{"id":"https://openalex.org/W4392687904","doi":"https://doi.org/10.1158/1535-7163.c.6537673","title":"Data from Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells","display_name":"Data from Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392687904","doi":"https://doi.org/10.1158/1535-7163.c.6537673"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6537673","doi":"https://doi.org/10.1158/1535-7163.c.6537673","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537673","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.c.6537673","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041993659","display_name":"Emiliano Cocco","orcid":"https://orcid.org/0000-0002-1397-2656","observed_orcids":["https://orcid.org/0000-0002-1397-2656"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emiliano Cocco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100540911","display_name":"Yang Deng","orcid":"https://orcid.org/0009-0009-2727-0960","observed_orcids":["https://orcid.org/0009-0009-2727-0960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Deng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049750913","display_name":"Erik M. Shapiro","orcid":"https://orcid.org/0000-0002-0901-5781","observed_orcids":["https://orcid.org/0000-0002-0901-5781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik M. Shapiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075330842","display_name":"Ileana Bortolomai","orcid":"https://orcid.org/0000-0002-2592-1274","observed_orcids":["https://orcid.org/0000-0002-2592-1274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ileana Bortolomai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045925318","display_name":"Salvatore Lopez","orcid":"https://orcid.org/0000-0001-7705-3715","observed_orcids":["https://orcid.org/0000-0001-7705-3715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvatore Lopez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101200665","display_name":"Ken Lin","orcid":"https://orcid.org/0000-0001-9643-5858","observed_orcids":["https://orcid.org/0000-0001-9643-5858","https://orcid.org/0000-0001-7714-6671"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046857977","display_name":"Stefania Bellone","orcid":"https://orcid.org/0000-0001-5909-5292","observed_orcids":["https://orcid.org/0000-0001-5909-5292"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefania Bellone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060497988","display_name":"Jiajia Cui","orcid":"https://orcid.org/0000-0002-7437-1133","observed_orcids":["https://orcid.org/0000-0002-7437-1133"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiajia Cui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014098371","display_name":"Gulden Menderes","orcid":"https://orcid.org/0000-0002-3140-3860","observed_orcids":["https://orcid.org/0000-0002-3140-3860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gulden Menderes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103653978","display_name":"Jonathan D. Black","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan D. Black","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110450300","display_name":"Carlton L. Schwab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlton L. Schwab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027337412","display_name":"Elena Bonazzoli","orcid":"https://orcid.org/0000-0003-2024-8102","observed_orcids":["https://orcid.org/0000-0003-2024-8102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Bonazzoli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100346633","display_name":"Fan Yang","orcid":"https://orcid.org/0000-0003-3730-8503","observed_orcids":["https://orcid.org/0000-0003-3730-8503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fan Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004959453","display_name":"Federica Predolini","orcid":"https://orcid.org/0000-0001-6032-6772","observed_orcids":["https://orcid.org/0000-0001-6032-6772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federica Predolini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084497328","display_name":"Luca Arrigo Zammataro","orcid":"https://orcid.org/0000-0002-4348-6341","observed_orcids":["https://orcid.org/0000-0002-4348-6341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luca Zammataro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080849182","display_name":"Gary H. Altwerger","orcid":"https://orcid.org/0000-0002-2252-947X","observed_orcids":["https://orcid.org/0000-0002-2252-947X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Altwerger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070634515","display_name":"Christopher de Haydu","orcid":"https://orcid.org/0000-0001-9470-5041","observed_orcids":["https://orcid.org/0000-0001-9470-5041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher de Haydu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042405282","display_name":"Mitchell B. Clark","orcid":"https://orcid.org/0000-0003-1118-9585","observed_orcids":["https://orcid.org/0000-0003-1118-9585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitchell Clark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103728511","display_name":"Julio Alvarenga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julio Alvarenga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021257078","display_name":"Elena Ratner","orcid":"https://orcid.org/0000-0002-6277-6002","observed_orcids":["https://orcid.org/0000-0002-6277-6002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Ratner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032849063","display_name":"Masoud Azodi","orcid":"https://orcid.org/0000-0002-0570-8089","observed_orcids":["https://orcid.org/0000-0002-0570-8089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masoud Azodi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108433612","display_name":"Dan\u2010Arin Silasi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan-Arin Silasi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026827320","display_name":"Peter E. Schwartz","orcid":"https://orcid.org/0000-0002-0845-3624","observed_orcids":["https://orcid.org/0000-0002-0845-3624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter E. Schwartz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036908259","display_name":"Babak Litkouhi","orcid":"https://orcid.org/0000-0003-3124-4350","observed_orcids":["https://orcid.org/0000-0003-3124-4350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Babak Litkouhi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Mark Saltzman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010339370","display_name":"Alessandro Davide Santin","orcid":"https://orcid.org/0000-0003-4724-9738","observed_orcids":["https://orcid.org/0000-0003-4724-9738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro D. Santin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5659000277519226,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5659000277519226,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.4115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9150000214576721},{"id":"https://openalex.org/keywords/suicide-gene-therapy","display_name":"suicide gene therapy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/claudin-3","display_name":"claudin-3","score":0.7630000114440918},{"id":"https://openalex.org/keywords/claudin-4","display_name":"claudin-4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/clostridium-perfringens-enterotoxin","display_name":"Clostridium perfringens enterotoxin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.6480000019073486},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.6570000052452087},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.7160000205039978},{"id":"https://openalex.org/keywords/intraperitoneal-injection","display_name":"intraperitoneal injection","score":0.8199999928474426},{"id":"https://openalex.org/keywords/nanoparticle-biodistribution","display_name":"nanoparticle biodistribution","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7217473983764648},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6882891654968262},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6028167009353638},{"id":"https://openalex.org/C34981463","wikidata":"https://www.wikidata.org/wiki/Q3311663","display_name":"Suicide gene","level":4,"score":0.5756648778915405},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4527930021286011},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4465911090373993},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.44459161162376404},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4377664625644684},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.430547833442688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39888837933540344},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3540523946285248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3466184139251709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31588250398635864},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.20140594244003296},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.13644590973854065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12165874242782593},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.06923586130142212},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.c.6537673","doi":"https://doi.org/10.1158/1535-7163.c.6537673","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537673","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.c.6537673.v1","doi":"https://doi.org/10.1158/1535-7163.c.6537673.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537673.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6537673","doi":"https://doi.org/10.1158/1535-7163.c.6537673","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537673","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2566910113","https://openalex.org/W4362534549","https://openalex.org/W4361822281","https://openalex.org/W2121811064","https://openalex.org/W1982723015","https://openalex.org/W2069877303","https://openalex.org/W2096821705","https://openalex.org/W2055836462","https://openalex.org/W2129234932","https://openalex.org/W3158883533"],"abstract_inverted_index":{"Abstract":[0],"Ovarian":[1],"cancer":[2,55,87,155,202,251],"is":[3],"the":[4,12,39,46,67,73,77,97,136,242],"most":[5],"lethal":[6],"gynecologic":[7],"cancer.":[8],"Claudin-3":[9],"and":[10,31,91,169],"-4,":[11],"receptors":[13],"for":[14,45,66,241],"Clostridium":[15],"perfringens":[16],"enterotoxin":[17],"(CPE),":[18],"are":[19],"overexpressed":[20],"in":[21,85,120,128,152,158,197,213,224],"more":[22,107,145],"than":[23,109,147],"70%":[24],"of":[25,42,48,76,184,193,208,217,245],"these":[26],"tumors.":[27],"Here,":[28],"we":[29,61],"synthesized":[30],"characterized":[32],"poly(lactic-co-glycolic-acid)":[33],"(PLGA)":[34],"nanoparticles":[35],"(NPs)":[36],"modified":[37,112],"with":[38,113,221],"carboxy-terminal\u2013binding":[40],"domain":[41],"CPE":[43],"(c-CPE-NP)":[44],"delivery":[47,244],"suicide":[49],"gene":[50,81,246],"therapy":[51,247],"to":[52,248],"chemotherapy-resistant":[53,123,200,225,249],"ovarian":[54,86,124,154,201,250],"cells.":[56,88,252],"As":[57],"a":[58,63,80,114,214,236],"therapeutic":[59,239],"payload,":[60],"generated":[62],"plasmid":[64,101],"encoding":[65],"diphtheria":[68],"toxin":[69],"subunit-A":[70],"(DT-A)":[71],"under":[72],"transcriptional":[74],"control":[75,110,148,222],"p16":[78,137,149,209,231],"promoter,":[79],"highly":[82],"differentially":[83],"expressed":[84],"Flow":[89],"cytometry":[90],"immunofluorescence":[92],"demonstrated":[93,181],"that":[94],"c-CPE-NPs":[95,134],"encapsulating":[96,135],"cytomegalovirus":[98],"(CMV)":[99],"GFP":[100,103,118,195],"(CMV":[102,117],"c-CPE-NP)":[104,142],"were":[105,143],"significantly":[106,144],"efficient":[108,182],"NPs":[111],"scrambled":[115],"peptide":[116],"scr-NP)":[119],"transfecting":[121],"primary":[122],"tumor":[125,185,218],"cell":[126,156],"lines":[127],"vitro":[129,159],"(P":[130,228],"=":[131,165,175,229],"0.03).":[132,176],"Importantly,":[133],"DT-A":[138,141,150,210,232],"vector":[139],"(p16":[140],"effective":[146],"scr-NP":[151],"inducing":[153],"death":[157],"(%":[160],"cytotoxicity:":[161],"mean":[162],"\u00b1":[163,167,171],"SD":[164],"32.9":[166],"0.15":[168],"7.45":[170],"7.93,":[172],"respectively,":[173],"P":[174],"In":[177],"vivo":[178],"biodistribution":[179],"studies":[180],"transfection":[183],"cells":[186],"within":[187],"12":[188],"hours":[189],"after":[190],"intraperitoneal":[191,206],"injection":[192],"CMV":[194],"c-CPE-NP":[196,211,233],"mice":[198,227],"harboring":[199],"xenografts.":[203],"Finally,":[204],"multiple":[205],"injections":[207],"resulted":[212],"significant":[215],"inhibition":[216],"growth":[219],"compared":[220],"NP":[223],"tumor-bearing":[226],"0.041).":[230],"may":[234],"represent":[235],"novel":[237],"dual-targeting":[238],"approach":[240],"selective":[243],"Mol":[253],"Cancer":[254],"Ther;":[255],"16(2);":[256],"323\u201333.":[257],"\u00a92016":[258],"AACR.":[259]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-13T00:00:00"}
