{"id":"https://openalex.org/W4392689623","doi":"https://doi.org/10.1158/1541-7786.c.6540022","title":"Data from HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells","display_name":"Data from HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392689623","doi":"https://doi.org/10.1158/1541-7786.c.6540022"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6540022","doi":"https://doi.org/10.1158/1541-7786.c.6540022","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6540022","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.c.6540022","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086042240","display_name":"Carmella Romeo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmella Romeo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054960373","display_name":"Matthew C. Weber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew C. Weber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101465800","display_name":"Mahsa Zarei","orcid":"https://orcid.org/0000-0002-0554-6163","observed_orcids":["https://orcid.org/0000-0002-0554-6163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahsa Zarei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048685843","display_name":"Danielle DeCicco","orcid":"https://orcid.org/0000-0003-4216-2617","observed_orcids":["https://orcid.org/0000-0003-4216-2617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danielle DeCicco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084946107","display_name":"Saswati N. Chand","orcid":"https://orcid.org/0000-0001-5625-0517","observed_orcids":["https://orcid.org/0000-0001-5625-0517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saswati N. Chand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063963474","display_name":"Angie D. Lobo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angie D. Lobo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067354904","display_name":"Jordan Michael Winter","orcid":"https://orcid.org/0000-0002-5200-6557","observed_orcids":["https://orcid.org/0000-0002-5200-6557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan M. Winter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045501","display_name":"Janet A. Sawicki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet A. Sawicki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005690158","display_name":"Jonathan N. Sachs","orcid":"https://orcid.org/0000-0003-1403-5960","observed_orcids":["https://orcid.org/0000-0003-1403-5960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan N. Sachs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078662144","display_name":"Nicole C. Meisner-Kober","orcid":"https://orcid.org/0000-0003-0912-5902","observed_orcids":["https://orcid.org/0000-0003-0912-5902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Meisner-Kober","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025415933","display_name":"Charles J. Yeo","orcid":"https://orcid.org/0000-0001-8097-0071","observed_orcids":["https://orcid.org/0000-0001-8097-0071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles J. Yeo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039987858","display_name":"Rajanikanth Vadigepalli","orcid":"https://orcid.org/0000-0002-8405-1037","observed_orcids":["https://orcid.org/0000-0002-8405-1037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajanikanth Vadigepalli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055325270","display_name":"Mark L. Tykocinski","orcid":"https://orcid.org/0000-0002-3520-5300","observed_orcids":["https://orcid.org/0000-0002-3520-5300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark L. Tykocinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079398934","display_name":"Jonathan Robert Brody","orcid":"https://orcid.org/0000-0003-3680-3270","observed_orcids":["https://orcid.org/0000-0003-3680-3270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan R. Brody","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hur","display_name":"HuR","score":0.9200000166893005},{"id":"https://openalex.org/keywords/trail-resistance","display_name":"TRAIL resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/death-receptor-4","display_name":"death receptor 4","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dr5","display_name":"DR5","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.597000002861023},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.7070000171661377},{"id":"https://openalex.org/keywords/antiapoptotic-genes","display_name":"anti-apoptotic genes","score":0.6439999938011169},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6657246947288513},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.5300694704055786},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4719618558883667},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4588421583175659},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4478951394557953},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43216168880462646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3975217342376709},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19553691148757935},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14018133282661438},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09848091006278992},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.c.6540022","doi":"https://doi.org/10.1158/1541-7786.c.6540022","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6540022","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6540022","doi":"https://doi.org/10.1158/1541-7786.c.6540022","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6540022","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2320793935","https://openalex.org/W2522633900","https://openalex.org/W2312216093","https://openalex.org/W2887503709","https://openalex.org/W2039644505","https://openalex.org/W4244714530","https://openalex.org/W2146549722","https://openalex.org/W4407250704","https://openalex.org/W2408196705","https://openalex.org/W4409634262"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1],"ductal":[2],"adenocarcinoma":[3],"(PDA)":[4],"is":[5,129],"one":[6],"of":[7,29,139,143,154,182,204,209],"the":[8,122,125,135,180],"most":[9],"lethal":[10],"cancers,":[11],"in":[12,85,91,102,172,190],"part,":[13],"due":[14],"to":[15,17,59,115,124,224],"resistance":[16,70,98,215],"both":[18],"conventional":[19],"and":[20,35,37,53,83,159,164,227],"targeted":[21],"therapeutics.":[22],"TRAIL":[23,52,69,97,110,117,166,174,214],"directly":[24],"induces":[25,118],"apoptosis":[26],"through":[27],"engagement":[28],"cell":[30,94,113,161],"surface":[31,162],"Death":[32],"Receptors":[33],"(DR4":[34],"DR5),":[36],"has":[38],"been":[39],"explored":[40],"as":[41,200,231],"a":[42,67,79,201],"molecular":[43],"target":[44],"for":[45,235],"cancer":[46],"treatment.":[47],"Clinical":[48],"trials":[49],"with":[50,134,146],"recombinant":[51],"DR-targeting":[54],"agents,":[55],"however,":[56],"have":[57],"failed":[58],"show":[60],"overall":[61],"positive":[62],"outcomes.":[63],"Herein,":[64],"we":[65],"identify":[66],"novel":[68],"mechanism":[71,216],"governed":[72],"by":[73,106],"Hu":[74],"antigen":[75],"R":[76],"(HuR,":[77],"ELAV1),":[78],"stress-response":[80],"protein":[81],"abundant":[82],"functional":[84],"PDA":[86,93,104,112,144,184,236],"cells.":[87],"Exogenous":[88],"HuR":[89,101,119,132,220],"overexpression":[90],"TRAIL-sensitive":[92],"lines":[95],"increases":[96,189,222],"whereas":[99],"silencing":[100],"TRAIL-resistant":[103],"cells,":[105],"siRNA":[107],"oligo-transfection,":[108],"decreases":[109],"resistance.":[111,176],"exposure":[114],"soluble":[116],"translocation":[120],"from":[121],"nucleus":[123],"cytoplasm.":[126],"Furthermore,":[127],"it":[128],"demonstrated":[130],"that":[131,218],"interacts":[133],"3\u2032-untranslated":[136],"region":[137],"(UTR)":[138],"DR4":[140,158],"mRNA.":[141],"Pre-treatment":[142],"cells":[145,185],"MS-444":[147],"(Novartis),":[148],"an":[149,210,232],"established":[150],"small":[151],"molecule":[152],"inhibitor":[153],"HuR,":[155],"substantially":[156],"increased":[157],"DR5":[160],"levels":[163],"enhanced":[165],"sensitivity,":[167],"further":[168],"validating":[169],"HuR's":[170,198],"role":[171,199],"affecting":[173],"apoptotic":[175],"NanoString":[177],"analyses":[178],"on":[179],"transcriptome":[181],"TRAIL-exposed":[183],"identified":[186],"global":[187],"HuR-mediated":[188,213],"antiapoptotic":[191],"processes.":[192],"Taken":[193],"together,":[194],"these":[195],"data":[196],"extend":[197],"key":[202],"regulator":[203],"TRAIL-induced":[205],"apoptosis.":[206],"Implications:":[207],"Discovery":[208],"important":[211],"new":[212],"suggests":[217],"tumor-targeted":[219],"inhibition":[221],"sensitivity":[223],"TRAIL-based":[225],"therapeutics":[226],"supports":[228],"their":[229],"re-evaluation":[230],"effective":[233],"treatment":[234],"patients.":[237],"Mol":[238],"Cancer":[239],"Res;":[240],"14(7);":[241],"599\u2013611.":[242],"\u00a92016":[243],"AACR.":[244]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-03-13T00:00:00"}
