{"id":"https://openalex.org/W4392703301","doi":"https://doi.org/10.1158/1940-6207.c.6546949.v1","title":"Data from Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo","display_name":"Data from Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392703301","doi":"https://doi.org/10.1158/1940-6207.c.6546949.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.c.6546949.v1","doi":"https://doi.org/10.1158/1940-6207.c.6546949.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6546949.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1940-6207.c.6546949.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060553009","display_name":"L. Allyson Checkley","orcid":"https://orcid.org/0000-0002-3764-9693","observed_orcids":["https://orcid.org/0000-0002-3764-9693"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Allyson Checkley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018614999","display_name":"Michael C. Rudolph","orcid":"https://orcid.org/0000-0002-6147-212X","observed_orcids":["https://orcid.org/0000-0002-6147-212X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael C. Rudolph","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007617029","display_name":"Elizabeth A. Wellberg","orcid":"https://orcid.org/0000-0001-7342-390X","observed_orcids":["https://orcid.org/0000-0001-7342-390X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth A. Wellberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063955906","display_name":"Erin Danielle Giles","orcid":"https://orcid.org/0000-0002-8677-2831","observed_orcids":["https://orcid.org/0000-0002-8677-2831"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erin D. Giles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009629498","display_name":"Reema S. Wahdan-Alaswad","orcid":"https://orcid.org/0000-0002-9382-9891","observed_orcids":["https://orcid.org/0000-0002-9382-9891"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reema S. Wahdan-Alaswad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068543970","display_name":"Julie A. Houck","orcid":"https://orcid.org/0000-0002-5906-1022","observed_orcids":["https://orcid.org/0000-0002-5906-1022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie A. Houck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108527484","display_name":"Susan M. Edgerton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan M. Edgerton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013400628","display_name":"Ann D. Thor","orcid":"https://orcid.org/0000-0001-7725-1869","observed_orcids":["https://orcid.org/0000-0001-7725-1869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann D. Thor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062418760","display_name":"Pepper S. Schedin","orcid":"https://orcid.org/0000-0003-4244-987X","observed_orcids":["https://orcid.org/0000-0003-4244-987X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pepper Schedin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017369626","display_name":"Steven Michael Anderson","orcid":"https://orcid.org/0000-0001-8667-7319","observed_orcids":["https://orcid.org/0000-0001-8667-7319"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven M. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043317034","display_name":"Paul S. MacLean","orcid":"https://orcid.org/0000-0002-1123-6612","observed_orcids":["https://orcid.org/0000-0002-1123-6612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul S. MacLean","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/organic-cation-transporter-2","display_name":"organic cation transporter 2","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oct2","display_name":"OCT2","score":0.8410000205039978},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.921999990940094},{"id":"https://openalex.org/keywords/intratumoral-drug-accumulation","display_name":"intratumoral drug accumulation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ampk-activation","display_name":"AMPK activation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.49000000953674316},{"id":"https://openalex.org/keywords/drug-response-prediction","display_name":"drug response prediction","score":0.44699999690055847},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7551573514938354},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.6622275114059448},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6098334789276123},{"id":"https://openalex.org/C189613389","wikidata":"https://www.wikidata.org/wiki/Q70479817","display_name":"Organic cation transport proteins","level":4,"score":0.5293835997581482},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.5273336172103882},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47217053174972534},{"id":"https://openalex.org/C123584848","wikidata":"https://www.wikidata.org/wiki/Q18034026","display_name":"Organic anion transporter 1","level":4,"score":0.47153741121292114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44388338923454285},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.418855220079422},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.369781494140625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3375629782676697},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32131755352020264},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2349146604537964},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2129201889038086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20432782173156738},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1747625172138214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13259625434875488},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.07992523908615112},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1940-6207.c.6546949.v1","doi":"https://doi.org/10.1158/1940-6207.c.6546949.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6546949.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.c.6546949.v1","doi":"https://doi.org/10.1158/1940-6207.c.6546949.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6546949.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2585504477","https://openalex.org/W4247949869","https://openalex.org/W4245781750","https://openalex.org/W2022927589","https://openalex.org/W2808137256","https://openalex.org/W2061836637","https://openalex.org/W2943014205","https://openalex.org/W2151191898","https://openalex.org/W2900111543","https://openalex.org/W2054217344"],"abstract_inverted_index":{"Abstract":[0],"Several":[1],"epidemiologic":[2],"studies":[3,41],"have":[4,42],"associated":[5,178],"metformin":[6,34,52,91,124,151,175,192,225,235],"treatment":[7,125,201],"with":[8,68,97,126,160,179],"a":[9,76,221],"reduction":[10,196],"in":[11,15,39,190,197,208,226],"breast":[12,72],"cancer":[13],"incidence":[14],"prediabetic":[16],"and":[17,36,66,82,99,139,185,228,237],"type":[18],"II":[19],"diabetic":[20],"populations.":[21],"Uncertainty":[22],"exists":[23],"regarding":[24],"which":[25,63],"patient":[26],"populations":[27],"and/or":[28],"tumor":[29,128,180,198,238],"subtypes":[30],"will":[31],"benefit":[32],"from":[33],"treatment,":[35],"most":[37],"preclinical":[38,216],"vivo":[40,227],"given":[43],"little":[44],"attention":[45],"to":[46,85,123],"the":[47],"cellular":[48],"pharmacology":[49],"of":[50,71,79,118,224],"intratumoral":[51,87,174,191],"uptake.":[53],"Epidemiologic":[54],"reports":[55],"consistently":[56],"link":[57],"western-style":[58],"high":[59],"fat":[60],"diets":[61],"(HFD),":[62],"drive":[64],"overweight":[65,81],"obesity,":[67],"increased":[69],"risk":[70],"cancer.":[73],"We":[74],"used":[75],"rat":[77],"model":[78],"HFD-induced":[80],"mammary":[83,120],"carcinogenesis":[84],"define":[86],"factors":[88],"that":[89,156,230],"confer":[90],"sensitivity.":[92],"Mammary":[93],"tumors":[94,121,147,210],"were":[95,101,157],"initiated":[96],"1-methyl-1-nitrosourea,":[98],"rats":[100],"randomized":[102],"into":[103],"metformin-treated":[104],"(2":[105],"mg/mL":[106],"drinking":[107],"water)":[108],"or":[109],"control":[110],"groups":[111],"(water":[112],"only)":[113],"for":[114,220],"8":[115],"weeks.":[116],"Two-thirds":[117],"existing":[119],"responded":[122],"decreased":[127,203],"volumes":[129],"(P":[130,136,142,153,182,211],"<":[131,137,143,154],"0.05),":[132],"reduced":[133],"proliferative":[134],"index":[135],"0.01),":[138],"activated":[140],"AMPK":[141],"0.05).":[144],"Highly":[145],"responsive":[146,209],"accumulated":[148],"3-fold":[149],"greater":[150],"amounts":[152],"0.05)":[155],"positively":[158],"correlated":[159],"organic":[161],"cation":[162],"transporter-2":[163],"(OCT2)":[164],"protein":[165],"expression":[166,232],"(r":[167],"=":[168,171,183,212],"0.57;":[169],"P":[170],"0.038).":[172],"Importantly,":[173],"concentration":[176],"negatively":[177],"volume":[181],"0.03),":[184],"each":[186],"10":[187],"pmol":[188],"increase":[189],"predicted":[193],">0.11":[194],"cm3":[195],"volume.":[199],"Metformin":[200],"also":[202],"proinflammatory":[204],"arachidonic":[205],"acid":[206],">1.5-fold":[207],"0.023).":[213],"Collectively,":[214],"these":[215],"data":[217],"provide":[218],"evidence":[219],"direct":[222],"effect":[223],"suggest":[229],"OCT2":[231],"may":[233],"predict":[234],"uptake":[236],"response.":[239],"Cancer":[240],"Prev":[241],"Res;":[242],"10(3);":[243],"198\u2013207.":[244],"\u00a92017":[245],"AACR.":[246]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-03-13T00:00:00"}
