{"id":"https://openalex.org/W4392721664","doi":"https://doi.org/10.1158/2159-8290.c.6546348.v1","title":"Data from Macrophage PI3K\u03b3 Drives Pancreatic Ductal Adenocarcinoma Progression","display_name":"Data from Macrophage PI3K\u03b3 Drives Pancreatic Ductal Adenocarcinoma Progression","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392721664","doi":"https://doi.org/10.1158/2159-8290.c.6546348.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.c.6546348.v1","doi":"https://doi.org/10.1158/2159-8290.c.6546348.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6546348.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.c.6546348.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079638904","display_name":"Megan M. Kaneda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megan M. Kaneda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050414562","display_name":"Paola Cappello","orcid":"https://orcid.org/0000-0002-5321-7794","observed_orcids":["https://orcid.org/0000-0002-5321-7794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Cappello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063799745","display_name":"Abraham V. Nguyen","orcid":"https://orcid.org/0000-0001-6648-3365","observed_orcids":["https://orcid.org/0000-0001-6648-3365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abraham V. Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026240220","display_name":"Natacha Ralainirina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natacha Ralainirina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045248665","display_name":"Chanae R. Hardamon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chanae R. Hardamon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083825087","display_name":"Philippe Foubert","orcid":"https://orcid.org/0000-0002-2161-0436","observed_orcids":["https://orcid.org/0000-0002-2161-0436"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philippe Foubert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056700264","display_name":"Michael C. Schmid","orcid":"https://orcid.org/0000-0002-3445-0013","observed_orcids":["https://orcid.org/0000-0002-3445-0013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael C. Schmid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614097","display_name":"Ping Sun","orcid":"https://orcid.org/0009-0007-1886-7680","observed_orcids":["https://orcid.org/0009-0007-1886-7680","https://orcid.org/0000-0003-4607-0592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024917310","display_name":"Evangeline Sari. Mose","orcid":"https://orcid.org/0009-0000-6493-3860","observed_orcids":["https://orcid.org/0009-0000-6493-3860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evangeline Mose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009960666","display_name":"Michael Bouvet","orcid":"https://orcid.org/0000-0002-0086-2159","observed_orcids":["https://orcid.org/0000-0002-0086-2159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Bouvet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089839809","display_name":"Andrew M. Lowy","orcid":"https://orcid.org/0000-0002-7106-0735","observed_orcids":["https://orcid.org/0000-0002-7106-0735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew M. Lowy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058059723","display_name":"Mark A. Valasek","orcid":"https://orcid.org/0000-0003-1721-3451","observed_orcids":["https://orcid.org/0000-0003-1721-3451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark A. Valasek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045848542","display_name":"Roman \u0160\u00e1\u0161ik","orcid":"https://orcid.org/0000-0002-9266-8993","observed_orcids":["https://orcid.org/0000-0002-9266-8993"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roman Sasik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040743234","display_name":"Francesco Novelli","orcid":"https://orcid.org/0000-0002-6259-5666","observed_orcids":["https://orcid.org/0000-0002-6259-5666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Novelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085452501","display_name":"Emilio Hirsch","orcid":"https://orcid.org/0000-0002-9073-6024","observed_orcids":["https://orcid.org/0000-0002-9073-6024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emilio Hirsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007491235","display_name":"Judith A. Varner","orcid":"https://orcid.org/0000-0002-9251-0600","observed_orcids":["https://orcid.org/0000-0002-9251-0600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judith A. Varner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.7592999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.7592999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.2345000058412552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pi3kgamma","display_name":"PI3K\u03b3","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9520000219345093},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.777999997138977},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.875},{"id":"https://openalex.org/keywords/desmoplasia","display_name":"desmoplasia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7490000128746033},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.8090000152587891},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.8154195547103882},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6228328347206116},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5458300113677979},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4152185916900635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41318970918655396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3712877929210663},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2970541715621948},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.2934780716896057},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1678624153137207},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.14721110463142395},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.10144853591918945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05879455804824829},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2159-8290.c.6546348.v1","doi":"https://doi.org/10.1158/2159-8290.c.6546348.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6546348.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.c.6546348.v1","doi":"https://doi.org/10.1158/2159-8290.c.6546348.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6546348.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2359522094","https://openalex.org/W7058294886","https://openalex.org/W1498780184","https://openalex.org/W4406224751","https://openalex.org/W2293645537","https://openalex.org/W4392690513","https://openalex.org/W4385650337","https://openalex.org/W4380291623","https://openalex.org/W4409628014","https://openalex.org/W3104558684"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1],"ductal":[2],"adenocarcinoma":[3],"(PDAC)":[4],"is":[5,189],"a":[6,10,36,126,173],"devastating":[7,132],"disease":[8],"with":[9],"low":[11],"5-year":[12],"survival":[13,48],"rate,":[14],"yet":[15],"new":[16,127,174],"immunotherapeutic":[17],"modalities":[18],"may":[19],"offer":[20],"hope":[21],"for":[22,130,178],"this":[23,131],"and":[24,49,72,77,96,103,118,150,165],"other":[25],"intractable":[26],"cancers.":[27],"Here,":[28],"we":[29],"report":[30,137],"that":[31,67,111,120,139],"inhibitory":[32],"targeting":[33],"of":[34,57,82,123,159],"PI3K\u03b3,":[35],"key":[37],"macrophage":[38,112,142],"lipid":[39],"kinase,":[40],"stimulates":[41],"antitumor":[42,162],"immune":[43,70,163,176],"responses,":[44],"leading":[45,145],"to":[46,51,90,97,146,168],"improved":[47],"responsiveness":[50,167],"standard-of-care":[52,169],"chemotherapy":[53],"in":[54,65,79,84,115,152,191],"animal":[55],"models":[56],"PDAC.":[58,80],"PI3K\u03b3":[59,83,113,124,140,160,171],"selectively":[60],"drives":[61],"immunosuppressive":[62],"transcriptional":[63,143],"programming":[64],"macrophages":[66,89],"inhibits":[68],"adaptive":[69],"responses":[71,164],"promotes":[73],"tumor":[74,94,99,133],"cell":[75,100],"invasion":[76],"desmoplasia":[78],"Blockade":[81],"PDAC-bearing":[85],"mice":[86],"reprograms":[87],"tumor-associated":[88],"stimulate":[91],"CD8+":[92],"T-cell\u2013mediated":[93],"suppression":[95],"inhibit":[98],"invasion,":[101],"metastasis,":[102],"desmoplasia.":[104],"These":[105],"data":[106],"indicate":[107],"the":[108,192],"central":[109],"role":[110],"plays":[114],"PDAC":[116],"progression":[117],"demonstrate":[119],"pharmacologic":[121,157],"inhibition":[122,158],"represents":[125,172],"therapeutic":[128,175],"modality":[129],"type.":[134],"Significance:":[135],"We":[136],"here":[138],"regulates":[141],"programming,":[144],"T-cell":[147],"suppression,":[148],"desmoplasia,":[149],"metastasis":[151],"pancreas":[153,179],"adenocarcinoma.":[154],"Genetic":[155],"or":[156],"restores":[161],"improves":[166],"chemotherapy.":[170],"target":[177],"cancer.":[180],"Cancer":[181],"Discov;":[182],"6(8);":[183],"870\u201385.":[184],"\u00a92016":[185],"AACR.":[186],"This":[187,194],"article":[188],"highlighted":[190],"In":[193],"Issue":[195],"feature,":[196],"p.":[197],"803":[198]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-03-13T00:00:00"}