{"id":"https://openalex.org/W4392763396","doi":"https://doi.org/10.1117/12.3003272","title":"Perfluorocarbon nanodroplets for photoacoustic image-guided oxygen-enhanced photodynamic therapy of hypoxic tumors","display_name":"Perfluorocarbon nanodroplets for photoacoustic image-guided oxygen-enhanced photodynamic therapy of hypoxic tumors","publication_year":2024,"publication_date":"2024-03-13","ids":{"openalex":"https://openalex.org/W4392763396","doi":"https://doi.org/10.1117/12.3003272"},"language":"en","primary_location":{"id":"doi:10.1117/12.3003272","doi":"https://doi.org/10.1117/12.3003272","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.3003272","pdf_url":null,"source":{"id":"https://openalex.org/S7407115334","display_name":"Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055333704","display_name":"Marvin Xavierselvan","orcid":"https://orcid.org/0000-0002-8361-7318","observed_orcids":["https://orcid.org/0000-0002-8361-7318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marvin Xavierselvan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005010432","display_name":"Jason R. Cook","orcid":"https://orcid.org/0000-0001-6192-9970","observed_orcids":["https://orcid.org/0000-0001-6192-9970"]},"institutions":[{"id":"https://openalex.org/I4210143261","display_name":"NanoHybrids (United States)","ror":"https://ror.org/057j2mw04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210143261"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Cook","raw_affiliation_strings":["NanoHybrids Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NanoHybrids Inc. (United States)","institution_ids":["https://openalex.org/I4210143261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058568678","display_name":"Srivalleesha Mallidi","orcid":"https://orcid.org/0000-0003-1547-1764","observed_orcids":["https://orcid.org/0000-0003-1547-1764"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srivalleesha Mallidi","raw_affiliation_strings":["Tufts Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Univ. (United States)","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"15","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.3386000096797943,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perfluorocarbon-nanodroplets","display_name":"perfluorocarbon nanodroplets","score":1.0},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.9580000042915344},{"id":"https://openalex.org/keywords/oxygen-delivery","display_name":"oxygen delivery","score":0.7829999923706055},{"id":"https://openalex.org/keywords/photoacoustic-imaging","display_name":"photoacoustic imaging","score":0.925000011920929},{"id":"https://openalex.org/keywords/image-guided-therapy","display_name":"image-guided therapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-oxygenation","display_name":"tumor oxygenation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cancer-treatment-resistance","display_name":"cancer therapy resistance","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8858234882354736},{"id":"https://openalex.org/C54932901","wikidata":"https://www.wikidata.org/wiki/Q7187705","display_name":"Photoacoustic imaging in biomedicine","level":2,"score":0.7807824611663818},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.7091664671897888},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.634244441986084},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.629814863204956},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6109175682067871},{"id":"https://openalex.org/C2779081379","wikidata":"https://www.wikidata.org/wiki/Q7852677","display_name":"Tumor hypoxia","level":3,"score":0.57968670129776},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.556827962398529},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.42108213901519775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3670817017555237},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.36628663539886475},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.356665700674057},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3459644913673401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30426815152168274},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.18978574872016907},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13305780291557312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10371297597885132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07666033506393433},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.07438483834266663},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.3003272","doi":"https://doi.org/10.1117/12.3003272","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.3003272","pdf_url":null,"source":{"id":"https://openalex.org/S7407115334","display_name":"Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3203147153","https://openalex.org/W2598344401","https://openalex.org/W4408244047","https://openalex.org/W2520458702","https://openalex.org/W2791255177","https://openalex.org/W7162315833","https://openalex.org/W2256492013","https://openalex.org/W2986434230","https://openalex.org/W4406796638","https://openalex.org/W3080592088"],"abstract_inverted_index":{"Solid":[0],"tumors":[1],"face":[2],"the":[3,74],"challenge":[4],"of":[5],"hypoxia,":[6],"resulting":[7],"from":[8],"an":[9],"imbalance":[10],"between":[11],"oxygen":[12,35,46,57],"demands":[13],"and":[14,26,47,52,59],"supply.":[15],"Hypoxia":[16],"leads":[17],"to":[18,20,80],"resistance":[19],"conventional":[21],"cancer":[22],"therapies":[23],"like":[24],"radiation":[25],"chemotherapy,":[27],"including":[28],"photodynamic":[29],"therapy":[30],"(PDT)":[31],"that":[32],"relies":[33],"on":[34],"radicals.":[36],"To":[37],"address":[38],"this,":[39],"we":[40],"developed":[41],"perfluorocarbon":[42],"nanodroplets":[43,75,86],"for":[44,95],"co-delivering":[45],"a":[48,81,92],"photosensitizer.":[49],"In":[50],"vitro":[51],"in":[53,69],"vivo":[54],"studies":[55],"validated":[56],"release":[58],"enhanced":[60],"tumor":[61,97],"oxygenation.":[62],"Histological":[63],"analysis":[64],"confirmed":[65],"reduced":[66],"hypoxic":[67,96],"regions":[68],"nanodroplet-treated":[70],"tumors.":[71],"PDT":[72],"using":[73],"demonstrated":[76],"superior":[77],"efficacy":[78],"compared":[79],"liposomal":[82],"formulation.":[83],"Overall,":[84],"oxygen-loaded":[85],"guided":[87],"by":[88],"photoacoustic":[89],"imaging":[90],"offer":[91],"promising":[93],"approach":[94],"treatment.":[98]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-03-14T00:00:00"}