{"id":"https://openalex.org/W4392722201","doi":"https://doi.org/10.1158/1535-7163.c.6537012.v1","title":"Data from Mechanisms of Resistance to Cabazitaxel","display_name":"Data from Mechanisms of Resistance to Cabazitaxel","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392722201","doi":"https://doi.org/10.1158/1535-7163.c.6537012.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6537012.v1","doi":"https://doi.org/10.1158/1535-7163.c.6537012.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6537012.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.c.6537012.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049738459","display_name":"George E. Dur\u00e1n","orcid":"https://orcid.org/0000-0003-2692-3906","observed_orcids":["https://orcid.org/0000-0003-2692-3906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George E. Duran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091119871","display_name":"Yan C. Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan C. Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030725568","display_name":"E. Brian Francisco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Brian Francisco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John C. Rose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John C. Rose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Francisco J. Martinez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco J. Martinez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John Coller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Coller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111948864","display_name":"Diana Brassard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana Brassard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019005462","display_name":"Patricia Vrignaud","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia Vrignaud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019649110","display_name":"Branimir Ivan Sikic","orcid":"https://orcid.org/0000-0001-6814-2070","observed_orcids":["https://orcid.org/0000-0001-6814-2070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Branimir I. Sikic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taxane-resistance","display_name":"taxane resistance","score":0.9710000157356262},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9549999833106995},{"id":"https://openalex.org/keywords/psc-833","display_name":"PSC833","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8230000138282776},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.7870000004768372},{"id":"https://openalex.org/keywords/beta-iii-tubulin","display_name":"TUBB3","score":0.9390000104904175},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microtubule-dynamics","display_name":"microtubule dynamics","score":0.9120000004768372},{"id":"https://openalex.org/keywords/microtubule-polymerization","display_name":"microtubule assembly","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2778971682","wikidata":"https://www.wikidata.org/wiki/Q412963","display_name":"Cabazitaxel","level":5,"score":0.9014874696731567},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.5816969275474548},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33080974221229553},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.32867124676704407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17843827605247498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17641466856002808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09193769097328186},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.08136564493179321},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.05663982033729553},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.055916666984558105},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.c.6537012.v1","doi":"https://doi.org/10.1158/1535-7163.c.6537012.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6537012.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6537012.v1","doi":"https://doi.org/10.1158/1535-7163.c.6537012.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6537012.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2141724777","https://openalex.org/W1558601361","https://openalex.org/W2063853097","https://openalex.org/W4392723105","https://openalex.org/W2114282601","https://openalex.org/W7098445307","https://openalex.org/W7097865107","https://openalex.org/W2148408457","https://openalex.org/W2527239283","https://openalex.org/W2498896558"],"abstract_inverted_index":{"Abstract":[0],"We":[1,18],"studied":[2],"mechanisms":[3,212],"of":[4,15,102,144,234,242],"resistance":[5,78,94,98,107,190,211],"to":[6,79,85,95,99,108,133,153,159],"the":[7,38,205,240],"novel":[8],"taxane":[9,16],"cabazitaxel":[10,47,89,109,189,210],"in":[11,31,59,65,151,172,191,204,226],"established":[12],"cellular":[13],"models":[14],"resistance.":[17],"also":[19,82,186],"developed":[20],"cabazitaxel-resistant":[21],"variants":[22],"from":[23],"MCF-7":[24,160,193],"breast":[25],"cancer":[26],"cells":[27,69,130],"by":[28,231,239],"stepwise":[29],"selection":[30],"drug":[32,36],"alone":[33,90],"(MCF-7/CTAX)":[34,91],"or":[35,156],"plus":[37],"transport":[39],"inhibitor":[40],"PSC-833":[41],"(MCF-7/CTAX-P).":[42],"Among":[43],"multidrug-resistant":[44],"(MDR)":[45],"variants,":[46,194],"was":[48],"relatively":[49],"less":[50],"cross-resistant":[51],"than":[52,220],"paclitaxel":[53,80,221],"and":[54,61,104,127,138,147,168,175,179,195,222,224,238],"docetaxel":[55],"(15-":[56],"vs.":[57,63],"200-fold":[58],"MES-SA/Dx5":[60],"9-":[62],"60-fold":[64],"MCF-7/TxT50,":[66],"respectively).":[67],"MCF-7/TxTP50":[68],"that":[70],"were":[71,81,170],"negative":[72],"for":[73,201],"MDR":[74,111,214],"but":[75],"had":[76],"9-fold":[77,83],"resistant":[84],"cabazitaxel.":[86],"Selection":[87],"with":[88,110,188],"yielded":[92],"33-fold":[93],"cabazitaxel,":[96],"52-fold":[97],"paclitaxel,":[100,126],"activation":[101],"ABCB1,":[103,119],"3-fold":[105],"residual":[106],"inhibition.":[112],"The":[113],"MCF-7/CTAX-P":[114],"variant":[115],"did":[116,121],"not":[117],"express":[118],"nor":[120],"it":[122],"efflux":[123],"rhodamine-123,":[124],"BODIPY-labeled":[125],"[3H]-docetaxel.":[128],"These":[129],"are":[131,185],"hypersensitive":[132],"depolymerizing":[134],"agents":[135],"(vinca":[136],"alkaloids":[137],"colchicine),":[139],"have":[140],"reduced":[141],"baseline":[142],"levels":[143],"stabilized":[145],"microtubules,":[146],"impaired":[148],"tubulin":[149],"polymerization":[150],"response":[152],"taxanes":[154],"(cabazitaxel":[155],"docetaxel)":[157],"relative":[158],"parental":[161],"cells.":[162],"Class":[163],"III":[164],"\u03b2-tubulin":[165],"(TUBB3)":[166],"RNA":[167],"protein":[169],"elevated":[171],"both":[173],"MCF-7/CTAX":[174],"MCF-7/CTAX-P.":[176],"Decreased":[177],"BRCA1":[178],"altered":[180],"epithelial\u2013mesenchymal":[181],"transition":[182],"(EMT)":[183],"markers":[184],"associated":[187],"these":[192],"may":[196],"serve":[197],"as":[198,229],"predictive":[199],"biomarkers":[200],"its":[202],"activity":[203],"clinical":[206],"setting.":[207],"In":[208],"summary,":[209],"include":[213],"(although":[215],"at":[216],"a":[217],"lower":[218],"level":[219],"docetaxel),":[223],"alterations":[225],"microtubule":[227],"dynamicity,":[228],"manifested":[230],"higher":[232],"expression":[233],"TUBB3,":[235],"decreased":[236],"BRCA1,":[237],"induction":[241],"EMT.":[243],"Mol":[244],"Cancer":[245],"Ther;":[246],"14(1);":[247],"193\u2013201.":[248],"\u00a92014":[249],"AACR.":[250]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-03-13T00:00:00"}