.org/W2884690956","https://openalex.org/W2898692674","https://openalex.org/W2917615841","https://openalex.org/W2921629728","https://openalex.org/W2923411756","https://openalex.org/W2937578637","https://openalex.org/W2966981559","https://openalex.org/W2967878216","https://openalex.org/W2989769687","https://openalex.org/W2991767540","https://openalex.org/W2999538052","https://openalex.org/W3000979264","https://openalex.org/W3004180430","https://openalex.org/W3006422924","https://openalex.org/W3007938047","https://openalex.org/W3009008467","https://openalex.org/W3009624374","https://openalex.org/W3012525259","https://openalex.org/W3022139000","https://openalex.org/W3026782848","https://openalex.org/W3033939745","https://openalex.org/W3043328517","https://openalex.org/W3045282623","https://openalex.org/W3048150372","https://openalex.org/W3094762267","https://openalex.org/W3111020918","https://openalex.org/W3112582248","https://openalex.org/W3120276386","https://openalex.org/W3122148549","https://openalex.org/W3123142536","https://openalex.org/W3134989361","https://openalex.org/W3136544212","https://openalex.org/W3152835662","https://openalex.org/W3157724466","https://openalex.org/W3160971709","https://openalex.org/W3164651210","https://openalex.org/W3169239182","https://openalex.org/W3173664503","https://openalex.org/W3177316604","https://openalex.org/W3214035824","https://openalex.org/W4220779063","https://openalex.org/W4224275478","https://openalex.org/W4229371139","https://openalex.org/W4255861653","https://openalex.org/W4256605237","https://openalex.org/W4280544619","https://openalex.org/W4283122078","https://openalex.org/W4291019518","https://openalex.org/W4304203504","https://openalex.org/W4308723541","https://openalex.org/W4308800352","https://openalex.org/W4313256856","https://openalex.org/W4313425954","https://openalex.org/W4313489155","https://openalex.org/W4379052453","https://openalex.org/W4382400244","https://openalex.org/W4385264673","https://openalex.org/W4386073966","https://openalex.org/W4386091825","https://openalex.org/W4386135075","https://openalex.org/W4386530233","https://openalex.org/W4387419288","https://openalex.org/W4387745772","https://openalex.org/W4389049640","https://openalex.org/W4389081319"],"related_works":["https://openalex.org/W4220779063","https://openalex.org/W4386091825","https://openalex.org/W3008297594","https://openalex.org/W6922240292","https://openalex.org/W4389917534","https://openalex.org/W3007736104","https://openalex.org/W4382400244","https://openalex.org/W3004180430","https://openalex.org/W3007938047","https://openalex.org/W4280544619"],"abstract_inverted_index":{"AIM:":[0],"Polycystic":[1],"ovary":[2],"syndrome":[3],"(PCOS)":[4],"is":[5],"a":[6,190,207,226],"common":[7],"endocrine":[8],"disorder":[9],"characterized":[10],"by":[11],"menstrual":[12],"irregularities,":[13],"androgen":[14,31],"excess,":[15],"and":[16,42,47,58,70,113,121,134,203],"polycystic":[17],"ovarian":[18],"morphology,":[19,101],"but":[20],"its":[21],"pathogenesis":[22,55],"remains":[23],"largely":[24],"unknown.":[25],"This":[26],"review":[27],"focuses":[28],"on":[29,61],"how":[30],"excess":[32,126],"influences":[33],"the":[34,54,96,130,137,180,216,232,239,243],"molecular":[35],"basis":[36],"of":[37,53,56,68,89,104,129,136,145,168,175,198,209,218,238,242],"energy":[38],"metabolism,":[39],"mitochondrial":[40,100,109,146,151,154,160,172],"function,":[41],"mitophagy":[43,114,185],"in":[44,118],"granulosa":[45],"cells":[46],"oocytes,":[48],"summarizes":[49],"our":[50],"current":[51],"understanding":[52],"PCOS,":[57],"discuss":[59],"perspectives":[60],"future":[62],"research":[63],"directions.":[64],"METHODS:":[65],"A":[66,148],"search":[67],"PubMed":[69],"Google":[71],"Scholar":[72],"databases":[73],"were":[74],"used":[75],"to":[76,93,107,166,186,201,215,225],"identify":[77],"relevant":[78],"studies":[79],"for":[80,171],"this":[81],"narrative":[82],"literature":[83],"review.":[84],"RESULTS:":[85],"Female":[86],"offspring":[87],"born":[88],"pregnant":[90],"animals":[91],"exposed":[92,224],"androgens":[94],"recapitulates":[95],"PCOS":[97,119,233],"phenotype.":[98,192],"Abnormal":[99],"altered":[102,196],"expression":[103,197],"genes":[105,199],"related":[106,200],"glycolysis,":[108],"biogenesis,":[110],"fission/fusion":[111],"dynamics,":[112],"have":[115],"been":[116],"identified":[117],"patients":[120],"androgenic":[122],"animal":[123],"models.":[124],"Androgen":[125],"causes":[127],"uncoupling":[128],"electron":[131],"transport":[132],"chain":[133],"depletion":[135],"cellular":[138],"adenosine":[139],"5'-triphosphate":[140],"pool,":[141],"indicating":[142],"further":[143],"impairment":[144],"function.":[147],"shift":[149],"toward":[150],"fission":[152,161],"restores":[153],"quality":[155,181],"control":[156,182],"mechanisms.":[157],"However,":[158],"prolonged":[159],"disrupts":[162],"autophagy/mitophagy":[163],"induction":[164],"due":[165],"loss":[167],"compensatory":[169,176,240],"reserve":[170],"biogenesis.":[173],"Disruption":[174],"mechanisms":[177],"that":[178],"mediate":[179],"switch":[183],"from":[184],"apoptosis":[187],"may":[188,212,230],"cause":[189,231],"disease":[191],"Furthermore,":[193],"genetic":[194],"predisposition,":[195],"glycolysis":[202],"oxidative":[204],"phosphorylation,":[205],"or":[206],"combination":[208],"these":[210],"factors":[211],"also":[213],"contribute":[214],"development":[217],"PCOS.":[219],"CONCLUSION:":[220],"In":[221],"conclusion,":[222],"fetuses":[223],"hyperandrogenemic":[227],"intrauterine":[228],"environment":[229],"phenotype":[234],"possibly":[235],"through":[236],"disruption":[237],"regulation":[241],"mitophagy-apoptosis":[244],"axis.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-03-14T00:00:00"}
