{"id":"https://openalex.org/W4392771990","doi":"https://doi.org/10.1111/jop.13523","title":"Depth of invasion of oral squamous cell carcinoma in Nos2\u2010knockout mice correlated to alterations in systemic inflammatory markers following 4NQO treatment","display_name":"Depth of invasion of oral squamous cell carcinoma in Nos2\u2010knockout mice correlated to alterations in systemic inflammatory markers following 4NQO treatment","publication_year":2024,"publication_date":"2024-02-28","ids":{"openalex":"https://openalex.org/W4392771990","doi":"https://doi.org/10.1111/jop.13523","pmid":"https://pubmed.ncbi.nlm.nih.gov/38418292"},"language":"en","primary_location":{"id":"doi:10.1111/jop.13523","doi":"https://doi.org/10.1111/jop.13523","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jop.13523","pdf_url":null,"source":{"id":"https://openalex.org/S86809486","display_name":"Journal of Oral Pathology and Medicine","issn_l":"0300-9777","issn":["0300-9777","0904-2512","1600-0714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oral Pathology &amp; Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11449/306216","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103059463","display_name":"D\u00e9bora de Oliveira Santos","orcid":"https://orcid.org/0000-0002-8895-9907","observed_orcids":["https://orcid.org/0000-0002-8895-9907","https://orcid.org/0000-0002-0517-7708"]},"institutions":[{"id":"https://openalex.org/I80850581","display_name":"Universidade Federal de Uberl\u00e2ndia","ror":"https://ror.org/04x3wvr31","country_code":"BR","type":"education","lineage":["https://openalex.org/I80850581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"D\u00e9bora de Oliveira Santos","raw_affiliation_strings":["Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil","institution_ids":["https://openalex.org/I80850581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068602637","display_name":"Ana\u00edra Ribeiro Guedes Fonseca Costa","orcid":"https://orcid.org/0000-0001-7560-6531","observed_orcids":["https://orcid.org/0000-0001-7560-6531"]},"institutions":[{"id":"https://openalex.org/I80850581","display_name":"Universidade Federal de Uberl\u00e2ndia","ror":"https://ror.org/04x3wvr31","country_code":"BR","type":"education","lineage":["https://openalex.org/I80850581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana\u00edra Ribeiro Guedes Fonseca Costa","raw_affiliation_strings":["Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7560-6531","affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil","institution_ids":["https://openalex.org/I80850581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062835612","display_name":"Pedro Victor Silva Duarte","orcid":"https://orcid.org/0000-0002-7286-8875","observed_orcids":["https://orcid.org/0000-0002-7286-8875"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Victor Silva Duarte","raw_affiliation_strings":["Department of Diagnosis and Surgery J\u00falio de Mesquita Filho S\u00e3o Paulo State University  S\u00e3o Paulo Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnosis and Surgery J\u00falio de Mesquita Filho S\u00e3o Paulo State University  S\u00e3o Paulo Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069165249","display_name":"T\u00e1ssio Edno Atan\u00e1sio Pitorro","orcid":"https://orcid.org/0000-0002-0073-0527","observed_orcids":["https://orcid.org/0000-0002-0073-0527"]},"institutions":[{"id":"https://openalex.org/I80850581","display_name":"Universidade Federal de Uberl\u00e2ndia","ror":"https://ror.org/04x3wvr31","country_code":"BR","type":"education","lineage":["https://openalex.org/I80850581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"T\u00e1ssio Edno Atan\u00e1sio Pitorro","raw_affiliation_strings":["Department of Periodontology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil","institution_ids":["https://openalex.org/I80850581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013831307","display_name":"L\u00fabia Cristina Fonseca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80850581","display_name":"Universidade Federal de Uberl\u00e2ndia","ror":"https://ror.org/04x3wvr31","country_code":"BR","type":"education","lineage":["https://openalex.org/I80850581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L\u00fabia Cristina Fonseca","raw_affiliation_strings":["Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil","institution_ids":["https://openalex.org/I80850581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044925516","display_name":"S\u00e9rgio Vitorino Cardoso","orcid":"https://orcid.org/0000-0003-1809-0617","observed_orcids":["https://orcid.org/0000-0003-1809-0617"]},"institutions":[{"id":"https://openalex.org/I80850581","display_name":"Universidade Federal de Uberl\u00e2ndia","ror":"https://ror.org/04x3wvr31","country_code":"BR","type":"education","lineage":["https://openalex.org/I80850581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"S\u00e9rgio Vitorino Cardoso","raw_affiliation_strings":["Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil","institution_ids":["https://openalex.org/I80850581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028101933","display_name":"Paulo Rog\u00e9rio de Faria","orcid":"https://orcid.org/0000-0003-2650-3960","observed_orcids":["https://orcid.org/0000-0003-2650-3960"]},"institutions":[{"id":"https://openalex.org/I80850581","display_name":"Universidade Federal de Uberl\u00e2ndia","ror":"https://ror.org/04x3wvr31","country_code":"BR","type":"education","lineage":["https://openalex.org/I80850581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Rog\u00e9rio de Faria","raw_affiliation_strings":["Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil","institution_ids":["https://openalex.org/I80850581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083299475","display_name":"Adriano Mota Loyola","orcid":"https://orcid.org/0000-0001-9707-9365","observed_orcids":["https://orcid.org/0000-0001-9707-9365"]},"institutions":[{"id":"https://openalex.org/I80850581","display_name":"Universidade Federal de Uberl\u00e2ndia","ror":"https://ror.org/04x3wvr31","country_code":"BR","type":"education","lineage":["https://openalex.org/I80850581"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Adriano Mota Loyola","raw_affiliation_strings":["Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Pathology Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Minas Gerais Brazil","institution_ids":["https://openalex.org/I80850581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083299475"],"corresponding_institution_ids":["https://openalex.org/I80850581"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.6465,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.67292858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"53","issue":"3","first_page":"208","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nos2-knockout-mice","display_name":"NOS2 knockout mice","score":0.9269999861717224},{"id":"https://openalex.org/keywords/4-nitroquinoline-1-oxide","display_name":"4-nitroquinoline 1-oxide","score":0.9190000295639038},{"id":"https://openalex.org/keywords/oral-carcinogenesis","display_name":"oral carcinogenesis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumor-invasion-depth","display_name":"depth of invasion","score":0.765999972820282},{"id":"https://openalex.org/keywords/systemic-inflammatory-markers","display_name":"systemic inflammatory markers","score":0.8320000171661377},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9449999928474426},{"id":"https://openalex.org/keywords/platelet-to-lymphocyte-ratio","display_name":"platelet-to-lymphocyte ratio","score":0.9990000128746033},{"id":"https://openalex.org/keywords/systemic-immune-inflammation-index","display_name":"systemic immune-inflammation index","score":0.968999981880188},{"id":"https://openalex.org/keywords/peripheral-blood-parameters","display_name":"peripheral blood parameters","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.69169020652771},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.6759045720100403},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6201137900352478},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6077584028244019},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5895084142684937},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.503372848033905},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4855615794658661},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.48026323318481445},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4678310453891754},{"id":"https://openalex.org/C2778963024","wikidata":"https://www.wikidata.org/wiki/Q17132454","display_name":"Neutrophil to lymphocyte ratio","level":3,"score":0.44688811898231506},{"id":"https://openalex.org/C2779813244","wikidata":"https://www.wikidata.org/wiki/Q7168697","display_name":"Peripheral blood cell","level":3,"score":0.4167903959751129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41423341631889343},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4034176468849182},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.33460113406181335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.285566121339798},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.22116729617118835}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/jop.13523","doi":"https://doi.org/10.1111/jop.13523","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jop.13523","pdf_url":null,"source":{"id":"https://openalex.org/S86809486","display_name":"Journal of Oral Pathology and Medicine","issn_l":"0300-9777","issn":["0300-9777","0904-2512","1600-0714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oral Pathology &amp; Medicine","raw_type":"journal-article"},{"id":"pmid:38418292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38418292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.unesp.br:11449/306216","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11449/306216","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"pmh:oai:repositorio.unesp.br:11449/306216","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11449/306216","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G368731567","display_name":null,"funder_award_id":"APQ-3020/21","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G929959801","display_name":null,"funder_award_id":"409081-21-3","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W204476817","https://openalex.org/W1609740833","https://openalex.org/W1969760237","https://openalex.org/W1969853188","https://openalex.org/W1980549664","https://openalex.org/W1991433828","https://openalex.org/W2005941714","https://openalex.org/W2021992999","https://openalex.org/W2078608203","https://openalex.org/W2108895019","https://openalex.org/W2131630923","https://openalex.org/W2168935452","https://openalex.org/W2752861455","https://openalex.org/W2801803191","https://openalex.org/W2810601516","https://openalex.org/W2901662426","https://openalex.org/W2902674355","https://openalex.org/W2904370498","https://openalex.org/W2912245984","https://openalex.org/W2948190856","https://openalex.org/W2959920052","https://openalex.org/W2964577644","https://openalex.org/W2975762881","https://openalex.org/W2996039207","https://openalex.org/W2999500174","https://openalex.org/W3023971869","https://openalex.org/W3114566026","https://openalex.org/W3128646645","https://openalex.org/W3166875728","https://openalex.org/W3184272913","https://openalex.org/W4368377144"],"related_works":["https://openalex.org/W1972550413","https://openalex.org/W4391220473","https://openalex.org/W2964577644","https://openalex.org/W4391220491","https://openalex.org/W2377054439","https://openalex.org/W1974895032","https://openalex.org/W1184679548","https://openalex.org/W2168361031","https://openalex.org/W2110605934","https://openalex.org/W2086581267"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Peripheral":[2],"blood":[3,43,101,104,140,249],"analysis":[4],"is":[5],"a":[6],"non\u2010invasive":[7],"and":[8,45,70,91,97,106,117,159,168,205,234,250],"low\u2010cost":[9],"technique":[10],"of":[11,23,38,58,127,129,144,166],"prognostic":[12],"value":[13],"for":[14,78,84,95],"several":[15,139],"diseases,":[16],"including":[17],"oral":[18,51],"cancer.":[19],"Considering":[20],"the":[21,36,118],"role":[22,230],"inducible":[24],"nitric":[25,222],"oxide":[26,61,223],"synthase":[27,224],"in":[28,138,146,152,216,231,242],"tumor\u2010associated":[29],"inflammation,":[30],"this":[31,39],"study":[32],"purposed":[33],"to":[34,64,226,240],"evaluate":[35],"influence":[37],"enzyme":[40],"on":[41],"peripheral":[42,248],"parameters":[44,109],"systemic":[46,119,206,251],"inflammatory":[47,252],"biomarkers":[48],"during":[49],"murine":[50],"carcinogenesis.":[52],"Methods":[53],"A":[54],"50":[55],"\u03bcg/mL":[56],"solution":[57],"4\u2010nitroquinoleine\u2010N":[59],"\u2010":[60],"was":[62,132,149],"provided":[63],"15":[65],"C57BL/6J":[66],"(Nos2":[67,75],"+/+":[68,154],")":[69,77],"16":[71,79],"B6.129P2\u2010Nos2":[72],"tm1Lau":[73],"/J":[74],"\u2212/\u2212":[76,148,218],"weeks.":[80],"Animals":[81],"were":[82,93,110,122,136,162],"followed":[83],"8":[85],"weeks":[86],"after":[87],"treatment.":[88],"Blood":[89],"samples":[90],"tongues":[92],"collected":[94],"hematological":[96],"histopathological":[98],"analyses.":[99],"Red":[100],"cells,":[102,105],"white":[103],"platelet":[107],"cell":[108,244],"analyzed.":[111],"The":[112,125,142],"neutrophil\u2010to\u2010lymphocyte":[113,187],"ratio,":[114,116],"platelet\u2010to\u2010lymphocyte":[115,196],"immune\u2010inflammation":[120,207],"index":[121,208],"also":[123],"calculated.":[124],"depth":[126,143,165],"invasion":[128,145,167,233],"all":[130],"carcinomas":[131],"measured.":[133],"Results":[134],"Differences":[135],"found":[137,163],"parameters.":[141],"Nos2":[147,153,217],"lower":[150],"than":[151],"(":[155,171,180,189,198,209],"p":[156,175,184,193,202,213],"=":[157,173,176,182,185,191,194,200,203,211,214],"0.009),":[158],"strong":[160],"correlations":[161],"between":[164],"neutrophil":[169],"count":[170,179],"\u03c1":[172,181,190,199,210],"\u22120.68,":[174],"0.017),":[177],"lymphocyte":[178],"0.72,":[183],"0.011),":[186],"ratio":[188,197],"\u22120.65,":[192],"0.025),":[195],"\u22120.73,":[201],"0.013),":[204],"\u22120.67,":[212],"0.037)":[215],"mice.":[219],"Conclusion":[220],"Inducible":[221],"seems":[225],"have":[227],"an":[228],"important":[229],"OSCC":[232],"progression,":[235],"which":[236],"might":[237],"be":[238],"associated":[239],"alterations":[241],"immune\u2010inflammatory":[243],"dynamics":[245],"evidenced":[246],"by":[247],"biomarkers.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-03-14T00:00:00"}
