{"id":"https://openalex.org/W4392723574","doi":"https://doi.org/10.1158/0008-5472.c.6510818","title":"Data from Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1","display_name":"Data from Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4392723574","doi":"https://doi.org/10.1158/0008-5472.c.6510818"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6510818","doi":"https://doi.org/10.1158/0008-5472.c.6510818","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6510818","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6510818","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041525182","display_name":"Thomas A. Werfel","orcid":"https://orcid.org/0000-0002-6005-1243","observed_orcids":["https://orcid.org/0000-0002-6005-1243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas A. Werfel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005134586","display_name":"David L. Elion","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L. Elion","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031507912","display_name":"Bushra Rahman","orcid":"https://orcid.org/0000-0002-3335-3879","observed_orcids":["https://orcid.org/0000-0002-3335-3879","https://orcid.org/0000-0003-3453-2497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bushra Rahman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041028923","display_name":"Donna J. Hicks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donna J. Hicks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037252693","display_name":"Violeta M. Sanchez","orcid":"https://orcid.org/0000-0001-6639-9024","observed_orcids":["https://orcid.org/0000-0001-6639-9024","https://orcid.org/0000-0001-7967-8233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Violeta Sanchez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030367169","display_name":"Paula I. Gonz\u00e1lez Ericsson","orcid":"https://orcid.org/0000-0002-6292-6963","observed_orcids":["https://orcid.org/0000-0002-6292-6963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula I. Gonzales-Ericsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6292-6963","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051194540","display_name":"Mellissa J. Nixon","orcid":"https://orcid.org/0000-0002-7749-5414","observed_orcids":["https://orcid.org/0000-0002-7749-5414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mellissa J. Nixon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7749-5414","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007448556","display_name":"Jamaal L. James","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamaal L. James","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089113899","display_name":"Justin Micah Balko","orcid":"https://orcid.org/0000-0002-4263-5974","observed_orcids":["https://orcid.org/0000-0002-4263-5974"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin M. Balko","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4263-5974","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018193992","display_name":"Peggy Scherle","orcid":"https://orcid.org/0000-0003-0783-6815","observed_orcids":["https://orcid.org/0000-0003-0783-6815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peggy A. Scherle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023090545","display_name":"Holly K. Koblish","orcid":"https://orcid.org/0000-0002-9745-3561","observed_orcids":["https://orcid.org/0000-0002-9745-3561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holly K. Koblish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102944784","display_name":"Rebecca S. Cook","orcid":"https://orcid.org/0000-0001-7749-5361","observed_orcids":["https://orcid.org/0000-0001-7749-5361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca S. Cook","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/efferocytosis","display_name":"efferocytosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-cell-apoptosis","display_name":"tumor cell apoptosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/secondary-necrosis","display_name":"secondary necrosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ido1","display_name":"IDO1","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mertk","display_name":"MERTK","score":0.9129999876022339},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mmtv-neu-mice","display_name":"MMTV-Neu mice","score":0.8849999904632568},{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":0.9300000071525574},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":1.0},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6639999747276306},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7160000205039978},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2781185341","wikidata":"https://www.wikidata.org/wiki/Q18035403","display_name":"MERTK","level":4,"score":0.938590407371521},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6841026544570923},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5931253433227539},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5409215092658997},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5401673913002014},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5357218384742737},{"id":"https://openalex.org/C155512373","wikidata":"https://www.wikidata.org/wiki/Q287450","display_name":"Residual","level":2,"score":0.512031614780426},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.4825112819671631},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43102607131004333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.311470627784729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3026096224784851},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1877082884311676},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14102187752723694},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11833950877189636},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09687933325767517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05462506413459778},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6510818","doi":"https://doi.org/10.1158/0008-5472.c.6510818","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6510818","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6510818","doi":"https://doi.org/10.1158/0008-5472.c.6510818","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6510818","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2900429601","https://openalex.org/W3164646445","https://openalex.org/W7108480677","https://openalex.org/W2320980676","https://openalex.org/W4386916034","https://openalex.org/W2408726265","https://openalex.org/W3018690097","https://openalex.org/W2491453414","https://openalex.org/W2007820695","https://openalex.org/W1770744671"],"abstract_inverted_index":{"Abstract":[0],"Efferocytosis":[1,33],"is":[2],"the":[3,143],"process":[4],"by":[5,13,38,48],"which":[6,141],"apoptotic":[7,19,55,87,120,169,191],"cells":[8,20,70,89,106,111],"are":[9],"cleared":[10,86],"from":[11,23,54],"tissue":[12,36,46],"phagocytic":[14],"cells.":[15,56],"The":[16],"removal":[17],"of":[18,93,114,119,139,145,160,185,213],"prevents":[21],"them":[22],"undergoing":[24],"secondary":[25,117,219],"necrosis":[26,118,218],"and":[27,42,44,108,130,162,171,179,192,198,204,228],"releasing":[28],"their":[29],"inflammation-inducing":[30],"intracellular":[31],"contents.":[32],"also":[34],"limits":[35],"damage":[37],"increasing":[39],"immunosuppressive":[40,102,131,174],"cytokines":[41],"leukocytes":[43],"maintains":[45],"homeostasis":[47],"promoting":[49],"tolerance":[50,67],"to":[51,68,124,220,225],"antigens":[52],"derived":[53],"Thus,":[57],"tumor":[58,69,78,88,127,165,177,181,194,202,229],"cell":[59],"efferocytosis":[60,85,115,136,161,197,222],"following":[61],"cytotoxic":[62],"cancer":[63,216],"treatment":[64],"could":[65],"impart":[66],"evading":[71],"treatment-induced":[72],"apoptosis":[73],"with":[74],"deleterious":[75],"consequences":[76],"in":[77,90,98,164,183,210],"residual":[79,91,166],"disease.":[80],"We":[81,133],"report":[82],"here":[83],"that":[84,135,190,217],"disease":[92,167],"lapatinib-treated":[94],"HER2+":[95,214],"mammary":[96],"tumors":[97],"MMTV-Neu":[99,186],"mice,":[100],"increased":[101,126],"cytokines,":[103],"myeloid-derived":[104],"suppressor":[105],"(MDSC),":[107],"regulatory":[109],"T":[110],"(Treg).":[112],"Blockade":[113],"induced":[116],"cells,":[121,195],"but":[122],"failed":[123],"prevent":[125],"MDSCs,":[128],"Treg,":[129],"cytokines.":[132],"found":[134],"stimulated":[137,142],"expression":[138,144],"IFN-\u03b3,":[140],"indoleamine-2,3-dioxegenase":[146],"(IDO)":[147],"1,":[148],"an":[149],"immune":[150],"regulator":[151],"known":[152],"for":[153],"driving":[154],"maternal-fetal":[155],"antigen":[156],"tolerance.":[157],"Combined":[158],"inhibition":[159],"IDO1":[163,224],"decreased":[168],"cell-":[170],"necrotic":[172,193],"cell-induced":[173],"phenotypes,":[175],"blocked":[176],"metastasis,":[178],"caused":[180],"regression":[182],"60%":[184],"mice.":[187],"This":[188],"suggests":[189],"via":[196],"IDO1,":[199],"respectively,":[200],"promote":[201],"\u2018homeostasis\u2019":[203],"progression.":[205,230],"Significance:":[206],"These":[207],"findings":[208],"show":[209],"a":[211],"model":[212],"breast":[215],"impaired":[221],"activates":[223],"drive":[226],"immunosuppression":[227]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2024-03-13T00:00:00"}
