{"id":"https://openalex.org/W4392699323","doi":"https://doi.org/10.1158/1541-7786.c.6540565.v1","title":"Data from Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition","display_name":"Data from Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392699323","doi":"https://doi.org/10.1158/1541-7786.c.6540565.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6540565.v1","doi":"https://doi.org/10.1158/1541-7786.c.6540565.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6540565.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.c.6540565.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020967351","display_name":"Ryan A. Denu","orcid":"https://orcid.org/0000-0001-9698-9201","observed_orcids":["https://orcid.org/0000-0001-9698-9201"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan A. Denu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082363506","display_name":"Gulpreet Kaur","orcid":"https://orcid.org/0009-0000-3016-8646","observed_orcids":["https://orcid.org/0009-0000-3016-8646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gulpreet Kaur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034776692","display_name":"Madilyn M. Sass","orcid":"https://orcid.org/0000-0002-3084-1084","observed_orcids":["https://orcid.org/0000-0002-3084-1084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madilyn M. Sass","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3084-1084","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057359171","display_name":"Aparna Lakkaraju","orcid":"https://orcid.org/0000-0002-2869-7378","observed_orcids":["https://orcid.org/0000-0002-2869-7378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aparna Lakkaraju","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050180604","display_name":"Mark E. Burkard","orcid":"https://orcid.org/0000-0002-4215-7722","observed_orcids":["https://orcid.org/0000-0002-4215-7722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark E. Burkard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4215-7722","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrosome-amplification","display_name":"centrosome amplification","score":1.0},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/autophagy-inhibitors","display_name":"autophagy inhibitors","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.3400000035762787},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7900000214576721},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.6909999847412109},{"id":"https://openalex.org/keywords/microtubule-cytoskeleton","display_name":"microtubule cytoskeleton","score":0.7369999885559082},{"id":"https://openalex.org/keywords/chromosome-missegregation","display_name":"chromosome missegregation","score":0.953000009059906},{"id":"https://openalex.org/keywords/proteotoxic-stress","display_name":"proteotoxic stress","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9677444696426392},{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.927087128162384},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5509098768234253},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4484265148639679},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3666922450065613},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34878939390182495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3237067461013794},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16024497151374817},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15391555428504944},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14726939797401428},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.07862317562103271}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.c.6540565.v1","doi":"https://doi.org/10.1158/1541-7786.c.6540565.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6540565.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6540565.v1","doi":"https://doi.org/10.1158/1541-7786.c.6540565.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6540565.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2979617270","https://openalex.org/W2570078163","https://openalex.org/W4285718444","https://openalex.org/W2973068838","https://openalex.org/W2588499144","https://openalex.org/W4220978128","https://openalex.org/W2754990733","https://openalex.org/W4296767489","https://openalex.org/W6960143670","https://openalex.org/W3094740519"],"abstract_inverted_index":{"Abstract":[0],"Centrosome":[1],"amplification":[2],"(CA),":[3],"or":[4],"a":[5,33,117,162,176,194],"numerical":[6],"increase":[7],"in":[8,12,124,181],"centrosomes,":[9],"is":[10,148],"common":[11],"human":[13],"cancers,":[14],"particularly":[15],"those":[16],"with":[17,25,56,109,131,199],"high-risk":[18,182],"features.":[19],"We":[20,63],"have":[21,27],"discovered":[22],"that":[23,68,100,146,188],"cells":[24,154],"CA":[26,57,69,101,132,151,168,189],"an":[28,59,103],"increased":[29],"burden":[30],"of":[31,61,105,128,157],"autophagy,":[32],"catabolic":[34],"process":[35],"whereby":[36,167],"autophagosomes":[37,106],"engulf":[38],"damaged":[39],"organelles":[40],"and":[41,43,52,76,83,94,137,152,173],"proteins":[42],"deliver":[44],"these":[45],"contents":[46],"to":[47,135,155],"the":[48,65],"lysosome":[49,81],"for":[50,178,197],"degradation":[51],"subsequent":[53],"recycling.":[54],"Cells":[55,130],"demonstrate":[58,99],"accumulation":[60,104],"autophagosomes.":[62],"evaluated":[64],"alternative":[66],"hypotheses":[67],"alters":[70],"autophagy":[71,122,139,147,172,179,200],"by":[72,107,150],"modulating":[73],"microtubule":[74],"networks":[75],"impairing":[77],"trafficking":[78],"versus":[79,85],"altering":[80],"clustering":[82],"organization":[84],"chromosome":[86],"missegregation-induced":[87],"proteotoxic":[88],"stress.":[89],"Using":[90],"LC3":[91],"reporter":[92],"assays":[93],"autophagosome":[95,110],"tracking":[96],"experiments,":[97],"we":[98,120],"causes":[102],"interfering":[108],"trafficking.":[111],"To":[112],"establish":[113],"whether":[114],"this":[115],"was":[116],"druggable":[118],"weakness,":[119],"tested":[121],"inhibitors":[123,180],"our":[125,143],"cell":[126],"models":[127],"CA.":[129],"are":[133],"sensitized":[134],"chemical":[136],"genetic":[138],"inhibition.":[140],"Taken":[141],"together,":[142],"results":[144],"suggest":[145,161],"disrupted":[149],"sensitizes":[153],"inhibition":[156],"autophagy.":[158],"These":[159],"findings":[160],"novel":[163],"precision":[164],"medicine":[165],"strategy,":[166],"increases":[169],"reliance":[170],"on":[171],"serves":[174],"as":[175,193],"biomarker":[177,196],"cancers.":[183],"Implications:":[184],"Our":[185],"study":[186],"suggests":[187],"could":[190],"be":[191],"used":[192],"predictive":[195],"treatment":[198],"inhibitors.":[201]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2024-03-13T00:00:00"}