{"id":"https://openalex.org/W4392725311","doi":"https://doi.org/10.1158/0008-5472.c.6504162","title":"Data from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide","display_name":"Data from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392725311","doi":"https://doi.org/10.1158/0008-5472.c.6504162"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6504162","doi":"https://doi.org/10.1158/0008-5472.c.6504162","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6504162","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6504162","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Miran Jang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miran Jang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008549367","display_name":"Yeonghwan Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yeonghwan Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017141073","display_name":"Hyeran Won","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyeran Won","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018153152","display_name":"Sang-Bin Lim","orcid":"https://orcid.org/0000-0003-3653-5034","observed_orcids":["https://orcid.org/0000-0003-3653-5034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sangbin Lim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009059833","display_name":"Jyothi K.R","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jyothi K.R","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060383399","display_name":"Amarjargal Dashdorj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amarjargal Dashdorj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063101533","display_name":"Yoo Hong Min","orcid":"https://orcid.org/0000-0001-8542-9583","observed_orcids":["https://orcid.org/0000-0001-8542-9583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoo Hong Min","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080803960","display_name":"Siyoung Kim","orcid":"https://orcid.org/0000-0003-4670-9747","observed_orcids":["https://orcid.org/0000-0003-4670-9747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Si-Young Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079376363","display_name":"Kevan M. Shokat","orcid":"https://orcid.org/0000-0001-8590-7741","observed_orcids":["https://orcid.org/0000-0001-8590-7741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevan M. Shokat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073499303","display_name":"Joohun Ha","orcid":"https://orcid.org/0000-0002-2704-9547","observed_orcids":["https://orcid.org/0000-0002-2704-9547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joohun Ha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100337398","display_name":"Sung Soo Kim","orcid":"https://orcid.org/0000-0002-6817-7668","observed_orcids":["https://orcid.org/0000-0002-6817-7668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sung Soo Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbonyl-reductase-1","display_name":"carbonyl reductase 1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cbr1","display_name":"CBR1","score":0.890999972820282},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5529999732971191},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8339999914169312},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.8029999732971191},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9950000047683716},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"myeloid leukemia","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.9360609650611877},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.5537018179893494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4570167362689972},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.421223521232605},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.392719566822052},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2843574285507202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1602993905544281},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12953835725784302}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6504162","doi":"https://doi.org/10.1158/0008-5472.c.6504162","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6504162","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6504162.v1","doi":"https://doi.org/10.1158/0008-5472.c.6504162.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6504162.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6504162","doi":"https://doi.org/10.1158/0008-5472.c.6504162","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6504162","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2165935184","https://openalex.org/W1981540618","https://openalex.org/W1790556391","https://openalex.org/W2039400110","https://openalex.org/W1967887325","https://openalex.org/W7098700235","https://openalex.org/W1965948236","https://openalex.org/W1969062733","https://openalex.org/W2042365243","https://openalex.org/W1996982049"],"abstract_inverted_index":{"Abstract":[0],"Arsenic":[1],"trioxide":[2],"(As2O3)":[3],"is":[4,177],"used,":[5],"in":[6,29,38,60,133,136,142,158,189],"current":[7],"practice,":[8],"as":[9],"an":[10],"effective":[11],"chemotherapeutic":[12],"agent":[13],"for":[14,181],"acute":[15,146],"promyelocytic":[16],"leukemia":[17,150],"(APL).":[18],"However,":[19],"the":[20,42,48,56,69,74,77,95,102,117,170,182],"side":[21],"effects":[22],"and":[23,135,147],"relatively":[24],"low":[25,171],"efficacy":[26,172],"of":[27,50,76,94,97,104,173,184],"As2O3":[28,59,64,91,130,174,188],"treating":[30],"other":[31],"leukemias":[32,191],"have":[33],"limited":[34],"its":[35],"wider":[36],"use":[37],"therapeutic":[39],"applications.":[40],"In":[41],"present":[43],"study,":[44],"we":[45],"found":[46],"that":[47,166],"expression":[49,67],"carbonyl":[51],"reductase":[52],"1":[53],"(CBR1)":[54],"affects":[55],"resistance":[57],"to":[58,87,108,111,169],"leukemias,":[61],"including":[62,192],"APL;":[63],"upregulated":[65],"CBR1":[66,83,105,119,167],"at":[68],"transcriptional":[70],"level":[71],"by":[72],"stimulating":[73],"activity":[75],"transcription":[78],"factor":[79],"activator":[80],"protein-1.":[81],"Moreover,":[82],"overexpression":[84],"was":[85,106],"sufficient":[86,107],"protect":[88],"cells":[89,110],"against":[90],"through":[92],"modulation":[93],"generation":[96],"reactive":[98],"oxygen":[99],"species,":[100],"whereas":[101],"attenuation":[103],"sensitize":[109],"As2O3.":[112],"A":[113],"combination":[114,185],"treatment":[115],"with":[116,129,152,187],"specific":[118],"inhibitor":[120],"hydroxy-PP-Me":[121],"remarkably":[122],"increased":[123],"As2O3-induced":[124],"apoptotic":[125],"cell":[126,155],"death":[127,156],"compared":[128],"alone,":[131],"both":[132],"vitro":[134],"vivo.":[137],"These":[138],"results":[139],"were":[140],"confirmed":[141],"primary":[143],"cultured":[144],"human":[145],"chronic":[148],"myeloid":[149],"cells,":[151],"no":[153],"significant":[154],"observed":[157],"normal":[159],"leukocytes.":[160],"Taken":[161],"together,":[162],"our":[163],"findings":[164],"indicate":[165],"contributes":[168],"and,":[175],"therefore,":[176],"a":[178],"rational":[179],"target":[180],"development":[183],"chemotherapy":[186],"diverse":[190],"APL.":[193],"Cancer":[194],"Res;":[195],"72(16);":[196],"4214\u201324.":[197],"\u00a92012":[198],"AACR.":[199]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-13T00:00:00"}
