{"id":"https://openalex.org/W4392700965","doi":"https://doi.org/10.1158/1940-6207.c.6544130.v1","title":"Data from KAVA Chalcone, Flavokawain A, Inhibits Urothelial Tumorigenesis in the UPII-SV40T Transgenic Mouse Model","display_name":"Data from KAVA Chalcone, Flavokawain A, Inhibits Urothelial Tumorigenesis in the UPII-SV40T Transgenic Mouse Model","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392700965","doi":"https://doi.org/10.1158/1940-6207.c.6544130.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.c.6544130.v1","doi":"https://doi.org/10.1158/1940-6207.c.6544130.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6544130.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1940-6207.c.6544130.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082785833","display_name":"Zhongbo Liu","orcid":"https://orcid.org/0000-0003-0075-1261","observed_orcids":["https://orcid.org/0000-0003-0075-1261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhongbo Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319798","display_name":"Xia Xu","orcid":"https://orcid.org/0000-0002-3384-3237","observed_orcids":["https://orcid.org/0000-0002-3384-3237"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xia Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086187744","display_name":"Xuesen Li","orcid":"https://orcid.org/0000-0001-9286-476X","observed_orcids":["https://orcid.org/0000-0001-9286-476X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuesen Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101363001","display_name":"Shuman Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuman Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064775495","display_name":"Anne R. Simoneau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne R. Simoneau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100701068","display_name":"Feng He","orcid":"https://orcid.org/0000-0002-4717-2243","observed_orcids":["https://orcid.org/0000-0002-4717-2243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101198661","display_name":"Xue-Ru Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xue-Ru Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036496290","display_name":"Xiaolin Zi","orcid":"https://orcid.org/0000-0002-5312-7158","observed_orcids":["https://orcid.org/0000-0002-5312-7158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaolin Zi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.22679999470710754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavokawain-a","display_name":"flavokawain A","score":0.9369999766349792},{"id":"https://openalex.org/keywords/chalcones","display_name":"chalcones","score":0.8080000281333923},{"id":"https://openalex.org/keywords/kava","display_name":"kava","score":0.9620000123977661},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.847000002861023},{"id":"https://openalex.org/keywords/bladder-cancer-prevention","display_name":"bladder cancer prevention","score":0.7540000081062317},{"id":"https://openalex.org/keywords/p53-deficient-tumors","display_name":"p53-deficient tumors","score":0.6660000085830688},{"id":"https://openalex.org/keywords/retinoblastoma-pathway","display_name":"retinoblastoma pathway","score":0.9629999995231628},{"id":"https://openalex.org/keywords/papillary-urothelial-carcinoma","display_name":"papillary urothelial carcinoma","score":0.8220000267028809},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.6499999761581421},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.8690000176429749},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dr5","display_name":"DR5","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8299999833106995},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.49799999594688416},{"id":"https://openalex.org/keywords/non-muscle-invasive-bladder-cancer","display_name":"non-muscle-invasive bladder cancer","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C2780764945","wikidata":"https://www.wikidata.org/wiki/Q899416","display_name":"Chalcone","level":2,"score":0.775387167930603},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6359716653823853},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5985745787620544},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5892760157585144},{"id":"https://openalex.org/C2776910463","wikidata":"https://www.wikidata.org/wiki/Q161067","display_name":"Kava","level":2,"score":0.5769058465957642},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4810124337673187},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4363260269165039},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41793158650398254},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32945555448532104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2929426431655884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2152215540409088},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.1674521267414093},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1940-6207.c.6544130.v1","doi":"https://doi.org/10.1158/1940-6207.c.6544130.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6544130.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.c.6544130.v1","doi":"https://doi.org/10.1158/1940-6207.c.6544130.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6544130.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2112035541","https://openalex.org/W2323567244","https://openalex.org/W1970492578","https://openalex.org/W4214655144","https://openalex.org/W2314092775","https://openalex.org/W1965518808","https://openalex.org/W4361253448","https://openalex.org/W4319924607","https://openalex.org/W4362614987","https://openalex.org/W2109526314"],"abstract_inverted_index":{"Abstract":[0],"Flavokawain":[1],"A":[2,210],"(FKA)":[3],"is":[4],"the":[5,10,21,45,59,62,96,114,139,143,163,169,188,196,231,247,262],"predominant":[6],"chalcone":[7],"identified":[8],"from":[9],"kava":[11],"plant.":[12],"We":[13],"have":[14],"previously":[15],"shown":[16],"that":[17,49,124],"FKA":[18,34,78,144,158,193,259],"preferentially":[19],"inhibits":[20],"growth":[22],"of":[23,90,95,107,113,133,198,213,219,226,233,250,258,266],"p53":[24,60],"defective":[25],"bladder":[26,37,131],"cancer":[27,38],"cell":[28,53],"lines.":[29],"Here,":[30],"we":[31],"examined":[32],"whether":[33],"could":[35],"inhibit":[36],"development":[39],"and":[40,61,166,180,216,223,228,230,264],"progression":[41,265],"in":[42,44,58,168,187,246,260],"vivo":[43],"UPII-SV40T":[46,68],"transgenic":[47,136],"model":[48],"resembles":[50],"human":[51],"urothelial":[52,206,248],"carcinoma":[54],"(UCC)":[55],"with":[56,73,100,118,138],"defects":[57],"retinoblastoma":[63],"(Rb)":[64],"protein":[65],"pathways.":[66],"Genotyped":[67],"mice":[69,98,116,137],"were":[70,146,244],"fed":[71,99,117],"orally":[72],"vehicle":[74,119],"control":[75,120,140],"(AIN-93M)":[76],"or":[77],"(6":[79],"g/kg":[80],"food;":[81],"0.6%)":[82],"for":[83],"318":[84,105],"days":[85,89,106],"starting":[86],"at":[87],"28":[88],"age.":[91],"More":[92],"than":[93,186],"64%":[94],"male":[97,115,135],"FKA-containing":[101],"food":[102,121],"survived":[103,122],"beyond":[104],"age,":[108],"whereas":[109],"only":[110],"about":[111,176],"38%":[112],"to":[123,172,204],"age":[125],"(P":[126,155,190],"=":[127,156,191],"0.0383).":[128],"The":[129],"mean":[130],"weights":[132],"surviving":[134],"diet":[141,145],"versus":[142,150],"234.6":[147],"\u00b1":[148,152],"72.5":[149],"96.1":[151],"69.4":[153],"mg":[154],"0.0002).":[157],"was":[159],"excreted":[160],"primarily":[161],"through":[162],"urinary":[164],"tract":[165],"concentrated":[167,185],"urine":[170],"up":[171],"8.4":[173],"\u03bcmol/L,":[174],"averaging":[175],"38":[177],"times":[178,182],"(males)":[179],"15":[181],"(females)":[183],"more":[184],"plasma":[189],"0.0001).":[192],"treatment":[194],"inhibited":[195],"occurrence":[197],"high-grade":[199],"papillary":[200],"UCC,":[201],"a":[202,256],"precursor":[203],"invasive":[205],"cancer,":[207],"by":[208],"42.1%.":[209],"decreased":[211],"expression":[212,225],"Ki67,":[214],"survivin,":[215],"X-linked":[217],"inhibitor":[218],"apoptotic":[220,242],"proteins":[221],"(XIAP)":[222],"increased":[224],"p27":[227],"DR5,":[229],"number":[232],"terminal":[234],"deoxynucleotidyl":[235],"transferase\u2013mediated":[236],"dUTP":[237],"nick":[238],"end":[239],"labeling":[240],"(TUNEL)-positive":[241],"cells":[243],"observed":[245],"tissue":[249],"FKA-fed":[251],"mice.":[252],"These":[253],"results":[254],"suggest":[255],"potential":[257],"preventing":[261],"recurrence":[263],"non\u2013muscle-invasive":[267],"UCC.":[268],"Cancer":[269],"Prev":[270],"Res;":[271],"6(12);":[272],"1365\u201375.":[273],"\u00a92013":[274],"AACR.":[275]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2024-03-13T00:00:00"}
