{"id":"https://openalex.org/W4392702986","doi":"https://doi.org/10.1158/1940-6207.c.6547165.v1","title":"Data from Cervical Microbiota Associated with Higher Grade Cervical Intraepithelial Neoplasia in Women Infected with High-Risk Human Papillomaviruses","display_name":"Data from Cervical Microbiota Associated with Higher Grade Cervical Intraepithelial Neoplasia in Women Infected with High-Risk Human Papillomaviruses","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392702986","doi":"https://doi.org/10.1158/1940-6207.c.6547165.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.c.6547165.v1","doi":"https://doi.org/10.1158/1940-6207.c.6547165.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6547165.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1940-6207.c.6547165.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003551118","display_name":"Chandrika Jayanthi Piyathilake","orcid":"https://orcid.org/0000-0003-3857-7035","observed_orcids":["https://orcid.org/0000-0003-3857-7035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chandrika J. Piyathilake","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065675644","display_name":"Nicholas Jay Ollberding","orcid":"https://orcid.org/0000-0001-9404-7368","observed_orcids":["https://orcid.org/0000-0001-9404-7368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas J. Ollberding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100695007","display_name":"Ranjit Kumar","orcid":"https://orcid.org/0000-0002-2170-1274","observed_orcids":["https://orcid.org/0000-0002-2170-1274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ranjit Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054540023","display_name":"Maurizio Macaluso","orcid":"https://orcid.org/0000-0002-2977-9690","observed_orcids":["https://orcid.org/0000-0002-2977-9690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maurizio Macaluso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009816072","display_name":"Ronald David Alvarez","orcid":"https://orcid.org/0000-0002-0933-5398","observed_orcids":["https://orcid.org/0000-0002-0933-5398"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald D. Alvarez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055664540","display_name":"Casey D. Morrow","orcid":"https://orcid.org/0000-0001-8812-2341","observed_orcids":["https://orcid.org/0000-0001-8812-2341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Casey D. Morrow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.41850000619888306,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-microbiota","display_name":"cervical microbiota","score":0.9869999885559082},{"id":"https://openalex.org/keywords/high-grade-cervical-intraepithelial-neoplasia","display_name":"high-grade cervical intraepithelial neoplasia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/human-papillomavirus-infection","display_name":"HPV infection","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cervical-carcinogenesis","display_name":"cervical carcinogenesis","score":0.796999990940094},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.9070000052452087},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.8389999866485596},{"id":"https://openalex.org/keywords/limosilactobacillus-reuteri","display_name":"Lactobacillus reuteri","score":0.8849999904632568},{"id":"https://openalex.org/keywords/lactobacillaceae","display_name":"Lactobacillaceae","score":0.859000027179718},{"id":"https://openalex.org/keywords/cervical-mucus","display_name":"cervical mucus","score":0.7879999876022339},{"id":"https://openalex.org/keywords/microbiome","display_name":"microbiome","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.6178436875343323},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.5487828254699707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5099600553512573},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.46994736790657043},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.42096033692359924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2846859097480774},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.117678701877594},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.059424638748168945}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1940-6207.c.6547165.v1","doi":"https://doi.org/10.1158/1940-6207.c.6547165.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6547165.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.c.6547165.v1","doi":"https://doi.org/10.1158/1940-6207.c.6547165.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6547165.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2288314807","https://openalex.org/W7140328643","https://openalex.org/W2795606969","https://openalex.org/W3087489449","https://openalex.org/W4414967904","https://openalex.org/W4388727782","https://openalex.org/W2284695203","https://openalex.org/W2201127965","https://openalex.org/W7064776214","https://openalex.org/W7214095738"],"abstract_inverted_index":{"Abstract":[0],"It":[1],"is":[2],"increasingly":[3],"recognized":[4],"that":[5,7,33,220,236],"microbes":[6,29],"reside":[8],"in":[9,18,64,212],"and":[10,57,73,107,159,182,219,253],"on":[11,246],"human":[12,70],"body":[13],"sites":[14],"play":[15],"major":[16],"roles":[17],"modifying":[19],"the":[20,47,52,77,89,122,224,241,244,247],"pathogenesis":[21],"of":[22,46,91,121,135,243,250],"several":[23,183],"diseases,":[24],"including":[25],"cancer.":[26],"However,":[27,148],"specific":[28],"or":[30,144],"microbial":[31],"communities":[32],"can":[34],"be":[35],"mechanistically":[36],"linked":[37],"to":[38,50,74,177],"cervical":[39,55,59,78,92,131,150],"carcinogenesis":[40],"remain":[41],"largely":[42],"unexplored.":[43],"The":[44,97],"purpose":[45],"study":[48,98],"was":[49,116,163],"examine":[51],"association":[53],"between":[54],"microbiota":[56,79],"high-grade":[58],"intraepithelial":[60],"neoplasia":[61],"(CIN":[62],"2+)":[63],"women":[65,101],"infected":[66],"with":[67,82,103,110,140,165,193],"high-risk":[68],"(HR)":[69],"papillomaviruses":[71],"(HPV)":[72],"assess":[75],"whether":[76],"are":[80],"associated":[81,139,164,192],"oxidative":[83,145,238],"DNA":[84,128,146,237],"damage":[85,239],"as":[86],"indicated":[87],"by":[88,118,156],"presence":[90],"cells":[93],"positive":[94],"for":[95],"8-hydroxy-2\u2032-deoxyguanosine.":[96],"included":[99],"340":[100],"diagnosed":[102,109],"CIN":[104,111,142,166,194,254],"2+":[105,167,195],"(cases)":[106],"90":[108],"1":[112],"(non-cases).":[113],"Microbiota":[114],"composition":[115],"determined":[117],"Illumina":[119],"sequencing":[120,208,218],"16S":[123,206],"rRNA":[124,207],"gene":[125],"amplified":[126],"from":[127,130],"extracted":[129],"mucus":[132],"samples.":[133],"Measures":[134],"alpha/beta-diversity":[136],"were":[137,190],"not":[138],"either":[141],"severity":[143],"damage.":[147],"a":[149],"mucosal":[151],"community":[152],"type":[153],"(CT)":[154],"dominated":[155],"L.":[157,180],"iners":[158],"unclassified":[160],"Lactobacillus":[161,186],"spp.":[162],"(OR":[168],"=":[169],"3.48;":[170],"95%":[171],"CI,":[172],"1.27\u20139.55).":[173],"Sequence":[174],"reads":[175],"mapping":[176],"Lactobacillaceae,":[178],"Lactobacillus,":[179],"reuteri,":[181],"sub\u2013genus":[184],"level":[185],"operational":[187],"taxonomic":[188,229],"units":[189],"also":[191],"when":[196],"examined":[197],"independently":[198],"(effect":[199],"size":[200],">2.0;":[201],"P":[202],"<":[203],"0.05).":[204],"Our":[205,231],"results":[209,232],"need":[210],"confirmation":[211],"independent":[213],"studies":[214],"using":[215],"whole-genome":[216],"shotgun":[217],"would":[221],"allow":[222],"sharpening":[223],"suggested":[225],"associations":[226],"at":[227],"finer":[228],"levels.":[230],"provide":[233],"little":[234],"evidence":[235],"mediates":[240],"effect":[242],"microbiome":[245],"natural":[248],"history":[249],"HPV":[251],"infection":[252],"severity.":[255],"Cancer":[256],"Prev":[257],"Res;":[258],"9(5);":[259],"357\u201366.":[260],"\u00a92016":[261],"AACR.":[262]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-03-13T00:00:00"}