{"id":"https://openalex.org/W4392689770","doi":"https://doi.org/10.1158/2159-8290.c.6546641","title":"Data from Identification of a DNA Damage\u2013Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers","display_name":"Data from Identification of a DNA Damage\u2013Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392689770","doi":"https://doi.org/10.1158/2159-8290.c.6546641"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.c.6546641","doi":"https://doi.org/10.1158/2159-8290.c.6546641","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.c.6546641","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/2159-8290.c.6546641","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115593774","display_name":"Jing Chen","orcid":"https://orcid.org/0009-0005-3472-7704","observed_orcids":["https://orcid.org/0009-0005-3472-7704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060875335","display_name":"John Crutchley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Crutchley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015379338","display_name":"Dadong Zhang","orcid":"https://orcid.org/0000-0001-6419-8886","observed_orcids":["https://orcid.org/0000-0001-6419-8886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dadong Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031078301","display_name":"Kouros Owzar","orcid":"https://orcid.org/0000-0002-3340-1287","observed_orcids":["https://orcid.org/0000-0002-3340-1287","https://orcid.org/0000-0002-4641-786X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kouros Owzar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021559507","display_name":"Michael B. Kastan","orcid":"https://orcid.org/0000-0002-1719-7562","observed_orcids":["https://orcid.org/0000-0002-1719-7562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael B. Kastan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9700000286102295},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9120000004768372},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/smg1","display_name":"SMG1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/rpl26","display_name":"RPL26","score":0.9419999718666077},{"id":"https://openalex.org/keywords/srsf7","display_name":"SRSF7","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.800000011920929},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5659999847412109},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.765389621257782},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7238361239433289},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.7031431198120117},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6801524758338928},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5723822116851807},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5364559292793274},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5361108183860779},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5027272701263428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.490852415561676},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4102054238319397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40186750888824463},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17435216903686523},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.17233121395111084},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.15867429971694946},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.06615185737609863},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.06446531414985657}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2159-8290.c.6546641","doi":"https://doi.org/10.1158/2159-8290.c.6546641","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.c.6546641","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2159-8290.c.6546641.v1","doi":"https://doi.org/10.1158/2159-8290.c.6546641.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6546641.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.c.6546641","doi":"https://doi.org/10.1158/2159-8290.c.6546641","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.c.6546641","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6707000136375427}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2595953303","https://openalex.org/W4324332996","https://openalex.org/W2776815947","https://openalex.org/W3119043121","https://openalex.org/W1990628815","https://openalex.org/W2748017857","https://openalex.org/W2048491334","https://openalex.org/W4361253670","https://openalex.org/W1964129430","https://openalex.org/W4213318023"],"abstract_inverted_index":{"Abstract":[0],"Cellular":[1],"responses":[2],"to":[3,65,85,102,139],"DNA":[4,41],"damage":[5],"are":[6],"critical":[7],"determinants":[8],"of":[9,29,53,63,72,80,96,107,113,119,125,144,155,163,171,178],"cancer":[10],"development":[11],"and":[12,18,39,76,105,133,147],"aging-associated":[13],"pathogenesis.":[14],"Here,":[15],"we":[16],"identify":[17],"characterize":[19],"a":[20,55,66,152],"DNA-damage":[21,176],"response":[22],"(DDR)":[23],"pathway":[24,115,126,158,174],"that":[25,159],"regulates":[26,160],"alternative":[27,161],"splicing":[28,99,162],"numerous":[30],"gene":[31],"products,":[32],"including":[33,166],"the":[34,51,61,78,94,97,156,193],"human":[35,167],"tumor":[36],"suppressor":[37],"TP53,":[38],"controls":[40],"damage\u2013induced":[42],"cellular":[43,145,179],"senescence.":[44],"In":[45,194],"brief,":[46],"ionizing":[47],"radiation":[48],"(IR)":[49],"inhibits":[50],"activity":[52],"SMG1,":[54],"phosphoinositide-3-kinase-like":[56],"kinase":[57],"family":[58],"member,":[59],"reducing":[60],"binding":[62,79],"SMG1":[64],"specific":[67],"region":[68],"near":[69],"exon":[70],"9":[71],"p53":[73,86,103],"precursor":[74],"mRNA":[75],"promoting":[77],"ribosomal":[81],"protein":[82],"L26":[83],"(RPL26)":[84],"pre-mRNA.":[87],"RPL26,":[88],"in":[89,192],"turn,":[90],"is":[91,190],"required":[92],"for":[93],"recruitment":[95],"serine/arginine-rich":[98],"factor":[100],"SRSF7":[101],"pre-mRNA":[104],"generation":[106],"alternatively":[108],"spliced":[109],"p53\u03b2":[110,120,136],"RNA.":[111],"Disruption":[112],"this":[114,172],"via":[116],"selective":[117],"knockout":[118],"by":[121],"CRISPR/Cas9":[122],"or":[123],"downregulation":[124],"constituents":[127],"significantly":[128],"reduces":[129],"IR-induced":[130],"senescence":[131,146,180],"markers,":[132],"cells":[134],"lacking":[135],"expression":[137],"fail":[138],"transcriptionally":[140],"repress":[141],"negative":[142],"regulators":[143],"aging.":[148],"Significance:":[149],"We":[150],"identified":[151],"new":[153],"component":[154],"DDR":[157],"messenger":[164],"RNAs,":[165],"TP53":[168],"mRNA.":[169],"Modulation":[170],"regulatory":[173],"affects":[175],"induction":[177],"markers.":[181],"Cancer":[182],"Discov;":[183],"7(7);":[184],"766\u201381.":[185],"\u00a92017":[186],"AACR.":[187],"This":[188,195],"article":[189],"highlighted":[191],"Issue":[196],"feature,":[197],"p.":[198],"653":[199]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-13T00:00:00"}
