{"id":"https://openalex.org/W4392698253","doi":"https://doi.org/10.1158/1535-7163.c.6538933.v1","title":"Data from Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8+/PDL1+ Immune Infiltration in Inflammatory Breast Cancer Tumors","display_name":"Data from Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8+/PDL1+ Immune Infiltration in Inflammatory Breast Cancer Tumors","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392698253","doi":"https://doi.org/10.1158/1535-7163.c.6538933.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6538933.v1","doi":"https://doi.org/10.1158/1535-7163.c.6538933.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6538933.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.c.6538933.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089025780","display_name":"Christopher Allan Hamm","orcid":"https://orcid.org/0000-0002-1273-9617","observed_orcids":["https://orcid.org/0000-0002-1273-9617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher A. Hamm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075462213","display_name":"Diarmuid Martin Moran","orcid":"https://orcid.org/0009-0002-9812-7239","observed_orcids":["https://orcid.org/0009-0002-9812-7239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diarmuid Moran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011906255","display_name":"Kakuturu Rao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kakuturu Rao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085870277","display_name":"Patricia B. Trusk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia B. Trusk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049961374","display_name":"Karen J. Pry","orcid":"https://orcid.org/0000-0001-7625-6203","observed_orcids":["https://orcid.org/0000-0001-7625-6203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen Pry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081353089","display_name":"Mark Sausen","orcid":"https://orcid.org/0000-0002-2916-5269","observed_orcids":["https://orcid.org/0000-0002-2916-5269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Sausen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001000201","display_name":"Si\u00e2n Jones","orcid":"https://orcid.org/0000-0002-2374-8391","observed_orcids":["https://orcid.org/0000-0002-2374-8391"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Si\u00e2n Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006560755","display_name":"Victor E. Velculescu","orcid":"https://orcid.org/0000-0003-1195-438X","observed_orcids":["https://orcid.org/0000-0003-1195-438X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor E. Velculescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032987754","display_name":"Massimo Cristofanilli","orcid":"https://orcid.org/0000-0002-4194-7175","observed_orcids":["https://orcid.org/0000-0002-4194-7175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo Cristofanilli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037786564","display_name":"Sarah S. Bacus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah Bacus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.07590000331401825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-breast-cancer","display_name":"inflammatory breast cancer","score":1.0},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.6299999952316284},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-immune-infiltration","display_name":"tumor immune infiltration","score":0.8050000071525574},{"id":"https://openalex.org/keywords/iscore","display_name":"iScore","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.8450000286102295},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6439999938011169},{"id":"https://openalex.org/keywords/immunotherapy-response-biomarkers","display_name":"immunotherapy response biomarkers","score":0.7459999918937683},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6975733041763306},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5844055414199829},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5770208239555359},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5649319291114807},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.4713197350502014},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43220990896224976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38674625754356384},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3603356182575226},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27137291431427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24082744121551514},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13081508874893188},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1281965970993042},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.c.6538933.v1","doi":"https://doi.org/10.1158/1535-7163.c.6538933.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6538933.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6538933.v1","doi":"https://doi.org/10.1158/1535-7163.c.6538933.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6538933.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2340472203","https://openalex.org/W2563900200","https://openalex.org/W3194196346","https://openalex.org/W4220907670","https://openalex.org/W3091070974","https://openalex.org/W2327501875","https://openalex.org/W2886753269","https://openalex.org/W1948524999","https://openalex.org/W2944183783","https://openalex.org/W4410430439"],"abstract_inverted_index":{"Abstract":[0],"Inflammatory":[1],"breast":[2,12],"cancer":[3,13],"(IBC)":[4],"is":[5],"a":[6,110,122,191,219],"rare":[7],"and":[8,38,71,88,150,189,201,228],"aggressive":[9],"form":[10],"of":[11,55,96,124,141,197,209,239],"that":[14,181],"remains":[15],"poorly":[16],"understood":[17],"at":[18,167],"the":[19,53,146,195],"molecular":[20],"level.":[21],"Comprehensive":[22],"tumor":[23,48,63],"profiling":[24],"was":[25],"performed":[26,41],"to":[27,42,163,184,222,241],"understand":[28],"clinically":[29,198],"actionable":[30],"alterations":[31,81,180],"in":[32,46,59,82,91,103,115,170,187,213,226],"IBC.":[33],"Targeted":[34],"next-generation":[35],"sequencing":[36],"(NGS)":[37],"IHC":[39],"were":[40,65,101],"identify":[43],"activated":[44],"pathways":[45],"IBC":[47,56,62,104,116,125,188,227],"tissues.":[49],"siRNA":[50],"studies":[51,108],"examined":[52],"impact":[54],"genomic":[57,179],"variants":[58,90],"cellular":[60],"models.":[61],"tissues":[64],"further":[66],"characterized":[67],"for":[68,112,194],"immune":[69,72,174,224],"infiltration":[70,134,225],"checkpoint":[73],"expression":[74],"by":[75],"IHC.":[76],"Genomic":[77],"analysis":[78,120],"identified":[79],"recurrent":[80],"core":[83],"biologic":[84],"pathways,":[85],"including":[86],"activating":[87,97],"targetable":[89],"HER/PI3K/mTOR":[92],"signaling.":[93],"High":[94],"rates":[95],"HER3":[98,114],"point":[99],"mutations":[100],"discovered":[102],"tumors.":[105],"Cell":[106],"line":[107],"confirmed":[109],"role":[111],"mutant":[113,151],"cell":[117],"proliferation.":[118],"Immunologic":[119],"revealed":[121],"subset":[123],"tumors":[126,171],"associated":[127,235],"with":[128,137,172,236],"high":[129],"CD8+/PD-L1+":[130],"lymphocyte":[131],"infiltration.":[132,175],"Immune":[133],"positively":[135],"correlated":[136],"an":[138,206],"NGS-based":[139,207],"estimate":[140,208],"neoantigen":[142,210],"exposure":[143,211],"derived":[144],"from":[145],"somatic":[147],"mutation":[148],"rate":[149],"allele":[152],"frequency,":[153],"iScore.":[154],"Additionally,":[155],"DNA":[156],"mismatch":[157],"repair":[158],"alterations,":[159],"which":[160],"may":[161,217,233],"contribute":[162,183],"higher":[164,173],"iScores,":[165],"occurred":[166],"greater":[168,237],"frequency":[169],"Our":[176],"study":[177,215],"identifies":[178],"mechanistically":[182],"oncogenic":[185],"signaling":[186],"provides":[190],"genetic":[192],"basis":[193],"selection":[196],"relevant":[199],"targeted":[200],"combination":[202],"therapeutic":[203],"strategies.":[204],"Furthermore,":[205],"developed":[212],"this":[214],"(iScore)":[216],"be":[218,234],"useful":[220],"biomarker":[221],"predict":[223],"other":[229],"cancers.":[230],"The":[231],"iScore":[232],"levels":[238],"response":[240],"immunotherapies,":[242],"such":[243],"as":[244],"PD-L1/PD-1\u2013targeted":[245],"therapies.":[246],"Mol":[247],"Cancer":[248],"Ther;":[249],"15(7);":[250],"1746\u201356.":[251],"\u00a92016":[252],"AACR.":[253]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-03-13T00:00:00"}