{"id":"https://openalex.org/W4392725903","doi":"https://doi.org/10.1158/0008-5472.c.6504353","title":"Data from miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma","display_name":"Data from miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392725903","doi":"https://doi.org/10.1158/0008-5472.c.6504353"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6504353","doi":"https://doi.org/10.1158/0008-5472.c.6504353","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6504353","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6504353","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082310628","display_name":"Andrea L. Kasinski","orcid":"https://orcid.org/0000-0002-9602-7827","observed_orcids":["https://orcid.org/0000-0002-9602-7827"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea L. Kasinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013989133","display_name":"Frank John Slack","orcid":"https://orcid.org/0000-0001-8263-0409","observed_orcids":["https://orcid.org/0000-0001-8263-0409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank J. Slack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-34a","display_name":"miR-34a","score":0.902999997138977},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8339999914169312},{"id":"https://openalex.org/keywords/p53-r172h","display_name":"p53 R172H","score":0.9470000267028809},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.35100001096725464},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.5910000205039978},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.4320000112056732},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7329999804496765},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.7699999809265137},{"id":"https://openalex.org/keywords/mir-155","display_name":"miR-155","score":1.0},{"id":"https://openalex.org/keywords/met","display_name":"MET","score":0.7710000276565552},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6974235773086548},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6305191516876221},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5988147258758545},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5914386510848999},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5000059604644775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4453003406524658},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4405378997325897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3416425585746765},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2570059299468994},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23692893981933594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22807201743125916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17392262816429138}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6504353","doi":"https://doi.org/10.1158/0008-5472.c.6504353","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6504353","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6504353","doi":"https://doi.org/10.1158/0008-5472.c.6504353","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6504353","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2388653379","https://openalex.org/W2090944178","https://openalex.org/W1990258390","https://openalex.org/W2912158592","https://openalex.org/W3087296890","https://openalex.org/W2315905831","https://openalex.org/W6925393248","https://openalex.org/W2493214705","https://openalex.org/W2334721997","https://openalex.org/W2755937982"],"abstract_inverted_index":{"Abstract":[0],"Lung":[1],"cancer":[2,8,108],"is":[3,71],"the":[4,20,33,102,170,205,231],"leading":[5],"cause":[6],"of":[7,23,32,47,66,145,160,172,216,225,233],"deaths":[9],"worldwide,":[10],"and":[11,27,52,68,121,130,149,156,167,184,194,218,239],"current":[12,50],"therapies":[13,51],"fail":[14],"to":[15,49,93,213],"treat":[16],"this":[17,98],"disease":[18],"in":[19,38,45,73,114,196],"vast":[21],"majority":[22],"cases.":[24],"The":[25,56],"RAS":[26],"p53":[28,74],"pathways":[29,37],"are":[30,62,151],"two":[31],"most":[34],"frequently":[35],"altered":[36],"lung":[39,95,107,132,237],"cancers,":[40],"with":[41,85,189,201],"such":[42,164],"alterations":[43],"resulting":[44],"loss":[46],"responsiveness":[48],"decreased":[53],"patient":[54],"survival.":[55],"microRNA-34":[57],"(mir-34)":[58],"gene":[59],"family":[60],"members":[61],"downstream":[63],"transcriptional":[64],"targets":[65],"p53,":[67],"miR-34":[69,86,161,234],"expression":[70,159],"reduced":[72,182],"mutant":[75,82],"tumors;":[76],"thus,":[77],"we":[78,100],"hypothesized":[79],"that":[80],"treating":[81],"Kras;p53":[83],"tumors":[84,123,180],"would":[87],"represent":[88],"a":[89,236],"powerful":[90],"new":[91],"therapeutic":[92],"suppress":[94],"tumorigenesis.":[96],"To":[97],"end":[99],"examined":[101],"therapeutically":[103],"resistant":[104],"KrasLSL-G12D/+;Trp53LSL-R172H/+":[105,197],"mouse":[106],"model.":[109],"We":[110],"characterized":[111],"tumor":[112,192],"progression":[113,195,224],"these":[115,140,179],"mice":[116],"following":[117],"lung-specific":[118],"transgene":[119,209],"activation":[120,210],"found":[122],"as":[124,126,165,208,235],"early":[125],"10":[127],"weeks":[128],"postactivation,":[129],"severe":[131],"inflammation":[133],"by":[134],"22":[135],"weeks.":[136],"Tumors":[137],"harvested":[138],"from":[139,178],"lungs":[141],"have":[142,157],"elevated":[143],"levels":[144],"oncogenic":[146],"miRNAs,":[147],"miR-21":[148],"miR-155;":[150],"deficient":[152],"for":[153],"p53-regulated":[154],"miRNAs;":[155],"heightened":[158],"target":[162],"genes,":[163],"Met":[166],"Bcl-2.":[168],"In":[169,186],"presence":[171],"exogenous":[173],"miR-34,":[174],"epithelial":[175],"cells":[176],"derived":[177],"show":[181],"proliferation":[183],"invasion.":[185],"vivo":[187],"treatment":[188],"miR-34a":[190,220],"prevented":[191,222],"formation":[193],"mice.":[198],"Animals":[199],"infected":[200],"mir-34a-expressing":[202],"lentivirus":[203],"at":[204],"same":[206],"time":[207],"had":[211],"little":[212],"no":[214],"evidence":[215],"tumorigenesis,":[217],"lentivirus-induced":[219],"also":[221],"further":[223],"preformed":[226],"tumors.":[227],"These":[228],"data":[229],"support":[230],"use":[232],"tumor-preventative":[238],"tumor-static":[240],"agent.":[241],"Cancer":[242],"Res;":[243],"72(21);":[244],"5576\u201387.":[245],"\u00a92012":[246],"AACR.":[247]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-03-13T00:00:00"}
