{"id":"https://openalex.org/W4392722609","doi":"https://doi.org/10.1158/2326-6066.c.6548647","title":"Data from Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes","display_name":"Data from Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392722609","doi":"https://doi.org/10.1158/2326-6066.c.6548647"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.c.6548647","doi":"https://doi.org/10.1158/2326-6066.c.6548647","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6548647","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2326-6066.c.6548647","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052821976","display_name":"Vishwajith Sridharan","orcid":"https://orcid.org/0000-0001-6766-2285","observed_orcids":["https://orcid.org/0000-0001-6766-2285"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vishwajith Sridharan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005477709","display_name":"Evisa Gjini","orcid":"https://orcid.org/0000-0002-6951-9279","observed_orcids":["https://orcid.org/0000-0002-6951-9279","https://orcid.org/0009-0004-4495-6255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evisa Gjini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100569863","display_name":"Xiaoyun Liao","orcid":"https://orcid.org/0009-0000-8904-0102","observed_orcids":["https://orcid.org/0009-0000-8904-0102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoyun Liao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112374129","display_name":"Nicole Grace Chau","orcid":"https://orcid.org/0000-0002-9317-3642","observed_orcids":["https://orcid.org/0000-0002-9317-3642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole G. Chau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080875822","display_name":"Robert I. Haddad","orcid":"https://orcid.org/0000-0003-1413-0079","observed_orcids":["https://orcid.org/0000-0003-1413-0079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert I. Haddad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061431553","display_name":"Mariano Severgnini","orcid":"https://orcid.org/0000-0001-6783-8500","observed_orcids":["https://orcid.org/0000-0001-6783-8500"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariano Severgnini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004171995","display_name":"Peter S. Hammerman","orcid":"https://orcid.org/0009-0006-9143-899X","observed_orcids":["https://orcid.org/0009-0006-9143-899X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Hammerman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078173230","display_name":"Adel K. El\u2010Naggar","orcid":"https://orcid.org/0000-0002-7175-9466","observed_orcids":["https://orcid.org/0000-0002-7175-9466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adel El-Naggar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075310347","display_name":"Gordon James Freeman","orcid":"https://orcid.org/0000-0002-7210-5616","observed_orcids":["https://orcid.org/0000-0002-7210-5616"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon J. Freeman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084967339","display_name":"Frank Stephen Hodi","orcid":"https://orcid.org/0000-0001-6825-091X","observed_orcids":["https://orcid.org/0000-0001-6825-091X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Stephen Hodi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058975989","display_name":"Scott J. Rodig","orcid":"https://orcid.org/0000-0003-1761-9769","observed_orcids":["https://orcid.org/0000-0003-1761-9769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott J. Rodig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028608171","display_name":"Glenn Dranoff","orcid":"https://orcid.org/0000-0002-2341-7517","observed_orcids":["https://orcid.org/0000-0002-2341-7517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenn Dranoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024024612","display_name":"Jonathan Daniel Schoenfeld","orcid":"https://orcid.org/0000-0002-5119-0401","observed_orcids":["https://orcid.org/0000-0002-5119-0401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan D. Schoenfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11035","display_name":"Salivary Gland Tumors Diagnosis and Treatment","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11035","display_name":"Salivary Gland Tumors Diagnosis and Treatment","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenoid-cystic-carcinoma","display_name":"adenoid cystic carcinoma","score":1.0},{"id":"https://openalex.org/keywords/salivary-gland-tumors","display_name":"salivary gland tumors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pd-l2","display_name":"PD-L2","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8489999771118164},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":1.0},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.8960000276565552},{"id":"https://openalex.org/keywords/metastatic-disease","display_name":"metastatic disease","score":0.5929999947547913},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.9070000052452087},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8230000138282776},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2779231225","wikidata":"https://www.wikidata.org/wiki/Q356005","display_name":"Adenoid cystic carcinoma","level":3,"score":0.8021126389503479},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6358778476715088},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.47837749123573303},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.4703260660171509},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.4664577543735504},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.44197240471839905},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.43782398104667664},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41478797793388367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3522564172744751},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33669817447662354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3305222690105438},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2930412292480469},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.21453580260276794},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19655588269233704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1251886487007141},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08991628885269165},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05902710556983948},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6066.c.6548647","doi":"https://doi.org/10.1158/2326-6066.c.6548647","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6548647","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.c.6548647","doi":"https://doi.org/10.1158/2326-6066.c.6548647","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6548647","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2431949017","https://openalex.org/W3138877472","https://openalex.org/W2901565128","https://openalex.org/W2185338246","https://openalex.org/W7009817863","https://openalex.org/W3132084426","https://openalex.org/W2917390036","https://openalex.org/W4221027176","https://openalex.org/W3030856240","https://openalex.org/W4322719403"],"abstract_inverted_index":{"Abstract":[0],"Adenoid":[1],"cystic":[2],"carcinoma":[3],"(ACC)":[4],"is":[5],"among":[6,109],"the":[7,57,93],"most":[8],"lethal":[9],"salivary":[10],"gland":[11],"tumors,":[12],"with":[13,88,148],"no":[14],"treatments":[15],"for":[16,36,138,146],"metastatic":[17,29,112],"disease":[18],"that":[19],"prolong":[20],"survival.":[21],"We":[22,54],"examined":[23],"tissue":[24],"from":[25,33],"28":[26],"primary":[27,110],"and":[28,40,43,51,95,104,111,126,141],"ACC":[30],"deposits":[31],"obtained":[32],"21":[34],"patients":[35,147],"infiltrating":[37,79],"immune":[38,62,80,142],"cells":[39],"PD-L1/PD-L2":[41],"expression":[42,89],"determined":[44],"mRNA":[45],"profiles":[46],"of":[47,59,83,90],"over":[48],"1,400":[49],"oncogenic":[50],"immune-related":[52],"genes.":[53],"also":[55],"assessed":[56],"effect":[58],"chemoradiation":[60],"on":[61],"mediators":[63],"in":[64,92],"a":[65,128,135],"patient":[66],"who":[67],"had":[68,77],"serial":[69],"biopsies":[70],"available.":[71],"Most":[72],"tumors":[73],"expressed":[74,108],"PD-L2":[75,139],"but":[76],"few":[78],"cells.":[81],"Lack":[82],"immune-cell":[84],"infiltrate":[85],"was":[86],"associated":[87],"genes":[91],"\u03b2-catenin/Wnt":[94],"PI3K":[96],"pathways.":[97],"Additionally,":[98],"certain":[99],"transcripts":[100],"linked":[101],"to":[102,116],"growth":[103],"invasion":[105],"were":[106],"differentially":[107],"deposits.":[113],"Chemoradiation":[114],"appeared":[115],"increase":[117],"CD8+":[118],"effector":[119],"T":[120,124],"cells,":[121,125],"decrease":[122],"regulatory":[123],"promote":[127],"systemic":[129],"humoral":[130],"response.":[131],"These":[132],"data":[133],"suggest":[134],"potential":[136],"role":[137],"inhibition":[140],"modulation":[143],"as":[144],"treatment":[145],"ACC.":[149],"Cancer":[150],"Immunol":[151],"Res;":[152],"4(8);":[153],"679\u201387.":[154],"\u00a92016":[155],"AACR.":[156]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-13T00:00:00"}