{"id":"https://openalex.org/W4392724024","doi":"https://doi.org/10.1158/0008-5472.c.6510341","title":"Data from NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model","display_name":"Data from NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4392724024","doi":"https://doi.org/10.1158/0008-5472.c.6510341"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6510341","doi":"https://doi.org/10.1158/0008-5472.c.6510341","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6510341","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6510341","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yan Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100317610","display_name":"Yuyang Li","orcid":"https://orcid.org/0000-0001-8489-3296","observed_orcids":["https://orcid.org/0000-0001-8489-3296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuyang Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058532984","display_name":"Shengwu Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shengwu Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026258084","display_name":"Dennis O. Adeegbe","orcid":"https://orcid.org/0000-0001-9233-3328","observed_orcids":["https://orcid.org/0000-0001-9233-3328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis O. Adeegbe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013721197","display_name":"Camilla Laulund Christensen","orcid":"https://orcid.org/0009-0007-3313-2615","observed_orcids":["https://orcid.org/0009-0007-3313-2615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camilla L. Christensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065891566","display_name":"Max M. Quinn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Max M. Quinn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000624568","display_name":"Ruben Dries","orcid":"https://orcid.org/0000-0001-7650-7754","observed_orcids":["https://orcid.org/0000-0001-7650-7754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruben Dries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102508016","display_name":"Shiwei Han","orcid":"https://orcid.org/0009-0002-4264-6320","observed_orcids":["https://orcid.org/0009-0002-4264-6320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiwei Han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063189800","display_name":"Kevin A. Buczkowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Buczkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071614134","display_name":"Xiaoen Wang","orcid":"https://orcid.org/0000-0001-7713-7062","observed_orcids":["https://orcid.org/0000-0001-7713-7062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoen Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443212","display_name":"Ting Chen","orcid":"https://orcid.org/0000-0003-1725-7956","observed_orcids":["https://orcid.org/0000-0003-1725-7956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362398","display_name":"Peng Gao","orcid":"https://orcid.org/0000-0002-1290-6972","observed_orcids":["https://orcid.org/0000-0002-1290-6972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408674","display_name":"Hua Zhang","orcid":"https://orcid.org/0000-0001-7704-4712","observed_orcids":["https://orcid.org/0000-0001-7704-4712","https://orcid.org/0000-0002-4700-5971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325819","display_name":"Fei Li","orcid":"https://orcid.org/0000-0002-3989-8124","observed_orcids":["https://orcid.org/0000-0002-3989-8124","https://orcid.org/0009-0009-7325-2923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004171995","display_name":"Peter S. Hammerman","orcid":"https://orcid.org/0009-0006-9143-899X","observed_orcids":["https://orcid.org/0009-0006-9143-899X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter S. Hammerman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110274677","display_name":"James E. Bradner","orcid":"https://orcid.org/0000-0002-2718-4415","observed_orcids":["https://orcid.org/0000-0002-2718-4415","https://orcid.org/0000-0003-1422-5318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James E. Bradner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110477505","display_name":"Steven N. Quayle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven N. Quayle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019034689","display_name":"Kwok\u2010Kin Wong","orcid":"https://orcid.org/0000-0001-6323-235X","observed_orcids":["https://orcid.org/0000-0001-6323-235X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwok-Kin Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.4652999937534332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.4652999937534332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.4528999924659729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/hdac6-inhibition","display_name":"HDAC6 inhibition","score":0.7979999780654907},{"id":"https://openalex.org/keywords/bet-inhibition","display_name":"BET inhibition","score":0.9070000052452087},{"id":"https://openalex.org/keywords/jq1","display_name":"JQ1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ricolinostat","display_name":"ricolinostat","score":0.9409999847412109},{"id":"https://openalex.org/keywords/acy-1215","display_name":"ACY-1215","score":0.9089999794960022},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.8610000014305115},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.7049999833106995},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6140000224113464},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6949999928474426},{"id":"https://openalex.org/keywords/recurrent-cancer","display_name":"recurrent cancer","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C23681527","wikidata":"https://www.wikidata.org/wiki/Q18034953","display_name":"HDAC6","level":5,"score":0.5374404191970825},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45961517095565796},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3589547872543335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3279440402984619},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25714707374572754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08842122554779053},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06858167052268982},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.0},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6510341","doi":"https://doi.org/10.1158/0008-5472.c.6510341","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6510341","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6510341","doi":"https://doi.org/10.1158/0008-5472.c.6510341","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6510341","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2803891124","https://openalex.org/W4361876333","https://openalex.org/W4362422536","https://openalex.org/W4361876317","https://openalex.org/W4362422558","https://openalex.org/W4361876323","https://openalex.org/W4362422484","https://openalex.org/W7118819625","https://openalex.org/W2480274405","https://openalex.org/W4362476834"],"abstract_inverted_index":{"Abstract":[0],"Small-cell":[1],"lung":[2,11],"cancer":[3],"(SCLC)":[4],"has":[5],"the":[6,35,76,117],"highest":[7],"malignancy":[8],"among":[9],"all":[10],"cancers,":[12],"exhibiting":[13],"aggressive":[14],"growth":[15],"and":[16,45,57,80,93,109,122,180],"early":[17],"metastasis":[18],"to":[19,32],"distant":[20],"sites.":[21],"For":[22],"30":[23],"years,":[24],"treatment":[25,106,152,161],"options":[26],"for":[27,37,162,173],"SCLC":[28,53,65,90,111,150,174],"have":[29],"been":[30],"limited":[31],"chemotherapy,":[33],"warranting":[34],"need":[36],"more":[38],"effective":[39],"treatments.":[40],"Frequent":[41],"inactivation":[42],"of":[43,107,127,136,178],"TP53":[44],"RB1":[46],"as":[47,49,96],"well":[48],"histone":[50],"dysmodifications":[51],"in":[52,64,88,101,149],"suggest":[54,157],"that":[55,140],"transcriptional":[56],"epigenetic":[58,86],"regulations":[59],"play":[60,146],"a":[61,71,97,147,158,169,176],"major":[62],"role":[63,148],"disease":[66],"evolution.":[67],"Here":[68],"we":[69],"performed":[70],"synthetic":[72,98],"lethal":[73,99],"screen":[74],"using":[75,175],"BET":[77,181],"inhibitor":[78,119],"JQ1":[79,123],"an":[81],"shRNA":[82],"library":[83],"targeting":[84],"550":[85],"genes":[87],"treatment-refractory":[89],"xenograft":[91,114],"models":[92],"identified":[94],"HDAC6":[95,118,179],"target":[100],"combination":[102,177],"with":[103,116],"JQ1.":[104],"Combined":[105],"human":[108],"mouse":[110],"cell":[112],"line\u2013derived":[113],"tumors":[115],"ricolinostat":[120],"(ACY-1215)":[121],"demonstrated":[124],"significant":[125],"inhibition":[126],"tumor":[128,151],"growth;":[129],"this":[130],"effect":[131],"was":[132],"abolished":[133],"upon":[134],"depletion":[135],"NK":[137],"cells,":[138],"suggesting":[139],"these":[141,155],"innate":[142],"immune":[143],"lymphoid":[144],"cells":[145],"response.":[153],"Collectively,":[154],"findings":[156,167],"potential":[159],"new":[160],"recurrent":[163],"SCLC.":[164],"Significance:":[165],"These":[166],"identify":[168],"novel":[170],"therapeutic":[171],"strategy":[172],"inhibitors.":[182],"Cancer":[183],"Res;":[184],"78(13);":[185],"3709\u201317.":[186],"\u00a92018":[187],"AACR.":[188]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-03-13T00:00:00"}