{"id":"https://openalex.org/W4392726077","doi":"https://doi.org/10.1158/0008-5472.c.6499085","title":"Data from BCL9 Promotes Tumor Progression by Conferring Enhanced Proliferative, Metastatic, and Angiogenic Properties to Cancer Cells","display_name":"Data from BCL9 Promotes Tumor Progression by Conferring Enhanced Proliferative, Metastatic, and Angiogenic Properties to Cancer Cells","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392726077","doi":"https://doi.org/10.1158/0008-5472.c.6499085"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6499085","doi":"https://doi.org/10.1158/0008-5472.c.6499085","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6499085","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6499085","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112248878","display_name":"Mala Mani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mala Mani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102814475","display_name":"Daniel E. Carrasco","orcid":"https://orcid.org/0009-0004-0258-4107","observed_orcids":["https://orcid.org/0009-0004-0258-4107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel E. Carrasco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106403338","display_name":"Yunyu Zhang","orcid":"https://orcid.org/0000-0002-2232-807X","observed_orcids":["https://orcid.org/0000-0002-2232-807X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yunyu Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052282410","display_name":"Kohichi Takada","orcid":"https://orcid.org/0000-0002-1393-9442","observed_orcids":["https://orcid.org/0000-0002-1393-9442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kohichi Takada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001981855","display_name":"Moshe E. Gatt","orcid":"https://orcid.org/0000-0002-9426-4482","observed_orcids":["https://orcid.org/0000-0002-9426-4482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moshe E. Gatt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052441190","display_name":"Jui Dutta-Simmons","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jui Dutta-Simmons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Ikeda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Ikeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083959244","display_name":"Felipe Diaz\u2010Griffero","orcid":"https://orcid.org/0000-0002-7021-6152","observed_orcids":["https://orcid.org/0000-0002-7021-6152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felipe Diaz-Griffero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046258772","display_name":"Victor Pe\u00f1a\u2010Cruz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor Pena-Cruz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017709484","display_name":"Monica M. Bertagnolli","orcid":"https://orcid.org/0000-0002-0248-3849","observed_orcids":["https://orcid.org/0000-0002-0248-3849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monica Bertagnolli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039268801","display_name":"Lois L. Myeroff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lois L. Myeroff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052550785","display_name":"Sanford D. Markowitz","orcid":"https://orcid.org/0000-0001-5369-5254","observed_orcids":["https://orcid.org/0000-0001-5369-5254"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanford D. Markowitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032464400","display_name":"Kenneth Carl Anderson","orcid":"https://orcid.org/0000-0002-6418-0886","observed_orcids":["https://orcid.org/0000-0002-6418-0886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth C. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111780622","display_name":"Daniel Ruben Carrasco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel R. Carrasco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl9","display_name":"BCL9","score":1.0},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.7540000081062317},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9559999704360962},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8169999718666077},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/beta-catenin-transcriptional-activity","display_name":"\u03b2-catenin transcriptional activity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6000688672065735},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5841004252433777},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.502596378326416},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4607599079608917},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.4319770336151123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3832235336303711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32008135318756104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18301767110824585}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6499085","doi":"https://doi.org/10.1158/0008-5472.c.6499085","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6499085","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6499085","doi":"https://doi.org/10.1158/0008-5472.c.6499085","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6499085","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2143311031","https://openalex.org/W2589750625","https://openalex.org/W3201590296","https://openalex.org/W2592164174","https://openalex.org/W2156270102","https://openalex.org/W4229453473","https://openalex.org/W4364379018","https://openalex.org/W1529276297","https://openalex.org/W6939828739","https://openalex.org/W2146582846"],"abstract_inverted_index":{"Abstract":[0],"Several":[1],"components":[2,42,106],"of":[3,28,39,98,102,117,123,127,138,142,154,174,187],"the":[4,26,34,67,99,103,114,136],"Wnt":[5,40,68,104,209],"signaling":[6,41,105],"cascade":[7],"have":[8],"been":[9],"shown":[10],"to":[11,181],"function":[12],"either":[13],"as":[14,19,43,54,56,84,86,196],"tumor":[15,118,146,166,182],"suppressor":[16],"proteins":[17],"or":[18],"oncogenes":[20],"in":[21,31,57,60,80,190,203],"multiple":[22,82],"human":[23,81],"cancers,":[24],"underscoring":[25],"relevance":[27],"this":[29,191],"pathway":[30,69],"oncogenesis":[32],"and":[33,59,107,113,125,149,159],"need":[35],"for":[36,46,200],"further":[37],"investigation":[38],"potential":[44,116],"targets":[45],"cancer":[47,143],"therapy.":[48],"Here,":[49],"using":[50],"expression":[51,164],"profiling":[52],"analysis":[53],"well":[55,85],"vitro":[58],"vivo":[61],"functional":[62],"studies,":[63],"we":[64],"show":[65,90],"that":[66,76,91,172],"component":[70],"BCL9":[71,92,132,175,188],"is":[72,77,176],"a":[73,197],"novel":[74],"oncogene":[75],"aberrantly":[78],"expressed":[79],"myeloma":[83],"colon":[87],"carcinoma.":[88],"We":[89],"enhances":[93],"\u03b2-catenin\u2013mediated":[94],"transcriptional":[95],"activity":[96],"regardless":[97],"mutational":[100],"status":[101],"increases":[108],"cell":[109],"proliferation,":[110],"migration,":[111],"invasion,":[112],"metastatic":[115],"cells":[119],"by":[120,144,165],"promoting":[121],"loss":[122],"epithelial":[124],"gain":[126],"mesenchymal-like":[128],"phenotype.":[129],"Most":[130],"importantly,":[131],"knockdown":[133],"significantly":[134],"increased":[135],"survival":[137],"xenograft":[139],"mouse":[140],"models":[141],"reducing":[145],"load,":[147],"metastasis,":[148],"host":[150],"angiogenesis":[151],"through":[152],"down-regulation":[153],"c-Myc,":[155],"cyclin":[156],"D1,":[157],"CD44,":[158],"vascular":[160],"endothelial":[161],"growth":[162],"factor":[163,180],"cells.":[167],"Together,":[168],"these":[169],"findings":[170],"suggest":[171],"deregulation":[173],"an":[177],"important":[178],"contributing":[179],"progression.":[183],"The":[184],"pleiotropic":[185],"roles":[186],"reported":[189],"study":[192],"underscore":[193],"its":[194],"value":[195],"drug":[198],"target":[199],"therapeutic":[201],"intervention":[202],"several":[204],"malignancies":[205],"associated":[206],"with":[207],"aberrant":[208],"signaling.":[210],"[Cancer":[211],"Res":[212],"2009;69(19):7577\u201386]":[213]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-03-13T00:00:00"}