{"id":"https://openalex.org/W4392723643","doi":"https://doi.org/10.1158/0008-5472.c.6513553","title":"Data from ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma","display_name":"Data from ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4392723643","doi":"https://doi.org/10.1158/0008-5472.c.6513553"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6513553","doi":"https://doi.org/10.1158/0008-5472.c.6513553","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6513553","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6513553","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076150034","display_name":"Cristina Aguirre\u2010Portol\u00e9s","orcid":"https://orcid.org/0000-0001-9074-8386","observed_orcids":["https://orcid.org/0000-0001-9074-8386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Aguirre-Portol\u00e9s","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023780575","display_name":"Riley J. Payne","orcid":"https://orcid.org/0000-0002-4179-4746","observed_orcids":["https://orcid.org/0000-0002-4179-4746"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Riley Payne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058147502","display_name":"Aspen Trautz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aspen Trautz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030221375","display_name":"J. Kevin Foskett","orcid":"https://orcid.org/0000-0002-8854-0268","observed_orcids":["https://orcid.org/0000-0002-8854-0268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Kevin Foskett","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8854-0268","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009336063","display_name":"Christopher A. Natale","orcid":"https://orcid.org/0000-0003-4949-3849","observed_orcids":["https://orcid.org/0000-0003-4949-3849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher A. Natale","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4949-3849","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064309595","display_name":"John T. Seykora","orcid":"https://orcid.org/0000-0003-0383-031X","observed_orcids":["https://orcid.org/0000-0003-0383-031X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John T. Seykora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085814203","display_name":"Todd W. Ridky","orcid":"https://orcid.org/0000-0001-8482-1284","observed_orcids":["https://orcid.org/0000-0001-8482-1284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todd W. Ridky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8482-1284","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.921999990940094},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7940000295639038},{"id":"https://openalex.org/keywords/zip9","display_name":"ZIP9","score":0.8240000009536743},{"id":"https://openalex.org/keywords/zinc-transporters","display_name":"zinc transporters","score":0.8659999966621399},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.9850000143051147},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mapk-activation","display_name":"MAPK activation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/yap-nuclear-translocation","display_name":"YAP nuclear translocation","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.9528061151504517},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6076229214668274},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3955272138118744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3862159848213196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33834460377693176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33305102586746216},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32465660572052},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07172489166259766}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6513553","doi":"https://doi.org/10.1158/0008-5472.c.6513553","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6513553","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6513553","doi":"https://doi.org/10.1158/0008-5472.c.6513553","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6513553","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3210418304","https://openalex.org/W3099539355","https://openalex.org/W4361900690","https://openalex.org/W2064746517","https://openalex.org/W4361899922","https://openalex.org/W2890583861","https://openalex.org/W4361899858","https://openalex.org/W2590645778","https://openalex.org/W2477296437","https://openalex.org/W1758723133"],"abstract_inverted_index":{"Abstract":[0],"Melanoma":[1],"and":[2,9,28,77,137,166,177],"most":[3,35],"other":[4,138],"cancers":[5,139],"occur":[6],"more":[7],"frequently":[8],"have":[10],"worse":[11],"prognosis":[12],"in":[13,34,56,99,124,135,164,180],"males":[14],"compared":[15],"with":[16],"females.":[17,125],"Although":[18],"sex":[19,162],"steroids":[20],"are":[21,31,146],"thought":[22],"to":[23,174],"be":[24,132,172],"involved,":[25],"classical":[26,86],"androgen":[27,87,104,142],"estrogen":[29],"receptors":[30],"not":[32,60],"detectable":[33],"melanomas.":[36],"Here":[37],"we":[38],"show":[39],"that":[40,52,129,145,168],"testosterone":[41,67,98],"promotes":[42],"melanoma":[43,58,136,179],"proliferation":[44],"by":[45,63,140],"activating":[46],"ZIP9":[47,120,130,157,176],"(SLC39A9),":[48],"a":[49],"zinc":[50],"transporter":[51],"is":[53],"widely":[54],"expressed":[55],"human":[57],"but":[59,112],"intentionally":[61],"targeted":[62,134],"available":[64],"therapeutics.":[65],"This":[66],"activity":[68],"required":[69],"an":[70],"influx":[71],"of":[72,75,80,84,97,109,160],"zinc,":[73],"activation":[74],"MAPK,":[76],"nuclear":[78],"translocation":[79],"YAP.":[81],"FDA-approved":[82],"inhibitors":[83,106,144],"the":[85,94,161],"receptor":[88,105,143],"also":[89],"inhibited":[90],"ZIP9,":[91],"thereby":[92],"antagonizing":[93],"protumorigenic":[95],"effects":[96],"melanoma.":[100],"In":[101],"male":[102],"mice,":[103],"suppressed":[107],"growth":[108],"ZIP9-expressing":[110],"melanomas":[111,118,123],"had":[113],"no":[114],"effect":[115],"on":[116,122],"isogenic":[117],"lacking":[119],"or":[121],"These":[126],"data":[127],"suggest":[128],"might":[131],"effectively":[133],"repurposing":[141],"currently":[147],"approved":[148],"only":[149],"for":[150],"prostate":[151],"cancer.":[152],"Significance:":[153],"Testosterone":[154],"signaling":[155],"through":[156],"mediates":[158],"some":[159],"differences":[163],"melanoma,":[165],"drugs":[167],"target":[169],"AR":[170],"can":[171],"repurposed":[173],"block":[175],"inhibit":[178],"males.":[181]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-03-13T00:00:00"}