{"id":"https://openalex.org/W4392689997","doi":"https://doi.org/10.1158/1535-7163.c.6543508","title":"Data from CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment","display_name":"Data from CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392689997","doi":"https://doi.org/10.1158/1535-7163.c.6543508"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6543508","doi":"https://doi.org/10.1158/1535-7163.c.6543508","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6543508","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.c.6543508","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048311006","display_name":"Tomohiro Fujiwara","orcid":"https://orcid.org/0000-0003-4257-9180","observed_orcids":["https://orcid.org/0000-0003-4257-9180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomohiro Fujiwara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002799992","display_name":"Mohamed A. Yakoub","orcid":"https://orcid.org/0000-0002-6400-660X","observed_orcids":["https://orcid.org/0000-0002-6400-660X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed A. Yakoub","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Chandler","orcid":"https://orcid.org/0000-0002-2527-0125","observed_orcids":["https://orcid.org/0000-0002-2527-0125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Chandler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2527-0125","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039172212","display_name":"Alexander B. Christ","orcid":"https://orcid.org/0000-0002-0447-5762","observed_orcids":["https://orcid.org/0000-0002-0447-5762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander B. Christ","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0447-5762","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101775546","display_name":"Guangli Yang","orcid":"https://orcid.org/0000-0002-5097-5266","observed_orcids":["https://orcid.org/0000-0002-5097-5266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guangli Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049208970","display_name":"Ouathek Ouerfelli","orcid":"https://orcid.org/0000-0002-7038-0219","observed_orcids":["https://orcid.org/0000-0002-7038-0219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ouathek Ouerfelli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7038-0219","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069187383","display_name":"Vinagolu K. Rajasekhar","orcid":"https://orcid.org/0000-0002-7364-2675","observed_orcids":["https://orcid.org/0000-0002-7364-2675"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinagolu K. Rajasekhar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109157538","display_name":"Aki Yoshida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aki Yoshida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021885153","display_name":"Hiroya Kondo","orcid":"https://orcid.org/0000-0002-4642-5448","observed_orcids":["https://orcid.org/0000-0002-4642-5448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroya Kondo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Toshiaki Hata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiaki Hata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015421086","display_name":"Hiroshi Tazawa","orcid":"https://orcid.org/0000-0003-4658-1050","observed_orcids":["https://orcid.org/0000-0003-4658-1050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Tazawa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4658-1050","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yildirim Dogan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yildirim Dogan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110863459","display_name":"Malcolm A.S. Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malcolm A.S. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068717107","display_name":"Toshiyoshi Fujiwara","orcid":"https://orcid.org/0000-0002-5377-6051","observed_orcids":["https://orcid.org/0000-0002-5377-6051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiyoshi Fujiwara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005444399","display_name":"Toshifumi Ozaki","orcid":"https://orcid.org/0000-0003-1732-9307","observed_orcids":["https://orcid.org/0000-0003-1732-9307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshifumi Ozaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110770929","display_name":"Ed Purdue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ed Purdue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022207361","display_name":"John H. Healey","orcid":"https://orcid.org/0000-0002-0802-1186","observed_orcids":["https://orcid.org/0000-0002-0802-1186"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John H. Healey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0802-1186","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pexidartinib","display_name":"pexidartinib","score":0.9819999933242798},{"id":"https://openalex.org/keywords/plx3397","display_name":"PLX3397","score":0.9950000047683716},{"id":"https://openalex.org/keywords/csf1r-inhibition","display_name":"CSF1R inhibition","score":0.8230000138282776},{"id":"https://openalex.org/keywords/csf-1","display_name":"CSF-1","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9980000257492065},{"id":"https://openalex.org/keywords/macrophage-m2-polarization","display_name":"macrophage M2 polarization","score":0.7310000061988831},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.7580000162124634},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.746999979019165},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.7639999985694885},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9150000214576721},{"id":"https://openalex.org/keywords/bone-marrow-derived-macrophages","display_name":"bone marrow-derived macrophages","score":0.8140000104904175},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/macrophage-chemotaxis","display_name":"macrophage chemotaxis","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.6451936960220337},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6190177202224731},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5677089095115662},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4320516884326935},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4173320233821869},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3759525418281555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3358442187309265},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.180283784866333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06706589460372925},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.c.6543508","doi":"https://doi.org/10.1158/1535-7163.c.6543508","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6543508","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6543508","doi":"https://doi.org/10.1158/1535-7163.c.6543508","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6543508","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3164752908","https://openalex.org/W2562101058","https://openalex.org/W2045420985","https://openalex.org/W2610126477","https://openalex.org/W4308346200","https://openalex.org/W4391353088","https://openalex.org/W2955741664","https://openalex.org/W4251060961","https://openalex.org/W2740169469","https://openalex.org/W3126678327"],"abstract_inverted_index":{"Abstract":[0],"Colony-stimulating":[1],"factor":[2],"1":[3],"(CSF1)":[4],"is":[5,48],"a":[6,49,61],"primary":[7,179,213],"regulator":[8],"of":[9,15,22,33,41,57,64,95,103,148,168,204,211],"the":[10,19,31,34,39,42,55,65,74,171,178,209],"survival,":[11,161],"proliferation,":[12],"and":[13,76,86,117,140,157,162,182,185,195,214,227,238],"differentiation":[14],"monocyte/macrophage":[16],"that":[17,107,222,230],"sustains":[18],"protumorigenic":[20],"functions":[21],"tumor-associated":[23],"macrophages":[24,131],"(TAMs).":[25],"Considering":[26],"current":[27],"advances":[28],"in":[29,128,164],"understanding":[30],"role":[32],"inflammatory":[35],"tumor":[36,85,180],"microenvironment,":[37,44],"targeting":[38],"components":[40],"sarcoma":[43],"such":[45],"as":[46,60],"TAMs,":[47],"viable":[50],"strategy.":[51],"Here,":[52],"we":[53,98],"investigated":[54],"effect":[56],"PLX3397":[58,69,149,169,190,223],"(pexidartinib)":[59],"potent":[62],"inhibitor":[63],"CSF1":[66,110,154],"receptor":[67],"(CSF1R).":[68],"was":[70],"recently":[71],"approved":[72],"by":[73,100,153],"Food":[75],"Drug":[77],"Administration":[78],"(FDA)":[79],"to":[80,170],"treat":[81],"tenosynovial":[82],"giant":[83],"cell":[84],"reprogram":[87],"TAMs":[88,194],"whose":[89],"infiltration":[90,203],"correlates":[91],"with":[92],"unfavorable":[93],"prognosis":[94],"sarcomas.":[96,240],"First,":[97],"confirmed":[99],"cytokine":[101],"arrays":[102],"tumor-conditioned":[104],"media":[105],"(TCM)":[106],"cytokines":[108],"including":[109],"are":[111],"secreted":[112],"from":[113],"LM8":[114],"osteosarcoma":[115,172,216],"cells":[116,199,207],"NFSa":[118],"fibrosarcoma":[119],"cells.":[120],"The":[121],"TCM,":[122,156],"like":[123],"CSF1,":[124],"stimulated":[125],"ERK1/2":[126],"phosphorylation":[127],"bone":[129,237],"marrow\u2013derived":[130],"(BMDMs),":[132],"polarized":[133],"BMDMs":[134],"toward":[135],"an":[136],"M2":[137,159],"(TAM-like)":[138],"phenotype,":[139],"strikingly":[141],"promoted":[142],"BMDM":[143],"chemotaxis.":[144],"In":[145],"vitro":[146],"administration":[147,167],"suppressed":[150,177],"pERK1/2":[151],"stimulation":[152],"or":[155],"reduced":[158],"polarization,":[160],"chemotaxis":[163],"BMDMs.":[165],"Systemic":[166],"orthotopic":[173],"xenograft":[174],"model":[175],"significantly":[176],"growth":[181],"lung":[183],"metastasis,":[184],"thus":[186],"improved":[187],"metastasis-free":[188],"survival.":[189],"treatment":[191],"concurrently":[192],"depleted":[193],"FOXP3+":[196],"regulatory":[197],"T":[198,206],"and,":[200],"surprisingly,":[201],"enhanced":[202],"CD8+":[205],"into":[208,233],"microenvironments":[210],"both":[212],"metastatic":[215],"sites.":[217],"Our":[218],"preclinical":[219],"results":[220],"show":[221],"has":[224],"strong":[225],"macrophage-":[226],"T-cell\u2013modulating":[228],"effects":[229],"may":[231],"translate":[232],"cancer":[234],"immunotherapy":[235],"for":[236],"soft-tissue":[239]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-03-13T00:00:00"}
