{"id":"https://openalex.org/W4392684737","doi":"https://doi.org/10.1158/0008-5472.c.6505226","title":"Data from Multimodal Elucidation of Choline Metabolism in a Murine Glioma Model Using Magnetic Resonance Spectroscopy and 11C-Choline Positron Emission Tomography","display_name":"Data from Multimodal Elucidation of Choline Metabolism in a Murine Glioma Model Using Magnetic Resonance Spectroscopy and 11C-Choline Positron Emission Tomography","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392684737","doi":"https://doi.org/10.1158/0008-5472.c.6505226"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6505226","doi":"https://doi.org/10.1158/0008-5472.c.6505226","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6505226","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6505226","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019683699","display_name":"Hans F. Wehrl","orcid":"https://orcid.org/0000-0003-4692-3209","observed_orcids":["https://orcid.org/0000-0003-4692-3209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans F. Wehrl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Julian Schwab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julian Schwab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085497578","display_name":"Kathy Hasenbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathy Hasenbach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004578739","display_name":"Gerald Reischl","orcid":"https://orcid.org/0000-0003-3961-116X","observed_orcids":["https://orcid.org/0000-0003-3961-116X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald Reischl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091648075","display_name":"Ghazaleh Tabatabai","orcid":"https://orcid.org/0000-0002-3542-8782","observed_orcids":["https://orcid.org/0000-0002-3542-8782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ghazaleh Tabatabai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029333060","display_name":"Leticia Quintanilla\u2010Mart\u00ednez","orcid":"https://orcid.org/0000-0001-7156-5365","observed_orcids":["https://orcid.org/0000-0001-7156-5365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leticia Quintanilla-Martinez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005797516","display_name":"Filip J\u00edr\u016f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Filip Jiru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089484227","display_name":"Kamila Chughtai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamila Chughtai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Andras Kiss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andras Kiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031200903","display_name":"Funda Cay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Funda Cay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027912902","display_name":"Daniel Bukala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Bukala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057609112","display_name":"Ron M. A. Heeren","orcid":"https://orcid.org/0000-0002-6533-7179","observed_orcids":["https://orcid.org/0000-0002-6533-7179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ron M.A. Heeren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018788118","display_name":"Bernd J\u00fcrgen Pichler","orcid":"https://orcid.org/0000-0001-6784-5524","observed_orcids":["https://orcid.org/0000-0001-6784-5524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernd J. Pichler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087787477","display_name":"Alexander Walter Sauter","orcid":"https://orcid.org/0000-0002-6707-2258","observed_orcids":["https://orcid.org/0000-0002-6707-2258"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander W. Sauter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.7627000212669373,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.7627000212669373,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.05380000174045563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choline-metabolism","display_name":"choline metabolism","score":1.0},{"id":"https://openalex.org/keywords/11c-choline-pet","display_name":"11C-choline PET","score":0.9330000281333923},{"id":"https://openalex.org/keywords/magnetic-resonance-spectroscopic-imaging","display_name":"magnetic resonance spectroscopic imaging","score":0.7919999957084656},{"id":"https://openalex.org/keywords/total-choline","display_name":"total choline","score":0.8690000176429749},{"id":"https://openalex.org/keywords/astrocytoma","display_name":"astrocytoma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.4410000145435333},{"id":"https://openalex.org/keywords/tumor-to-brain-ratio","display_name":"tumor-to-brain ratio","score":0.7900000214576721},{"id":"https://openalex.org/keywords/gliosis","display_name":"gliosis","score":0.6809999942779541},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/choline-transporter","display_name":"choline transporter","score":0.6669999957084656},{"id":"https://openalex.org/keywords/multimodal-imaging","display_name":"multimodal imaging","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.8689319491386414},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.7382618188858032},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.5760753154754639},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.56996089220047},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.546161413192749},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5125893950462341},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.48533955216407776},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.41079437732696533},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39514148235321045},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.38488417863845825},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3773972690105438},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.33324041962623596},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.23703411221504211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21654465794563293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20622462034225464},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.09711834788322449},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6505226","doi":"https://doi.org/10.1158/0008-5472.c.6505226","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6505226","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6505226.v1","doi":"https://doi.org/10.1158/0008-5472.c.6505226.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6505226.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6505226","doi":"https://doi.org/10.1158/0008-5472.c.6505226","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6505226","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131767985","https://openalex.org/W2317458974","https://openalex.org/W1524965019","https://openalex.org/W2792381525","https://openalex.org/W2014049657","https://openalex.org/W2011829617","https://openalex.org/W2339988230","https://openalex.org/W2993283808","https://openalex.org/W1990741416","https://openalex.org/W1623087599"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"metabolites,":[2],"transporters,":[3],"and":[4,43,90,100,106,125,131,140,159,171,188,207,223,240],"enzymes":[5],"involved":[6],"in":[7,17,24,97,128,143,151,195,217,245],"choline":[8,41,141],"metabolism":[9],"are":[10],"regarded":[11],"as":[12,219],"biomarkers":[13],"for":[14,154,211,242],"disease":[15],"progression":[16],"a":[18,119,132,164,176,212],"variety":[19],"of":[20,156,234,237],"cancers,":[21],"but":[22,53],"their":[23],"vivo":[25],"detection":[26],"is":[27],"not":[28,56,183],"ideal.":[29],"Both":[30],"magnetic":[31],"resonance":[32],"spectroscopy":[33],"[MRS":[34],"using":[35,86],"chemical":[36],"shift":[37],"imaging":[38,89,243],"(CSI)":[39],"total":[40],"(tCho)]":[42],"11C-choline":[44,101,172,186,204],"positron":[45],"emission":[46],"tomography":[47],"(PET)":[48],"can":[49],"probe":[50],"this":[51,63],"pathway,":[52],"they":[54],"have":[55],"been":[57],"compared":[58],"side":[59],"by":[60,221],"side.":[61],"In":[62],"study,":[64],"we":[65],"used":[66],"the":[67,123,129,136,144,157,235],"spontaneous":[68],"murine":[69],"astrocytoma":[70],"model":[71],"SMA560":[72],"injected":[73],"intracranially":[74],"into":[75],"syngeneic":[76],"VM/Dk":[77],"mice,":[78],"analyzing":[79],"animals":[80],"at":[81,112],"various":[82],"postimplantation":[83],"time":[84],"points":[85],"dynamic":[87],"microPET":[88],"CSI":[91,170,181],"MRS.":[92],"We":[93,117],"observed":[94],"an":[95,202],"increase":[96],"tumor":[98,130,199],"volume":[99],"uptake":[102,142],"between":[103,122,135,169],"days":[104,113],"5":[105,114],"18.":[107,116],"Similarly,":[108],"tCho":[109,124,137,215],"levels":[110,153],"decreased":[111],"to":[115,192],"found":[118,168],"negative":[120,177],"correlation":[121,134,178],"PET":[126,173,187,241],"results":[127,147],"positive":[133],"tumor-to-brain":[138],"ratio":[139],"tumor.":[145],"PCR":[146],"confirmed":[148],"expected":[149],"increases":[150],"expression":[152],"most":[155],"transporters":[158],"enzymes.":[160],"Using":[161],"MRS":[162,189],"quantification,":[163],"good":[165],"agreement":[166],"was":[167,182],"data,":[174],"whereas":[175],"occurred":[179],"when":[180],"referenced.":[184],"Thus,":[185],"methods":[190],"seemed":[191],"be":[193],"complementary":[194],"strengths.":[196],"While":[197],"advancing":[198],"proliferation":[200],"caused":[201],"increasing":[203],"uptake,":[205],"gliosis":[206],"inflammation":[208],"potentially":[209],"accounted":[210],"high":[213],"peritumoral":[214],"signal":[216],"CSI,":[218,239],"supported":[220],"histology":[222],"secondary":[224],"ion":[225],"mass":[226],"spectrometry":[227],"imaging.":[228],"Our":[229],"findings":[230],"provide":[231],"definitive":[232],"evidence":[233],"use":[236],"MRS,":[238],"tumors":[244],"vivo.":[246],"Cancer":[247],"Res;":[248],"73(5);":[249],"1470\u201380.":[250],"\u00a92012":[251],"AACR.":[252]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-13T00:00:00"}